A bizarre own goal from West Ham's James Collins helped Manchester City back to winning ways in the Premier League.
A fumble from Reading goalkeeper Adam Federici in extra time handed holders Arsenal a 2-1 victory and a place in the FA Cup final.
Chelsea have one hand on the Premier League title after Eden Hazard fired them to a 1-0 win at Stamford Bridge.
Raheem Sterling grabbed the headlines on and off the field as Liverpool reignited their Champions League hopes with a 2-0 defeat of 10-man Newcastle.
Louis van Gaal's dream turned into reality as Manchester United put four goals past City in a superb derby win at Old Trafford.
Cesc Fabregas scored an 88th-minute winner as Chelsea restored their seven-point lead at the top of the table with a 1-0 victory at West London rivals QPR.
Aaron Ramsey marked his 150th Premier League appearance with a first half winner as Arsenal closed the gap on leaders Chelsea to four points with a hard-fought 1-0 win at Turf Moor.
Christian Benteke scored his eighth goal in six games to hand Tim Sherwood a winning return to Tottenham and ease Aston Villa's relegation fears.
Playmaker Philippe Coutinho was Liverpool's FA Cup saviour again as his solitary goal beat Blackburn 1-0 to book a Wembley semifinal with Aston Villa.
Manchester City's grip on the Premier League title was loosened further after a controversial Glenn Murray goal put Crystal Palace on the way to a 2-1 victory.
Harry Kane's first outing as captain of Tottenham failed to inspire Spurs in an insipid 0-0 draw at Burnley.
Chelsea responded from conceding a Charlie Adam goal from his own half and losing Diego Costa to a hamstring injury to beat Stoke 2-1 and move seven points clear in the Premier League title race.
Manchester United climbed above their 'noisy neighbours' into third position thanks to a 3-1 win over Aston Villa which included a stunning strike from Wayne Rooney.
Arsenal kept up the pressure at the top of the Premier League as Liverpool were blown away 4-1 at the Emirates Stadium, where Reds contract rebel Raheem Sterling failed to make an impact.
A moment of madness from Liverpool captain Steven Gerrard saw him sent off just 43 seconds after coming on in his final appearance against Manchester United, whose 2-1 victory at Anfield.
Chelsea survived a major scare to secure a 3-2 win at Hull City and restore their six-point lead at the top of the Premier League.
Referee Neil Swarbrick took the gloss off Manchester City's return to winning ways as the Premier League suffered yet another mistaken identity controversy.
Harry Kane's dream week got even better on Saturday as the Tottenham striker followed his first England callup with a maiden Premier League hat trick as embattled Leicester were defeated in a thrilling 4-3 encounter.
Olivier Giroud's first-half double handed Arsenal a sixth successive Premier League victory as they survived a spirited fightback to win 2-1 at Newcastle.
Liverpool maintained the pressure in the race for Champions League qualification as Jordan Henderson's fortunate second-half goal saw off Swansea at the Liberty Stadium to seal a 1-0 win.
Wayne Rooney and Manchester United delivered a knockout performance as Tottenham were blown away at Old Trafford.
Chelsea missed the opportunity to go eight points clear at the top of the Premier League by drawing 1-1 against Southampton.
George Boyd struck a stunning second-half winner as Burnley enhanced their survival hopes by further ravaging Manchester City's fading title quest with a 1-0 victory at Turf Moor.
Olivier Giroud's thunderbolt helped Arsenal see off the challenge of West Ham and cement their place in the top four of the Premier League with a 3-0 victory.
Danny Welbeck came back to haunt Louis van Gaal as the Manchester United manager was subjected to a night of despair and defeat at Old Trafford.
There was little magic in this FA Cup quarterfinal on an afternoon when, for once, Liverpool's free-flowing football deserted them in the face of a committed and well-organised Blackburn side.
QPR's hopes of beating the drop received a major blow as Harry Kane underlined his England credentials with a match-winning brace for Tottenham.
Fabian Delph's first goal in a year helped fire Aston Villa to Wembley as they beat West Brom 2-0 to reach the FA Cup semifinals.
Olivier Giroud and Alexis Sanchez guided Arsenal to a routine 2-1 Premier League victory at struggling QPR, despite Charlie Austin striking back late on.
Chelsea followed up their Capital One Cup victory with a hard-fought 1-0 win on their return to Premier League business at West Ham.
Liverpool had far too much attacking power for Bournemouth to withstand as they moved back into the top four with a 4-0 win at the Vitality Stadium.
Manchester United held on for a 2-1 win at West Bromwich Albion to cut neighbours Manchester City's lead at the top of the Premier League back to 11 points.
Leaders Manchester City powered to their 16th successive win in the Premier League with a 4-1 thrashing of Tottenham at the Etihad Stadium.
Arsenal returned to winning ways but had Mesut Ozil to thank for scoring a wonderful winner as they toiled against out-of-form Newcastle.
Time was on Chelsea's side as Marcos Alonso's free-kick earned a 1-0 Premier League win over Southampton.
Arsenal lost further ground on the Premier League leaders after they were held to a goalless draw at West Ham.
Tottenham climbed back into the Premier League's top four as Serge Aurier's fluke-goal and a header from Son Heung-min sealed a 2-0 victory over Brighton.
Liverpool manager Jurgen Klopp reunited the "Fab Four" but his prolific attacking quartet were all distinctly off-key as West Brom held out for a goalless draw at Anfield.
Manchester City set a new Premier League record of 15 consecutive wins with a 4-0 victory at bottom club Swansea.
Romelu Lukaku got a much-needed goal as Manchester United moved on from their galling derby defeat by beating Bournemouth.
Willian scored one and made two others as Chelsea finally turned in a display worthy of Premier League champions to win 3-1 at Huddersfield.
Runaway Premier League leaders Manchester City opened up an eye-watering double-digit lead over rivals Manchester United after Nicolas Otamendi fired Pep Guardiola's men to derby victory.
Wayne Rooney's first Merseyside derby goal earned Everton a 1-1 draw at Anfield as Liverpool manager Jurgen Klopp's selection gamble backfired.
Olivier Giroud climbed off the bench to rescue a point for Arsenal in a 1-1 draw at Southampton.
Ayoze Perez's late own goal cost Newcastle a precious Premier League draw as Leicester ruined the Magpies' 125th birthday celebrations.
Tottenham ended a four-match Premier League winless streak in style with Harry Kane scoring a brace as they thrashed Stoke 5-1 at Wembley.
Marko Arnautovic's first West Ham goal secured a 1-0 victory over Chelsea and a first win for manager David Moyes.
Manchester City left it late for the third game in a row as they beat West Ham United 2-1 at the Etihad Stadium thanks to David Silva's strike and extended their Premier League lead.
Bournemouth and Southampton shared the spoils as an entertaining match on the south coast finished in a 1-1 draw.
Jesse Lingard scored twice but Paul Pogba was sent off as Manchester United beat Arsenal 3-1 in a breathless match at the Emirates Stadium.
Talk of Burnley qualifying for Europe was dealt a sobering blow with defeat at improving Leicester.
Gylfi Sigurdsson and Dominic Calvert-Lewin scored second-half goals as Sam Allardyce's first game in charge of Everton ended in a 2-0 home win over Huddersfield.
Davinson Sanchez's red card forced Tottenham to fight for a 1-1 draw at Watford, toughening their battle to climb back into the Premier League's top four.
Philippe Coutinho and Roberto Firmino demolished Brighton to keep Liverpool's top-four charge on track.
A sparkling two-goal performance from Eden Hazard helped Chelsea come from a goal down to beat Newcastle 3-1 at Stamford Bridge and go level on points with second-placed Manchester United.
Substitute Mohamed Salah's purple patch continued with two more goals as Liverpool ground out a controversial 3-0 win at Stoke.
Raheem Sterling scored a dramatic winner as Manchester City maintained their winning run with a last-gasp 2-1 defeat of Southampton.
Antonio Conte was sent off as Chelsea claimed a fifth Premier League win in six games with a 1-0 defeat of Swansea.
Arsenal strengthened their position in the Premier League top four as they made light work of Huddersfield to maintain their healthy home form.
Newcastle ended a run of four straight defeats after coming back from 2-0 down to claim a gutsy point at West Brom.