Atletico Madrid suffered their first major setback of the season as they lost 2-0 at Celta Vigo after defender Stefan Savic was sent off midway through a miserable second-half performance by Diego Simeone's side on Saturday.
Radja Nainggolan scored on his delayed Inter Milan debut to set them on the way to their first win of the season on Saturday as they beat Bologna 3-0 away in Serie A.
Kylian Mbappe scored a brilliant late goal before being sent off at the end of Paris Saint-Germain's pulsating 4-2 win at Nimes on Saturday.
Chelsea stretched their perfect Premier League start to four games after second-half goals from substitute Pedro and Eden Hazard gave them a 2-0 home win over Bournemouth on Saturday.
Sadio Mane and Roberto Firmino scored in the first half as Liverpool won their first four Premier League games for the first time with a 2-1 victory over Leicester City on Saturday at the King Power Stadium.
A late stoppage-time goal by substitute Patrick Cutrone gave AC Milan a 2-1 home win over Roma in an electrifying Serie A clash on Friday and eased the pressure on manager Gennaro Gattuso.
Striker Allan Saint-Maximin's powerful deflected shot gave struggling Nice a shock 1-0 away win over Olympique Lyonnais on Friday as Patrick Viera's side earned their first victory in Ligue 1 this season.
Borussia Dortmund twice hit the woodwork but could not score in their first-ever goalless Bundesliga draw against Hannover 96 on Friday.
Burnley's European adventure came to an end on Friday as the Premier League side crashed out of the Europa League playoff round with a 1-1 draw against Olympiakos.
Liverpool will host Chelsea while Frank Lampard's Derby County will visit Manchester United following the third-round draw for the Carabao Cup held on Thursday.
Juventus will face Manchester United in the Champions League group stage this season, giving Cristiano Ronaldo a chance to play against his former team.
A thrilling draw away to Salzburg enabled Serbian champions Red Star Belgrade to reach the Champions League group stage for the first time where they will be joined by Portugal's Benfica and Dutch side PSV Eindhoven.
Four-time European champion Ajax qualified for the Champions League group stage on Tuesday for the first time in four years, while AEK Athens and Young Boys Bern ended even longer absences.
Tottenham piled on more woe for Manchester United, running out 3-0 winners at Old Trafford on Monday night to hand the hosts a second Premier League defeat in as many weeks.
A second-half double from Karim Benzema helped Real Madrid to a 4-1 victory at Girona on Sunday and maintain their perfect La Liga start in the post-Cristiano Ronaldo era.
Inter seemed to be in absolute control, but fumbled a 2-0 lead and risked losing the game against a plucky Torino.
Borussia Dortmund eased past RB Leipzig 4-1 on Sunday after coming from a goal down, to make a winning Bundesliga start under new coach Lucien Favre and confirm their status as pre-season title contenders.
Chelsea left it late but came away with a 2-1 win over Newcastle thanks to a late DeAndre Yedlin own goal St James' Park on Sunday.
Bordeaux, without a permanent coach after a tumultuous start to the season, missed a late penalty but then scored in stoppage time to beat Monaco 2-1 and claim their first Ligue 1 points of the season on Sunday.
Unfancied Watford continued their great start to the Premier League season with a third successive win when they beat visiting Crystal Palace 2-1 on Sunday.
A last-minute VAR decision helped Barcelona secure an unconvincing 1-0 La Liga win over newly-promoted Valladolid on Saturday.
Dries Mertens came off the bench to grab the winner as Napoli rallied from 2-0 down to beat visiting AC Milan 3-2 and seize a second victory in two matches.
Mohamed Salah's 23rd-minute strike was enough to earn Liverpool a 1-0 win over a dogged Brighton and Hove Albion and give them an early top spot in the Premier League with three wins out of three.
Antoine Griezmann's second-half strike earned Atletico Madrid a first win of the Liga season on Saturday as they defeated local rivals Rayo Vallecano 1-0.
Cristiano Ronaldo missed an open goal but inadvertently provided an assist for Mario Mandzukic to score as titleholders Juventus beat Lazio 2-0 in Serie A on Saturday.
Paris Saint-Germain forward Edinson Cavani struck 12 minutes into his first match of the season while Kylian Mbappe and Neymar also scored in a 3-1 win over lowly Angers in Ligue 1 on Saturday.
Arsenal celebrated their first Premier League win of the season under new manager Unai Emery after coming from behind to beat London rivals West Ham United 3-1 in an action-packed match on Saturday.
VfL Wolfsburg's Daniel Ginczek snatched a stoppage-time winner to stun Schalke 04 2-1 on Saturday and give the Wolves a winning start to the Bundesliga campaign against last season's runners-up in a bad-tempered game.
Manchester City stumbled to a 1-1 draw at Wolves in a tense lunchtime encounter at Molineux.
Robert Lewandowski scored a penalty at the second time of asking to lift Bayern Munich to a 3-1 win over Hoffenheim to open the Bundesliga season on Friday night.
Manchester United will face Paris Saint-Germain in the Champions League round of 16, while Liverpool have been drawn against Bayern Munich.
Manchester City battled back to winning ways, coming from a goal down to overwhelm Hoffenheim 2-1 in the Champions League with a brilliant Leroy Sane double that ensured they progressed to the last-16 as winners of Group F on Wednesday.
Manchester United endured an undignified end to their topsy-turvy Champions League group stage campaign by losing 2-1 at already-eliminated Valencia on Wednesday and missing their chance of topping Group H.
Olympique Lyonnais earned the point they required to book their place in the Champions League last 16 but needed Nabil Fekir's equaliser 20 minutes into the second half to salvage a 1-1 draw away to Shakhtar Donetsk.
Two goals from striker Guillaume Hoarau led Young Boys to a shock 2-1 Champions League win over already-qualified Juventus on Wednesday to hand the Serie A side their first away defeat in a competitive match for over a year.
Striker Robert Lewandowski scored twice as Bayern Munich sealed top spot in Group E following a thrilling 3-3 Champions League draw at Ajax in which both sides ended with 10 men.
Benfica finished its Champions League campaign with a 1-0 win over AEK Athens on Wednesday.
Real Madrid suffered their heaviest ever home defeat in Europe on Wednesday when the already-qualified Spaniards were thumped 3-0 at the Santiago Bernabeu by CSKA Moscow in the Champions League.
Viktoria Plzen beat struggling Roma 2-1 in the Champions League on Wednesday to earn a Europa League spot.
Tottenham Hotspur made it into the round of 16 of the Champions League, coming from behind to grab a 1-1 draw at Barcelona on Tuesday which saw them finish second in Group B at the expense of Inter Milan.
Paris Saint-Germain reached the round of 16 of the Champions League on Tuesday thanks to an inspired performance by their three-pronged attack of Neymar, Edinson Cavani and Kylian Mbappe in a 4-1 win at Red Star Belgrade.
Inter Milan were knocked out of the Champions League after they could only manage a 1-1 draw at home to Group B's bottom club PSV Eindhoven on Tuesday to finish third behind Tottenham Hotspur.
Mohamed Salah's first-half strike gave Liverpool a 1-0 win over Napoli in Champions League Group C action on Tuesday.
An under-strength Borussia Dortmund deepened AS Monaco's season-long misery on Tuesday with a 2-0 away victory that ensured they finished top of Champions League Group A ahead of Atletico Madrid.
Atletico Madrid were denied top place in Group A of the Champions League on Tuesday after a goalless draw away at Club Brugge in Belgium meant they finished second behind Borussia Dortmund.
Alessandro Schoepf's stoppage time goal gave Schalke 04 a 1-0 win over Lokomotiv Moscow in Champions League Group D action on Tuesday.
Porto struggled to a 3-2 away victory over Galatasaray in their final Champions League group match on Tuesday but the Turks stayed third in Group D and secured a spot in the Europa League's round of 32.
Real Madrid midfielder Luka Modric has ended the Cristiano Ronaldo-Lionel Messi stranglehold on the Ballon d'Or.
Two first-half goals gave Paris Saint-Germain a crucial 2-1 Champions League home win over Liverpool, putting them in a great position to qualify and leaving Jurgen Klopp's side, finalists last season, in danger of elimination.
Napoli swept aside Red Star Belgrade with a typically entertaining performance as two goals from Dries Mertens helped them to a 3-1 win over the former European champions in their Champions League match on Wednesday.
Borussia Dortmund booked their spot in the Champions League knockout stage with a game to spare after a goalless draw against visitors Club Brugge in Group A on Wednesday.
Christian Eriksen kept Tottenham Hotspur's hopes of reaching the round of 16 in the Champions League alive when he came off the bench to score a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
Lionel Messi scored an excellent individual goal and laid on another as Barcelona beat PSV Eindhoven 2-1 to secure top spot in Champions League Group B on Wednesday.
Atletico Madrid clinched their place in the Champions League round of 16 on Wednesday by beating AS Monaco 2-0 at home while also ensuring that Thierry Henry's hapless visitors will now even miss out on qualification for the Europa League.
A goal in each half was enough for Lokomotiv Moscow to earn a 2-0 win over Galatasaray in Champions League Group D on Wednesday, ending Galatasaray's hopes of qualifying for the knockout stages and sending both Porto and Schalke through.
Juventus clinched a place in the Champions League knockout stages when a brilliant Cristiano Ronaldo assist set up Mario Mandzukic to give them a 1-0 win over Valencia on Tuesday.
Manchester United's Marouane Fellaini struck a controversial stoppage-time winner to bring blessed relief to Old Trafford after a laboured 1-0 win over Young Boys edged them into the Champions League last 16 on Tuesday.
Manchester City progressed to the knockout stages of the Champions League after twice coming from behind to draw 2-2 with Olympique Lyonnais in Group F on Tuesday.
Bayern Munich's Arjen Robben and Robert Lewandowski scored two goals each as the German champions demolished Benfica 5-1 on Tuesday to reach the Champions League round of 16 and lift some of the pressure off boss Niko Kovac.
Real Madrid secured first place in Champions League Group G with 2-0 victory over Roma at the Stadio Olimpico on Tuesday although the Italians are also through to round of 16.