Arsenal will play Russian club CSKA Moscow in the quarterfinals as they look to win the Europa League for the first time and seal a place in next season's Champions League.
Atletico Madrid, twice winners, face Sporting Lisbon while Bundesliga side RB Leipzig, in the competition for the first time, take on Marseille.
Lazio, meanwhile, face Austrian side RB Salzburg.
All the first legs of the quarterfinal matches will be played on April 5, with the return games taking place on April 12.
The Europa League final is held in Lyon on May 16.