Kevin Gameiro scored the only goal of the game as Valencia defeated 10-man Celtic at the Mestalla in their Europa League tie.
Celtic started brightly, with six unanswered attempts on goal as they attempted to overhaul a 2-0 first-leg deficit.
On 37 minutes, Jeremy Toljan earned a foolish second yellow after bringing down Goncalo Guedes who had sprung the offside trap.
Celtic there then had to spend the majority of the game playing with 10 men, and immediately faced pressure, with Scott Bain pulling off two excellent saves towards the end of the half.
In the second half, Valencia continued to press and finally found a way through when Gameiro finished from close range after Daniel Wass??ôs clever header in the box, taking the game beyond Brendan Rodgers' side.