Manchester City's defensive frailties cost them as they crashed out of the Champions League with a 3-1 defeat at Monaco.
Juventus coasted into the quarterfinals of the Champions League as they saw off 10-man Porto 1-0 in Turin on Tuesday night.
Leicester City reached the Champions League quarterfinals with a 2-0 victory over Sevilla on Tuesday, turning around their round-of-16 tie to advance 3-2 on aggregate.
Barcelona's amazing 6-1 victory over Paris St Germain that sent them through to the Champions League quarter-finals on Wednesday was down to hard work and taking risks, according to coach Luis Enrique.
Barcelona needed to become the first team in European history to overcome a 4-0 first-leg Champions League deficit and did so against Paris Saint-Germain as they scored six goals to knock out the French champions.
Pierre-Emerick Aubameyang scored a hat trick as Borussia Dortmund beat Benfica 4-0 to ease into the Champions League quarterfinals with a 4-1 aggregate victory.
Real Madrid weathered an early storm before easing through to the quarterfinals of the Champions League with a 3-1 victory over Napoli that gave them a 6-2 win on aggregate.
Bayern Munich confirmed their spot in the Champions League quarterfinals with a 5-1 win at 10-man Arsenal on Tuesday to advance 10-2 on aggregate.
Juventus struck twice in the second half to take control of their Champions League round-of-16 tie against 10-man Porto.
Jamie Vardy's first Champions League strike gave Leicester a crucial away goal in a 2-1 defeat at Sevilla, giving them a foothold in a tie in which they had trailed 2-0.
Manchester City overcame Monaco in an eight-goal thriller at the Etihad Stadium, coming from behind to run out 5-3 winners in their Champions League round-of-16 first leg.
Atletico Madrid opened their Champions League knockout stage with a 4-2 win away to Bayer Leverkusen in the round of 16 first leg on Tuesday.
Two goals in five second-half minutes helped Real Madrid come from behind to beat Napoli 3-1 in the first leg of their UEFA Champions League last-16 clash at the Bernabeu on Wednesday.
Arsenal will have to produce something special to reach a first Champions League quarterfinal since 2010 after suffering a 5-1 defeat to a rampant Bayern Munich side in the first leg of their round-of-16 tie at the Allianz Arena.
Two goals from Angel Di Maria and one apiece from Julian Draxler and Edinson Cavani gave Paris Saint-Germain an unexpected and potentially unassailable 4-0 lead against Barcelona in their Champions League round of 16 first leg tie.
Kostas Mitroglou scored the only goal of the game as Benfica took advantage of Pierre-Emerick Aubameyang's off day to grab control of their Champions League last-16 tie against Borussia Dortmund in Lisbon.
Cristiano Ronaldo scored a hat trick as Real Madrid claimed their second Club World Cup title in three years, but the Spanish giants needed extra time to see off the spirited Kashima Antlers 4-2 in Yokohama.
Arsenal have been drawn against Bayern Munich in the Champions League's round of 16, while Barcelona will take on Paris Saint-Germain.
Real Madrid's Cristiano Ronaldo won the Ballon d'Or for a fourth time on Monday night, beating Barcelona's Lionel Messi and Atletico Madrid's Antoine Griezmann to world football's top individual prize for 2016.
Sevilla qualified for the last 16 of the Champions League after holding Lyon to a goalless draw.
Legia Warsaw secured a place in the Europa League at the expense of 10-man Sporting Lisbon after a 1-0 Champions League Group F win at the Polish Army Stadium.
FC Copenhagen ended their Champions League Group G with a 2-0 victory over Club Brugge but Porto's thumping win over Leicester condemned them to the Europa League.
Bayer Leverkusen inflicted a first defeat in 10 matches on Monaco in their Champions League Group E match on Wednesday.
Woeful Leicester lost their unbeaten Champions League record as a second string side suffered a humiliating 5-0 thumping in Porto.
Tottenham's winless Wembley run is over but their Europa League campaign has just begun after Mauricio Pochettino's men sealed a 3-1 win over CSKA Moscow.
Gonzalo Higuain's stunning strike saw Juventus finish on top of Champions League Group H as they beat Dinamo Zagreb 2-0 in Turin.
Real Madrid squandered a two-goal lead and with it top spot in Group F as record-breaking Borussia Dortmund fought back to draw 2-2 late on at the Bernabeu.
Napoli secured top spot in Group B with a 2-1 victory at Benfica as both sides progressed into the knockout stages of the Champions League.
Rostov battled to a goalless draw in their final Champions League Group D fixture away at PSV Eindhoven, which was enough for the Russians to reach the Europa League.
Robert Lewandowski's first-half free kick proved enough to give Bayern Munich a 1-0 win over Atletico Madrid at the Allianz Arena and end the Spanish side's hopes of finishing their Champions League Group D campaign with six wins from six.
Manchester United will face Paris Saint-Germain in the Champions League round of 16, while Liverpool have been drawn against Bayern Munich.
Manchester City battled back to winning ways, coming from a goal down to overwhelm Hoffenheim 2-1 in the Champions League with a brilliant Leroy Sane double that ensured they progressed to the last-16 as winners of Group F on Wednesday.
Manchester United endured an undignified end to their topsy-turvy Champions League group stage campaign by losing 2-1 at already-eliminated Valencia on Wednesday and missing their chance of topping Group H.
Olympique Lyonnais earned the point they required to book their place in the Champions League last 16 but needed Nabil Fekir's equaliser 20 minutes into the second half to salvage a 1-1 draw away to Shakhtar Donetsk.
Two goals from striker Guillaume Hoarau led Young Boys to a shock 2-1 Champions League win over already-qualified Juventus on Wednesday to hand the Serie A side their first away defeat in a competitive match for over a year.
Striker Robert Lewandowski scored twice as Bayern Munich sealed top spot in Group E following a thrilling 3-3 Champions League draw at Ajax in which both sides ended with 10 men.
Benfica finished its Champions League campaign with a 1-0 win over AEK Athens on Wednesday.
Real Madrid suffered their heaviest ever home defeat in Europe on Wednesday when the already-qualified Spaniards were thumped 3-0 at the Santiago Bernabeu by CSKA Moscow in the Champions League.
Viktoria Plzen beat struggling Roma 2-1 in the Champions League on Wednesday to earn a Europa League spot.
Tottenham Hotspur made it into the round of 16 of the Champions League, coming from behind to grab a 1-1 draw at Barcelona on Tuesday which saw them finish second in Group B at the expense of Inter Milan.
Paris Saint-Germain reached the round of 16 of the Champions League on Tuesday thanks to an inspired performance by their three-pronged attack of Neymar, Edinson Cavani and Kylian Mbappe in a 4-1 win at Red Star Belgrade.
Inter Milan were knocked out of the Champions League after they could only manage a 1-1 draw at home to Group B's bottom club PSV Eindhoven on Tuesday to finish third behind Tottenham Hotspur.
Mohamed Salah's first-half strike gave Liverpool a 1-0 win over Napoli in Champions League Group C action on Tuesday.
An under-strength Borussia Dortmund deepened AS Monaco's season-long misery on Tuesday with a 2-0 away victory that ensured they finished top of Champions League Group A ahead of Atletico Madrid.
Atletico Madrid were denied top place in Group A of the Champions League on Tuesday after a goalless draw away at Club Brugge in Belgium meant they finished second behind Borussia Dortmund.
Alessandro Schoepf's stoppage time goal gave Schalke 04 a 1-0 win over Lokomotiv Moscow in Champions League Group D action on Tuesday.
Porto struggled to a 3-2 away victory over Galatasaray in their final Champions League group match on Tuesday but the Turks stayed third in Group D and secured a spot in the Europa League's round of 32.
Real Madrid midfielder Luka Modric has ended the Cristiano Ronaldo-Lionel Messi stranglehold on the Ballon d'Or.
Two first-half goals gave Paris Saint-Germain a crucial 2-1 Champions League home win over Liverpool, putting them in a great position to qualify and leaving Jurgen Klopp's side, finalists last season, in danger of elimination.
Napoli swept aside Red Star Belgrade with a typically entertaining performance as two goals from Dries Mertens helped them to a 3-1 win over the former European champions in their Champions League match on Wednesday.
Borussia Dortmund booked their spot in the Champions League knockout stage with a game to spare after a goalless draw against visitors Club Brugge in Group A on Wednesday.
Christian Eriksen kept Tottenham Hotspur's hopes of reaching the round of 16 in the Champions League alive when he came off the bench to score a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
Lionel Messi scored an excellent individual goal and laid on another as Barcelona beat PSV Eindhoven 2-1 to secure top spot in Champions League Group B on Wednesday.
Atletico Madrid clinched their place in the Champions League round of 16 on Wednesday by beating AS Monaco 2-0 at home while also ensuring that Thierry Henry's hapless visitors will now even miss out on qualification for the Europa League.
A goal in each half was enough for Lokomotiv Moscow to earn a 2-0 win over Galatasaray in Champions League Group D on Wednesday, ending Galatasaray's hopes of qualifying for the knockout stages and sending both Porto and Schalke through.
Juventus clinched a place in the Champions League knockout stages when a brilliant Cristiano Ronaldo assist set up Mario Mandzukic to give them a 1-0 win over Valencia on Tuesday.
Manchester United's Marouane Fellaini struck a controversial stoppage-time winner to bring blessed relief to Old Trafford after a laboured 1-0 win over Young Boys edged them into the Champions League last 16 on Tuesday.
Manchester City progressed to the knockout stages of the Champions League after twice coming from behind to draw 2-2 with Olympique Lyonnais in Group F on Tuesday.
Bayern Munich's Arjen Robben and Robert Lewandowski scored two goals each as the German champions demolished Benfica 5-1 on Tuesday to reach the Champions League round of 16 and lift some of the pressure off boss Niko Kovac.
Real Madrid secured first place in Champions League Group G with 2-0 victory over Roma at the Stadio Olimpico on Tuesday although the Italians are also through to round of 16.