Raheem Sterling celebrated his 21st birthday with a quickfire double to send Manchester City through to the Champions League last 16 as group winners.
PSV Eindhoven secured their place in the knockout stages of the Champions League with a late 2-1 win against Group B's bottom club CSKA Moscow.
Cristiano Ronaldo and Karim Benzema both scored hat-tricks as Real Madrid hammered Malmo 8-0 to equal the highest ever victory in the Champions League.
Shakhtar Donetsk held on to a Europa League place despite suffering a fifth defeat in six games in Champions League Group A against Paris Saint-Germain.
Atletico Madrid clinched first place in Champions League Group C after winning their top-of-the-table encounter with Benfica 2-1 at the Estadio da Luz.
Galatasaray secured themselves a Europa League spot with a 1-1 Champions League Group C draw against Astana.
Mario Mandzukic scored the only goal as Juventus leapfrogged Manchester City in Champions League Group D with a 1-0 win in Turin.
Manchester United were held to a goalless draw by PSV Eindhoven at Old Trafford on Wednesday night, meaning their Champions League hopes will depend on their final group game away at Wolfsburg.
Zlatan Ibrahimovic marked his return to his hometown club by helping PSG to a 5-0 Champions League victory over Malmo at the Swedbank Stadion.
Under-fire Rafael Benitez survived a late scare on a night when Real Madrid won their Champions League group, conceding three late goals against Shakhtar Donetsk.
Wolfsburg are on the brink of qualifying for the Champions League knock-out stages after winning 2-0 at CSKA Moscow.
Atletico Madrid made sure of their place in the Champions League knock-out stages with a comfortable 2-0 win against Galatasaray at the Vicente Calderon Stadium.
Sevilla's hopes of reaching the Champions League knockout stages ended in Germany with a 4-2 defeat to Borussia Monchengladbach.
Raul Jimenez scored twice as Benfica fought back from two goals down to draw 2-2 with FC Astana in their Champions League Group C fixture and move to the brink of reaching the tournament's last 16.
Bayern Munich booked their place in the Champions League group stage with an emphatic 4-0 victory over Olympiakos.
Lionel Messi, Luis Suarez and Neymar tore Roma to shreds as Barcelona heralded their Champions League glory march with a 6-1 thumping at the Camp Nou.
Arsenal kept their Champions League hopes alive with a routine victory over Dinamo Zagreb.
Chelsea's Champions League fate will go to the final group game after an unconvincing 4-0 win over 10-man Maccabi Tel Aviv earned successive victories for the first time in two months.
Lyon are out of the Champions League after they lost their crunch Group H clash with Gent 2-1 as the Stade de Gerland hosted its final European encounter.
Porto crashed to their first defeat of the season as Group G rivals Dynamo Kiev kept their Champions League hopes alive with goals from Andriy Yarmolenko and Derlis Gonzalez at the Estadio do Dragao.
Zenit St Petersburg maintained their 100 percent record in Group H of the Champions League and guaranteed themselves top spot with a 2-0 win against Valencia.
Admir Mehmedi struck a second-half equaliser against Champions League Group E rivals BATE Borisov in Belarus to keep Bayer Leverkusen's hopes of securing a place in the knockout stages alive.
Arsenal's Champions League hopes are hanging by a thread after they were blown away by Bayern Munich on Wednesday night.
Jose Mourinho was granted a reprieve as Willian's free-kick earned a 2-1 Champions League Group G victory over Dynamo Kiev at Stamford Bridge.
Miralem Pjanic's late penalty allowed Roma to edge a resilient Bayer Leverkusen 3-2 on Wednesday and keep their hopes of qualifying for the knockout stages of the Champions League alive.
Neymar struck twice as Barcelona moved ever closer towards a place in the knockout stages of the Champions League with a 3-0 win over Group E rivals BATE Borisov.
Two second-half strikes from substitute Felipe Pardo inspired Olympiakos to a 2-1 victory over 10-man Dinamo Zagreb, sending the hosts six points clear of third-placed Arsenal in Champions League Group F.
Porto moved closer to booking their place in the last 16 of the UEFA Champions League with a 3-1 win over Maccabi Tel Aviv in Israel.
Artem Dzyuba scored twice as Zenit St. Petersburg sealed their place in the Champions League knockout stages with a 2-0 win over Lyon in France.
Sven Kums' second-half penalty was enough for Gent to down Valencia in Belgium on Wednesday night and earn the hosts an historic first win in the Champions League.
Manchester City battled back to winning ways, coming from a goal down to overwhelm Hoffenheim 2-1 in the Champions League with a brilliant Leroy Sane double that ensured they progressed to the last-16 as winners of Group F on Wednesday.
Manchester United endured an undignified end to their topsy-turvy Champions League group stage campaign by losing 2-1 at already-eliminated Valencia on Wednesday and missing their chance of topping Group H.
Olympique Lyonnais earned the point they required to book their place in the Champions League last 16 but needed Nabil Fekir's equaliser 20 minutes into the second half to salvage a 1-1 draw away to Shakhtar Donetsk.
Two goals from striker Guillaume Hoarau led Young Boys to a shock 2-1 Champions League win over already-qualified Juventus on Wednesday to hand the Serie A side their first away defeat in a competitive match for over a year.
Striker Robert Lewandowski scored twice as Bayern Munich sealed top spot in Group E following a thrilling 3-3 Champions League draw at Ajax in which both sides ended with 10 men.
Benfica finished its Champions League campaign with a 1-0 win over AEK Athens on Wednesday.
Real Madrid suffered their heaviest ever home defeat in Europe on Wednesday when the already-qualified Spaniards were thumped 3-0 at the Santiago Bernabeu by CSKA Moscow in the Champions League.
Viktoria Plzen beat struggling Roma 2-1 in the Champions League on Wednesday to earn a Europa League spot.
Tottenham Hotspur made it into the round of 16 of the Champions League, coming from behind to grab a 1-1 draw at Barcelona on Tuesday which saw them finish second in Group B at the expense of Inter Milan.
Paris Saint-Germain reached the round of 16 of the Champions League on Tuesday thanks to an inspired performance by their three-pronged attack of Neymar, Edinson Cavani and Kylian Mbappe in a 4-1 win at Red Star Belgrade.
Inter Milan were knocked out of the Champions League after they could only manage a 1-1 draw at home to Group B's bottom club PSV Eindhoven on Tuesday to finish third behind Tottenham Hotspur.
Mohamed Salah's first-half strike gave Liverpool a 1-0 win over Napoli in Champions League Group C action on Tuesday.
An under-strength Borussia Dortmund deepened AS Monaco's season-long misery on Tuesday with a 2-0 away victory that ensured they finished top of Champions League Group A ahead of Atletico Madrid.
Atletico Madrid were denied top place in Group A of the Champions League on Tuesday after a goalless draw away at Club Brugge in Belgium meant they finished second behind Borussia Dortmund.
Alessandro Schoepf's stoppage time goal gave Schalke 04 a 1-0 win over Lokomotiv Moscow in Champions League Group D action on Tuesday.
Porto struggled to a 3-2 away victory over Galatasaray in their final Champions League group match on Tuesday but the Turks stayed third in Group D and secured a spot in the Europa League's round of 32.
Real Madrid midfielder Luka Modric has ended the Cristiano Ronaldo-Lionel Messi stranglehold on the Ballon d'Or.
Two first-half goals gave Paris Saint-Germain a crucial 2-1 Champions League home win over Liverpool, putting them in a great position to qualify and leaving Jurgen Klopp's side, finalists last season, in danger of elimination.
Napoli swept aside Red Star Belgrade with a typically entertaining performance as two goals from Dries Mertens helped them to a 3-1 win over the former European champions in their Champions League match on Wednesday.
Borussia Dortmund booked their spot in the Champions League knockout stage with a game to spare after a goalless draw against visitors Club Brugge in Group A on Wednesday.
Christian Eriksen kept Tottenham Hotspur's hopes of reaching the round of 16 in the Champions League alive when he came off the bench to score a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
Lionel Messi scored an excellent individual goal and laid on another as Barcelona beat PSV Eindhoven 2-1 to secure top spot in Champions League Group B on Wednesday.
Atletico Madrid clinched their place in the Champions League round of 16 on Wednesday by beating AS Monaco 2-0 at home while also ensuring that Thierry Henry's hapless visitors will now even miss out on qualification for the Europa League.
A goal in each half was enough for Lokomotiv Moscow to earn a 2-0 win over Galatasaray in Champions League Group D on Wednesday, ending Galatasaray's hopes of qualifying for the knockout stages and sending both Porto and Schalke through.
Juventus clinched a place in the Champions League knockout stages when a brilliant Cristiano Ronaldo assist set up Mario Mandzukic to give them a 1-0 win over Valencia on Tuesday.
Manchester United's Marouane Fellaini struck a controversial stoppage-time winner to bring blessed relief to Old Trafford after a laboured 1-0 win over Young Boys edged them into the Champions League last 16 on Tuesday.
Manchester City progressed to the knockout stages of the Champions League after twice coming from behind to draw 2-2 with Olympique Lyonnais in Group F on Tuesday.
Bayern Munich's Arjen Robben and Robert Lewandowski scored two goals each as the German champions demolished Benfica 5-1 on Tuesday to reach the Champions League round of 16 and lift some of the pressure off boss Niko Kovac.
Real Madrid secured first place in Champions League Group G with 2-0 victory over Roma at the Stadio Olimpico on Tuesday although the Italians are also through to round of 16.
Ajax Amsterdam reached the Champions League knockout stages for the first time since 2005-06 after a Dusan Tadic brace gave the Dutch side a 2-0 win at 10-man AEK Athens in a match marred by crowd trouble at the Olympic Stadium on Tuesday.