Sadio Mane scored twice against Tottenham as Jurgen Klopp's Liverpool recorded their first Premier League victory of 2017.
Anthony Martial impressed on his return to the Manchester United starting lineup, scoring one and providing the other as Jose Mourinho's men comfortably overcame Watford.
A double from Alexis Sanchez saw Arsenal seal a crucial home win over Hull in a largely forgettable Premier League clash at the Emirates Stadium on Saturday.
Leicester provided some much-needed joy for boss Claudio Ranieri with a 3-1 win against East Midlands rivals Derby in the FA Cup.
Two goals in less than two minutes at the end of the first half put Manchester United on their way to an easy 3-0 victory at Leicester City as the Premier League champions' relegation worries deepened.
Gabriel Jesus scored a stoppage-time winner as Manchester City snatched a 2-1 victory over Swansea City in the Premier League.
Harry Kane put Tottenham clear in second place at the top of the Premier League table by scoring a second-half penalty to seal a 1-0 victory over Middlesbrough.
Jurgen Klopp's Liverpool lurched to another painful and potentially costly defeat as Italian defender Andrea Ranocchia inspired a famous 2-0 win for relegation-threatened Hull at the KC Stadium.
Marcos Alonso, Eden Hazard and Cesc Fabregas were all on target as Chelsea defeated Arsenal 3-1 at Stamford Bridge to consolidate their lead at the top of the Premier League table.
Manchester United failed to capitalise on their top-four rivals' struggles as rejuvenated Hull left Old Trafford with a hard-fought point from a goalless stalemate.
Gabriel Jesus scored on his full Premier League debut as Manchester City mauled West Ham 4-0.
Liverpool manager Jurgen Klopp delivered on his promise of a big performance after a miserable week of results but Chelsea had the better night at Anfield.
Sunderland boss David Moyes was given some respite at the end of a frustrating January as Tottenham wasted the chance to maintain their pursuit of Premier League leaders Chelsea.
Arsenal suffered a setback in their Premier League title bid as Watford secured a surprise 2-1 victory at Emirates Stadium on Tuesday night.
Burnley's run of home victories continued as a controversial late goal from substitute Sam Vokes secured a 1-0 triumph over Leicester -- the Foxes' third successive Premier League defeat.
Bastian Schweinsteiger enjoyed a memorable Manchester United return, wrapping up a comprehensive FA Cup fourth-round win against Wigan on his first start for more than a year.
Talk of a crisis may be premature but Liverpool's season is certainly in freefall after an FA Cup exit to Wolves heaped more scrutiny on Jurgen Klopp and his players.
Son Heung-Min scored in the sixth minute of stoppage time as Tottenham completed an incredible 4-3 comeback victory against a spirited Wycombe in the fourth round of the FA Cup.
Branislav Ivanovic scored on his potential farewell appearance as Chelsea beat neighbours Brentford 4-0 in the FA Cup fourth round at Stamford Bridge.
Theo Walcott's hat trick helped Arsenal coast past Southampton 5-0 and into the FA Cup fifth round, with Danny Welbeck also scoring his first goals in eight months.
Manchester City eased into the fifth round of the FA Cup with a 3-0 win at Crystal Palace that showed why their hosts are at such risk of relegation.
Wes Morgan gave Leicester an FA Cup lifeline after his late equaliser denied Derby in a 2-2 draw at Pride Park.
Manchester United will meet Southampton in the final of the EFL Cup on Feb. 26 despite losing 2-1 to Hull City at the KCOM Stadium, going through 3-2 on aggregate.
Southampton reached their first major final since 2003 to leave Liverpool's season in danger of unravelling.
Diego Costa made a goal scoring return as Chelsea extended their lead at the top of the Premier League to eight points with a 2-0 win over Hull City.
Alexis Sanchez kept his cool to score a last-gasp penalty as 10-man Arsenal beat Burnley to go second in the Premier League.
James Ward-Prowse, Jay Rodriguez and Dusan Tadic condemned Leicester to their 11th Premier League defeat of the season as Southampton triumphed 3-0 at St Mary's.
Tottenham Hotspur staged a dramatic second-half comeback to snatch a controversial 2-2 draw at Premier League title rivals Manchester City.
Wayne Rooney broke Manchester United's all-time scoring record in dramatic fashion, bending home a stunning 250th goal to secure a hard-fought 1-1 draw at Stoke deep in stoppage time.
Liverpool's winless run in the Premier League extended to three games as they were beaten 3-2 by struggling Swansea City at Anfield.
Manchester City's quadruple trophy bid was sensationally derailed by a shocking 1-0 defeat at third-division Wigan in the FA Cup fifth round on Monday.
Substitute Steve Davies earned Rochdale an FA Cup fifth-round replay at Wembley Stadium with his remarkable stoppage-time equaliser against Tottenham Hotspur at Spotland.
Manchester United overcame the video assistant referee's controversial intervention and reached the FA Cup quarterfinals thanks to Romelu Lukaku's brace at Huddersfield.
Willian dispatched two inch-perfect finishes as Chelsea cruised past Hull 4-0 and into the FA Cup quarter-finals.
Sheffield Wednesday fan Jamie Vardy put the Blades to the sword as Leicester knocked Sheffield United out of the FA Cup.
Chelsea eased the growing pressure on Antonio Conte and returned to the Premier League's top four with a convincing 3-0 win over West Brom.
Liverpool moved back above Tottenham and into third place in the Premier League table as two first-half goals gave them a routine 2-0 victory at struggling Southampton.
Matt Ritchie scored a second-half winner for Newcastle as they lifted themselves out of the relegation places with a 1-0 victory over Manchester United at St James' Park.
Sergio Aguero scored four times as Manchester City extended their Premier League lead to 16 points with a 5-1 demolition of Leicester at the Etihad Stadium.
Everton's Sam Allardyce won the battle of ex-England managers at Goodison Park to ease growing pressure with a 3-1 victory over Roy Hodgson's struggling Crystal Palace.
Harry Kane proved Arsenal's nemesis again as his bullet header earned Tottenham a deserved 1-0 victory in the North London derby.
Erik Lamela scored his first goal in 17 months as Tottenham sauntered past Newport and into the fifth round of the FA Cup.
Swansea recorded their biggest-ever FA Cup win as Notts County were demolished 8-1 at the Liberty Stadium.
Antonio Conte's future as Chelsea boss was cast into further doubt as his 10 men were thrashed 4-1 by Watford on Monday night.
Mohamed Salah and Harry Kane traded stoppage-time goals as Liverpool and Tottenham drew 2-2 in a wild affair at Anfield on Sunday.
Newcastle resisted intense pressure from Crystal Palace to earn a 1-1 draw at Selhurst Park that again took them clear of the bottom three.
`Aaron Ramsey hit a hat trick with Arsenal fans treated to their first showing of their January transfers in tandem as both Henrikh Mkhitaryan and Pierre-Emerick Aubameyang shone in a comfortable 5-1 win over Everton.
Alexis Sanchez's first goal for Manchester United wrapped up a 2-0 victory against Huddersfield on a day when the clubs came together to remember those who lost their lives in the Munich air disaster.
Swansea's resurgence continued as they climbed out of the Premier League relegation zone with a 1-1 draw at Leicester, who were again without want-away midfielder Riyad Mahrez.
Johann Berg Gudmundsson struck a late equaliser as Burnley grabbed a 1-1 draw against Premier League leaders Manchester City at Turf Moor.
Christian Eriksen scored within 11 seconds as Tottenham brushed aside a below-par Manchester United to seal a crunch 2-0 victory in the race for the top four.
Kevin De Bruyne was again the inspiration as Manchester City opened up a 15-point lead at the top of the Premier League with a 3-0 win over West Brom.
Theo Walcott's maiden Everton goals secured a first win in eight matches as a 2-1 triumph over Leicester arrested their slide under Sam Allardyce.
Bournemouth scored three goals in 16 remarkable second-half minutes to record a sensational 3-0 victory against Chelsea at Stamford Bridge on Wednesday evening.
Arsenal have completed the signing of striker Pierre-Emerick Aubameyang from Borussia Dortmund for a fee of €63.75 million (£56m).
Chelsea have completed the signing of Olivier Giroud from Arsenal for a reported £16.25 million on an 18-month contract.
Tottenham Hotspur have completed the signing of winger Lucas Moura from Paris Saint-Germain for a fee of в‚¬28 million.
Liverpool bounced back to winning ways in the Premier League and maintained their Champions League challenge with a 3-0 win at Huddersfield.
Swansea climbed out of the relegation zone for the first time in three months as Petr Cech's dreadful howler helped condemn Arsenal to a 3-1 defeat at the Liberty Stadium.
Two first-half goals were enough to see Manchester City comfortably through to the FA Cup fifth round at Championship side Cardiff City.