Jurgen Klopp's Liverpool will take on Villarreal for a place in the final of the Europa League.
Sevilla remain on course for a third successive Europa League title after securing a dramatic 5-4 penalty shootout victory over Athletic Bilbao in the quarterfinals at the Estadio Ramon Sanchez Pizjuan.
Cedric Bakambu scored twice as Villarreal glided to a 4-2 win at Sparta Prague to advance 6-3 on aggregate.
Captain Darijo Srna toasted breaking Shakhtar Donetsk's all-time appearance record by blasting the penalty that sent the Ukrainians into the Europa League semi-finals.
Liverpool incredibly stormed into the Europa League semifinals 5-4 on aggregate after an improbable 4-3 defeat of Borussia Dortmund in their second leg tie on Thursday at Anfield.
Substitute Vicente Iborra struck seven minutes from time to keep Sevilla on course for a third straight UEFA Europa League title after a 2-1 win at Athletic Bilbao.
Liverpool striker Divock Origi fully justified his manager's faith with a vital away goal against Borussia Dortmund and a 1-1 draw on Jurgen Klopp's homecoming that kept everyone happy.
Shakhtar Donetsk soaked up pressure from Braga and then scored in either half to take a 2-1 away win in the first leg of their Europa League quarterfinal.
The in-form Cedric Bakambu scored twice as Villarreal took a 2-1 first-leg lead in their Europa League quarterfinal against Sparta Prague.
Liverpool will face Borussia Dortmund in the Europa League quarterfinals in a clash that sees Jurgen Klopp come up against his former club.
Philippe Coutinho's moment of brilliance extinguished Manchester United's faint hopes and saw Liverpool through to the Europa League quarter-finals.
Tottenham were left to focus fully on their Premier League title challenge as Mauricio Pochettino's side bowed of the Europa League last 16 following a 2-1 defeat to Borussia Dortmund.
Villarreal shut out Bayer Leverkusen to book their place in the quarterfinals of the Europa League.
Aritz Aduriz struck late on as Athletic Bilbao edged past Gary Neville's Valencia on away goals to reach the Europa League quarterfinals.
Sparta Prague produced a brilliant first-half performance to thrash Lazio 3-0 and advance to the quarterfinals of the Europa League on Thursday.
Europa League holders Sevilla coasted into the quarterfinals with a 3-0 win over Basel at Ramon Sanchez Pizjuan Stadium.
Liverpool drew first blood against Manchester United with a 2-0 win at Anfield in the first leg of their Europa League last-16 clash.
Tottenham were given a lesson in the demands of top-level European football as Borussia Dortmund blew Mauricio Pochettino's men away with an emphatic 3-0 victory in the Europa League last 16.
Cedric Bakambu scored in either half to give Villarreal a 2-0 victory over Bayer Leverkusen and leave them in charge of their Europa League last-16 tie.
Sparta Prague and Lazio could not be split in a 1-1 draw in the first leg of their Europa League last-16 clash.
Shakhtar Donetsk kept their Europa League dreams alive with a 3-1 win over Anderlecht in the last-16 clash on Thursday evening.
Marcus Rashford was the unlikely hero in Manchester United's make-or-break clash with FC Midtjylland, marking an unexpected debut with a dream brace that saw Louis van Gaal's men through a tricky Europa League tie.
Tomas Pina's fortuitous second-half goal saw favourites Napoli crash out of the Europa League after a 1-1 draw against Villarreal.
Tottenham proved themselves capable of coping without Harry Kane as they sailed into the last 16 of the Europa League with a 3-0 win over Fiorentina.
Liverpool scraped past Augsburg and into the last 16 of the Europa League after a nervy 1-0 win at Anfield.
Borussia Dortmund recorded their fifth straight win in all competitions by defeating Porto 1-0 at the Estadio do Dragao to advance beyond the Europa League's last 32.
Manchester United's chances of progressing in the Europa League are in the balance after they threw away the lead to go down 2-1 at FC Midtjylland in the first leg of their Europa League last-32 tie.
Tottenham remain in the hunt for three trophies this season after leaving Italy with a hard-fought draw in their Europa League round of 32 tie against Fiorentina.
Goals from Lukasz Piszczek and Marco Reus handed Borussia Dortmund a 2-0 victory over Porto in the first leg of their Europa League last-32 tie.
Galatasaray and Lazio played out a 1-1 draw in the first leg of their Europa League last-32 clash in Istanbul.
Arsenal will face Belarusian side BATE Borisov in the Europa League round of 32, while Chelsea have been drawn against Sweden's Malmo.
Alexandre Lacazette's first-half goal gave Arsenal a 1-0 win over FK Qarabag in Europa League Group E action on Thursday.
Olympiakos pulled off a stunning 3-1 Europa League win over AC Milan that put them into the round of 32 and sent the Italians crashing out as the remaining places in the knockout stage were decided on Thursday.
Table-toppers Chelsea drew 2-2 at Vidi in their final Group L in the Europa League on Thursday.
Chelsea made it five wins in five tries in the Europa League with a convincing 4-0 win against 10-man PAOK at Stamford Bridge on Thursday.
Arsenal maintained their three-point lead atop Europa League Group E on Thursday with a 3-0 win against Vorskla.
AC Milan came from behind before stepping on the gas to pull away from F91 Dudelange for a 5-2 Europa League win on Thursday.
Arsenal qualified for the Europa League knockout stage with a 0-0 draw against Sporting at The Emirates, although striker Danny Welbeck was carried off on a stretcher in the first half with a serious ankle injury.
AC Milan and Real Betis took a step towards qualifying for the Europa League knockout stage with a 1-1 draw in Group F on Thursday.
Olivier Giroud ended his drought by scoring the only goal as Chelsea won 1-0 at BATE Borisov on Thursday to clinch a place in the knockout stage of the Europa League with two group games to spare.
Arsenal and Chelsea were among seven teams to reach the Europa League knockout stage on Thursday, while last year's runners-up Olympique de Marseille were eliminated at the group phase.
Ruben Loftus-Cheek scored three goals as Chelsea dispatched BATE Borisov 3-1 in Europa League action on Thursday.
Real Betis stunned AC Milan with a 2-1 win at the San Siro in Europa League group play on Thursday.
Danny Welbeck's goal in the 77th minute was enough for Arsenal to get a 1-0 win over Sporting CP in Europa League action on Thursday.
Sevilla suffered a shock defeat by Russians Krasnodar, going down 2-1 in Europa League Group J.
Ten-man Celtic threw away an early lead to succumb to a 3-1 defeat to Red Bull Salzburg in Austria.
Alvaro Morata provided the lone goal in Chelsea's 1-0 win over Vidi in Europa League group-stage action on Thursday.
Emile Smith Rowe scored his first career goal in Arsenal's 3-0 win over FK Qarabag in Europa League group-stage action on Thursday.
Substitute Patrick Cutrone netted twice in nine minutes to lift AC Milan to a 3-1 comeback win at home to Olympiakos in Europa League group-stage action.
Arsenal's superb form continued into the Europa League as they thrashed Ukrainian side Vorksla Poltava 4-2 on Thursday.
Gonzalo Higuain's deflected effort in the 59th minute sealed a 1-0 victory for AC Milan over Luxembourg side F91 Dudelange on Thursday night in Europa League action.
Chelsea's Europa League campaign kicked off in style with a 1-0 win at PAOK Salonika on Thursday.
Leigh Griffiths made the difference for Celtic in their Europa League opener, coming off the bench to score a late winner against Rosenborg.
Burnley's European adventure came to an end on Friday as the Premier League side crashed out of the Europa League playoff round with a 1-1 draw against Olympiakos.
Celtic were held to a 1-1 draw by Lithuanian side Suduva Marijampole in the first leg of their Europa League play-off at the ARVI Futbolo Arena.
Antoine Griezmann struck twice as Atletico Madrid powered past Marseille to lift their third Europa League title in nine years.
Atletico Madrid advanced to the Europe League final 2-1 on aggregate after a 1-0 victory over Arsenal at the Wanda Metropolitano on Thursday.
Marseille scored a dramatic extra-time decider against Red Bull Salzburg to earn a Europa League final showdown with Atletico Madrid in Lyon on May 16.
If Arsene Wenger's Arsenal finale is to be a Europa League final in Lyon his side will have to do it the hard way after surrendering a well-deserved lead to draw against 10-man Atletico Madrid in the first leg of their semi-final.
Florian Thauvin put Marseille within touching distance of a place in the UEFA Europa League final with a controversial opener as his side beat Red Bull Salzburg 2-0 at the Stade Velodrome.