Harry Kane scored twice as Tottenham Hotspur brushed Liverpool aside 4-1 at Wembley on an afternoon of glaring defensive frailty from Jurgen Klopp's visitors.
The pressure on Everton manager Ronald Koeman increased as his side dropped into the relegation zone after a 5-2 defeat to Arsenal at Goodison Park.
Sergio Aguero equalled Manchester City's goal-scoring record as the Premier League leaders saw off hard-working Burnley 3-0 at the Etihad Stadium.
Huddersfield are celebrating one of their best wins in decades after Aaron Mooy and Laurent Depoitre brought Manchester United's unbeaten Premier League start to a shock halt.
Michy Batshuayi came off the bench to score twice as Chelsea fought back from behind to win a six-goal thriller against Watford.
A late Wayne Rooney penalty snatched a 1-1 draw for Everton at Brighton.
Manolo Gabbiadini's double rescued Southampton as his side twice came from behind to salvage a 2-2 Premier League draw against Newcastle.
Arsenal gave away a lead to lose 2-1 away to Watford as Tom Cleverley netted an injury time winner.
Tottenham are finally off the mark at Wembley after Christian Eriksen sealed a narrow win over Bournemouth and his side's first Premier League victory under the arch.
Kevin De Bruyne orchestrated a Manchester City masterclass as Pep Guardiola's freescoring side thrashed Stoke 7-2 at the Etihad Stadium.
Crystal Palace deservedly claimed a first Premier League win of the season with a 2-1 victory over champions Chelsea at Selhurst Park.
Liverpool versus Manchester United again failed to live up to the hype as Jose Mourinho's safety-first policy saw him once more frustrate the hosts at Anfield.
Joselu handed Newcastle boss Rafael Benitez a draw against former club Liverpool as missed chances cost the visitors dearly.
Arsene Wenger celebrated his 21st anniversary as Arsenal manager with a 2-0 win over Brighton and a brilliant team goal scored by Alex Iwobi.
Manchester City demonstrated their Premier League title credentials with a dominant 1-0 victory at champions Chelsea.
Marouane Fellaini's first Manchester United brace helped Jose Mourinho's men to another comprehensive victory, leaving Crystal Palace reeling from a seventh straight Premier League defeat without a goal.
Harry Kane stole the show as Premier League title challengers Tottenham cruised to a 4-0 win over Huddersfield at the John Smith's Stadium.
Alexandre Lacazette's first double in English football continued Arsenal's excellent home form as they beat West Brom 2-0 at the Emirates Stadium.
A solitary goal from striker Tomer Hemed was enough to give Brighton and Hove Albion a 1-0 home win over Newcastle, the club that pipped them to the Championship title last season.
Chelsea continued to show there is life after Diego Costa with another Premier League victory at Stoke, with Alvaro Morata scoring a hat-trick in a 4-0 win.
Sergio Aguero moved within a goal of Manchester City's all-time record as Pep Guardiola's men thrashed bottom side Crystal Palace 5-0 in the Premier League.
Romelu Lukaku secured Manchester United a hard-fought victory at Southampton as Jose Mourinho's men managed to batten down the hatches after half-time.
Simon Mignolet saved Jamie Vardy's penalty to clinch a thrilling 3-2 win for Liverpool at Leicester.
Harry Kane kept up his impressive scoring record against West Ham with his brace inspiring 10-man Tottenham to a 3-2 victory at the London Stadium.
Marcus Rashford's brace inspired holders Manchester United to as comprehensive a Carabao Cup victory as you would expect against much-changed Burton.
Leroy Sane booked Manchester City's place in the Carabao Cup fourth round after they survived a scare at West Brom.
Michy Batshuayi scored a hat trick as Chelsea provided a glimpse of the future with a 5-1 Carabao Cup rout of Nottingham Forest on Wednesday night.
Arsenal made heavy weather of seeing off Doncaster 1-0 to reach the fourth round of the Carabao Cup with Theo Walcott scoring the only goal on a night where the returning Jack Wilshere stood out for the Gunners.
Dele Alli spared Tottenham's blushes in front of a sparse Wembley crowd by scoring the winner against Barnsley and sending his side into the Carabao Cup fourth round.
Marko Arnautovic marked his home debut for West Ham by orchestrating a 3-0 Carabao Cup victory over Bolton at London Stadium.
Liverpool had far too much attacking power for Bournemouth to withstand as they moved back into the top four with a 4-0 win at the Vitality Stadium.
Manchester United held on for a 2-1 win at West Bromwich Albion to cut neighbours Manchester City's lead at the top of the Premier League back to 11 points.
Leaders Manchester City powered to their 16th successive win in the Premier League with a 4-1 thrashing of Tottenham at the Etihad Stadium.
Arsenal returned to winning ways but had Mesut Ozil to thank for scoring a wonderful winner as they toiled against out-of-form Newcastle.
Time was on Chelsea's side as Marcos Alonso's free-kick earned a 1-0 Premier League win over Southampton.
Arsenal lost further ground on the Premier League leaders after they were held to a goalless draw at West Ham.
Tottenham climbed back into the Premier League's top four as Serge Aurier's fluke-goal and a header from Son Heung-min sealed a 2-0 victory over Brighton.
Liverpool manager Jurgen Klopp reunited the "Fab Four" but his prolific attacking quartet were all distinctly off-key as West Brom held out for a goalless draw at Anfield.
Manchester City set a new Premier League record of 15 consecutive wins with a 4-0 victory at bottom club Swansea.
Romelu Lukaku got a much-needed goal as Manchester United moved on from their galling derby defeat by beating Bournemouth.
Willian scored one and made two others as Chelsea finally turned in a display worthy of Premier League champions to win 3-1 at Huddersfield.
Runaway Premier League leaders Manchester City opened up an eye-watering double-digit lead over rivals Manchester United after Nicolas Otamendi fired Pep Guardiola's men to derby victory.
Wayne Rooney's first Merseyside derby goal earned Everton a 1-1 draw at Anfield as Liverpool manager Jurgen Klopp's selection gamble backfired.
Olivier Giroud climbed off the bench to rescue a point for Arsenal in a 1-1 draw at Southampton.
Ayoze Perez's late own goal cost Newcastle a precious Premier League draw as Leicester ruined the Magpies' 125th birthday celebrations.
Tottenham ended a four-match Premier League winless streak in style with Harry Kane scoring a brace as they thrashed Stoke 5-1 at Wembley.
Marko Arnautovic's first West Ham goal secured a 1-0 victory over Chelsea and a first win for manager David Moyes.
Manchester City left it late for the third game in a row as they beat West Ham United 2-1 at the Etihad Stadium thanks to David Silva's strike and extended their Premier League lead.
Bournemouth and Southampton shared the spoils as an entertaining match on the south coast finished in a 1-1 draw.
Jesse Lingard scored twice but Paul Pogba was sent off as Manchester United beat Arsenal 3-1 in a breathless match at the Emirates Stadium.
Talk of Burnley qualifying for Europe was dealt a sobering blow with defeat at improving Leicester.
Gylfi Sigurdsson and Dominic Calvert-Lewin scored second-half goals as Sam Allardyce's first game in charge of Everton ended in a 2-0 home win over Huddersfield.
Davinson Sanchez's red card forced Tottenham to fight for a 1-1 draw at Watford, toughening their battle to climb back into the Premier League's top four.
Philippe Coutinho and Roberto Firmino demolished Brighton to keep Liverpool's top-four charge on track.
A sparkling two-goal performance from Eden Hazard helped Chelsea come from a goal down to beat Newcastle 3-1 at Stamford Bridge and go level on points with second-placed Manchester United.
Substitute Mohamed Salah's purple patch continued with two more goals as Liverpool ground out a controversial 3-0 win at Stoke.
Raheem Sterling scored a dramatic winner as Manchester City maintained their winning run with a last-gasp 2-1 defeat of Southampton.
Antonio Conte was sent off as Chelsea claimed a fifth Premier League win in six games with a 1-0 defeat of Swansea.
Arsenal strengthened their position in the Premier League top four as they made light work of Huddersfield to maintain their healthy home form.
Newcastle ended a run of four straight defeats after coming back from 2-0 down to claim a gutsy point at West Brom.