Aritz Aduriz scored twice as Athletic Bilbao hit back from behind to heap more woe on pointless Valencia at San Mames on Sunday.
Antoine Griezmann and Fernando Torres both scored twice as Atletico Madrid claimed a 5-0 win over Sporting Gijon.
Lionel Messi scored twice as Barcelona thumped Leganes 5-1 in La Liga.
Ten-man Valencia almost sealed a draw from a two-goal deficit but lost 3-2 in the 93rd minute against Real Betis on Sunday.
Barcelona slumped to a shock 2-1 defeat to Alaves as the champions' hopes of retaining their league title suffered an early setback.
Las Palmas were within minutes of extending their 100 per cent start to three matches at Sevilla but somehow ended up beaten 2-1 after the hosts launched an incredible late comeback.
Atletico Madrid picked up their first win of the La Liga season at Celta Vigo.
Cristiano Ronaldo took just six minutes to mark his return from a knee injury as Real Madrid maintained their 100 per cent start to the season in LaLiga with a 5-2 win over hapless Osasuna at the Bernabeu.
Manchester City midfielder Samir Nasri has completed a season-long loan move to La Liga side Sevilla.
Ivan Rakitic's firm header steered Barcelona to a 1-0 victory away to Athletic Bilbao as Luis Enrique's champions made it two wins from two in La Liga.
Jorge Sampaoli's free-wheeling Sevilla side were held goalless at Villarreal as goalkeeper Sergio Rico was kept busy by the Yellow Submarine at El Madrigal.
Real Madrid made it two wins out of two in La Liga on Saturday, but were made to work hard to claim all three points against Celta Vigo at the Bernabeu.
Gareth Bale made it five goals in four trips to San Sebastian as his early goal set Real Madrid on the way to a comfortable 3-0 victory away to Real Sociedad.
Atletico Madrid dropped two points in extraordinary fashion after conceding a stoppage-time equaliser to Alaves in a 1-1 draw having only gone in front two minutes earlier.
Villarreal drew 1-1 in their opening LaLiga fixture of the season at Granada, and their first under new coach Fran Escriba.
Sevilla secured victory in their opening fixture of LaLiga season with an entertaining 6-3 defeat of Espanyol.
Barcelona got their La Liga title defence off to the perfect start with a comfortable home win over Real Betis in which Lionel Messi scored twice and Luis Suarez grabbed a hat trick.
Arda Turan scored twice as Barcelona eased to a 3-0 second-leg win against Sevilla to secure the Spanish Super Cup by a 5-0 aggregate following Sunday's first leg.
Real Madrid ran out 5-3 winners against Ligue 1 club Reims in the Santiago Bernabeu trophy match -- a friendly -- with Alvaro Morata scoring for the first time since returning to Los Blancos from Juventus.
Luis Suarez was back in the goal-scoring routine as Barcelona claimed a Spanish Super Cup advantage with a 2-0 victory away to Sevilla.
Lionel Messi scored twice as Barcelona beat Sampdoria 3-2 in the annual Joan Gamper Trophy match at the Camp Nou.
Villarreal have further bolstered their attacking options by signing Nicola Sansone from Sassuolo.
A 79th-minute goal by Danilo earned Real Madrid a 1-0 International Champions Cup win over Bayern Munich in New Jersey.
Munir El Haddadi scored twice and Barcelona held off a second-half rally from Leicster City to win 4-2 in the International Champions Cup on Wednesday in Stockholm.
Celtic were out-gunned but not out-classed as they fell to a 3-1 defeat to Barcelona in Dublin.
Real Madrid rode a dominating first half performance to defeat English Premier League side Chelsea 3-2 in an International Champions Cup match on Saturday.
Atletico Madrid have agreed a deal to sign Kevin Gameiro from Sevilla on a four-year contract.
Villarreal have signed Alexandre Pato from Corinthians on a four-year deal. Pato's contract with Corinthians was set to expire in December, allowing him to negotiate a free transfer with any club.
Barcelona have agreed a deal to sign Portugal midfielder Andre Gomes from La Liga rivals Valencia.
Valencia presented new signing Nani on Thursday in front of more than 12,000 fans at the Mestalla.
Barcelona lifted the Spanish Super Cup for a record-extending 13th time by coming from behind to beat Sevilla 2-1 on Sunday thanks to a stunning strike from France winger Ousmane Dembele and a penalty save in stoppage time from Marc-Andre ter Stegen.
Thibaut Courtois is set for a move from Chelsea to Real Madrid pending a medical, after the clubs announced they had agreed to a deal on Wednesday.
Barcelona have agreed a deal with Bayern Munich for Arturo Vidal, announcing the midfielder is set to sign a three-year contract.
Barcelona confirmed a deal to sign Malcom from Bordeaux on Tuesday, dramatically hijacking the Brazilian forward's move to Roma at the 11th hour.
Spain national team coach Julen Lopetegui will take over as Real Madrid manager after the World Cup, the Spanish club announced on Tuesday, just two days before the tournament begins in Russia.
Zinedine Zidane has shocked the football world by resigning as Real Madrid coach just days after winning a third consecutive Champions League with the La Liga giants.
Andres Iniesta's final Barcelona appearance ended in victory on an emotional evening at the Nou Camp.
Fernando Torres scored twice on his final appearance for 10-man Atletico Madrid in Sunday's 2-2 draw against Eibar.
Real Madrid blew a two-goal lead to draw 2-2 with Villarreal in their final La Liga match ahead of the Champions League final against Liverpool.
Barcelona's quest for an unbeaten La Liga season came to a shocking end with a 5-4 defeat away to Levante on Sunday.
Gareth Bale scored twice to lead Real Madrid to a 6-0 rout over Celta Vigo in La Liga on Saturday.
Atletico Madrid warmed up for the Europa League final by taking a big step towards securing second spot in LaLiga with a 1-0 success at Getafe.
Sevilla remain in the hunt for a Europa League spot as Joaquin Caparros secured his first win since taking temporary charge with a 3-2 win over Real Madrid at the Ramon Sanchez-Pizjuan.
Andres Iniesta provided two world-class assists and Ousmane Dembele added two late goals as La Liga champions Barcelona saw off Villarreal 5-1 on Wednesday to maintain their quest for an unbeaten domestic league season.
Gareth Bale's equaliser helped Real Madrid rally for a 2-2 draw against 10-man Barcelona in a combative affair on Sunday night at the Camp Nou.
Atletico Madrid slumped to their first La Liga home defeat of the season as they were beaten 2-0 by Espanyol at the Wanda Metropolitano Stadium.
Sevilla ended their winless streak and boosted their Europa League hopes with a 1-0 victory against Real Sociedad.
Lionel Messi put the icing on the cake as Barcelona clinched the La Liga title with a 4-2 victory over Deportivo La Coruna, who were relegated.
Atletico Madrid stayed mathematically in the La Liga title race, for a few hours at least, with a 1-0 victory over Alaves.
Real Madrid warmed up for the second leg of their Champions League semifinal against Bayern Munich with a 2-1 home win over Leganes.
Barcelona won their fourth successive Copa del Rey with a merciless 5-0 thrashing of Sevilla as departing hero Andres Iniesta joined the usual suspects on the scoresheet.
Substitute Juanmi struck twice to dent Atletico Madrid's hopes of a top-two La Liga finish as they went down 3-0 at Real Sociedad.
Cristiano Ronaldo scored an exquisite back-heel to rescue a point for Real Madrid in their 1-1 draw against Athletic Bilbao on Wednesday.
Barcelona's charge towards the La Liga title was held up after a much-changed side was held to a 2-2 draw at Celta Vigo, where Sergi Roberto was sent off with his side's first league red card in over a year.
A much-changed Real Madrid edged past basement club Malaga 2-1 to leapfrog Valencia into third place in LaLiga.
Atletico Madrid eased to a 3-0 win at home over Levante to strengthen their hold on second place in La Liga on Sunday.
Barcelona broke a 38-year-old La Liga record on Saturday as they extended their unbeaten streak in Spain's top flight to 39 games by beating Valencia 2-1 at the Camp Nou.
Real Madrid had to settle for a 1-1 draw at home to city rivals Atletico as Antoine Griezmann struck to cancel out Cristiano Ronaldo's opening goal.
Lionel Messi fired a hat trick as Barcelona took another big step towards the La Liga title with a 3-1 home win against Leganes.
Kevin Gameiro converted a match-winning penalty as Atletico Madrid beat struggling Deportivo La Coruna 1-0 to remain in contention for the La Liga title.