Jose Mourinho was back in the dugout and Diego Costa returned to the score sheet as Chelsea claimed a much-needed 1-0 win over Norwich.
Troy Deeney went from hero to villain in the space of five minutes as the Watford striker scored a late penalty and then an own goal to give Manchester United a 2-1 victory at Vicarage Road.
Arsenal missed the chance to go top of the Premier League as they were held to a 1-1 draw by Tottenham in Sunday's North London derby at the Emirates Stadium.
Scott Dann ended Jurgen Klopp's unbeaten start as Liverpool manager with a late header which gave a vibrant Crystal Palace their third successive Premier League victory over the Reds.
Aston Villa claimed a vital point in their survival fight as they held Manchester City in Remi Garde's first game in charge.
Chelsea suffered a third straight Barclays Premier League defeat as they were beaten 1-0 at Stoke to heap the pressure back on their absent manager Jose Mourinho.
Jesse Lingard gave the home support inside Old Trafford something to cheer as he helped Manchester United to a 2-0 victory over 10-man West Brom with his first goal for the club.
New Aston Villa manager Remi Garde watched his team lose 3-1 at White Hart Lane on Monday night as Tottenham moved up to fifth in the Premier League table.
Arouna Kone's hat trick saw Everton rack up their biggest Premier League win in eight years with as they demolished Sunderland 6-2 at Goodison Park.
Manchester United lost ground in the race for the Premier League title with a 0-0 draw at Crystal Palace that could easily have ended in defeat.
Arsenal made light of their injury problems with a comprehensive 3-0 Premier League win at Swansea.
Yaya Toure struck a late penalty winner as Premier League leaders Manchester City snatched a dramatic 2-1 win over 10-man Norwich.
Jose Mourinho's position as Chelsea boss appears ever more precarious after Jurgen Klopp's Liverpool inflicted Chelsea's sixth defeat in 11 Premier League games.
Wayne Rooney, Michael Carrick and Ashley Young all missed penalties as Middlesbrough knocked Manchester United out of the Capital One Cup on penalties at Old Trafford.
Wilfried Bony and Kelechi Iheanacho were among the goalscorers as Manchester City eased into the Capital One Cup quarterfinals with a 5-1 win over Crystal Palace.
Jurgen Klopp's first victory as Liverpool manager was secured via the unlikeliest of sources as defender Nathaniel Clyne scored the only goal to beat Bournemouth 1-0.
The pressure on Jose Mourinho cranked up another notch as holders Chelsea crashed out of the Capital One Cup with a 5-4 loss on penalties at 10-man Stoke following a 1-1 draw after 120 minutes.
Arsenal were unceremoniously dumped out of the Capital One Cup on a damaging night as Sheffield Wednesday blew them away with a stunning 3-0 victory at Hillsborough.
Southampton's Sadio Mane scored late to deny Jurgen Klopp his first win as Liverpool manager, with Sunday's Premier League match finishing 1-1.
Harry Kane returned to form as he struck a hat trick to sink sorry Bournemouth in the Premier League on Sunday.
Manchester City moved to the top of the Premier League despite a dull goalless draw in the Manchester derby at Old Trafford.
Arsenal moved to the top of the Premier League following a hard-earned 2-1 win over Everton at the Emirates Stadium.
Chelsea slumped to their fifth defeat of the Premier League season amid controversial scenes as West Ham won 2-1 at Upton Park.
Georginio Wijnaldum hit Norwich for four as Newcastle finally ended their wait for a Premier League victory at the ninth attempt with a 6-2 win on Sunday.
Arsenal moved to second in the Premier League with an impressive 3-0 win at Watford.
Wayne Rooney scored his first goal at Goodison Park for eight years as Manchester United coasted to a 3-0 victory on an emotional afternoon for Everton.
Raheem Sterling hit a first-half hat-trick and Wilfried Bony struck twice as Barclays Premier League leaders Manchester City overcame promoted Bournemouth 5-1 at the Etihad Stadium.
Diego Costa eased Chelsea manager Jose Mourinho's concerns as Aston Villa's hapless defenders heaped more misery on Tim Sherwood at Stamford Bridge.
Jurgen Klopp, the self-proclaimed "Normal One," left White Hart Lane with what he labelled a "normal result" as his new Liverpool side drew 0-0 with Tottenham.
Cristiano Ronaldo became Real Madrid's all-time top scorer as Rafael Benitez's side saw off Levante 3-0 to go top of the Primera Division.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.
Yaya Toure bade farewell to the Etihad Stadium as champions Manchester City set a hat trick of Premier League records in a routine 3-1 win over Brighton.
Jamie Vardy returned to haunt Arsene Wenger on his farewell tour as Leicester cruised past 10-man Arsenal 3-1.
Tottenham overcame a nervy night at Wembley to book their Champions League place for next season with a 1-0 win over Newcastle.
Huddersfield secured their Premier League status with a valiant 1-1 draw at Stamford Bridge which significantly dented Chelsea's slim top-four hopes.
Southampton took a huge step towards safety as a 1-0 win at Swansea inched their Welsh rivals towards the Premier League trapdoor and relegated West Brom in the process.
Arsenal gave Arsene Wenger a memorable Emirates Stadium send-off as the outgoing boss saw his side thrash Burnley.
Chelsea's Champions League hopes for next season received a boost following Sunday's narrow victory over Liverpool.
Manchester City failed to fire on the day they were presented with the Premier League trophy as Huddersfield Town claimed a vital point at the Etihad Stadium.
Tom Davies scored deep into added time as Everton salvaged a 1-1 draw against 10-man Southampton at Goodison Park, preventing their opponents from escaping the Premier League relegation zone.
West Bromwich Albion kept their slim survival hopes alive after Jake Livemore's dramatic injury time goal earned a 1-0 win against Tottenham Hotspur.
Pascal Gross scored the goal which sank Manchester United 1-0 to guarantee Premier League football for Brighton next season.
Harry Kane did his talking on the pitch as Tottenham reasserted themselves in the race for the Champions League with a 2-0 win over Watford.
Arsene Wenger was denied a point on his last visit to Old Trafford as Arsenal manager when Marouane Fellaini's injury-time header snatched victory for Manchester United.
Manchester City surpassed 100 Premier League goals for the season and left West Ham waiting to confirm top flight football next season with a 4-1 win at the London Stadium.
Chelsea's chase for a top-four Premier League spot gathered pace as Cesc Fabregas scored a landmark goal to deepen Swansea's relegation concerns.
Premier League leading scorer Mohamed Salah had a rare off day as Liverpool continue to stumble towards guaranteeing a top-four finish after a goalless draw at home to Stoke.
Manchester City celebrated their title success in style with a resounding 5-0 win over Swansea at the Etihad Stadium.
Olivier Giroud proved the scourge of Southampton once again, setting Chelsea on course for FA Cup semifinal success and a mouth-watering clash with Manchester United.
A late flurry of goals saw Arsenal secure a 4-1 win over West Ham in their first game since Arsene Wenger revealed he is stepping down as boss.
Ander Herrera has Manchester United dreaming of FA Cup glory after Tottenham Hotspur again suffered semifinal sorrow.
A late strike from Salomon Rondon helped bottom-of-the-table West Bromwich Albion come from behind to draw 2-2 against Liverpool on Saturday at The Hawthorns.
Victor Moses was the match-winner as Chelsea eased the pressure on London rivals Arsenal by denting Burnley's surge for sixth place.
Southampton halted their losing run but a goalless draw at Leicester does little for their Premier League survival hopes.