Hal Robson-Kanu fired his first goal of the season as West Brom clinched a 2-1 Premier League win over 10-man Southampton at St Mary's.
Islam Slimani eased any growing relegation pressure at Leicester as the champions held on to beat West Ham 1-0.
Anthony Martial and Paul Pogba struck in the closing minutes to hand Manchester United a deserved three points against Middlesbrough at Old Trafford.
Willian scored twice as Chelsea held off valiant Stoke for a Premier League record 13th successive win in a single season.
Jurgen Klopp won the battle of managerial masterminds at Anfield as Liverpool's 1-0 victory put a dent in Manchester City's title aspirations.
Liverpool warmed up for their mouthwatering clash against top-four rivals Manchester City later this week with a confident 4-1 win over Stoke.
Three goals in the final 18 minutes saw Manchester City climb to second in the Premier League table courtesy of a laboured 3-0 win at Hull.
Kevin Mirallas and Romelu Lukaku struck to sink Leicester and hand Everton their first away win since September.
Henrikh Mkhitaryan's moment of magic capped a comprehensive 3-1 Manchester United win and chastening Old Trafford return for Sunderland manager David Moyes.
Chelsea set a new club record of 12 straight Premier League wins and extended their lead at the top of the table with a 3-0 victory over Bournemouth at Stamford Bridge on Monday.
Olivier Giroud marked his first Premier League start of the season by heading home a late winner as Arsenal eked out a 1-0 victory over a resolute West Brom.
Striker Daniel Sturridge came off the bench to play a pivotal part in Liverpool snatching a winner in the fifth minute of added time of the 227th Merseyside derby.
Manchester City recovered from an early Arsenal goal to produce a dominant second-half display and record a 2-1 win that moves them up to second place in the Premier League table.
Danny Rose broke Burnley hearts with a second-half winner as Tottenham snatched a 2-1 victory and moved to within a point of the Premier League's top four.
Manchester United moved level on points with fifth-placed Tottenham Hotspur, for 24 hours at least, after beating West Bromwich Albion 2-0 at The Hawthorns.
Ten-man Leicester City rallied against the odds to overcome Jamie Vardy's 28th-minute dismissal and a two-goal deficit to draw 2-2 at Stoke City.
Chelsea extended their lead at the top of the Premier League to nine points, for at least a day, with a 1-0 win against Crystal Palace at Selhurst Park as Diego Costa scored his 50th goal for the club.
Zlatan Ibrahimovic struck a late winner as Manchester United secured victory at Crystal Palace after once again threatening to drop points from a winning position.
Jurgen Klopp's decision to drop goalkeeper Loris Karius was vindicated on a night when the brilliance of Adam Lallana swept Liverpool to a 3-0 win over Middlesbrough at the Riverside Stadium.
Christian Eriksen laid on an attacking masterclass by scoring twice and setting up another as Tottenham cruised to a 3-0 victory over struggling Hull.
Pablo Zabaleta's first goal for two years and a late David Silva strike fired Manchester City to a much-needed -- but unconvincing -- 2-0 win over Watford.
Cesc Fabregas' first Premier League goal of the season handed Chelsea victory at Sunderland and sent them six points clear at the top of the table.
Ashley Williams scored a late winner for Everton as they came from behind to win 2-1 and inflict a first Premier League defeat on Arsenal since the opening day of the season.
Marc Pugh capped his first start of the season with a smart strike as Bournemouth outclassed Leicester 1-0 on the south coast.
Liverpool lost ground on leaders Chelsea as they were held to a 2-2 draw by struggling West Ham United at Anfield.
Manchester United closed the gap on fifth place to three points thanks to a scrappy 1-0 win against Tottenham Hotspur at Old Trafford on Sunday.
Diego Costa's fifth goal in six games broke West Brom's stubborn resistance and sealed Chelsea's ninth consecutive Premier League victory.
Jamie Vardy scored a hat trick as Leicester City put their recent poor form behind them with a 4-2 win over Manchester City at the King Power Stadium.
Arsenal came from behind to go top of the Premier League table and extend their unbeaten league run to 14 league games with a 3-1 win over Stoke at the Emirates Stadium.
Marouane Fellaini gave away a late penalty as his old club Everton snatched a 1-1 draw with Manchester United to leave Jose Mourinho frustrated again.
Manchester City's quadruple trophy bid was sensationally derailed by a shocking 1-0 defeat at third-division Wigan in the FA Cup fifth round on Monday.
Substitute Steve Davies earned Rochdale an FA Cup fifth-round replay at Wembley Stadium with his remarkable stoppage-time equaliser against Tottenham Hotspur at Spotland.
Manchester United overcame the video assistant referee's controversial intervention and reached the FA Cup quarterfinals thanks to Romelu Lukaku's brace at Huddersfield.
Willian dispatched two inch-perfect finishes as Chelsea cruised past Hull 4-0 and into the FA Cup quarter-finals.
Sheffield Wednesday fan Jamie Vardy put the Blades to the sword as Leicester knocked Sheffield United out of the FA Cup.
Chelsea eased the growing pressure on Antonio Conte and returned to the Premier League's top four with a convincing 3-0 win over West Brom.
Liverpool moved back above Tottenham and into third place in the Premier League table as two first-half goals gave them a routine 2-0 victory at struggling Southampton.
Matt Ritchie scored a second-half winner for Newcastle as they lifted themselves out of the relegation places with a 1-0 victory over Manchester United at St James' Park.
Sergio Aguero scored four times as Manchester City extended their Premier League lead to 16 points with a 5-1 demolition of Leicester at the Etihad Stadium.
Everton's Sam Allardyce won the battle of ex-England managers at Goodison Park to ease growing pressure with a 3-1 victory over Roy Hodgson's struggling Crystal Palace.
Harry Kane proved Arsenal's nemesis again as his bullet header earned Tottenham a deserved 1-0 victory in the North London derby.
Erik Lamela scored his first goal in 17 months as Tottenham sauntered past Newport and into the fifth round of the FA Cup.
Swansea recorded their biggest-ever FA Cup win as Notts County were demolished 8-1 at the Liberty Stadium.
Antonio Conte's future as Chelsea boss was cast into further doubt as his 10 men were thrashed 4-1 by Watford on Monday night.
Mohamed Salah and Harry Kane traded stoppage-time goals as Liverpool and Tottenham drew 2-2 in a wild affair at Anfield on Sunday.
Newcastle resisted intense pressure from Crystal Palace to earn a 1-1 draw at Selhurst Park that again took them clear of the bottom three.
`Aaron Ramsey hit a hat trick with Arsenal fans treated to their first showing of their January transfers in tandem as both Henrikh Mkhitaryan and Pierre-Emerick Aubameyang shone in a comfortable 5-1 win over Everton.
Alexis Sanchez's first goal for Manchester United wrapped up a 2-0 victory against Huddersfield on a day when the clubs came together to remember those who lost their lives in the Munich air disaster.
Swansea's resurgence continued as they climbed out of the Premier League relegation zone with a 1-1 draw at Leicester, who were again without want-away midfielder Riyad Mahrez.
Johann Berg Gudmundsson struck a late equaliser as Burnley grabbed a 1-1 draw against Premier League leaders Manchester City at Turf Moor.
Christian Eriksen scored within 11 seconds as Tottenham brushed aside a below-par Manchester United to seal a crunch 2-0 victory in the race for the top four.
Kevin De Bruyne was again the inspiration as Manchester City opened up a 15-point lead at the top of the Premier League with a 3-0 win over West Brom.
Theo Walcott's maiden Everton goals secured a first win in eight matches as a 2-1 triumph over Leicester arrested their slide under Sam Allardyce.
Bournemouth scored three goals in 16 remarkable second-half minutes to record a sensational 3-0 victory against Chelsea at Stamford Bridge on Wednesday evening.
Arsenal have completed the signing of striker Pierre-Emerick Aubameyang from Borussia Dortmund for a fee of €63.75 million (£56m).
Chelsea have completed the signing of Olivier Giroud from Arsenal for a reported £16.25 million on an 18-month contract.
Tottenham Hotspur have completed the signing of winger Lucas Moura from Paris Saint-Germain for a fee of в‚¬28 million.
Liverpool bounced back to winning ways in the Premier League and maintained their Champions League challenge with a 3-0 win at Huddersfield.
Swansea climbed out of the relegation zone for the first time in three months as Petr Cech's dreadful howler helped condemn Arsenal to a 3-1 defeat at the Liberty Stadium.
Two first-half goals were enough to see Manchester City comfortably through to the FA Cup fifth round at Championship side Cardiff City.