Antoine Griezmann found the net but Atletico Madrid failed to put pressure on leaders Barcelona as they were held 1-1 at home by Girona on Saturday.
Sevilla ended a run of five games without a win with a 3-0 victory at Espanyol.
Marco Asensio's late strike earned Real Madrid a 1-0 first-leg lead in their Copa del Rey quarterfinal with Leganes.
Sevilla scored two late goals to come from behind and beat Atletico Madrid 2-1 in the first leg of their Copa del Rey quarterfinal on Wednesday.
Lionel Messi missed a penalty as Barcelona's 29-match unbeaten record came to a shuddering halt at rivals Espanyol.
Barcelona fought back from two goals down at Real Sociedad to secure their first La Liga win at Anoeta in 11 years as the leaders kept their unbeaten record intact.
Atletico Madrid were indebted to goalkeeper Jan Oblak as they closed the gap on leaders Barcelona to six points with a narrow 1-0 win at Eibar.
Villarreal piled the pressure on under-fire Real Madrid coach Zinedine Zidane as they snatched a 1-0 win over the struggling La Liga champions at the Bernabeu.
Lionel Messi scored twice as holders Barcelona cruised into the quarterfinals of the Copa del Rey with a 5-0 victory over Celta Vigo at the Camp Nou on Thursday night.
Lucas Vazquez scored a brace as Real Madrid booked their place in the quarterfinals of the Copa del Rey following a 2-2 second-leg draw with Numancia at the Bernabeu.
Maxi Gomez headed a late equaliser to earn Celta Vigo a 2-2 draw against Real Madrid at Balaidos, where Gareth Bale had scored twice in as many first-half minutes.
Lionel Messi marked his 400th LaLiga appearance with an early goal as leaders Barcelona beat Levante 3-0 at the Nou Camp to restore their nine-point advantage.
Barcelona have reached an agreement with Liverpool to acquire midfielder Philippe Coutinho, the clubs confirmed on Saturday.
Diego Costa was sent off in his first La Liga appearance since returning to Atletico Madrid after picking up a second yellow card for his celebrations after scoring in a 2-0 win over Getafe.
Gareth Bale's penalty set Real Madrid on their way to an ultimately comfortable 3-0 win in the first leg of their Copa del Rey last-16 tie at Numancia.
Barcelona's record signing Ousmane Dembele made his long-awaited return from injury as the Catalan giants drew the first leg of their Copa del Rey round-of-16 tie with Celta Vigo 1-1.
Barcelona moved 14 points clear of Real Madrid in La Liga as three second-half goals wrapped up a convincing 3-0 victory at the Bernabeu.
Luis Suarez and Paulinho each scored twice as Barcelona tuned up for next week's Clasico with a handsome 4-0 win over Deportivo La Coruna.
Fernando Torres' first goal in La Liga this season gave Atletico Madrid a hard-fought 1-0 win over Alaves on Saturday and lifted the club into second place behind Barcelona.
Eduardo Berizzo's return to the Sevilla dugout delivered some defensive steel but no cutting edge up front as Levante ground out a goalless draw at the Ramon Sanchez Pizjuan.
Barcelona seized on the second-half dismissal of Dani Raba to beat Villarreal 2-0 and restore their five-point lead at the top of La Liga on Sunday night.
Saul Niguez scored the only goal as Atletico Madrid beat Real Betis 1-0 to keep Diego Simeone's team in the chase for the La Liga title.
Cristiano Ronaldo celebrated his fifth Ballon d'Or award with a brace as Real Madrid swept past Sevilla 5-0 following a blistering first-half display at the Bernabeu.
Markel Bergara fired 10-man Getafe to a shock victory over second-placed Valencia to leave Barcelona five points clear at the top of the La Liga table.
Sergio Ramos was sent off for a record 19th time in La Liga as Real Madrid drew 0-0 Athletic Bilbao and failed to take advantage of Barcelona's earlier slip.
Atletico Madrid cut the gap on La Liga leaders Barcelona to six points with a 2-1 comeback win against Real Sociedad.
Barcelona failed to stretch their lead at the top of the Liga table to seven points as Celta Vigo held them to a 2-2 draw in a fine match at the Bernabeu.
Fernando Torres scored his first two goals of the season to help Atletico Madrid reach the Copa del Rey last 16 with a 3-0 win over Elche on Wednesday.
Barcelona swept into the last 16 of the Copa del Rey with a 5-0 win over Real Murcia at the Camp Nou.
Gareth Bale made a welcome return from injury to spare Real Madrid embarrassment in their Copa del Rey clash with Segunda B leaders Fuenlabrada.
Barcelona's quest for an unbeaten La Liga season came to a shocking end with a 5-4 defeat away to Levante on Sunday.
Gareth Bale scored twice to lead Real Madrid to a 6-0 rout over Celta Vigo in La Liga on Saturday.
Atletico Madrid warmed up for the Europa League final by taking a big step towards securing second spot in LaLiga with a 1-0 success at Getafe.
Sevilla remain in the hunt for a Europa League spot as Joaquin Caparros secured his first win since taking temporary charge with a 3-2 win over Real Madrid at the Ramon Sanchez-Pizjuan.
Andres Iniesta provided two world-class assists and Ousmane Dembele added two late goals as La Liga champions Barcelona saw off Villarreal 5-1 on Wednesday to maintain their quest for an unbeaten domestic league season.
Gareth Bale's equaliser helped Real Madrid rally for a 2-2 draw against 10-man Barcelona in a combative affair on Sunday night at the Camp Nou.
Atletico Madrid slumped to their first La Liga home defeat of the season as they were beaten 2-0 by Espanyol at the Wanda Metropolitano Stadium.
Sevilla ended their winless streak and boosted their Europa League hopes with a 1-0 victory against Real Sociedad.
Lionel Messi put the icing on the cake as Barcelona clinched the La Liga title with a 4-2 victory over Deportivo La Coruna, who were relegated.
Atletico Madrid stayed mathematically in the La Liga title race, for a few hours at least, with a 1-0 victory over Alaves.
Real Madrid warmed up for the second leg of their Champions League semifinal against Bayern Munich with a 2-1 home win over Leganes.
Barcelona won their fourth successive Copa del Rey with a merciless 5-0 thrashing of Sevilla as departing hero Andres Iniesta joined the usual suspects on the scoresheet.
Substitute Juanmi struck twice to dent Atletico Madrid's hopes of a top-two La Liga finish as they went down 3-0 at Real Sociedad.
Cristiano Ronaldo scored an exquisite back-heel to rescue a point for Real Madrid in their 1-1 draw against Athletic Bilbao on Wednesday.
Barcelona's charge towards the La Liga title was held up after a much-changed side was held to a 2-2 draw at Celta Vigo, where Sergi Roberto was sent off with his side's first league red card in over a year.
A much-changed Real Madrid edged past basement club Malaga 2-1 to leapfrog Valencia into third place in LaLiga.
Atletico Madrid eased to a 3-0 win at home over Levante to strengthen their hold on second place in La Liga on Sunday.
Barcelona broke a 38-year-old La Liga record on Saturday as they extended their unbeaten streak in Spain's top flight to 39 games by beating Valencia 2-1 at the Camp Nou.
Real Madrid had to settle for a 1-1 draw at home to city rivals Atletico as Antoine Griezmann struck to cancel out Cristiano Ronaldo's opening goal.
Lionel Messi fired a hat trick as Barcelona took another big step towards the La Liga title with a 3-1 home win against Leganes.
Kevin Gameiro converted a match-winning penalty as Atletico Madrid beat struggling Deportivo La Coruna 1-0 to remain in contention for the La Liga title.
Lionel Messi came off the bench to net a stunning last-minute equaliser as La Liga leaders Barcelona fought back from two-goals down to draw 2-2 at Sevilla.
Gareth Bale scored twice as Real Madrid warmed up for their Champions League clash against Juventus with a 3-0 win at struggling Las Palmas, where Cristiano Ronaldo was rested.
Substitute Enes Unal scored twice in the final nine minutes as Villarreal dealt a major blow to Atletico Madrid's hopes of catching Barcelona at the top of La Liga with a 2-1 victory.
Cristiano Ronaldo scored his 50th career hat trick, then went on to add a fourth goal as Real Madrid beat Girona 6-3 in La Liga on Sunday.
Lionel Messi scored for the sixth consecutive game in all competitions as Barcelona tightened their grip in the title race with a 2-0 La Liga win over Athletic Bilbao.
Simone Zaza scored one goal and set up another for Rodrigo Moreno as Valencia claimed a 3-1 La Liga win over Alaves at the Mestalla Stadium.
Atletico Madrid returned to winning ways in style by easing past Celta Vigo in a 3-0 win to reduce the gap to league leaders Barcelona to eight points.
Barcelona tightened their grip at the top of La Liga with a 2-0 win at bottom club Malaga, who played for an hour with 10 men.
Real Madrid overcame a shaky performance to maintain their fine recent form to defeat Eibar 2-1 at the Estadio Municipal de Ipurua.