Atletico Madrid will come away disappointed after a 1-1 draw against Rayo Vallecano to open their round of 16 tie.
A hat trick from Alvaro Negredo gave Valencia coach Gary Neville his second win for the club, 4-0 against Granada.
Zinedine Zidane has been appointed as new Real Madrid coach, with Rafa Benitez having been sacked from the position by club president Florentino Perez on Monday.
Gary Neville's Valencia twice came from behind to claim a 2-2 draw against 10-man Real Madrid in the Primera Division to turn up the heat on Rafael Benitez.
Thomas Partey came off the bench to fire Atletico Madrid to a 1-0 win over struggling Levante and take Diego Simeone's side two points clear at the top of the Primera Division.
Barcelona struck the woodwork twice but were unable to make a winning start to 2016 as they were held to a goalless draw at local rivals Espanyol.
Ten-man Atletico Madrid missed the chance to top the Primera Division at Christmas as they slipped to a shock 1-0 defeat against struggling Malaga.
Gareth Bale doubled his Primera Division tally for the season in one afternoon, scoring four goals as Real Madrid ruthlessly thrashed nine-man Rayo Vallecano 10-2 at the Bernabeu.
Valencia were held to a 2-2 draw by Getafe at the Mestalla as new head coach Gary Neville continued his wait for a first Primera Division victory.
Gary Neville oversaw his first victory as Valencia coach after Barakaldo were defeated 2-0 with goals from Alvaro Negredo and Santi Mina.
A thunderous strike from Antoine Griezmann saw Atletico Madrid come from behind and snatch a 2-1 victory over Athletic Bilbao to go joint-top of the Primera Division.
Real Madrid suffered their third league loss of the Primera Division season after going down 1-0 at Villarreal.
Valencia salvaged a 1-1 draw away to Eibar with a late own goal in Gary Neville's first league fixture as manager.
Barcelona threw away a two-goal lead against Deportivo La Coruna to draw 2-2 at the Nou Camp, dropping two vital points that could see them surrender their place at the top of the Primera Division by the end of the weekend.
Kevin Gameiro scored a late brace to give Sevilla a deserved 2-0 home win over Sporting Gijon.
Cedric Bakambu hit a late brace to hand Villarreal a 2-1 victory over Rayo Vallecano and snatch a first win for Marcelino's side in four league games.
Gary Neville watched from the stands as Valencia survived a Barcelona onslaught to claim a 1-1 draw.
Goals from Diego Godin and Antoine Griezmann maintained Atletico Madrid's title bid as they sank lowly Granada 2-0.
Real Madrid put their Copa del Rey controversy behind them with a thumping 4-1 derby win over Getafe.
Real Madrid have been expelled from this season's Copa del Rey for fielding ineligible player Denis Cheryshev in Wednesday's last-32 first-leg game at Cadiz.
Sandro Ramirez scored a hat trick as Barcelona eased to a 6-1 win over Villanovense in their Copa del Rey second leg encounter. The teams played to a 0-0 draw in the first leg.
Real Madrid sealed a comfortable victory in their Copa del Rey clash at Cadiz, but could be booted out of the competition for fielding an ineligible player.
Atletico Madrid fought back for a 2-1 win at third-division side Reus in their opening match of the Copa del Rey on Tuesday.
Nuno left his role as Valencia coach after his side lost 1-0 to Sevilla and were reduced to nine men.
Gareth Bale and Cristiano Ronaldo scored at the latter end of either half as Real Madrid overcame a testing match at Eibar to win 2-0.
A solitary goal by in-form Antoine Griezmann saw Atletico overcome Espanyol to keep the pressure on league leaders Barcelona -- but they were rocked by a serious injury to midfielder Tiago.
Lionel Messi, Luis Suarez and Neymar all netted as Barcelona eased to a 4-0 win over Real Sociedad, keeping them in the driving seat at the top of the Primera Division.
Atletico Madrid move up to second in the Primera Division after recording a narrow yet deserved 1-0 victory at Real Betis.
Neymar and Luis Suarez continued their superb scoring run to shock Real Madrid and send Barcelona on their way to a 4-0 Clasico thrashing at the Bernabeu.
Real Madrid suffered their first defeat under Rafael Benitez as Sevilla produced a remarkable turnaround to win 3-2 at the Ramon Sanchez Pizjuan on Sunday evening.
Champions Barcelona's domestic strife continued as they were held to a 1-1 draw at Valencia in an absorbing La Liga game on Sunday, with Lionel Messi again coming to their rescue by equalising with an 11th goal in 10 games this season.
Atletico Madrid defeated Real Betis 1-0 in a tight game on Sunday through a second-half strike from forward Angel Correa as coach Diego Simeone's substitutions paid off.
Sevilla moved provisionally top of La Liga by beating visitors Celta Vigo 2-1 on Sunday for a fourth straight victory that saw them climb above Atletico Madrid, who had led the table for a couple of hours after a 1-0 home win over over Real Betis.
Manu Garcia scored a last-minute winner as Deportivo AlavГ©s beat Real Madrid 1-0 at the Mendizorroza in La Liga.
Real Madrid missed the chance to go two points clear of Barcelona at the top of La Liga as they drew 0-0 with Atletico Madrid on Saturday in an edgy, but entertaining, local derby in which the outstanding players were the two goalkeepers.
Barcelona's run of poor form continued following a surprise 1-1 draw at home to Athletic Bilbao on Saturday.
Real Madrid crashed and burned in a 3-0 defeat at a rampant Sevilla on Wednesday, losing for the first time in La Liga under coach Julen Lopetegui and missing the chance to capitalise on Barcelona's shock 2-1 defeat at Leganes.
La Liga leaders Barcelona slumped to a shock first loss of the season on Wednesday, suffering a 2-1 defeat at struggling Leganes after conceding twice in two second-half minutes as coach Ernesto Valverde's squad rotation backfired.
First-half goals from Antoine Griezmann, Thomas Partey and Koke helped a resurgent Atletico Madrid secure a 3-0 home victory over Huesca in La Liga on Tuesday.
Barcelona's 100 percent winning start to the season came to a halt on Sunday when they were held to a 2-2 La Liga draw by Girona on Sunday, having been reduced to playing the final 55 minutes with 10 men.
Marco Asensio's strike earned Real Madrid a 1-0 win over dogged Espanyol to send them provisionally top of La Liga on Saturday.
Thomas Lemar produced an impressive performance as he scored his first goal for Atletico Madrid in their 2-0 win at Getafe that provisionally lifted them to fifth in La Liga on Saturday.
Atletico Madrid averted an embarrassing home defeat to minnows Eibar by drawing 1-1 thanks to a strike from teenage debutant Borja Garces deep in stoppage time but continued their poor start to the La Liga season.
Real Madrid's perfect start to the La Liga season came to a halt on Saturday as they drew 1-1 in an ill-tempered game at Athletic Bilbao and fell two points behind champions Barcelona at the top of the standings.
Barcelona rode their luck to come from behind and win 2-1 at Real Sociedad on Saturday, continuing to banish their awful record in San Sebastian and maintaining their perfect start to the La Liga season.
Lionel Messi and Luis Suarez scored twice each as La Liga champions Barcelona turned on the style to hammer Huesca 8-2 on Sunday and join Real Madrid as the only teams in the league to win their opening three games.
Real Madrid continued their perfect start to the Liga season by thrashing neighbours Leganes 4-1 at the Bernabeu helped by a Karim Benzema double on Saturday.
Atletico Madrid suffered their first major setback of the season as they lost 2-0 at Celta Vigo after defender Stefan Savic was sent off midway through a miserable second-half performance by Diego Simeone's side on Saturday.
A second-half double from Karim Benzema helped Real Madrid to a 4-1 victory at Girona on Sunday and maintain their perfect La Liga start in the post-Cristiano Ronaldo era.
A last-minute VAR decision helped Barcelona secure an unconvincing 1-0 La Liga win over newly-promoted Valladolid on Saturday.
Antoine Griezmann's second-half strike earned Atletico Madrid a first win of the Liga season on Saturday as they defeated local rivals Rayo Vallecano 1-0.
Real Madrid got off to a winning start in La Liga on Sunday by comfortably beating neighbours Getafe 2-0 at home with an inspiring performance from Gareth Bale in the European champions' first league game in the post-Cristiano Ronaldo era.
La Liga champions Barcelona began the new campaign with a 3-0 win over Alaves on Saturday with the help of a spectacular under-the-wall free kick from Lionel Messi, who scored twice, and a curling shot from substitute Philippe Coutinho.
Barcelona lifted the Spanish Super Cup for a record-extending 13th time by coming from behind to beat Sevilla 2-1 on Sunday thanks to a stunning strike from France winger Ousmane Dembele and a penalty save in stoppage time from Marc-Andre ter Stegen.
Thibaut Courtois is set for a move from Chelsea to Real Madrid pending a medical, after the clubs announced they had agreed to a deal on Wednesday.
Barcelona have agreed a deal with Bayern Munich for Arturo Vidal, announcing the midfielder is set to sign a three-year contract.
Barcelona confirmed a deal to sign Malcom from Bordeaux on Tuesday, dramatically hijacking the Brazilian forward's move to Roma at the 11th hour.
Spain national team coach Julen Lopetegui will take over as Real Madrid manager after the World Cup, the Spanish club announced on Tuesday, just two days before the tournament begins in Russia.
Zinedine Zidane has shocked the football world by resigning as Real Madrid coach just days after winning a third consecutive Champions League with the La Liga giants.
Andres Iniesta's final Barcelona appearance ended in victory on an emotional evening at the Nou Camp.