Lionel Messi is one goal shy of 500 career goals and aims to hit that milestone against Real Madrid in El Clasico.
Gary Neville has been sacked by Valencia after less than four months in charge, with former coach Pako Ayestaran taking charge until the end of the season.
Barcelona missed out on the chance to go 11 points clear at the top of the Primera Division as they squandered a two-goal advantage in a 2-2 draw at Villarreal.
Cristiano Ronaldo scored and missed a penalty as Real Madrid cut the gap to neighbours Atletico in second place in the Primera Division to a single point by thrashing Sevilla 4-0 at the Bernabeu.
Atletico Madrid stumbled in their pursuit of Barcelona for the Liga title after conceding two late goals to lose at relegation-threatened Sporting Gijon 2-1 on Saturday.
Brazilian midfielder Casemiro's late header gave Real Madrid a 2-1 victory at Las Palmas where Sergio Ramos was sent off for the 20th time in his career.
Yevhen Konoplyanka scored a brilliant long-range goal as Sevilla beat Villarreal 4-2 win in a thrilling game to keep Unai Emery's side's hopes of a top-four finish alive.
Antoine Griezmann fired his 23rd goal of the season as Atletico Madrid kept the gap to leaders Barcelona to eight points with a comfortable 3-0 home win against Deportivo La Coruna.
Lionel Messi created three goals and scored another as Barcelona warmed up for their Champions League showdown with Arsenal by thrashing Getafe 6-0 at the Camp Nou to equal a club record 12 consecutive La Liga wins.
Two inspirational substitutions from Diego Simeone helped give Atletico Madrid a 3-1 win at Valencia that keeps the Rojiblancos within eight points of Primera Division leaders Barcelona.
A mesmeric performance from Lionel Messi ensured Barcelona barely noticed the absence of Neymar as they eased to a 4-0 win at Eibar.
Cristiano Ronaldo returned to the top of the Primera Division scoring charts by grabbing four goals in the second half as Real Madrid thrashed Celta Vigo 7-1 at the Bernabeu.
Las Palmas took another step towards Primera Division survival by unexpectedly beating Champions League hopefuls Villarreal 1-0 to record a third consecutive victory.
Lionel Messi scored a third hat trick of the season as Barcelona smashed nine-man Rayo Vallecano 5-1 and recorded a tenth straight league win.
A depleted Real Madrid side failed to produce a galvanising performance at Levante following their derby defeat to Atletico Madrid but still earned a 3-1 win.
Atletico Madrid built on their Madrid derby triumph by comfortably beating Real Sociedad 3-0 at the Vicente Calderon to record their biggest home league win of the season.
Goals from Lionel Messi and Gerard Pique saw Barcelona come from behind to beat Sevilla 2-1 at the Nou Camp and equal a Spanish record of 34 games without defeat in all competitions.
Villarreal tightened their grip on a place in the Champions League and moved just two points behind Real Madrid with a comprehensive 3-0 win over 10-man Levante.
Zinedine Zidane suffered his first defeat as Real Madrid coach as Antoine Griezmann gave local rivals Atletico Madrid a 1-0 victory at the Bernabeu.
Cristiano Ronaldo missed a penalty as Real Madrid slipped even further behind leaders Barcelona in the Primera Division title race by drawing 1-1 at Malaga.
Atletico Madrid's hopes of catching Primera Division leaders Barcelona suffered a setback on Sunday evening as they were held to a 0-0 draw by Villarreal at the Vicente Calderon.
Barcelona survived a late onslaught to beat Las Palmas and remain in the driving seat at the top of the Primera Division.
Lionel Messi passed 300 Primera Division goals as Barcelona extended their lead at the top to six points with a 3-1 victory over Sporting Gijon.
Luis Suarez finished off a collector's item from the penalty spot to score a hat trick as Barcelona hammered Celta Vigo 6-1 with a majestic second-half display.
Fernando Torres scored in consecutive matches for the first time in almost two and a half years as Atletico Madrid edged past Getafe to leapfrog rivals Real Madrid into second place in the Primera Division.
Sevilla boosted their chances of European qualification as they stretched their unbeaten run to 12 matches with a hard-fought 2-0 victory over Las Palmas at the Ramon Sanchez Pizjuan Stadium.
Cristiano Ronaldo scored twice as Real Madrid kept up the pressure on Primera Division title rivals Barcelona and Atletico Madrid with a 4-2 victory over Athletic Bilbao.
Villarreal's top-four hopes remain on track after Roberto Soldado's early goal earned them a 1-0 Primera Division win over Malaga.
Gary Neville ended his long wait for a first La Liga win as Valencia coach as late goals from Alvaro Negredo and Denis Cheryshev helped his side come from behind to beat Espanyol 2-1.
Gary Neville experienced yet more frustration as a late goal from teenager Wilfrid Kaptoum denied Valencia a much-needed win over Barcelona's reserves in the Copa del Rey.
Barcelona's quest for an unbeaten La Liga season came to a shocking end with a 5-4 defeat away to Levante on Sunday.
Gareth Bale scored twice to lead Real Madrid to a 6-0 rout over Celta Vigo in La Liga on Saturday.
Atletico Madrid warmed up for the Europa League final by taking a big step towards securing second spot in LaLiga with a 1-0 success at Getafe.
Sevilla remain in the hunt for a Europa League spot as Joaquin Caparros secured his first win since taking temporary charge with a 3-2 win over Real Madrid at the Ramon Sanchez-Pizjuan.
Andres Iniesta provided two world-class assists and Ousmane Dembele added two late goals as La Liga champions Barcelona saw off Villarreal 5-1 on Wednesday to maintain their quest for an unbeaten domestic league season.
Gareth Bale's equaliser helped Real Madrid rally for a 2-2 draw against 10-man Barcelona in a combative affair on Sunday night at the Camp Nou.
Atletico Madrid slumped to their first La Liga home defeat of the season as they were beaten 2-0 by Espanyol at the Wanda Metropolitano Stadium.
Sevilla ended their winless streak and boosted their Europa League hopes with a 1-0 victory against Real Sociedad.
Lionel Messi put the icing on the cake as Barcelona clinched the La Liga title with a 4-2 victory over Deportivo La Coruna, who were relegated.
Atletico Madrid stayed mathematically in the La Liga title race, for a few hours at least, with a 1-0 victory over Alaves.
Real Madrid warmed up for the second leg of their Champions League semifinal against Bayern Munich with a 2-1 home win over Leganes.
Barcelona won their fourth successive Copa del Rey with a merciless 5-0 thrashing of Sevilla as departing hero Andres Iniesta joined the usual suspects on the scoresheet.
Substitute Juanmi struck twice to dent Atletico Madrid's hopes of a top-two La Liga finish as they went down 3-0 at Real Sociedad.
Cristiano Ronaldo scored an exquisite back-heel to rescue a point for Real Madrid in their 1-1 draw against Athletic Bilbao on Wednesday.
Barcelona's charge towards the La Liga title was held up after a much-changed side was held to a 2-2 draw at Celta Vigo, where Sergi Roberto was sent off with his side's first league red card in over a year.
A much-changed Real Madrid edged past basement club Malaga 2-1 to leapfrog Valencia into third place in LaLiga.
Atletico Madrid eased to a 3-0 win at home over Levante to strengthen their hold on second place in La Liga on Sunday.
Barcelona broke a 38-year-old La Liga record on Saturday as they extended their unbeaten streak in Spain's top flight to 39 games by beating Valencia 2-1 at the Camp Nou.
Real Madrid had to settle for a 1-1 draw at home to city rivals Atletico as Antoine Griezmann struck to cancel out Cristiano Ronaldo's opening goal.
Lionel Messi fired a hat trick as Barcelona took another big step towards the La Liga title with a 3-1 home win against Leganes.
Kevin Gameiro converted a match-winning penalty as Atletico Madrid beat struggling Deportivo La Coruna 1-0 to remain in contention for the La Liga title.
Lionel Messi came off the bench to net a stunning last-minute equaliser as La Liga leaders Barcelona fought back from two-goals down to draw 2-2 at Sevilla.
Gareth Bale scored twice as Real Madrid warmed up for their Champions League clash against Juventus with a 3-0 win at struggling Las Palmas, where Cristiano Ronaldo was rested.
Substitute Enes Unal scored twice in the final nine minutes as Villarreal dealt a major blow to Atletico Madrid's hopes of catching Barcelona at the top of La Liga with a 2-1 victory.
Cristiano Ronaldo scored his 50th career hat trick, then went on to add a fourth goal as Real Madrid beat Girona 6-3 in La Liga on Sunday.
Lionel Messi scored for the sixth consecutive game in all competitions as Barcelona tightened their grip in the title race with a 2-0 La Liga win over Athletic Bilbao.
Simone Zaza scored one goal and set up another for Rodrigo Moreno as Valencia claimed a 3-1 La Liga win over Alaves at the Mestalla Stadium.
Atletico Madrid returned to winning ways in style by easing past Celta Vigo in a 3-0 win to reduce the gap to league leaders Barcelona to eight points.
Barcelona tightened their grip at the top of La Liga with a 2-0 win at bottom club Malaga, who played for an hour with 10 men.
Real Madrid overcame a shaky performance to maintain their fine recent form to defeat Eibar 2-1 at the Estadio Municipal de Ipurua.