Juventus were frustrated by a stubborn Sevilla side in Turin as the 2015 Champions League finalists started this year's campaign with a 0-0 draw.
Without the recently departed Alvaro Morata and Paul Pogba, two key figures in their run to the final in Berlin two seasons ago, Juve could not unlock the Spanish team that has won the previous three Europa League titles, the most recent of which ensured they went straight into the group stages this term.
Record signing Gonzalo Higuain came closest when he hit the crossbar, while Sami Khedira was wasteful with two clear openings in the first period.
The Italians would have been encouraged by how they got behind their Spanish opponents twice in the early exchanges, though Khedira should have done better on both counts.
The German midfielder, who has scored twice already in the league this year, screwed a first-time right-footed shot wide having been set up by Paulo Dybala, while the same player released Khedira to put an attempt straight at goalkeeper Sergio Rico as he lost his balance.
Just before the hour mark, former Napoli striker Higuain finally came alive and almost gave Juve the lead.
The Argentinian striker's movement to meet Dani Alves' cross was brilliant but he flicked his header against the woodwork with Rico only able to watch from a flat-footed position.
Ten minutes later boss Massimiliano Allegri made a double switch, replacing Kwadwo Asamoah and Patrice Evra with Alex Sandro and Miralem Pjanic, and the changes helped give the home side more urgency.
Alves' centre from the right was touched away from Dybala by Rico's outstretched hand while Pjanic's delivery from the same area of the pitch would have been turned in by Higuain had Nico Pareja not brilliantly read the danger to make a last-gasp block at the near post.
Juventus increasingly sensed it was going to be one of those nights and there was a hint of desperation when Marko Pjaca tried, in vain, to win a penalty when he felt Franco Vazquez's arm brush his back.
There was one final chance for the Serie A champions as Sandro raced in from the touchline and caught out Mariano with a back-post header which Rico did brilliantly to turn away in stoppage time.