Borussia Dortmund booked their place in the knockout stages of the Champions League, despite suspending star striker Pierre-Emerick Aubameyang ahead of the 1-0 Group F win over Sporting Lisbon.
Tottenham's Wembley curse struck again as Mauricio Pochettino's men slipped to a 1-0 defeat against Bayer Leverkusen in the Champions League.
Sevilla thrashed 10-man Dinamo Zagreb 4-0 to go top of Group H and put one foot in the round of 16.
Porto moved up to second in Champions League Group G with a 1-0 home victory over Club Brugge.
Leicester missed the chance to seal qualification to the knockout stages of the Champions League after a forgettable 0-0 draw in Copenhagen.
Gareth Bale scored Real Madrid's fastest-ever goal in Champions League play but Los Blancos dropped points in an entertaining 3-3 group stage draw with Legia Warsaw behind closed doors at the Pepsi Arena on Wednesday.
Radamel Falcao scored his first Champions League goals for Monaco as they comfortably defeated CSKA Moscow 3-0 at the Stade Louis II.
Manchester City produced an outstanding second-half performance to sweep past Barcelona 3-1 at the Etihad Stadium.
A late Mesut Ozil strike saw Arsenal come from two goals down to beat Ludogorets and book a place in the round of 16 of the Champions League.
Thomas Meunier volleyed home a stunning late winner as Paris Saint-Germain guaranteed their place in the last 16 of the Champions League with a dramatic 2-1 win over Basel.
Robert Lewandowski scored twice as Bayern Munich came from behind to beat PSV Eindhoven 2-1 at Philips Stadion and secure their place in the knockout stages of the Champions League.
Antoine Griezmann grabbed a stoppage-time winner as Atletico Madrid maintained their 100 per cent record in Champions League Group D with a 2-1 win over Rostov at the Vicente Calderon Stadium.
Moussa Dembele's second-half penalty gave Celtic a 1-1 draw at Borussia Monchengladbach on Tuesday to keep their Champions League hopes alive.
Eduardo Salvio's cool first-half penalty was enough to earn Benfica a valuable 1-0 win in their Champions League Group B clash with Dynamo Kiev at the Estadio da Luz.
A brilliant late goal from Napoli captain Marek Hamsik secured a 1-1 draw at Besiktas to keep the Italians a point ahead of their opponents in Champions League Group B.
Lionel Messi and Cristiano Ronaldo are set to resume their annual battle for the Ballon d'Or after both were named in the list of 30 nominees for the 2016 award on Monday.
Lionel Messi scored a hat trick in a sensational display as Barcelona beat Manchester City 4-0 at the Camp Nou on Wednesday.
Bayern Munich won for the first time in four games as Joshua Kimmich's scoring run continued in a 4-1 success over PSV Eindhoven.
Angel Di Maria scored his first goal of the season to put Paris St Germain on course for a 3-0 Champions League win over Basel.
A Mesut Ozil hat trick spearheaded Arsenal's 6-0 Champions League demolition of Ludogorets at the Emirates Stadium.
Yannick Carrasco scored the only goal of the game as Atletico Madrid maintained their 100 percent record in Champions League Group D with a 1-0 win at Rostov.
Celtic's Champions League aspirations were blown apart by Borussia Monchengladbach, who were more than worth their 2-0 win at Parkhead.
Under-fire Dynamo Kiev boss Sergei Rebrov saw his side suffer a 2-0 home defeat to Benfica to leave their Champions League hopes in tatters.
Vincent Aboubakar's header four minutes from time earned Besiktas victory at Napoli as the Turkish side edged a Champions League thriller 3-2.
Juan Cuadrado snatched victory for 10-men Juventus with the only goal in Lyon but the Italians had inspirational goalkeeper Gianluigi Buffon to thank for keeping them top of Group H.
Riyad Mahrez fired Leicester to the brink of the Champions League knockout stages after a 1-0 victory over FC Copenhagen.
Pierre-Emerick Aubameyang set Borussia Dortmund on their way to a 2-1 win in Lisbon against Champions League rivals Sporting at Estadio Jose Alvalade to keep them top of Group F.
Bayer Leverkusen and Tottenham Hotspur shared the spoils in a goalless draw at the BayArena that saw both sides come within a whisker of finding the all-important breakthrough.
Sevilla took a step closer to the Champions League knockout stages as Samir Nasri scored the only goal of a 1-0 win at Dinamo Zagreb.
Andre Silva's 90th-minute penalty snatched a 2-1 Champions League win for Porto at Club Brugge.
Late goals by central defenders Jose Gimenez and Diego Godin earned Atletico Madrid a 2-0 victory over Juventus in their Champions League round-of-16 first leg at the Wanda Metropolitano, amid more video assistant referee (VAR) controversy.
Late goals from Leroy Sane and Raheem Sterling gave Manchester City a 3-2 win at Schalke 04 in their Champions League round of 16 first leg on Wednesday that put the English side in the driving seat.
Liverpool and Bayern Munich cancelled each other out to draw 0-0 in the first leg of their Champions League round-of-16 clash on a tense night at Anfield.
Barcelona were held to a frustrating 0-0 draw at Olympique Lyonnais in their Champions League last-16 first leg on Tuesday as both sides remained unbeaten in this season's competition.
Marco Asensio scored a late winner for Real Madrid in a 2-1 victory at Ajax Amsterdam, who were left to rue a goal disallowed by the video assistant referee (VAR) in their Champions League round-of-16 first leg on Wednesday.
Tottenham Hotspur will take a commanding lead to the Westfalenstadion next month after beating Borussia Dortmund 3-0 in the first leg of their Champions League round-of-16 clash at Wembley.
Goals from Presnel Kimpembe and Kylian Mbappe left Manchester United with a mountain to climb as Paris Saint-Germain won 2-0 at Old Trafford in the Champions League round-of-16 first leg and Paul Pogba was sent off.
Teenager Nicolo Zaniolo scored a quick-fire double to earn AS Roma a 2-1 win against Porto in their Champions League last-16 first leg on Tuesday.
Manchester United will face Paris Saint-Germain in the Champions League round of 16, while Liverpool have been drawn against Bayern Munich.
Manchester City battled back to winning ways, coming from a goal down to overwhelm Hoffenheim 2-1 in the Champions League with a brilliant Leroy Sane double that ensured they progressed to the last-16 as winners of Group F on Wednesday.
Manchester United endured an undignified end to their topsy-turvy Champions League group stage campaign by losing 2-1 at already-eliminated Valencia on Wednesday and missing their chance of topping Group H.
Olympique Lyonnais earned the point they required to book their place in the Champions League last 16 but needed Nabil Fekir's equaliser 20 minutes into the second half to salvage a 1-1 draw away to Shakhtar Donetsk.
Two goals from striker Guillaume Hoarau led Young Boys to a shock 2-1 Champions League win over already-qualified Juventus on Wednesday to hand the Serie A side their first away defeat in a competitive match for over a year.
Striker Robert Lewandowski scored twice as Bayern Munich sealed top spot in Group E following a thrilling 3-3 Champions League draw at Ajax in which both sides ended with 10 men.
Benfica finished its Champions League campaign with a 1-0 win over AEK Athens on Wednesday.
Real Madrid suffered their heaviest ever home defeat in Europe on Wednesday when the already-qualified Spaniards were thumped 3-0 at the Santiago Bernabeu by CSKA Moscow in the Champions League.
Viktoria Plzen beat struggling Roma 2-1 in the Champions League on Wednesday to earn a Europa League spot.
Tottenham Hotspur made it into the round of 16 of the Champions League, coming from behind to grab a 1-1 draw at Barcelona on Tuesday which saw them finish second in Group B at the expense of Inter Milan.
Paris Saint-Germain reached the round of 16 of the Champions League on Tuesday thanks to an inspired performance by their three-pronged attack of Neymar, Edinson Cavani and Kylian Mbappe in a 4-1 win at Red Star Belgrade.
Inter Milan were knocked out of the Champions League after they could only manage a 1-1 draw at home to Group B's bottom club PSV Eindhoven on Tuesday to finish third behind Tottenham Hotspur.
Mohamed Salah's first-half strike gave Liverpool a 1-0 win over Napoli in Champions League Group C action on Tuesday.
An under-strength Borussia Dortmund deepened AS Monaco's season-long misery on Tuesday with a 2-0 away victory that ensured they finished top of Champions League Group A ahead of Atletico Madrid.
Atletico Madrid were denied top place in Group A of the Champions League on Tuesday after a goalless draw away at Club Brugge in Belgium meant they finished second behind Borussia Dortmund.
Alessandro Schoepf's stoppage time goal gave Schalke 04 a 1-0 win over Lokomotiv Moscow in Champions League Group D action on Tuesday.
Porto struggled to a 3-2 away victory over Galatasaray in their final Champions League group match on Tuesday but the Turks stayed third in Group D and secured a spot in the Europa League's round of 32.
Real Madrid midfielder Luka Modric has ended the Cristiano Ronaldo-Lionel Messi stranglehold on the Ballon d'Or.
Two first-half goals gave Paris Saint-Germain a crucial 2-1 Champions League home win over Liverpool, putting them in a great position to qualify and leaving Jurgen Klopp's side, finalists last season, in danger of elimination.
Napoli swept aside Red Star Belgrade with a typically entertaining performance as two goals from Dries Mertens helped them to a 3-1 win over the former European champions in their Champions League match on Wednesday.
Borussia Dortmund booked their spot in the Champions League knockout stage with a game to spare after a goalless draw against visitors Club Brugge in Group A on Wednesday.
Christian Eriksen kept Tottenham Hotspur's hopes of reaching the round of 16 in the Champions League alive when he came off the bench to score a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.