Liverpool will face Borussia Dortmund in the Europa League quarterfinals in a clash that sees Jurgen Klopp come up against his former club.
Klopp left Dortmund in July 2015, having taken the Bundesliga side to two league titles and the 2013 Champions League final at Wembley.
Liverpool drew 1-1 at Manchester United on Thursday night, which was enough to see them progress at the expense of their Premier League rivals, while Dortmund defeated Tottenham 5-1 on aggregate to progress.
Defending champions Sevilla, meanwhile, will take on fellow La Liga side Athletic Bilbao, who knocked out Valencia in the round-of-16.
Elsewhere, Czech side Sparta Prague take on Villarreal after their surprise success against Lazio.
Shakhtar Donetsk, the 2009 UEFA Cup winners, meet Portuguese club Braga.
Ties to be played April 5/6 and 12/13:
Braga v Shakhtar Donetsk
Villarreal v Sparta Prague
Athletic Bilbao v Sevilla
Borussia Dortmund v Liverpool