Manchester City strengthened their hopes of a top-four Premier League finish and moved up to third in the table thanks to a 5-0 victory over Crystal Palace at the Etihad Stadium on Saturday.
Tottenham's title hopes were dealt a decisive blow as Manuel Lanzini's strike gave West Ham a memorable 1-0 win over their London rivals.
Liverpool took a significant step to sealing Champions League qualification as Emre Can scored a goal-of-the-season contender to down Watford on Monday night.
Tottenham Hotspur again ensured Chelsea's lead at the top of the Premier League remains at four points and guaranteed that they will finish above Arsenal as they won White Hart Lane's last-ever North London derby 2-0.
Gabriel Jesus marked his return to Manchester City's starting lineup by grabbing a dramatic late equaliser for his side in a 2-2 draw against relegation-haunted Middlesbrough at the Riverside Stadium.
Chelsea scored three second-half goals to win at Everton and re-establish a seven-point lead over Tottenham Hotspur, who take on their North London rivals Arsenal later on Sunday.
A late equaliser by Gylfi Sigurdsson denied Manchester United the chance to move up into third place and boosted Swansea's chances of escaping the drop in a 1-1 draw at Old Trafford.
Jamie Vardy continued his red-hot run in front of goal as Leicester eased their Premier League relegation fears with a 1-0 win at West Brom.
Marouane Fellaini was sent off as Manchester City and Manchester United settled for a share of the spoils in the Manchester derby, with the two neighbours playing out a goalless draw at the Etihad Stadium.
Christian Eriksen kept Tottenham's title hopes alive with a crucial strike to sink Crystal Palace 1-0.
Arsenal kept their hopes of a top-four Premier League finish alive as a late Robert Huth own goal was enough for them to see off reigning champions Leicester.
Diego Costa ended his lean streak with a double as Premier League leaders Chelsea beat Southampton 4-2 to restore their seven-point advantage over Tottenham.
Crystal Palace took a giant step towards Premier League safety and inflicted a setback on Liverpool's top four hopes as Christian Benteke struck twice on his return to Anfield.
Manchester United cruised to a routine victory at Burnley to move to within a point of fourth-placed Manchester City.
Alexis Sanchez struck an extra-time winner as Arsenal came from behind to beat Manchester City 2-1 in their FA Cup semifinal at Wembley.
Eden Hazard came off the bench to help inspire Chelsea to a 4-2 victory over Tottenham and send them into the FA Cup final, condemning Mauricio Pochettino's men to yet more Wembley woe and giving them a bloody nose ahead of the title run-in.
Mesut Ozil kept alive Arsenal's hopes of a top-four finish as Middlesbrough slid closer to the Premier League exit door on Monday night.
Manchester United threw the Premier League title race open and boosted their hopes of a top-four finish as Jose Mourinho masterminded a 2-0 Old Trafford victory over his former club Chelsea.
Roberto Firmino scored Liverpool's winner as they saw off West Bromwich Albion with a 1-0 victory to move up to third in the Premier League.
Crystal Palace recovered from two goals down to secure a 2-2 draw with Leicester and take their latest step towards preserving their Premier League status.
Manchester City moved into third place in the Premier League as Vincent Kompany scored to spark a 3-0 win at Southampton.
Tottenham Hotspur made it seven home league wins in a row and cut the gap on leaders Chelsea to four points ahead of Sunday's games with a dominant display as they won 4-0 against Bournemouth.
Crystal Palace dominated Arsenal 3-0 on Monday night to increase the pressure on Arsene Wenger while boosting their own Premier League survival hopes.
Romelu Lukaku's good form in front of goal at Goodison Park continued with a double as Everton's 4-2 victory over Leicester ended Foxes boss Craig Shakespeare's six-game winning run.
Zlatan Ibrahimovic scored his 17th Premier League goal of the season to set Manchester United on course for a 3-0 victory over 10-man Sunderland which moves them up to fifth in the table.
Eden Hazard's wonderful finish carried Chelsea ever closer to the Premier League title as the Blues saw off Bournemouth 3-1 at Dean Court.
Goals from Philippe Coutinho and Roberto Firmino dug Jurgen Klopp out of a hole as Liverpool came from behind to beat Stoke 2-1.
Manchester City ended a run of four Premier League games without a win by easing to a comfortable 3-1 victory over relegation-threatened Hull.
Son Heung-Min hit a brace as Tottenham kept their Premier League title ambitions alive with a comprehensive win over Watford at White Hart Lane.
Eden Hazard scored twice as Chelsea fought off the challenge of Manchester City to take a step closer to the Premier League title with a 2-1 win at Stamford Bridge.
Arsenal have hired former Paris Saint-Germain manager Unai Emery to take them into a new era following Arsene Wenger's departure, with sources telling that he has signed a three-year contract.
Eden Hazard fired Chelsea to FA Cup glory against Manchester United as Antonio Conte's expected farewell ended with a memorable triumph against old foe Jose Mourinho.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.
Yaya Toure bade farewell to the Etihad Stadium as champions Manchester City set a hat trick of Premier League records in a routine 3-1 win over Brighton.
Jamie Vardy returned to haunt Arsene Wenger on his farewell tour as Leicester cruised past 10-man Arsenal 3-1.
Tottenham overcame a nervy night at Wembley to book their Champions League place for next season with a 1-0 win over Newcastle.
Huddersfield secured their Premier League status with a valiant 1-1 draw at Stamford Bridge which significantly dented Chelsea's slim top-four hopes.
Southampton took a huge step towards safety as a 1-0 win at Swansea inched their Welsh rivals towards the Premier League trapdoor and relegated West Brom in the process.
Arsenal gave Arsene Wenger a memorable Emirates Stadium send-off as the outgoing boss saw his side thrash Burnley.
Chelsea's Champions League hopes for next season received a boost following Sunday's narrow victory over Liverpool.
Manchester City failed to fire on the day they were presented with the Premier League trophy as Huddersfield Town claimed a vital point at the Etihad Stadium.
Tom Davies scored deep into added time as Everton salvaged a 1-1 draw against 10-man Southampton at Goodison Park, preventing their opponents from escaping the Premier League relegation zone.
West Bromwich Albion kept their slim survival hopes alive after Jake Livemore's dramatic injury time goal earned a 1-0 win against Tottenham Hotspur.
Pascal Gross scored the goal which sank Manchester United 1-0 to guarantee Premier League football for Brighton next season.
Harry Kane did his talking on the pitch as Tottenham reasserted themselves in the race for the Champions League with a 2-0 win over Watford.
Arsene Wenger was denied a point on his last visit to Old Trafford as Arsenal manager when Marouane Fellaini's injury-time header snatched victory for Manchester United.
Manchester City surpassed 100 Premier League goals for the season and left West Ham waiting to confirm top flight football next season with a 4-1 win at the London Stadium.
Chelsea's chase for a top-four Premier League spot gathered pace as Cesc Fabregas scored a landmark goal to deepen Swansea's relegation concerns.
Premier League leading scorer Mohamed Salah had a rare off day as Liverpool continue to stumble towards guaranteeing a top-four finish after a goalless draw at home to Stoke.
Manchester City celebrated their title success in style with a resounding 5-0 win over Swansea at the Etihad Stadium.
Olivier Giroud proved the scourge of Southampton once again, setting Chelsea on course for FA Cup semifinal success and a mouth-watering clash with Manchester United.
A late flurry of goals saw Arsenal secure a 4-1 win over West Ham in their first game since Arsene Wenger revealed he is stepping down as boss.
Ander Herrera has Manchester United dreaming of FA Cup glory after Tottenham Hotspur again suffered semifinal sorrow.
A late strike from Salomon Rondon helped bottom-of-the-table West Bromwich Albion come from behind to draw 2-2 against Liverpool on Saturday at The Hawthorns.