Olivier Giroud inspired Arsenal to complete a Champions League group stage comeback as his hat trick at Olympiakos sealed their place in the last 16.
Bayer Leverkusen could not find a winner against Barcelona as their final Champions League Group E match ended 1-1, which saw the German side fail to qualify for the last 16 and drop into the Europa League.
Robert Lewandowski notched a quickfire brace as Bayern Munich rounded off their Champions League Group F fixtures with a 2-0 win at Dinamo Zagreb.
Gent beat Group H winners Zenit St Petersburg 2-1 at Ghelamco Arena to become the first Belgian club to get through to the knockout stages of the Champions League in 15 years.
Gary Neville watched his Valencia team slide into the Europa League after his Mestalla debut saw Lyon claim a 2-0 Champions League victory.
Denys Garmash's goal was enough to give Dynamo Kiev a 1-0 win over Maccabi Tel Aviv and send them through to the knockout stages of the Champions League.
Roma squeezed through to the Champions League last 16 after being held to a 0-0 draw at home by BATE Borisov in their final Group E game.
CSKA Moscow were unable to pull off a shock win over PSV Eindhoven, and United now face the prospect of playing Europa League football in the new year.
Sevilla will try to defend their Europa League crown after a 1-0 home win over Juventus secured them third place in Champions League Group D.
Raheem Sterling celebrated his 21st birthday with a quickfire double to send Manchester City through to the Champions League last 16 as group winners.
PSV Eindhoven secured their place in the knockout stages of the Champions League with a late 2-1 win against Group B's bottom club CSKA Moscow.
Cristiano Ronaldo and Karim Benzema both scored hat-tricks as Real Madrid hammered Malmo 8-0 to equal the highest ever victory in the Champions League.
Shakhtar Donetsk held on to a Europa League place despite suffering a fifth defeat in six games in Champions League Group A against Paris Saint-Germain.
Atletico Madrid clinched first place in Champions League Group C after winning their top-of-the-table encounter with Benfica 2-1 at the Estadio da Luz.
Galatasaray secured themselves a Europa League spot with a 1-1 Champions League Group C draw against Astana.
Mario Mandzukic scored the only goal as Juventus leapfrogged Manchester City in Champions League Group D with a 1-0 win in Turin.
Manchester United were held to a goalless draw by PSV Eindhoven at Old Trafford on Wednesday night, meaning their Champions League hopes will depend on their final group game away at Wolfsburg.
Zlatan Ibrahimovic marked his return to his hometown club by helping PSG to a 5-0 Champions League victory over Malmo at the Swedbank Stadion.
Under-fire Rafael Benitez survived a late scare on a night when Real Madrid won their Champions League group, conceding three late goals against Shakhtar Donetsk.
Wolfsburg are on the brink of qualifying for the Champions League knock-out stages after winning 2-0 at CSKA Moscow.
Atletico Madrid made sure of their place in the Champions League knock-out stages with a comfortable 2-0 win against Galatasaray at the Vicente Calderon Stadium.
Sevilla's hopes of reaching the Champions League knockout stages ended in Germany with a 4-2 defeat to Borussia Monchengladbach.
Raul Jimenez scored twice as Benfica fought back from two goals down to draw 2-2 with FC Astana in their Champions League Group C fixture and move to the brink of reaching the tournament's last 16.
Bayern Munich booked their place in the Champions League group stage with an emphatic 4-0 victory over Olympiakos.
Lionel Messi, Luis Suarez and Neymar tore Roma to shreds as Barcelona heralded their Champions League glory march with a 6-1 thumping at the Camp Nou.
Arsenal kept their Champions League hopes alive with a routine victory over Dinamo Zagreb.
Chelsea's Champions League fate will go to the final group game after an unconvincing 4-0 win over 10-man Maccabi Tel Aviv earned successive victories for the first time in two months.
Lyon are out of the Champions League after they lost their crunch Group H clash with Gent 2-1 as the Stade de Gerland hosted its final European encounter.
Porto crashed to their first defeat of the season as Group G rivals Dynamo Kiev kept their Champions League hopes alive with goals from Andriy Yarmolenko and Derlis Gonzalez at the Estadio do Dragao.
Zenit St Petersburg maintained their 100 percent record in Group H of the Champions League and guaranteed themselves top spot with a 2-0 win against Valencia.
Late goals by central defenders Jose Gimenez and Diego Godin earned Atletico Madrid a 2-0 victory over Juventus in their Champions League round-of-16 first leg at the Wanda Metropolitano, amid more video assistant referee (VAR) controversy.
Late goals from Leroy Sane and Raheem Sterling gave Manchester City a 3-2 win at Schalke 04 in their Champions League round of 16 first leg on Wednesday that put the English side in the driving seat.
Liverpool and Bayern Munich cancelled each other out to draw 0-0 in the first leg of their Champions League round-of-16 clash on a tense night at Anfield.
Barcelona were held to a frustrating 0-0 draw at Olympique Lyonnais in their Champions League last-16 first leg on Tuesday as both sides remained unbeaten in this season's competition.
Marco Asensio scored a late winner for Real Madrid in a 2-1 victory at Ajax Amsterdam, who were left to rue a goal disallowed by the video assistant referee (VAR) in their Champions League round-of-16 first leg on Wednesday.
Tottenham Hotspur will take a commanding lead to the Westfalenstadion next month after beating Borussia Dortmund 3-0 in the first leg of their Champions League round-of-16 clash at Wembley.
Goals from Presnel Kimpembe and Kylian Mbappe left Manchester United with a mountain to climb as Paris Saint-Germain won 2-0 at Old Trafford in the Champions League round-of-16 first leg and Paul Pogba was sent off.
Teenager Nicolo Zaniolo scored a quick-fire double to earn AS Roma a 2-1 win against Porto in their Champions League last-16 first leg on Tuesday.
Manchester United will face Paris Saint-Germain in the Champions League round of 16, while Liverpool have been drawn against Bayern Munich.
Manchester City battled back to winning ways, coming from a goal down to overwhelm Hoffenheim 2-1 in the Champions League with a brilliant Leroy Sane double that ensured they progressed to the last-16 as winners of Group F on Wednesday.
Manchester United endured an undignified end to their topsy-turvy Champions League group stage campaign by losing 2-1 at already-eliminated Valencia on Wednesday and missing their chance of topping Group H.
Olympique Lyonnais earned the point they required to book their place in the Champions League last 16 but needed Nabil Fekir's equaliser 20 minutes into the second half to salvage a 1-1 draw away to Shakhtar Donetsk.
Two goals from striker Guillaume Hoarau led Young Boys to a shock 2-1 Champions League win over already-qualified Juventus on Wednesday to hand the Serie A side their first away defeat in a competitive match for over a year.
Striker Robert Lewandowski scored twice as Bayern Munich sealed top spot in Group E following a thrilling 3-3 Champions League draw at Ajax in which both sides ended with 10 men.
Benfica finished its Champions League campaign with a 1-0 win over AEK Athens on Wednesday.
Real Madrid suffered their heaviest ever home defeat in Europe on Wednesday when the already-qualified Spaniards were thumped 3-0 at the Santiago Bernabeu by CSKA Moscow in the Champions League.
Viktoria Plzen beat struggling Roma 2-1 in the Champions League on Wednesday to earn a Europa League spot.
Tottenham Hotspur made it into the round of 16 of the Champions League, coming from behind to grab a 1-1 draw at Barcelona on Tuesday which saw them finish second in Group B at the expense of Inter Milan.
Paris Saint-Germain reached the round of 16 of the Champions League on Tuesday thanks to an inspired performance by their three-pronged attack of Neymar, Edinson Cavani and Kylian Mbappe in a 4-1 win at Red Star Belgrade.
Inter Milan were knocked out of the Champions League after they could only manage a 1-1 draw at home to Group B's bottom club PSV Eindhoven on Tuesday to finish third behind Tottenham Hotspur.
Mohamed Salah's first-half strike gave Liverpool a 1-0 win over Napoli in Champions League Group C action on Tuesday.
An under-strength Borussia Dortmund deepened AS Monaco's season-long misery on Tuesday with a 2-0 away victory that ensured they finished top of Champions League Group A ahead of Atletico Madrid.
Atletico Madrid were denied top place in Group A of the Champions League on Tuesday after a goalless draw away at Club Brugge in Belgium meant they finished second behind Borussia Dortmund.
Alessandro Schoepf's stoppage time goal gave Schalke 04 a 1-0 win over Lokomotiv Moscow in Champions League Group D action on Tuesday.
Porto struggled to a 3-2 away victory over Galatasaray in their final Champions League group match on Tuesday but the Turks stayed third in Group D and secured a spot in the Europa League's round of 32.
Real Madrid midfielder Luka Modric has ended the Cristiano Ronaldo-Lionel Messi stranglehold on the Ballon d'Or.
Two first-half goals gave Paris Saint-Germain a crucial 2-1 Champions League home win over Liverpool, putting them in a great position to qualify and leaving Jurgen Klopp's side, finalists last season, in danger of elimination.
Napoli swept aside Red Star Belgrade with a typically entertaining performance as two goals from Dries Mertens helped them to a 3-1 win over the former European champions in their Champions League match on Wednesday.
Borussia Dortmund booked their spot in the Champions League knockout stage with a game to spare after a goalless draw against visitors Club Brugge in Group A on Wednesday.
Christian Eriksen kept Tottenham Hotspur's hopes of reaching the round of 16 in the Champions League alive when he came off the bench to score a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.