Liverpool manager Brendan Rodgers maintained his unbeaten record in Merseyside derbies but could not keep his job as he was sacked after his side managed a 1-1 draw at Everton.
Chelsea capitulated and were booed off as Southampton won at Stamford Bridge for the first time in almost 14 years to leave Jose Mourinho contemplating a fourth loss from eight Premier League games this season.
Sergio Aguero scored five goals in a sensational 20-minute spell as Manchester City came from behind to crush Newcastle 6-1 in the Premier League.
Substitutes Ramires and Willian got Chelsea out of jail as they fought back from 2-0 down at Newcastle to snatch a point.
Wayne Rooney ended his 11-match goal drought as Manchester United climbed to the top of the Premier League for the first time in over two years with victory over Sunderland.
Arsenal came from behind to beat Leicester 5-2 on the road thanks to a hat trick from Alexis Sanchez.
Liverpool overcame Aston Villa with a 3-2 win in a thriller at Anfield.
Harry Kane netted his first Tottenham goal in over 640 minutes of football as he helped Tottenham come from behind to beat Premier League leaders Manchester City 4-1 at White Hart Lane.
Shkodran Mustafi's header saw Valencia get back to winning ways in a hard-fought Primera Division clash with Granada.
Mathieu Flamini struck twice as Arsenal beat north London rivals Tottenham 2-1 in the third round of the Capital One Cup at White Hart Lane.
Anthony Martial stepped off the bench and scored his fourth goal in four matches as Manchester United strolled into the fourth round of the Capital One Cup with a 3-0 win over Ipswich.
Chelsea continued to rebuild their season as they eased past Walsall in the Capital One Cup.
Liverpool manager Brendan Rodgers' torturous season continued as they scraped through a Capital One Cup tie on penalties against League Two Carlisle.
Everton reached the fourth round of the Capital One Cup after a deserved 2-1 defeat of Championship opponents Reading.
Kevin De Bruyne and Raheem Sterling were on top-form as Manchester City cruised to a 4-1 Capital One Cup victory at Sunderland to end a two-game losing run in explosive fashion.
Anthony Martial struck twice to make it three goals in two games for Manchester United as Louis van Gaal's men came from behind to beat Southampton 3-2 at St Mary's.
Liverpool's Danny Ings scored within two minutes of coming on -- but his side were held 1-1 by Norwich at Anfield.
Tottenham earned their first home win of the Premier League season with a convincing 1-0 defeat of Crystal Palace.
West Ham withstood a barrage of second-half pressure to condemn Manchester City to their first defeat of the Premier League season.
Gabriel Paulista and Santi Cazorla were both sent off for Arsenal as Chelsea clinched a 2-0 win over their Premier League rivals.
Ryan Mason fired Tottenham to their first Premier League victory of the season as Sunderland were made to wait for theirs.
Anthony Martial scored on his Manchester United debut to seal a 3-1 win over rivals Liverpool as goalkeeper David De Gea made his comeback.
Kelechi Iheanacho scored a dramatic late winner within seconds of coming on against Crystal Palace to preserve Manchester City's 100 percent record in the Premier League.
Goals from Theo Walcott and Olivier Giroud earned Arsenal a 2-0 win over Stoke, but it should have been far more convincing for Arsene Wenger's side.
Steven Naismith struck a brilliant hat trick as stuttering Premier League champions Chelsea crashed to a 3-1 defeat at Everton.
Manchester United goalkeeper David De Gea has signed a four-year contract extension less than two weeks after a proposed move to Real Madrid collapsed on transfer deadline day.
Manchester United have completed the signing of forward Anthony Martial from Monaco.
Two goals in five minutes saw Swansea beat Manchester United at the Liberty Stadium. Juan Mata gave the hosts the lead before Andre Ayew equalised and Bafetimbi Gomis netted the winner.
Manchester City have signed Kevin De Bruyne from Wolfsburg for around £54 million.
Tim Howard denied Tottenham their first Premier League win of the season with a string of superb saves that enabled Everton to leave White Hart Lane with a goalless draw.
Liverpool had far too much attacking power for Bournemouth to withstand as they moved back into the top four with a 4-0 win at the Vitality Stadium.
Manchester United held on for a 2-1 win at West Bromwich Albion to cut neighbours Manchester City's lead at the top of the Premier League back to 11 points.
Leaders Manchester City powered to their 16th successive win in the Premier League with a 4-1 thrashing of Tottenham at the Etihad Stadium.
Arsenal returned to winning ways but had Mesut Ozil to thank for scoring a wonderful winner as they toiled against out-of-form Newcastle.
Time was on Chelsea's side as Marcos Alonso's free-kick earned a 1-0 Premier League win over Southampton.
Arsenal lost further ground on the Premier League leaders after they were held to a goalless draw at West Ham.
Tottenham climbed back into the Premier League's top four as Serge Aurier's fluke-goal and a header from Son Heung-min sealed a 2-0 victory over Brighton.
Liverpool manager Jurgen Klopp reunited the "Fab Four" but his prolific attacking quartet were all distinctly off-key as West Brom held out for a goalless draw at Anfield.
Manchester City set a new Premier League record of 15 consecutive wins with a 4-0 victory at bottom club Swansea.
Romelu Lukaku got a much-needed goal as Manchester United moved on from their galling derby defeat by beating Bournemouth.
Willian scored one and made two others as Chelsea finally turned in a display worthy of Premier League champions to win 3-1 at Huddersfield.
Runaway Premier League leaders Manchester City opened up an eye-watering double-digit lead over rivals Manchester United after Nicolas Otamendi fired Pep Guardiola's men to derby victory.
Wayne Rooney's first Merseyside derby goal earned Everton a 1-1 draw at Anfield as Liverpool manager Jurgen Klopp's selection gamble backfired.
Olivier Giroud climbed off the bench to rescue a point for Arsenal in a 1-1 draw at Southampton.
Ayoze Perez's late own goal cost Newcastle a precious Premier League draw as Leicester ruined the Magpies' 125th birthday celebrations.
Tottenham ended a four-match Premier League winless streak in style with Harry Kane scoring a brace as they thrashed Stoke 5-1 at Wembley.
Marko Arnautovic's first West Ham goal secured a 1-0 victory over Chelsea and a first win for manager David Moyes.
Manchester City left it late for the third game in a row as they beat West Ham United 2-1 at the Etihad Stadium thanks to David Silva's strike and extended their Premier League lead.
Bournemouth and Southampton shared the spoils as an entertaining match on the south coast finished in a 1-1 draw.
Jesse Lingard scored twice but Paul Pogba was sent off as Manchester United beat Arsenal 3-1 in a breathless match at the Emirates Stadium.
Talk of Burnley qualifying for Europe was dealt a sobering blow with defeat at improving Leicester.
Gylfi Sigurdsson and Dominic Calvert-Lewin scored second-half goals as Sam Allardyce's first game in charge of Everton ended in a 2-0 home win over Huddersfield.
Davinson Sanchez's red card forced Tottenham to fight for a 1-1 draw at Watford, toughening their battle to climb back into the Premier League's top four.
Philippe Coutinho and Roberto Firmino demolished Brighton to keep Liverpool's top-four charge on track.
A sparkling two-goal performance from Eden Hazard helped Chelsea come from a goal down to beat Newcastle 3-1 at Stamford Bridge and go level on points with second-placed Manchester United.
Substitute Mohamed Salah's purple patch continued with two more goals as Liverpool ground out a controversial 3-0 win at Stoke.
Raheem Sterling scored a dramatic winner as Manchester City maintained their winning run with a last-gasp 2-1 defeat of Southampton.
Antonio Conte was sent off as Chelsea claimed a fifth Premier League win in six games with a 1-0 defeat of Swansea.
Arsenal strengthened their position in the Premier League top four as they made light work of Huddersfield to maintain their healthy home form.
Newcastle ended a run of four straight defeats after coming back from 2-0 down to claim a gutsy point at West Brom.