Atletico Madrid built on their Champions League success over Barcelona by beating Granada 3-0 to pile extra pressure on Luis Enrique's side in the title race.
Real Madrid continued to keep the pressure up in Spain as they beat Getafe 5-1 on the road to move to a point behind leaders Barcelona having played a game more.
Villarreal consolidated their grasp on fourth place with a 2-0 victory over strugglers Getafe.
Substitute Alvaro Negredo notched a dramatic stoppage-time winner as Valencia brought their Primera Division losing streak to an end with a 2-1 victory over Sevilla at the Mestalla.
An early goal from teenager Mikel Oyarzabal saw Real Sociedad beat Barcelona 1-0 and blow the Primera Division side wide open.
Fernando Torres, Antoine Griezmann and Koke were among the scorers as Atletico Madrid came from behind to beat Espanyol 3-1 and remain in the title race.
Real Madrid eased the pain of their shock defeat at Wolfsburg as Cristiano Ronaldo scored and provided two assists in a resounding 4-0 win over Eibar.
Sevilla's incredible run at home finally came to an end as they were beaten 2-1 by 10-man Real Sociedad, halting a run of 13 straight Primera Division wins.
Villarreal strengthened their grip on fourth place as they ended their Primera Division winless streak with a 2-1 come-from-behind triumph at Eibar.
Cristiano Ronaldo scored late as 10-man Real Madrid stunned Barcelona 2-1 at the Camp Nou on Saturday to win El Clasico and end their rivals' 39-game unbeaten streak.
Antoine Griezmann scored twice as Atletico Madrid got in the mood for Tuesday's Champions League quarter-final first leg against Barcelona by thrashing Real Betis 5-1 in the Primera Division.
Lionel Messi is one goal shy of 500 career goals and aims to hit that milestone against Real Madrid in El Clasico.
Gary Neville has been sacked by Valencia after less than four months in charge, with former coach Pako Ayestaran taking charge until the end of the season.
Barcelona missed out on the chance to go 11 points clear at the top of the Primera Division as they squandered a two-goal advantage in a 2-2 draw at Villarreal.
Cristiano Ronaldo scored and missed a penalty as Real Madrid cut the gap to neighbours Atletico in second place in the Primera Division to a single point by thrashing Sevilla 4-0 at the Bernabeu.
Atletico Madrid stumbled in their pursuit of Barcelona for the Liga title after conceding two late goals to lose at relegation-threatened Sporting Gijon 2-1 on Saturday.
Brazilian midfielder Casemiro's late header gave Real Madrid a 2-1 victory at Las Palmas where Sergio Ramos was sent off for the 20th time in his career.
Yevhen Konoplyanka scored a brilliant long-range goal as Sevilla beat Villarreal 4-2 win in a thrilling game to keep Unai Emery's side's hopes of a top-four finish alive.
Antoine Griezmann fired his 23rd goal of the season as Atletico Madrid kept the gap to leaders Barcelona to eight points with a comfortable 3-0 home win against Deportivo La Coruna.
Lionel Messi created three goals and scored another as Barcelona warmed up for their Champions League showdown with Arsenal by thrashing Getafe 6-0 at the Camp Nou to equal a club record 12 consecutive La Liga wins.
Two inspirational substitutions from Diego Simeone helped give Atletico Madrid a 3-1 win at Valencia that keeps the Rojiblancos within eight points of Primera Division leaders Barcelona.
A mesmeric performance from Lionel Messi ensured Barcelona barely noticed the absence of Neymar as they eased to a 4-0 win at Eibar.
Cristiano Ronaldo returned to the top of the Primera Division scoring charts by grabbing four goals in the second half as Real Madrid thrashed Celta Vigo 7-1 at the Bernabeu.
Las Palmas took another step towards Primera Division survival by unexpectedly beating Champions League hopefuls Villarreal 1-0 to record a third consecutive victory.
Lionel Messi scored a third hat trick of the season as Barcelona smashed nine-man Rayo Vallecano 5-1 and recorded a tenth straight league win.
A depleted Real Madrid side failed to produce a galvanising performance at Levante following their derby defeat to Atletico Madrid but still earned a 3-1 win.
Atletico Madrid built on their Madrid derby triumph by comfortably beating Real Sociedad 3-0 at the Vicente Calderon to record their biggest home league win of the season.
Goals from Lionel Messi and Gerard Pique saw Barcelona come from behind to beat Sevilla 2-1 at the Nou Camp and equal a Spanish record of 34 games without defeat in all competitions.
Villarreal tightened their grip on a place in the Champions League and moved just two points behind Real Madrid with a comprehensive 3-0 win over 10-man Levante.
Zinedine Zidane suffered his first defeat as Real Madrid coach as Antoine Griezmann gave local rivals Atletico Madrid a 1-0 victory at the Bernabeu.
Real Madrid got off to a winning start in La Liga on Sunday by comfortably beating neighbours Getafe 2-0 at home with an inspiring performance from Gareth Bale in the European champions' first league game in the post-Cristiano Ronaldo era.
La Liga champions Barcelona began the new campaign with a 3-0 win over Alaves on Saturday with the help of a spectacular under-the-wall free kick from Lionel Messi, who scored twice, and a curling shot from substitute Philippe Coutinho.
Barcelona lifted the Spanish Super Cup for a record-extending 13th time by coming from behind to beat Sevilla 2-1 on Sunday thanks to a stunning strike from France winger Ousmane Dembele and a penalty save in stoppage time from Marc-Andre ter Stegen.
Thibaut Courtois is set for a move from Chelsea to Real Madrid pending a medical, after the clubs announced they had agreed to a deal on Wednesday.
Barcelona have agreed a deal with Bayern Munich for Arturo Vidal, announcing the midfielder is set to sign a three-year contract.
Barcelona confirmed a deal to sign Malcom from Bordeaux on Tuesday, dramatically hijacking the Brazilian forward's move to Roma at the 11th hour.
Spain national team coach Julen Lopetegui will take over as Real Madrid manager after the World Cup, the Spanish club announced on Tuesday, just two days before the tournament begins in Russia.
Zinedine Zidane has shocked the football world by resigning as Real Madrid coach just days after winning a third consecutive Champions League with the La Liga giants.
Andres Iniesta's final Barcelona appearance ended in victory on an emotional evening at the Nou Camp.
Fernando Torres scored twice on his final appearance for 10-man Atletico Madrid in Sunday's 2-2 draw against Eibar.
Real Madrid blew a two-goal lead to draw 2-2 with Villarreal in their final La Liga match ahead of the Champions League final against Liverpool.
Barcelona's quest for an unbeaten La Liga season came to a shocking end with a 5-4 defeat away to Levante on Sunday.
Gareth Bale scored twice to lead Real Madrid to a 6-0 rout over Celta Vigo in La Liga on Saturday.
Atletico Madrid warmed up for the Europa League final by taking a big step towards securing second spot in LaLiga with a 1-0 success at Getafe.
Sevilla remain in the hunt for a Europa League spot as Joaquin Caparros secured his first win since taking temporary charge with a 3-2 win over Real Madrid at the Ramon Sanchez-Pizjuan.
Andres Iniesta provided two world-class assists and Ousmane Dembele added two late goals as La Liga champions Barcelona saw off Villarreal 5-1 on Wednesday to maintain their quest for an unbeaten domestic league season.
Gareth Bale's equaliser helped Real Madrid rally for a 2-2 draw against 10-man Barcelona in a combative affair on Sunday night at the Camp Nou.
Atletico Madrid slumped to their first La Liga home defeat of the season as they were beaten 2-0 by Espanyol at the Wanda Metropolitano Stadium.
Sevilla ended their winless streak and boosted their Europa League hopes with a 1-0 victory against Real Sociedad.
Lionel Messi put the icing on the cake as Barcelona clinched the La Liga title with a 4-2 victory over Deportivo La Coruna, who were relegated.
Atletico Madrid stayed mathematically in the La Liga title race, for a few hours at least, with a 1-0 victory over Alaves.
Real Madrid warmed up for the second leg of their Champions League semifinal against Bayern Munich with a 2-1 home win over Leganes.
Barcelona won their fourth successive Copa del Rey with a merciless 5-0 thrashing of Sevilla as departing hero Andres Iniesta joined the usual suspects on the scoresheet.
Substitute Juanmi struck twice to dent Atletico Madrid's hopes of a top-two La Liga finish as they went down 3-0 at Real Sociedad.
Cristiano Ronaldo scored an exquisite back-heel to rescue a point for Real Madrid in their 1-1 draw against Athletic Bilbao on Wednesday.
Barcelona's charge towards the La Liga title was held up after a much-changed side was held to a 2-2 draw at Celta Vigo, where Sergi Roberto was sent off with his side's first league red card in over a year.
A much-changed Real Madrid edged past basement club Malaga 2-1 to leapfrog Valencia into third place in LaLiga.
Atletico Madrid eased to a 3-0 win at home over Levante to strengthen their hold on second place in La Liga on Sunday.
Barcelona broke a 38-year-old La Liga record on Saturday as they extended their unbeaten streak in Spain's top flight to 39 games by beating Valencia 2-1 at the Camp Nou.
Real Madrid had to settle for a 1-1 draw at home to city rivals Atletico as Antoine Griezmann struck to cancel out Cristiano Ronaldo's opening goal.