AC Milan's offseason spending spree paid a quick dividend when new signing Ricardo Rodriguez scored in a 1-0 win at CSU Craiova.
The Switzerland defender's 44th-minute free kick from the right flank eluded everyone in the penalty area to find the net.
After a three-season absence from European action, Milan has invested around $250 million in strengthening their squad and should advance from the second leg at San Siro next Thursday.
Also in Romania, the son of Brazilian 2002 World Cup winner Rivaldo, known as Rivaldinho, scored from distance in the 54th to level the match and earn Dinamo Bucharest a 1-1 draw with Athletic Bilbao.
Graeme Shinnie struck a majestic winner as Aberdeen recorded a 2-1 victory over Apollon Limassol at Pittodrie.
The Dons skipper capped an inspirational display by swerving a 25-yard effort into the top corner in the 78th minute of the third qualifying-round first leg.
Valere Germain scored a hat trick in Marseille's 4-2 win over visiting Oostende.