Harry Kane rescued a point for Tottenham in a 1-1 draw at Anfield but that may not be enough with leaders Leicester handed the incentive to take a decisive step in the title race.
Returning forward Kevin De Bruyne got Manchester City's Champions League push back on track as they thumped Bournemouth 4-0 at the Vitality Stadium.
Arsenal put in one of their most dominant Premier League displays of the season on Saturday to beat Watford and keep their title ambitions alive.
Little changed post-Remi Garde for Aston Villa as their inevitable relegation from the Premier League drew ever closer after a 4-0 home defeat to a much-changed Chelsea side.
Teenage star Marcus Rashford struck again as Manchester United turned up the heat on rivals City with a 1-0 win a keenly contested derby at the Etihad Stadium.
Harry Kane grabbed a brace to move top of the Premier League scoring charts and help Tottenham keep the pressure on Leicester with a 3-0 win over Bournemouth.
Substitute Sadio Mane scored twice as Southampton came from two goals behind to beat Liverpool at St Mary's and increase their chances of qualifying for Europe.
Leicester earned three further points in their pursuit of a remarkable Premier League title with a 1-0 win at Crystal Palace.
A controversial penalty, scored by Cesc Fabregas, denied West Ham a first win at Chelsea in 14 years.
Arsenal ended a difficult week with a first league victory in a month after a 2-0 win at Everton kept their faint title hopes alive.
Shinji Okazaki's stunning goal restored Leicester's five-point lead in the title race as Rafael Benitez's Newcastle bow ended in defeat.
Anthony Martial came to the rescue of Manchester United and Louis van Gaal as his late equaliser against West Ham took this FA Cup quarterfinal to a replay.
A potentially defining seven days in Arsene Wenger's Arsenal reign started with FA Cup defeat as Watford knocked out the holders 2-1 in their quarterfinal clash at Emirates Stadium on Sunday.
Harry Kane scored twice as Tottenham closed the gap on Premier League leaders Leicester to two points with a 2-0 victory at rock-bottom Aston Villa.
Everton striker Romelu Lukaku produced two moments of magic to knock his former club Chelsea out of the FA Cup.
Manchester City's title aspirations slipped further in a goalless draw at Carrow Road that did little to boost Norwich's hopes of Premier League survival.
Yohan Cabaye and Fraizer Campbell claimed a late goal apiece as Crystal Palace progressed to the semifinals of the FA Cup with a deserved 2-0 win at Championship side Reading.
Olivier Giroud and Theo Walcott netted a brace each for injury-hit Arsenal as they beat Hull 4-0 to advance to the FA Cup quarterfinals on Tuesday.
Juan Mata's early red card was the catalyst for Manchester United's downfall as Salomon Rondon's goal saw West Brom halt a run of four successive wins for Louis van Gaal's side.
Liverpool's 10 men secured a 2-1 win at Crystal Palace with a late penalty from Christian Benteke after goalkeeper Alex McCarthy gifted Roberto Firmino an equalising goal with a horror slip in the second half.
A wonder goal from Riyad Mahrez saw Leicester took another step closer to completing the unthinkable and winning the Premier League.
Sergio Aguero struck twice as Manchester City scored four second-half goals to revitalise their title challenge with a 4-0 thrashing of basement side Aston Villa.
Mame Diouf stunned Chelsea with a late equaliser as Stoke battled back to earn a 1-1 draw at Stamford Bridge.
Ten-man Arsenal came from behind to take a point at Tottenham as the two north London clubs handed the Premier League title impetus to Leicester.
Liverpool gained some revenge for their Capital One Cup final defeat with a 3-0 victory to put a huge dent in Manchester City's title ambitions.
Arsenal suffered a major blow in the Premier League title race as struggling Swansea came from behind to win at the Emirates.
Juan Mata gave Manchester United's top-four hopes a timely shot in the arm, firing home a late free kick as Watford's missed chances came back to haunt them.
Tottenham's bid to take over at the top of the Premier League was thwarted by West Ham.
Leicester dropped two priceless points in their quest for the Premier League title after being held to a 2-2 draw at home by West Brom.
Norwich's luck deserted them once again as Diego Costa scored from an offside position in Chelsea's 2-1 win at Carrow Road.
Manchester City midfielder Kevin De Bruyne is facing a spell on the sidelines after injuring his right knee in training on Wednesday.
Manchester City, who romped to Premier League success by 19 points last season, began the defence of their title with a 2-0 win away against Arsenal and new manager Unai Emery on Sunday.
Sadio Mane had two goals for the first time since February 2017 and Mohamed Salah also scored as Liverpool opened their Premier League season with a 4-0 victory over West Ham United at Anfield.
Richarlison scored twice in his first Premier League appearance for 10-man Everton, but a late goal from Raul Jimenez helped Wolverhampton Wanderers salvage a 2-2 draw at the Molineux Stadium.
Chelsea manager Maurizio Sarri made a winning start to life in the Premier League as his team enjoyed a 3-0 win over Huddersfield Town at the John Smith's Stadium on Saturday.
Jan Vertonghen and Dele Alli scored first-half goals as Tottenham Hotspur opened their Premier League season with a 2-1 victory over Newcastle United at St James' Park.
Paul Pogba and Luke Shaw scored as Manchester City beat Leicester City 2-1 to open the 2018-19 Premier League season at Old Trafford on Friday night.
Leicester City striker Jamie Vardy has signalled his intention to see out his career with the Foxes as he signed a new contract until June 2022.
Athletic Bilbao have confirmed that Kepa Arrizabalaga has paid the €80 million buyout clause in his contract as he edges closer to completing a move to Chelsea.
Real Madrid midfielder Mateo Kovacic will join Chelsea on a season-long loan deal as part of the deal that sees goalkeeper Thibaut Courtois move to Real in a permanent deal.
Two goals from Sergio Aguero -- his 200th and 201st for the club -- proved decisive as Manchester City easily saw off FA Cup winners Chelsea 2-0 to win the Community Shield at Wembley.
Liverpool have completed the signing of Alisson on a six-year contract after agreeing with Roma on a world-record transfer for a goalkeeper.
Chelsea have completed the signing of Jorginho, beating Manchester City to the signature of the former Napoli midfielder.
Chelsea completed the long-expected hiring of Maurizio Sarri as their new manager on Saturday, appointing him after parting ways with Antonio Conte.
Chelsea have sacked coach Antonio Conte, paving the way for Maurizio Sarri to take over.
Manchester City have completed the signing of attacking midfielder Riyad Mahrez from Leicester City, the clubs announced on Tuesday.
Liverpool have announced that new signing Naby Keita will be given the No. 8 shirt last worn by former captain Steven Gerrard.
Manchester United have reached an agreement with Shakhtar Donetsk for the transfer of Brazil international midfielder Fred, the Premier League club confirmed on Tuesday.
Stephan Lichtsteiner has become Unai Emery's first signing for Arsenal after joining the Premier League side on a free transfer from Juventus.
Frank Lampard has been appointed the new manager of Derby County on a three-year contract, with former Chelsea academy coach Jody Morris as his assistant.
Liverpool have announced a deal to sign Brazilian midfielder Fabinho from Monaco.
Arsenal have hired former Paris Saint-Germain manager Unai Emery to take them into a new era following Arsene Wenger's departure, with sources telling that he has signed a three-year contract.
Eden Hazard fired Chelsea to FA Cup glory against Manchester United as Antonio Conte's expected farewell ended with a memorable triumph against old foe Jose Mourinho.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.