Bournemouth came back from 2-0 and 3-1 down to snatch a stunning 4-3 win over Liverpool in a thrilling match on the south coast.
Alexis Sanchez scored a hat trick as Arsenal thrashed West Ham 5-1 at the London Stadium to move up to second in the Premier League table.
Tottenham striker Harry Kane finished off a special week in style by scoring a brace in Spurs' 5-0 victory over Swansea at White Hart Lane on Saturday.
Jermain Defoe's eighth goal of the season condemned Premier League champions Leicester to yet another defeat as improving Sunderland won for the third time in four attempts.
Chelsea made it eight consecutive wins in the Premier League as they came from behind to keep their place at the top of the table with a 3-1 victory over title rivals Manchester City.
Jose Mourinho stayed out of sight as Manchester United swept into the EFL Cup semi-finals with a comfortable 4-1 win over West Ham.
Southampton outclassed a much-changed Arsenal side to seal a comfortable victory at the Emirates Stadium and secure an EFL Cup semifinal berth for the first time in 29 years.
Liverpool prodigy Ben Woodburn enhanced his burgeoning reputation by becoming the club's youngest ever goalscorer in the 2-0 EFL Cup quarterfinal win over Leeds.
Manchester United manager Jose Mourinho was sent to the stands as his side suffered another frustrating afternoon at Old Trafford, being held to a 1-1 draw by West Ham United.
Alexis Sanchez scored twice as Arsenal ended their usual barren November run with victory over Bournemouth at the Emirates Stadium on Sunday.
Chelsea returned to the top of the Premier League as they recovered from a goal down to beat Tottenham Hotspur at Stamford Bridge and notch a seventh league win a row.
Liverpool returned to the top of the Premier League with a 2-0 win over Sunderland at Anfield in a game overshadowed by injury to Philippe Coutinho.
Islam Slimani's injury-time penalty rescued a point for Leicester as they got out of jail against Middlesbrough.
Two goals from striker Sergio Aguero earned Manchester City three points at Burnley to take Pep Guardiola's side back to the top of the Premier League.
Chelsea made it six consecutive victories and six clean sheets in the Premier League as they beat Middlesbrough 1-0 to move to the top of the table.
Harry Kane brought Tottenham back from the dead by scoring twice in the last two minutes to snatch a thrilling 3-2 victory over West Ham.
Liverpool were forced to settle for a goalless draw at Southampton on Saturday as they dominated the hosts without being able to find a breakthrough.
Yaya Toure returned from his Manchester City exile to inspire a 2-1 victory at Crystal Palace that maintains their pursuit of the Premier League title.
Fast-starting Watford inflicted Premier League champions Leicester's sixth defeat of the season with a 2-1 win at Vicarage Road.
Arsene Wenger's inability to beat Jose Mourinho in a competitive game continued at Old Trafford on Saturday, though his Arsenal side secured a 1-1 draw against Manchester United thanks to a late equaliser from Olivier Giroud.
Liverpool went top of the Premier League with a convincing 6-1 victory against Watford courtesy of goals from Philippe Coutinho, Emre Can, Roberto Firmino, Georginio Wijnaldum and a brace from Sadio Mane.
A Harry Kane penalty stopped Arsenal going top of the Premier League as Tottenham Hotspur earned a 1-1 draw in the North London derby.
Manchester United and Jose Mourinho returned to winning ways with a 3-1 victory at Swansea.
Matt Phillips ended Leicester's 20-game unbeaten home league run as West Bromwich Albion clinched a 2-1 win at the King Power Stadium.
Eden Hazard scored twice as a dominant Chelsea inflicted a 5-0 thrashing on Everton at Stamford Bridge to move to the top of the Premier League table.
Marten de Roon headed a last-gasp equaliser as Middlesbrough snatched a 1-1 draw against Premier League leaders Manchester City at the Etihad Stadium.
Eden Hazard scored a goal and created another as Chelsea beat Southampton 2-0 at St Mary's to move up to fourth in the Premier League table.
Everton returned to winning ways as goals from Romelu Lukaku and Ross Barkley secured a 2-0 victory over West Ham United at Goodison Park.
Liverpool came out on top in a six-goal thriller at Selhurst Park as they secured a 4-2 victory over Crystal Palace.
Tottenham's revenge mission against Leicester ended in disappointment as Ahmed Musa earned the Premier League champions a 1-1 draw at White Hart Lane.
Manchester City's quadruple trophy bid was sensationally derailed by a shocking 1-0 defeat at third-division Wigan in the FA Cup fifth round on Monday.
Substitute Steve Davies earned Rochdale an FA Cup fifth-round replay at Wembley Stadium with his remarkable stoppage-time equaliser against Tottenham Hotspur at Spotland.
Manchester United overcame the video assistant referee's controversial intervention and reached the FA Cup quarterfinals thanks to Romelu Lukaku's brace at Huddersfield.
Willian dispatched two inch-perfect finishes as Chelsea cruised past Hull 4-0 and into the FA Cup quarter-finals.
Sheffield Wednesday fan Jamie Vardy put the Blades to the sword as Leicester knocked Sheffield United out of the FA Cup.
Chelsea eased the growing pressure on Antonio Conte and returned to the Premier League's top four with a convincing 3-0 win over West Brom.
Liverpool moved back above Tottenham and into third place in the Premier League table as two first-half goals gave them a routine 2-0 victory at struggling Southampton.
Matt Ritchie scored a second-half winner for Newcastle as they lifted themselves out of the relegation places with a 1-0 victory over Manchester United at St James' Park.
Sergio Aguero scored four times as Manchester City extended their Premier League lead to 16 points with a 5-1 demolition of Leicester at the Etihad Stadium.
Everton's Sam Allardyce won the battle of ex-England managers at Goodison Park to ease growing pressure with a 3-1 victory over Roy Hodgson's struggling Crystal Palace.
Harry Kane proved Arsenal's nemesis again as his bullet header earned Tottenham a deserved 1-0 victory in the North London derby.
Erik Lamela scored his first goal in 17 months as Tottenham sauntered past Newport and into the fifth round of the FA Cup.
Swansea recorded their biggest-ever FA Cup win as Notts County were demolished 8-1 at the Liberty Stadium.
Antonio Conte's future as Chelsea boss was cast into further doubt as his 10 men were thrashed 4-1 by Watford on Monday night.
Mohamed Salah and Harry Kane traded stoppage-time goals as Liverpool and Tottenham drew 2-2 in a wild affair at Anfield on Sunday.
Newcastle resisted intense pressure from Crystal Palace to earn a 1-1 draw at Selhurst Park that again took them clear of the bottom three.
`Aaron Ramsey hit a hat trick with Arsenal fans treated to their first showing of their January transfers in tandem as both Henrikh Mkhitaryan and Pierre-Emerick Aubameyang shone in a comfortable 5-1 win over Everton.
Alexis Sanchez's first goal for Manchester United wrapped up a 2-0 victory against Huddersfield on a day when the clubs came together to remember those who lost their lives in the Munich air disaster.
Swansea's resurgence continued as they climbed out of the Premier League relegation zone with a 1-1 draw at Leicester, who were again without want-away midfielder Riyad Mahrez.
Johann Berg Gudmundsson struck a late equaliser as Burnley grabbed a 1-1 draw against Premier League leaders Manchester City at Turf Moor.
Christian Eriksen scored within 11 seconds as Tottenham brushed aside a below-par Manchester United to seal a crunch 2-0 victory in the race for the top four.
Kevin De Bruyne was again the inspiration as Manchester City opened up a 15-point lead at the top of the Premier League with a 3-0 win over West Brom.
Theo Walcott's maiden Everton goals secured a first win in eight matches as a 2-1 triumph over Leicester arrested their slide under Sam Allardyce.
Bournemouth scored three goals in 16 remarkable second-half minutes to record a sensational 3-0 victory against Chelsea at Stamford Bridge on Wednesday evening.
Arsenal have completed the signing of striker Pierre-Emerick Aubameyang from Borussia Dortmund for a fee of €63.75 million (£56m).
Chelsea have completed the signing of Olivier Giroud from Arsenal for a reported £16.25 million on an 18-month contract.
Tottenham Hotspur have completed the signing of winger Lucas Moura from Paris Saint-Germain for a fee of в‚¬28 million.
Liverpool bounced back to winning ways in the Premier League and maintained their Champions League challenge with a 3-0 win at Huddersfield.
Swansea climbed out of the relegation zone for the first time in three months as Petr Cech's dreadful howler helped condemn Arsenal to a 3-1 defeat at the Liberty Stadium.
Two first-half goals were enough to see Manchester City comfortably through to the FA Cup fifth round at Championship side Cardiff City.