Tottenham's hopes of finishing a Premier League season above north London rivals Arsenal for the first time since 1995 were left in tatters as relegated Newcastle turned on the style at St James' Park.
Premier League champions Leicester refused to be beaten as they finished their remarkable season with a 1-1 draw at Chelsea.
Liverpool had their minds on Wednesday's Europa League final, but West Brom were still unable to end their Premier League campaign with a win as they drew 1-1 at The Hawthorns.
Manuel Pellegrini has all-but delivered Champions League football in his final game as Manchester City manager with a 1-1 draw at Swansea.
Liverpool striker Christian Benteke snatched an added-time equaliser as Jurgen Klopp's side snatched a late 1-1 draw against Chelsea.
Sunderland completed another improbable Premier League survival mission and relegated northeast rivals Newcastle in the process after cruising to victory over woeful Everton at the Stadium of Light.
West Ham closed out the Boleyn Ground in style after 112 years on Tuesday, beating Manchester United 3-2 and taking the wind out of the Red Devils' push for a top-four finish and a Champions League spot.
Arsenal twice came from behind to claim a 2-2 draw at Manchester City that had contrasting implications for both sides' Champions League hopes.
Liverpool have their eyes on a much bigger prize but stayed sharp enough to complete a routine 2-0 victory over Watford in the Premier League.
Tottenham failed to bounce back from their Premier League title disappointment as a Steven Davis double sealed a surprise 2-1 victory for Southampton.
Leicester celebrated the greatest day in their 132-year history in style as the newly crowned Premier League champions comprehensively beat Everton before lifting the trophy.
Jermain Defoe's 18th goal of the season blasted Sunderland out of the Premier League relegation zone as 10-man Chelsea twice squandered the lead on Wearside.
Manchester United's bid for Champions League football remains alive after a 1-0 win at Carrow Road which saw Norwich slip closer to Premier League relegation.
Leicester City are Premier League champions after Tottenham conceded a two-goal lead in a bad-tempered 2-2 draw at Chelsea on Monday.
Sadio Mane's hat trick helped Southampton thump Manchester City's disjointed and disinterested second string 4-2 in Sunday's Premier League clash at St Mary's.
Leicester City's title celebrations were put on hold as they were forced to cling on with 10 men for a 1-1 draw at Manchester United.
Swansea secured their Premier League status as a weakened Liverpool side suffered a 3-1 defeat before their European showdown with Villarreal.
Arsenal celebrated in unison as Danny Welbeck's strike earned a 1-0 win that leaves Norwich's Premier League position ever more precarious.
Andros Townsend's stunning free kick dragged Newcastle out of the Premier League relegation zone as Rafael Benitez's rescue mission gathered pace with a 1-0 win over Crystal Palace.
Leicester boss Claudio Ranieri admits the Foxes are on the brink of history and urged his players to pen a Hollywood ending.
Leicester will be crowned Premier League champions with a win next weekend after Craig Dawson's header held Tottenham to a 1-1 draw against West Brom.
Connor Wickham fired Crystal Palace into the FA Cup final to give manager Alan Pardew a third chance of lifting the trophy.
Leicester are a step closer to making their dream a reality after Claudio Ranieri's men swatted aside Swansea to tighten their grip on the Premier League title.
Petr Cech and the crossbar denied Sunderland a priceless Premier League victory, as Arsenal failed to reclaim third place from Manchester City.
A stoppage-time goal from Anthony Martial sent Manchester United into their first FA Cup final in nine years as they beat Everton at Wembley.
Eden Hazard finally found the back of the net in the Premier League as Chelsea thrashed Bournemouth 4-1.
Newcastle manager Rafa Benitez knows a thing or two about second-half comebacks and he duly effected another as his side came back from two goals down to draw 2-2 with former club Liverpool.
Manchester City warmed up for Real Madrid by moving back into third place in the Premier League with a 4-0 victory over Stoke.
Alexis Sanchez scored a brace as Arsenal moved up to third in the Premier League with a 2-0 victory over West Brom on a night when there were plenty of empty seats inside the Emirates Stadium.
Matteo Darmian's stunning strike helped Manchester United maintain their top-four push as fellow FA Cup semi-finalists Crystal Palace were swatted aside.
Manchester United were unable to match the intensity shown during Jose Mourinho's extraordinary pre-match press conference, but headers from Romelu Lukaku and Nemanja Matic saw them through to the FA Cup semi-finals at Brighton's expense.
Mohamed Salah's record-setting season shows no signs of slowing down as four goals in the 5-0 victory over Watford put him in pole position for the Premier League Golden Boot.
Tottenham Hotspur strolled into the semifinals of the FA Cup with a Christian Eriksen-inspired 3-0 victory over Swansea City.
David Silva struck twice as Manchester City took another stride towards their seemingly inevitable coronation as Premier League champions with a 2-0 victory at Stoke.
Tottenham Hotspur bounced back from their Champions League defeat to Juventus with a 4-1 win at Bournemouth in a game overshadowed by injury to Harry Kane.
Arsenal strolled to a much-needed win as Shkodran Mustafi, Pierre-Emerick Aubameyang and Henrikh Mkhitaryan saw off Watford 3-0 at the Emirates Stadium and Petr Cech kept his 200th Premier League clean sheet.
Two first-half goals gave Chelsea a 2-1 home victory over a Crystal Palace side whose relegation worries increase.
Everton registered a third successive victory at Goodison Park by beating Brighton 2-0.
Two goals from Marcus Rashford gave Manchester United a crucial 2-1 victory over Liverpool at Old Trafford, putting them five points clear of their rivals in second place in the Premier League.
Nemanja Matic struck in stoppage time as Manchester United came from two goals down to secure a vital 3-2 victory at Crystal Palace.
Bernardo Silva scored the only goal as Manchester City took another stride towards the Premier League title with a 1-0 victory over Chelsea.
Arsene Wenger remains under intense pressure as Arsenal were deservedly beaten 2-1 by Brighton & Hove Albion at the Amex Stadium on Sunday.
Tottenham warmed up for their Champions League tie with Juventus by easing to a 2-0 victory over Huddersfield at Wembley.
Mohamed Salah scored for the seventh successive match to continue a remarkable scoring spree that is the best in Europe as Liverpool comfortably beat Newcastle United 2-0.
Manchester City inflicted more pain on Arsene Wenger with a second crushing 3-0 victory over his Arsenal side in the space of four days.
Tottenham overcame Rochdale 6-1 in the FA Cup but video technology reduced the fifth-round replay at Wembley to a farce.
Swansea reached their first FA Cup quarterfinal since 1964 with a 2-0 home victory over Sheffield Wednesday.
Manchester City breezed past woeful Arsenal 3-0 to lift the Carabo Cup, Pep Guardiola's first trophy in English football, at Wembley.
Tottenham Hotspur grabbed an 89th-minute winner against Crystal Palace to move into fourth place after a determined home side had seemed set for a battling draw at Selhurst Park.
Substitute Jesse Lingard headed the winner as Manchester United came from a goal down to beat Chelsea 2-1 at Old Trafford and move back into second place in the Premier League.
Watford moved up to 10th in the table as Troy Deeney's late goal gave them a valuable 1-0 victory over Everton at Vicarage Road.
Liverpool took their goal tally for the season to 103 as they claimed second place in the Premier League with a comfortable 4-1 win over West Ham.
Stoke remain in the relegation zone after an error from goalkeeper Jack Butland meant they had to settle for a 1-1 draw at Leicester.
Manchester City's quadruple trophy bid was sensationally derailed by a shocking 1-0 defeat at third-division Wigan in the FA Cup fifth round on Monday.
Substitute Steve Davies earned Rochdale an FA Cup fifth-round replay at Wembley Stadium with his remarkable stoppage-time equaliser against Tottenham Hotspur at Spotland.
Manchester United overcame the video assistant referee's controversial intervention and reached the FA Cup quarterfinals thanks to Romelu Lukaku's brace at Huddersfield.
Willian dispatched two inch-perfect finishes as Chelsea cruised past Hull 4-0 and into the FA Cup quarter-finals.
Sheffield Wednesday fan Jamie Vardy put the Blades to the sword as Leicester knocked Sheffield United out of the FA Cup.
Chelsea eased the growing pressure on Antonio Conte and returned to the Premier League's top four with a convincing 3-0 win over West Brom.
Liverpool moved back above Tottenham and into third place in the Premier League table as two first-half goals gave them a routine 2-0 victory at struggling Southampton.