Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.
Willian scored twice and was fouled for two penalties as Chelsea cruised into the Champions League knockout stages with a 4-0 win over 10-man Qarabag at the Olympic Stadium in Baku.
Antoine Griezmann's stunning goal kept Atletico Madrid's Champions League hopes alive as they grabbed a vital victory over Roma.
Celtic suffered another night of European anguish against Paris St Germain in a 7-1 thrashing in the Parc des Princes.
Raheem Sterling struck a late winner as Manchester City secured top spot in Champions League Group F with a 1-0 win over Feyenoord.
Cristiano Ronaldo set another Champions League record as holders Real Madrid sealed their place in the knockout stages with a comprehensive victory against Apoel Nicosia.
Lorenzo Insigne's magical strike broke Shakhtar Donetsk's defences and Napoli went on to a 3-0 win, which gives them hope of Champions League progress.
Liverpool squandered a three-goal half-time lead to throw away the chance of early Champions League qualification as Sevilla netted a 93rd-minute equaliser in Spain.
Son Heung-Min proved the scourge of Borussia Dortmund again as his late winner ensured Tottenham will go through to the Champions League round of 16 as group winners.
Tottenham delivered one of the finest victories in the club's history as Dele Alli scored twice in a 3-1 demolition of Real Madrid.
Liverpool edged closer to qualifying for the Champions League knockout stages with a workmanlike 3-0 win over Maribor.
Porto struggled to a 3-2 away victory over Galatasaray in their final Champions League group match on Tuesday but the Turks stayed third in Group D and secured a spot in the Europa League's round of 32.
Real Madrid midfielder Luka Modric has ended the Cristiano Ronaldo-Lionel Messi stranglehold on the Ballon d'Or.
Two first-half goals gave Paris Saint-Germain a crucial 2-1 Champions League home win over Liverpool, putting them in a great position to qualify and leaving Jurgen Klopp's side, finalists last season, in danger of elimination.
Napoli swept aside Red Star Belgrade with a typically entertaining performance as two goals from Dries Mertens helped them to a 3-1 win over the former European champions in their Champions League match on Wednesday.
Borussia Dortmund booked their spot in the Champions League knockout stage with a game to spare after a goalless draw against visitors Club Brugge in Group A on Wednesday.
Christian Eriksen kept Tottenham Hotspur's hopes of reaching the round of 16 in the Champions League alive when he came off the bench to score a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
Lionel Messi scored an excellent individual goal and laid on another as Barcelona beat PSV Eindhoven 2-1 to secure top spot in Champions League Group B on Wednesday.
Atletico Madrid clinched their place in the Champions League round of 16 on Wednesday by beating AS Monaco 2-0 at home while also ensuring that Thierry Henry's hapless visitors will now even miss out on qualification for the Europa League.
A goal in each half was enough for Lokomotiv Moscow to earn a 2-0 win over Galatasaray in Champions League Group D on Wednesday, ending Galatasaray's hopes of qualifying for the knockout stages and sending both Porto and Schalke through.
Juventus clinched a place in the Champions League knockout stages when a brilliant Cristiano Ronaldo assist set up Mario Mandzukic to give them a 1-0 win over Valencia on Tuesday.
Manchester United's Marouane Fellaini struck a controversial stoppage-time winner to bring blessed relief to Old Trafford after a laboured 1-0 win over Young Boys edged them into the Champions League last 16 on Tuesday.
Manchester City progressed to the knockout stages of the Champions League after twice coming from behind to draw 2-2 with Olympique Lyonnais in Group F on Tuesday.
Bayern Munich's Arjen Robben and Robert Lewandowski scored two goals each as the German champions demolished Benfica 5-1 on Tuesday to reach the Champions League round of 16 and lift some of the pressure off boss Niko Kovac.
Real Madrid secured first place in Champions League Group G with 2-0 victory over Roma at the Stadio Olimpico on Tuesday although the Italians are also through to round of 16.
Ajax Amsterdam reached the Champions League knockout stages for the first time since 2005-06 after a Dusan Tadic brace gave the Dutch side a 2-0 win at 10-man AEK Athens in a match marred by crowd trouble at the Olympic Stadium on Tuesday.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.