Sevilla surged up to second in LaLiga as four goals in 10 first-half minutes swept Malaga aside at the Estadio Ramon Sanchez Pizjuan.
Saul Niguez made the difference as Atletico Madrid secured a hard-fought 1-0 win over Las Palmas in La Liga.
Villarreal leapfrogged Atletico Madrid and up to fourth in La Liga after a commendable 3-0 victory at El Madrigal.
Substitute Vicente Iborra scored a decisive second half hat-trick as Sevilla swept aside Celta Vigo 3-0 to move within a point of second-placed Barcelona.
La Liga leaders Real Madrid produced a remarkable comeback to beat Deportivo La Coruna 3-2 in stoppage time at the Santiago Bernabeu and make history as their unbeaten run extended to 35 matches.
Barcelona cruised to a comfortable win at Osasuna as second-half strikes from Luis Suarez and two from Lionel Messi secured the points.
Atletico Madrid failed to make up ground on their main La Liga rivals after being held to a goalless draw by Espanyol.
Granada recorded their first LaLiga win of the season at the 14th attempt as they put title-chasing Sevilla to the sword at Los Carmenes.
Sergio Ramos scored a late equaliser to keep Real Madrid's six-point lead at the top of La Liga intact as they extended their unbeaten run in all competitions to 33 games with a 1-1 draw against Barcelona.
Barcelona laboured to a 1-1 draw at Segunda Division B side Hercules in the first leg of their Copa del Rey fourth-round tie.
Mariano plundered a hat trick and Enzo Zidane scored on his senior debut as Real Madrid swept aside Cultural Leonesa 6-1 to cruise into the last 16 of the Copa del Rey with a 13-2 aggregate victory.
Valencia secured a 3-1 advantage from the first leg of their Copa del Rey fourth-round tie against Leganes.
Barcelona's terrible record at the Anoeta continued and they were fortunate to escape with even a point as Real Sociedad were denied a clear winner in their 1-1 draw.
Diego Godin and Kevin Gameiro scored within two minutes of each other as Atletico Madrid bounced back from their derby disappointment with a 3-0 La Liga victory at Osasuna.
Sevilla moved up to second place in LaLiga with a 2-1 win over Valencia at the Estadio Ramon Sanchez Pizjuan on Saturday evening.
Real Madrid reeled off their sixth straight La Liga victory to remain in control at the top of the table, but were made to sweat by Sporting Gijon as they clung on to win 2-1.
Athletic Bilbao moved within two points of fourth-placed Villarreal in LaLiga as Raul Garcia's goal midway through the second half proved the difference at San Mames.
Cristiano Ronaldo savoured derby delight again with yet another treble as Real Madrid opened up a four-point lead at the top of La Liga.
Barcelona looked as off-colour as their poorly superstar Lionel Messi as they struggled to break down Malaga at the Camp Nou.
Gabriel Mercado was the hugely controversial match-winner for Sevilla as they came from 2-0 down to beat Deportivo La Coruna 3-2 at the Estadio Riazor.
A goal and an assist from Lionel Messi kept Barcelona on Real Madrid's coat-tails at the top of La Liga as they came from behind to win a cracking encounter with Sevilla 2-1.
Gareth Bale scored two first-half goals as Real Madrid dispatched minnows Leganes 3-0 to record their first clean sheet in 11 matches.
Atletico Madrid missed the chance to return to the top of La Liga as two spot-kicks steered Real Sociedad to a 2-0 victory at the Estadio Anoeta.
Late goals from Ivan Ramis and Pedro Leon sealed a dramatic 2-1 win for Eibar and handed visitors Villarreal their first defeat of the new La Liga season.
Rafinha scored the only goal as Barcelona moved up to second in LaLiga with a laboured 1-0 victory over struggling Granada at the Nou Camp.
Yannick Carrasco and Kevin Gameiro both struck twice as Atletico Madrid beat Malaga 4-2 in a La Liga clash that saw both sides finish with 10 men.
Cristiano Ronaldo hit a hat-trick and missed a penalty as leaders Real Madrid came from behind to beat Alaves 4-1 in an entertaining LaLiga contest.
Sevilla missed the chance to record their best start to a league season after being held 1-1 by Sporting Gijon on another frustrating trip to El Molinon for the Andalusian side.
Real Madrid opened their Copa del Rey campaign with a 7-1 rout of third-tier Cultural Leonesa.
Substitute Alvaro Morata was the hero for Real Madrid as they claimed a hard-fought 2-1 win over Athletic Bilbao.
Barcelona's quest for an unbeaten La Liga season came to a shocking end with a 5-4 defeat away to Levante on Sunday.
Gareth Bale scored twice to lead Real Madrid to a 6-0 rout over Celta Vigo in La Liga on Saturday.
Atletico Madrid warmed up for the Europa League final by taking a big step towards securing second spot in LaLiga with a 1-0 success at Getafe.
Sevilla remain in the hunt for a Europa League spot as Joaquin Caparros secured his first win since taking temporary charge with a 3-2 win over Real Madrid at the Ramon Sanchez-Pizjuan.
Andres Iniesta provided two world-class assists and Ousmane Dembele added two late goals as La Liga champions Barcelona saw off Villarreal 5-1 on Wednesday to maintain their quest for an unbeaten domestic league season.
Gareth Bale's equaliser helped Real Madrid rally for a 2-2 draw against 10-man Barcelona in a combative affair on Sunday night at the Camp Nou.
Atletico Madrid slumped to their first La Liga home defeat of the season as they were beaten 2-0 by Espanyol at the Wanda Metropolitano Stadium.
Sevilla ended their winless streak and boosted their Europa League hopes with a 1-0 victory against Real Sociedad.
Lionel Messi put the icing on the cake as Barcelona clinched the La Liga title with a 4-2 victory over Deportivo La Coruna, who were relegated.
Atletico Madrid stayed mathematically in the La Liga title race, for a few hours at least, with a 1-0 victory over Alaves.
Real Madrid warmed up for the second leg of their Champions League semifinal against Bayern Munich with a 2-1 home win over Leganes.
Barcelona won their fourth successive Copa del Rey with a merciless 5-0 thrashing of Sevilla as departing hero Andres Iniesta joined the usual suspects on the scoresheet.
Substitute Juanmi struck twice to dent Atletico Madrid's hopes of a top-two La Liga finish as they went down 3-0 at Real Sociedad.
Cristiano Ronaldo scored an exquisite back-heel to rescue a point for Real Madrid in their 1-1 draw against Athletic Bilbao on Wednesday.
Barcelona's charge towards the La Liga title was held up after a much-changed side was held to a 2-2 draw at Celta Vigo, where Sergi Roberto was sent off with his side's first league red card in over a year.
A much-changed Real Madrid edged past basement club Malaga 2-1 to leapfrog Valencia into third place in LaLiga.
Atletico Madrid eased to a 3-0 win at home over Levante to strengthen their hold on second place in La Liga on Sunday.
Barcelona broke a 38-year-old La Liga record on Saturday as they extended their unbeaten streak in Spain's top flight to 39 games by beating Valencia 2-1 at the Camp Nou.
Real Madrid had to settle for a 1-1 draw at home to city rivals Atletico as Antoine Griezmann struck to cancel out Cristiano Ronaldo's opening goal.
Lionel Messi fired a hat trick as Barcelona took another big step towards the La Liga title with a 3-1 home win against Leganes.
Kevin Gameiro converted a match-winning penalty as Atletico Madrid beat struggling Deportivo La Coruna 1-0 to remain in contention for the La Liga title.
Lionel Messi came off the bench to net a stunning last-minute equaliser as La Liga leaders Barcelona fought back from two-goals down to draw 2-2 at Sevilla.
Gareth Bale scored twice as Real Madrid warmed up for their Champions League clash against Juventus with a 3-0 win at struggling Las Palmas, where Cristiano Ronaldo was rested.
Substitute Enes Unal scored twice in the final nine minutes as Villarreal dealt a major blow to Atletico Madrid's hopes of catching Barcelona at the top of La Liga with a 2-1 victory.
Cristiano Ronaldo scored his 50th career hat trick, then went on to add a fourth goal as Real Madrid beat Girona 6-3 in La Liga on Sunday.
Lionel Messi scored for the sixth consecutive game in all competitions as Barcelona tightened their grip in the title race with a 2-0 La Liga win over Athletic Bilbao.
Simone Zaza scored one goal and set up another for Rodrigo Moreno as Valencia claimed a 3-1 La Liga win over Alaves at the Mestalla Stadium.
Atletico Madrid returned to winning ways in style by easing past Celta Vigo in a 3-0 win to reduce the gap to league leaders Barcelona to eight points.
Barcelona tightened their grip at the top of La Liga with a 2-0 win at bottom club Malaga, who played for an hour with 10 men.
Real Madrid overcame a shaky performance to maintain their fine recent form to defeat Eibar 2-1 at the Estadio Municipal de Ipurua.