Lionel Messi is one goal shy of 500 career goals and aims to hit that milestone against Real Madrid in El Clasico.
Gary Neville has been sacked by Valencia after less than four months in charge, with former coach Pako Ayestaran taking charge until the end of the season.
Barcelona missed out on the chance to go 11 points clear at the top of the Primera Division as they squandered a two-goal advantage in a 2-2 draw at Villarreal.
Cristiano Ronaldo scored and missed a penalty as Real Madrid cut the gap to neighbours Atletico in second place in the Primera Division to a single point by thrashing Sevilla 4-0 at the Bernabeu.
Atletico Madrid stumbled in their pursuit of Barcelona for the Liga title after conceding two late goals to lose at relegation-threatened Sporting Gijon 2-1 on Saturday.
Brazilian midfielder Casemiro's late header gave Real Madrid a 2-1 victory at Las Palmas where Sergio Ramos was sent off for the 20th time in his career.
Yevhen Konoplyanka scored a brilliant long-range goal as Sevilla beat Villarreal 4-2 win in a thrilling game to keep Unai Emery's side's hopes of a top-four finish alive.
Antoine Griezmann fired his 23rd goal of the season as Atletico Madrid kept the gap to leaders Barcelona to eight points with a comfortable 3-0 home win against Deportivo La Coruna.
Lionel Messi created three goals and scored another as Barcelona warmed up for their Champions League showdown with Arsenal by thrashing Getafe 6-0 at the Camp Nou to equal a club record 12 consecutive La Liga wins.
Two inspirational substitutions from Diego Simeone helped give Atletico Madrid a 3-1 win at Valencia that keeps the Rojiblancos within eight points of Primera Division leaders Barcelona.
A mesmeric performance from Lionel Messi ensured Barcelona barely noticed the absence of Neymar as they eased to a 4-0 win at Eibar.
Cristiano Ronaldo returned to the top of the Primera Division scoring charts by grabbing four goals in the second half as Real Madrid thrashed Celta Vigo 7-1 at the Bernabeu.
Las Palmas took another step towards Primera Division survival by unexpectedly beating Champions League hopefuls Villarreal 1-0 to record a third consecutive victory.
Lionel Messi scored a third hat trick of the season as Barcelona smashed nine-man Rayo Vallecano 5-1 and recorded a tenth straight league win.
A depleted Real Madrid side failed to produce a galvanising performance at Levante following their derby defeat to Atletico Madrid but still earned a 3-1 win.
Atletico Madrid built on their Madrid derby triumph by comfortably beating Real Sociedad 3-0 at the Vicente Calderon to record their biggest home league win of the season.
Goals from Lionel Messi and Gerard Pique saw Barcelona come from behind to beat Sevilla 2-1 at the Nou Camp and equal a Spanish record of 34 games without defeat in all competitions.
Villarreal tightened their grip on a place in the Champions League and moved just two points behind Real Madrid with a comprehensive 3-0 win over 10-man Levante.
Zinedine Zidane suffered his first defeat as Real Madrid coach as Antoine Griezmann gave local rivals Atletico Madrid a 1-0 victory at the Bernabeu.
Cristiano Ronaldo missed a penalty as Real Madrid slipped even further behind leaders Barcelona in the Primera Division title race by drawing 1-1 at Malaga.
Atletico Madrid's hopes of catching Primera Division leaders Barcelona suffered a setback on Sunday evening as they were held to a 0-0 draw by Villarreal at the Vicente Calderon.
Barcelona survived a late onslaught to beat Las Palmas and remain in the driving seat at the top of the Primera Division.
Lionel Messi passed 300 Primera Division goals as Barcelona extended their lead at the top to six points with a 3-1 victory over Sporting Gijon.
Luis Suarez finished off a collector's item from the penalty spot to score a hat trick as Barcelona hammered Celta Vigo 6-1 with a majestic second-half display.
Fernando Torres scored in consecutive matches for the first time in almost two and a half years as Atletico Madrid edged past Getafe to leapfrog rivals Real Madrid into second place in the Primera Division.
Sevilla boosted their chances of European qualification as they stretched their unbeaten run to 12 matches with a hard-fought 2-0 victory over Las Palmas at the Ramon Sanchez Pizjuan Stadium.
Cristiano Ronaldo scored twice as Real Madrid kept up the pressure on Primera Division title rivals Barcelona and Atletico Madrid with a 4-2 victory over Athletic Bilbao.
Villarreal's top-four hopes remain on track after Roberto Soldado's early goal earned them a 1-0 Primera Division win over Malaga.
Gary Neville ended his long wait for a first La Liga win as Valencia coach as late goals from Alvaro Negredo and Denis Cheryshev helped his side come from behind to beat Espanyol 2-1.
Gary Neville experienced yet more frustration as a late goal from teenager Wilfrid Kaptoum denied Valencia a much-needed win over Barcelona's reserves in the Copa del Rey.
Gareth Bale scored an early winner as Real Madrid won 1-0 away to a spirited Huesca and moved up to fourth in La Liga, five points behind leaders Barcelona.
Atletico Madrid moved into provisional second place in La Liga with a 3-0 win over fourth-placed Alaves on Saturday to join leaders Barcelona on 28 points.
Lionel Messi scored two spectacular free kicks as Barcelona thrashed local rivals Espanyol 4-0 in Saturday's Catalan derby to move three points clear at the top of La Liga.
Real Madrid trounced third division side Melilla 6-1 in a Copa del Rey round of 32 second leg on Thursday, completing a 10-1 aggregate victory, to ease into the round of 16 of the competition.
Denis Suarez struck twice for Copa del Rey holders Barcelona as they thrashed Cultural Leonesa 4-1 on Wednesday to progress to the round of 16 with a 5-1 aggregate victory.
A second-half salvo from Atletico Madrid helped them sweep past Sant Andreu 4-0 on Wednesday and into the Copa del Rey round of 16 5-0 on aggregate.
Champions Barcelona overcame a dogged Villarreal side to win 2-0 at home on Sunday, with goals from stalwart defender Gerard Pique and youngster Carles Alena, to provisionally return to the top of La Liga.
Atletico Madrid's La Liga title ambitions suffered a setback on Sunday as they drew 1-1 away at Girona, only averting a first league defeat since September thanks to a late own goal by Jonas Ramalho.
Real Madrid produced another unconvincing display on Saturday but rode their luck to earn a 2-0 win at home to Valencia which allowed them to climb to fifth in the La Liga standings and soothe their recent troubles.
Sevilla leapfrogged Barcelona and Atletico Madrid to go top of La Liga after they beat Real Valladolid 1-0 at the Estadio Sanchez Pizjuan.
Ousmane Dembele's 90th-minute strike rescued Barcelona a point at Atletico Madrid in a 1-1 draw on Saturday that kept the Catalans top of La Liga.
Santiago Solari was handed a nightmare start as permanent Real Madrid manager after his side lost 3-0 at Eibar.
Real Madrid announced on Tuesday that interim manager Santiago Solari has signed a contract to make him the permanent coach of the club until 2021.
Real Madrid notched a fourth straight win under interim coach Santiago Solari by winning 4-2 at Celta Vigo on Sunday to move to within four points of La Liga leaders Barcelona.
Lionel Messi scored twice on his return to action following a broken arm but could not stop Barcelona suffering a surprise defeat at home to Real Betis.
Atletico Madrid twice came from behind to pull off a thrilling 3-2 win at home to Athletic Bilbao on Saturday, completing their comeback with a stoppage-time header from limping captain Diego Godin.
Sevilla failed to capitalise on a weekend of slip-ups for La Liga's chasing pack when they were held to a goalless draw away to Real Sociedad on Sunday, opening up a four-point gap behind leaders and champions Barcelona.
Late goals from Ousmane Dembele and Luis Suarez earned La Liga champions Barcelona a 3-2 win at struggling Rayo Vallecano on Saturday to keep them clear at the top of the standings.
Atletico Madrid threw away the chance to go top of La Liga by conceding a late equaliser to draw 1-1 away to neighbours Leganes on Saturday as their miserable run at the Madrid minnows dragged on.
Real Madrid ended their long wait for a La Liga victory by beating Real Valladolid 2-0 on Saturday with two late goals in interim coach Santiago Solari's first home game in charge of the struggling European champions.
Holders Barcelona scraped a 1-0 win at third-tier Cultural Leonesa thanks to Clement Lenglet's late header in their Copa del Rey first-leg match.
Santiago Solari got off to the perfect start as Real Madrid's interim coach when his side thrashed Melilla 4-0 in the Copa del Rey on Wednesday.
Real Madrid have sacked Julen Lopetegui after just four months in charge, with the ex-Spain coach paying the price following Sunday's 5-1 humiliation against Barcelona in El Clasico.
Barcelona forward Luis Suarez scored a hat-trick as his side thrashed arch-rivals Real Madrid 5-1 on Sunday in a highly entertaining Clasico which surely will signal the end of hapless coach Julen Lopetegui's spell in charge of Real.
Atletico Madrid climbed to the top of La Liga with a comfortable 2-0 win at home to Real Sociedad on Saturday, easing the pain of their humbling 4-0 defeat at Borussia Dortmund in the Champions League in midweek.
Barcelona moved back to the top of the La Liga table with their 4-2 win over Sevilla on Saturday night, but saw Lionel Messi exit early with a right arm injury.
Struggling Villarreal derailed Atletico Madrid's hopes of taking top spot in La Liga with a 1-1 draw at home on Saturday and were unfortunate not to win the game after squandering a number of chances in the second half.
Real Madrid narrowly avoided setting a new club-record goal drought as they fell to their fourth defeat in five games with a 2-1 defeat to Levante at the Bernabeu.
Champions Barcelona's domestic strife continued as they were held to a 1-1 draw at Valencia in an absorbing La Liga game on Sunday, with Lionel Messi again coming to their rescue by equalising with an 11th goal in 10 games this season.
Atletico Madrid defeated Real Betis 1-0 in a tight game on Sunday through a second-half strike from forward Angel Correa as coach Diego Simeone's substitutions paid off.