Heurelho Gomes made two superb saves as Watford and Chelsea had to settle for a point each at Vicarage Road.
Two late Ross Barkley penalties helped Everton secure a first home league win since November as the pressure on Newcastle manager Steve McClaren increased.
Manchester United eased the pressure on Louis van Gaal as they blew away Stoke with a fine display of ruthless attacking football in a 3-0 win at Old Trafford.
Jamie Vardy's wonder strike helped Leicester send out a title warning as they breezed past Liverpool 2-0.
An inspired display from Southampton goalkeeper Fraser Forster earned his side a point at Arsenal as the Gunners lost further ground on their Premier League title rivals.
Sergio Aguero served up a reminder that there is life before Pep Guardiola as Manchester City maintained their Premier League title challenge with a hard-fought victory at Sunderland.
Harry Kane scored a brace as Tottenham moved above rivals Arsenal in the Premier League with a 3-0 victory at Norwich.
Man City manager Manuel Pellegrini says he will depart the club on June. 30. Pep Guardiola has agreed a three-year deal to take over. Elsewhere, Stoke are set to sign Giannelli Imbula from Porto for £18m.
Chelsea and Everton both made light work of booking a place in the draw for the fifth round of the FA Cup.
Alexis Sanchez scored the winning goal in his first start since November as Arsenal saw off a resolute Burnley 2-1 to reach the fifth round of the FA Cup.
Kelechi Iheanacho's hat trick kept Manchester City's quadruple dream alive as they cruised to a 4-0 FA Cup thumping of Aston Villa.
Nacer Chadli scored twice as Tottenham Hotspur cruised into the FA Cup fifth round with a 4-1 win at Colchester United.
Liverpool were held to a goalless draw at home to West Ham in the FA Cup fourth round, adding yet another fixture to their packed schedule.
Louis van Gaal is able to breathe a little easier after Manchester United made light work of a potentially tricky FA Cup assignment against Derby, winning 3-1 at the iPro Stadium.
Manchester City came from behind to set up a Capital One Cup final meeting with Liverpool after beating Everton 3-1 at the Etihad Stadium to secure a 4-3 aggregate victory.
Joe Allen was the penalty shootout hero as his spot-kick sent Liverpool to Wembley after a tense Capital One Cup semifinal second leg at Anfield.
Arsenal missed the chance to return to top of the table as they lost 1-0 to Chelsea. Diego Costa got the only goal of the game in the 23rd minute shortly after the hosts had seen Per Mertesacker sent off for bringing down the Spain striker.
Francesco Guidolin collected three points in his first full game as Swansea City manager with an impressive 2-1 win against Everton at Goodison Park on Sunday.
Sergio Aguero scored twice to rescue a point for stuttering Manchester City in a 2-2 draw at West Ham.
All looks rosy again for Leicester after a return to winning ways coincided with Jamie Vardy ending his goal drought in a 3-0 victory over Stoke which sent the Foxes top of the Premier League.
Charlie Austin scored the winner with his first touch in a Southampton shirt to pile the pressure on beleaguered Manchester United manager Louis van Gaal.
Adam Lallana's last-minute strike gave Liverpool an astonishing first Premier League win of 2016 in a nine-goal thriller at Norwich.
Maiden Liverpool goals for youngsters Sheyi Ojo and Joao Carlos Teixeira sealed a 3-0 FA Cup third-round replay victory over Exeter.
Tottenham finally got the better of Leicester this season at the fourth time of asking as they reached the FA Cup fourth round with a 2-0 victory.
Arsenal reclaimed top spot in the Premier League with a goalless draw at Stoke on an afternoon when both teams' goalkeepers earned the plaudits.
Manchester United produced the ultimate smash-and-grab victory at Anfield as Wayne Rooney's 78th-minute goal decided a game barely befitting of England's two most decorated clubs.
Leicester City returned to the top of the Premier League despite being held to a 1-1 draw at Aston Villa.
Sergio Aguero struck twice as Manchester City pulled level with Arsenal in the title race with a comfortable 4-0 win over Crystal Palace.
John Terry scored a 98th-minute equaliser as fallen Premier League champions Chelsea avoided another chastening defeat in a 3-3 draw with Everton.
Substitute Joe Allen was Liverpool's unexpected saviour with an added-time equaliser - just when Arsenal appeared to have sent a significant message in the title race.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.
Yaya Toure bade farewell to the Etihad Stadium as champions Manchester City set a hat trick of Premier League records in a routine 3-1 win over Brighton.
Jamie Vardy returned to haunt Arsene Wenger on his farewell tour as Leicester cruised past 10-man Arsenal 3-1.
Tottenham overcame a nervy night at Wembley to book their Champions League place for next season with a 1-0 win over Newcastle.
Huddersfield secured their Premier League status with a valiant 1-1 draw at Stamford Bridge which significantly dented Chelsea's slim top-four hopes.
Southampton took a huge step towards safety as a 1-0 win at Swansea inched their Welsh rivals towards the Premier League trapdoor and relegated West Brom in the process.
Arsenal gave Arsene Wenger a memorable Emirates Stadium send-off as the outgoing boss saw his side thrash Burnley.
Chelsea's Champions League hopes for next season received a boost following Sunday's narrow victory over Liverpool.
Manchester City failed to fire on the day they were presented with the Premier League trophy as Huddersfield Town claimed a vital point at the Etihad Stadium.
Tom Davies scored deep into added time as Everton salvaged a 1-1 draw against 10-man Southampton at Goodison Park, preventing their opponents from escaping the Premier League relegation zone.
West Bromwich Albion kept their slim survival hopes alive after Jake Livemore's dramatic injury time goal earned a 1-0 win against Tottenham Hotspur.
Pascal Gross scored the goal which sank Manchester United 1-0 to guarantee Premier League football for Brighton next season.
Harry Kane did his talking on the pitch as Tottenham reasserted themselves in the race for the Champions League with a 2-0 win over Watford.
Arsene Wenger was denied a point on his last visit to Old Trafford as Arsenal manager when Marouane Fellaini's injury-time header snatched victory for Manchester United.
Manchester City surpassed 100 Premier League goals for the season and left West Ham waiting to confirm top flight football next season with a 4-1 win at the London Stadium.
Chelsea's chase for a top-four Premier League spot gathered pace as Cesc Fabregas scored a landmark goal to deepen Swansea's relegation concerns.
Premier League leading scorer Mohamed Salah had a rare off day as Liverpool continue to stumble towards guaranteeing a top-four finish after a goalless draw at home to Stoke.
Manchester City celebrated their title success in style with a resounding 5-0 win over Swansea at the Etihad Stadium.
Olivier Giroud proved the scourge of Southampton once again, setting Chelsea on course for FA Cup semifinal success and a mouth-watering clash with Manchester United.
A late flurry of goals saw Arsenal secure a 4-1 win over West Ham in their first game since Arsene Wenger revealed he is stepping down as boss.
Ander Herrera has Manchester United dreaming of FA Cup glory after Tottenham Hotspur again suffered semifinal sorrow.
A late strike from Salomon Rondon helped bottom-of-the-table West Bromwich Albion come from behind to draw 2-2 against Liverpool on Saturday at The Hawthorns.
Victor Moses was the match-winner as Chelsea eased the pressure on London rivals Arsenal by denting Burnley's surge for sixth place.
Southampton halted their losing run but a goalless draw at Leicester does little for their Premier League survival hopes.