Sven Kums' second-half penalty was enough for Gent to down Valencia in Belgium on Wednesday night and earn the hosts an historic first win in the Champions League.
Real Madrid beat Paris Saint-Germain 1-0 in the teams' Group A Champions League match Tuesday to secure a place in the Champions League knockout round for the 19th straight season.
Manchester City produced one of their greatest European performances to secure a place in the Champions League last 16 with a brilliant 3-1 win at Sevilla.
Stephan Lichtsteiner earned Juventus a 1-1 draw at Borussia Monchengladbach just a month after undergoing heart surgery.
Wayne Rooney ended Manchester United's 404-minute goal drought by scoring the winner against CSKA Moscow on a night of high emotion at Old Trafford.
PSV Eindhoven hauled themselves back into contention in Group B with a 2-0 win over Wolfsburg.
Shakhtar Donetsk kept their faint hopes of qualifying for the knockout stages alive after securing their first Champions League victory of the season in style with a 4-0 win at the Donbass Arena against Group A rivals Malmo.
Astana secured their second point but remain with out a win in the Champions League group stages following a goalless draw against Atletico Madrid in Kazakhstan.
Real Madrid and Paris St. Germain fought to a goalless draw in Paris to remain joint-leaders atop the Champions League Group A standings on Wednesday.
Kevin De Bruyne struck an injury-time winner as Manchester City came from behind to claim a dramatic 2-1 win over Sevilla in the Champions League.
Borussia Monchengladbach brought an end to Juventus' perfect start in the Champions League on Wednesday when they held the Serie A giants to a goalless draw in Turin.
Anthony Martial scored a delightful diving header to rescue Manchester United from a damaging defeat at CSKA Moscow.
Wolfsburg defeated PSV Eindhoven 2-0 at home in the Champions League to go top of Group B.
Atletico Madrid brushed aside Astana 4-0 on Wednesday evening to return to winning ways at the Vicente Calderon stadium in the Champions League.
Malmo remain in contention to reach the Champions League's last 16 after a 1-0 group A victory over Shakhtar Donetsk that took the Ukrainians to the brink of elimination.
Galatasaray defeated Benfica 2-1 to claim their first win in 10 fixtures in Europe and revive their hopes of advancing from Group C into the Champions League's final 16.
Olivier Giroud came off the bench to help give Arsenal a 2-0 win over Bayern Munich and keep alive their Champions League hopes.
Barcelona strengthened their position at the top of Champions League Group E as a brace from substitute Ivan Rakitic steered them to a comfortable 2-0 win at BATE Borisov.
Eden Hazard and Willian hit the woodwork as Chelsea were held to a goalless draw at Dynamo Kiev.
Bayer Leverkusen and Roma battled out a 4-4 draw in a thrilling Champions League Group E clash in Germany that saw both sides produce remarkable comebacks.
Zenit St Petersburg are on the brink of qualifying for the knockout stages of the Champions League after defeating Lyon 3-1 in Russia.
Vincent Aboubakar netted his seventh goal of the season as Porto beat Maccabi Tel-Aviv 2-0 to climb to the top of Champions League Group G.
Ideye Brown struck the decisive goal for Olympiakos at the Maksimir Stadium to send Dinamo Zagreb spinning to a second Group F Champions League defeat.
Stefan Mitrovic's own goal allowed Valencia to take a big step towards qualification from Champions League Group H as Gent were beaten 2-1 at the Mestalla.
Juan Mata was the star of the show as Manchester United got off the mark in the Champions League with a narrow 2-1 win over Wolfsburg.
Cristiano Ronaldo's double took him past 500 career goals and handed Real Madrid a narrow 2-0 Champions League victory over 10-man Malmo.
Sergio Aguero struck a last-gasp penalty winner as Manchester City came from behind to ignite their Champions League campaign with a 2-1 win at Borussia Monchengladbach.
Juventus may be struggling in Serie A but it is a different story in the Champions League with the Italian giants clinching the second win in as many games on Wednesday with a home triumph over Sevilla.
Zlatan Ibrahimovic was frustrated in his attempts to overhaul Paris St Germain's all-time goalscoring record as a late strike was officially recorded as an own goal.
Benfica came from a goal behind to beat Atletico Madrid 2-1 at the Vicente Calderon and go top of Group C.
Manchester United will face Paris Saint-Germain in the Champions League round of 16, while Liverpool have been drawn against Bayern Munich.
Manchester City battled back to winning ways, coming from a goal down to overwhelm Hoffenheim 2-1 in the Champions League with a brilliant Leroy Sane double that ensured they progressed to the last-16 as winners of Group F on Wednesday.
Manchester United endured an undignified end to their topsy-turvy Champions League group stage campaign by losing 2-1 at already-eliminated Valencia on Wednesday and missing their chance of topping Group H.
Olympique Lyonnais earned the point they required to book their place in the Champions League last 16 but needed Nabil Fekir's equaliser 20 minutes into the second half to salvage a 1-1 draw away to Shakhtar Donetsk.
Two goals from striker Guillaume Hoarau led Young Boys to a shock 2-1 Champions League win over already-qualified Juventus on Wednesday to hand the Serie A side their first away defeat in a competitive match for over a year.
Striker Robert Lewandowski scored twice as Bayern Munich sealed top spot in Group E following a thrilling 3-3 Champions League draw at Ajax in which both sides ended with 10 men.
Benfica finished its Champions League campaign with a 1-0 win over AEK Athens on Wednesday.
Real Madrid suffered their heaviest ever home defeat in Europe on Wednesday when the already-qualified Spaniards were thumped 3-0 at the Santiago Bernabeu by CSKA Moscow in the Champions League.
Viktoria Plzen beat struggling Roma 2-1 in the Champions League on Wednesday to earn a Europa League spot.
Tottenham Hotspur made it into the round of 16 of the Champions League, coming from behind to grab a 1-1 draw at Barcelona on Tuesday which saw them finish second in Group B at the expense of Inter Milan.
Paris Saint-Germain reached the round of 16 of the Champions League on Tuesday thanks to an inspired performance by their three-pronged attack of Neymar, Edinson Cavani and Kylian Mbappe in a 4-1 win at Red Star Belgrade.
Inter Milan were knocked out of the Champions League after they could only manage a 1-1 draw at home to Group B's bottom club PSV Eindhoven on Tuesday to finish third behind Tottenham Hotspur.
Mohamed Salah's first-half strike gave Liverpool a 1-0 win over Napoli in Champions League Group C action on Tuesday.
An under-strength Borussia Dortmund deepened AS Monaco's season-long misery on Tuesday with a 2-0 away victory that ensured they finished top of Champions League Group A ahead of Atletico Madrid.
Atletico Madrid were denied top place in Group A of the Champions League on Tuesday after a goalless draw away at Club Brugge in Belgium meant they finished second behind Borussia Dortmund.
Alessandro Schoepf's stoppage time goal gave Schalke 04 a 1-0 win over Lokomotiv Moscow in Champions League Group D action on Tuesday.
Porto struggled to a 3-2 away victory over Galatasaray in their final Champions League group match on Tuesday but the Turks stayed third in Group D and secured a spot in the Europa League's round of 32.
Real Madrid midfielder Luka Modric has ended the Cristiano Ronaldo-Lionel Messi stranglehold on the Ballon d'Or.
Two first-half goals gave Paris Saint-Germain a crucial 2-1 Champions League home win over Liverpool, putting them in a great position to qualify and leaving Jurgen Klopp's side, finalists last season, in danger of elimination.
Napoli swept aside Red Star Belgrade with a typically entertaining performance as two goals from Dries Mertens helped them to a 3-1 win over the former European champions in their Champions League match on Wednesday.
Borussia Dortmund booked their spot in the Champions League knockout stage with a game to spare after a goalless draw against visitors Club Brugge in Group A on Wednesday.
Christian Eriksen kept Tottenham Hotspur's hopes of reaching the round of 16 in the Champions League alive when he came off the bench to score a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
Lionel Messi scored an excellent individual goal and laid on another as Barcelona beat PSV Eindhoven 2-1 to secure top spot in Champions League Group B on Wednesday.
Atletico Madrid clinched their place in the Champions League round of 16 on Wednesday by beating AS Monaco 2-0 at home while also ensuring that Thierry Henry's hapless visitors will now even miss out on qualification for the Europa League.
A goal in each half was enough for Lokomotiv Moscow to earn a 2-0 win over Galatasaray in Champions League Group D on Wednesday, ending Galatasaray's hopes of qualifying for the knockout stages and sending both Porto and Schalke through.
Juventus clinched a place in the Champions League knockout stages when a brilliant Cristiano Ronaldo assist set up Mario Mandzukic to give them a 1-0 win over Valencia on Tuesday.
Manchester United's Marouane Fellaini struck a controversial stoppage-time winner to bring blessed relief to Old Trafford after a laboured 1-0 win over Young Boys edged them into the Champions League last 16 on Tuesday.
Manchester City progressed to the knockout stages of the Champions League after twice coming from behind to draw 2-2 with Olympique Lyonnais in Group F on Tuesday.
Bayern Munich's Arjen Robben and Robert Lewandowski scored two goals each as the German champions demolished Benfica 5-1 on Tuesday to reach the Champions League round of 16 and lift some of the pressure off boss Niko Kovac.
Real Madrid secured first place in Champions League Group G with 2-0 victory over Roma at the Stadio Olimpico on Tuesday although the Italians are also through to round of 16.