Southampton took a huge step towards safety as a 1-0 win at Swansea inched their Welsh rivals towards the Premier League trapdoor and relegated West Brom in the process.
Arsenal gave Arsene Wenger a memorable Emirates Stadium send-off as the outgoing boss saw his side thrash Burnley.
Chelsea's Champions League hopes for next season received a boost following Sunday's narrow victory over Liverpool.
Manchester City failed to fire on the day they were presented with the Premier League trophy as Huddersfield Town claimed a vital point at the Etihad Stadium.
Tom Davies scored deep into added time as Everton salvaged a 1-1 draw against 10-man Southampton at Goodison Park, preventing their opponents from escaping the Premier League relegation zone.
West Bromwich Albion kept their slim survival hopes alive after Jake Livemore's dramatic injury time goal earned a 1-0 win against Tottenham Hotspur.
Pascal Gross scored the goal which sank Manchester United 1-0 to guarantee Premier League football for Brighton next season.
Harry Kane did his talking on the pitch as Tottenham reasserted themselves in the race for the Champions League with a 2-0 win over Watford.
Arsene Wenger was denied a point on his last visit to Old Trafford as Arsenal manager when Marouane Fellaini's injury-time header snatched victory for Manchester United.
Manchester City surpassed 100 Premier League goals for the season and left West Ham waiting to confirm top flight football next season with a 4-1 win at the London Stadium.
Chelsea's chase for a top-four Premier League spot gathered pace as Cesc Fabregas scored a landmark goal to deepen Swansea's relegation concerns.
Premier League leading scorer Mohamed Salah had a rare off day as Liverpool continue to stumble towards guaranteeing a top-four finish after a goalless draw at home to Stoke.
Manchester City celebrated their title success in style with a resounding 5-0 win over Swansea at the Etihad Stadium.
Olivier Giroud proved the scourge of Southampton once again, setting Chelsea on course for FA Cup semifinal success and a mouth-watering clash with Manchester United.
A late flurry of goals saw Arsenal secure a 4-1 win over West Ham in their first game since Arsene Wenger revealed he is stepping down as boss.
Ander Herrera has Manchester United dreaming of FA Cup glory after Tottenham Hotspur again suffered semifinal sorrow.
A late strike from Salomon Rondon helped bottom-of-the-table West Bromwich Albion come from behind to draw 2-2 against Liverpool on Saturday at The Hawthorns.
Victor Moses was the match-winner as Chelsea eased the pressure on London rivals Arsenal by denting Burnley's surge for sixth place.
Southampton halted their losing run but a goalless draw at Leicester does little for their Premier League survival hopes.
Manchester United moved to within two points of securing a place in next season's Champions League with a 2-0 win at Bournemouth.
Tottenham's pursuit of Champions League football suffered a minor setback as they squandered a lead to draw 1-1 at Brighton.
Manchester United handed local rivals Manchester City the 2017-18 Premier League title after succumbing to a shock 1-0 defeat against West Bromwich Albion at Old Trafford that keeps the Baggies' slim survival hopes alive.
Arsenal's away woes in the Premier League continued on Sunday when they were beaten 2-1 by Newcastle United at St James' Park.
Mohamed Salah brought his remarkable goal tally to 40 in all competitions this season season by netting once more in a 3-0 win over Bournemouth.
Manchester City responded from a nightmare 10 days in style to put one hand on the Premier League title with a 3-1 win at Tottenham.
Olivier Giroud was the hero for Chelsea as the Blues fought back from two goals down to claim a 3-2 win over Premier League strugglers Southampton at St Mary's.
Javier Hernandez netted an equaliser for West Ham to thwart Chelsea again and dent their bid for Champions League football, while earning his side an important point in their bid to survive relegation in a 1-1 draw on Saturday.
Danny Welbeck scored twice as Arsenal deepened Southampton's relegation worries with a 3-2 win in a game that saw both sides reduced to 10 men in stoppage time at the Emirates Stadium.
Manchester United produced an incredible second-half comeback to beat rivals Manchester City 3-2 and leave them waiting for confirmation of the Premier League title after a thrilling game at the Etihad Stadium.
Christian Eriksen was credited with a brace as Harry Kane was denied a crucial goal in the Golden Boot race in Tottenham's 2-1 win over Stoke at the bet365 Stadium.
Manchester City midfielder Kevin De Bruyne is facing a spell on the sidelines after injuring his right knee in training on Wednesday.
Manchester City, who romped to Premier League success by 19 points last season, began the defence of their title with a 2-0 win away against Arsenal and new manager Unai Emery on Sunday.
Sadio Mane had two goals for the first time since February 2017 and Mohamed Salah also scored as Liverpool opened their Premier League season with a 4-0 victory over West Ham United at Anfield.
Richarlison scored twice in his first Premier League appearance for 10-man Everton, but a late goal from Raul Jimenez helped Wolverhampton Wanderers salvage a 2-2 draw at the Molineux Stadium.
Chelsea manager Maurizio Sarri made a winning start to life in the Premier League as his team enjoyed a 3-0 win over Huddersfield Town at the John Smith's Stadium on Saturday.
Jan Vertonghen and Dele Alli scored first-half goals as Tottenham Hotspur opened their Premier League season with a 2-1 victory over Newcastle United at St James' Park.
Paul Pogba and Luke Shaw scored as Manchester City beat Leicester City 2-1 to open the 2018-19 Premier League season at Old Trafford on Friday night.
Leicester City striker Jamie Vardy has signalled his intention to see out his career with the Foxes as he signed a new contract until June 2022.
Athletic Bilbao have confirmed that Kepa Arrizabalaga has paid the €80 million buyout clause in his contract as he edges closer to completing a move to Chelsea.
Real Madrid midfielder Mateo Kovacic will join Chelsea on a season-long loan deal as part of the deal that sees goalkeeper Thibaut Courtois move to Real in a permanent deal.
Two goals from Sergio Aguero -- his 200th and 201st for the club -- proved decisive as Manchester City easily saw off FA Cup winners Chelsea 2-0 to win the Community Shield at Wembley.
Liverpool have completed the signing of Alisson on a six-year contract after agreeing with Roma on a world-record transfer for a goalkeeper.
Chelsea have completed the signing of Jorginho, beating Manchester City to the signature of the former Napoli midfielder.
Chelsea completed the long-expected hiring of Maurizio Sarri as their new manager on Saturday, appointing him after parting ways with Antonio Conte.
Chelsea have sacked coach Antonio Conte, paving the way for Maurizio Sarri to take over.
Manchester City have completed the signing of attacking midfielder Riyad Mahrez from Leicester City, the clubs announced on Tuesday.
Liverpool have announced that new signing Naby Keita will be given the No. 8 shirt last worn by former captain Steven Gerrard.
Manchester United have reached an agreement with Shakhtar Donetsk for the transfer of Brazil international midfielder Fred, the Premier League club confirmed on Tuesday.
Stephan Lichtsteiner has become Unai Emery's first signing for Arsenal after joining the Premier League side on a free transfer from Juventus.
Frank Lampard has been appointed the new manager of Derby County on a three-year contract, with former Chelsea academy coach Jody Morris as his assistant.
Liverpool have announced a deal to sign Brazilian midfielder Fabinho from Monaco.
Arsenal have hired former Paris Saint-Germain manager Unai Emery to take them into a new era following Arsene Wenger's departure, with sources telling that he has signed a three-year contract.
Eden Hazard fired Chelsea to FA Cup glory against Manchester United as Antonio Conte's expected farewell ended with a memorable triumph against old foe Jose Mourinho.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.