Chelsea's march towards the Premier League title continued as they extended their lead to 13 points thanks to Gary Cahill's 87th-minute winner at Stoke.
Leicester made it four wins from four under Craig Shakespeare and picked up their first away victory of the season with a 3-2 success at West Ham.
Craig Dawson's double piled more pressure on Arsenal boss Arsene Wenger as the Gunners lost 3-1 at West Bromwich Albion.
Antonio Conte and Jose Mourinho had to be separated as N'Golo Kante's strike sent Chelsea into the FA Cup semi-finals with a 1-0 win over Manchester United at Stamford Bridge.
Liverpool consolidated fourth spot in the Premier League with a come-from-behind 2-1 home victory over Burnley.
Son Heung-Min's hat trick fired Tottenham into the FA Cup semifinals but their 6-0 demolition of Millwall was marred by racist chants towards the South Korean from visiting supporters.
Manchester City eased into the FA Cup semifinals as they produced a dominant display to win 2-0 at Middlesbrough.
Arsenal scored four second-half goals as they ended non-league Lincoln City's outstanding FA Cup run with an emphatic 5-0 victory at the Emirates Stadium.
Romelu Lukaku drew level with Harry Kane in the race for the Premier League's golden boot as Everton coasted against West Brom for their fifth straight home Premier League win.
Stoke frustrated Manchester City as they held out for a goalless draw in their re-arranged Premier League clash at the Etihad Stadium.
Eden Hazard and Diego Costa were on target as clinical Chelsea swatted aside West Ham 2-1 to take a 10-point lead at the top of the Premier League.
Sergio Aguero struck for the fifth time in three games as Manchester City eased past relegation-haunted Sunderland and back into third place in the Premier League.
Harry Kane won his top-scorer tussle with Romelu Lukaku by bagging a brace as Tottenham held on for a 3-2 victory over Everton.
Liverpool put their disappointing defeat at Leicester behind them to move up to third place in the Premier League with a 3-1 home win over Arsenal, who dropped to fifth.
Leicester continued to breathe new life into their Premier League survival bid under the guidance of Craig Shakespeare as he strengthened his claims for the manager's job with victory against relegation rivals Hull.
Zlatan Ibrahimovic had a second-half penalty saved as Manchester United were held 1-1 by Bournemouth and missed the opportunity to move ahead of Liverpool and into fifth in a feisty game at Old Trafford.
Jamie Vardy's double inspired Leicester to victory over Liverpool as the champions sparked in to life following Claudio Ranieri's sacking.
Zlatan Ibrahimovic's late header secured Manchester United the first major trophy of the Jose Mourinho era, breaking Southampton hearts close to the end of a thrilling EFL Cup final.
Harry Kane scored a first-half hat trick as Tottenham beat Stoke 4-0 and climbed up to second in the Premier League table.
Chelsea moved 11 points clear at the top of the Premier League with a hard-fought 3-1 win over Swansea.
Leicester City sacked manager Claudio Ranieri on Thursday, just nine months after he led the club to their first Premier League title.
Arsenal came through their FA Cup adventure away to non-league Sutton United at tiny Gander Green Lane with a 2-0 win on Monday night.
Zlatan Ibrahimovic spared Manchester United's blushes at Ewood Park as the FA Cup holders came from behind to beat Blackburn Rovers 2-1 and reach the quarterfinals.
Harry Kane scored a hat trick as Tottenham Hotspur saw off Fulham 3-0 at Craven Cottage to reach the quarterfinals of the FA Cup.
Pedro and Diego Costa were on target as Chelsea ended Wolves' FA Cup run at Molineux.
Ten-man Millwall booked their place in the sixth round of the FA Cup after Shaun Cummings' last-minute strike condemned Leicester to another miserable defeat.
Championship Huddersfield frustrated Manchester City to take their FA Cup fifth-round tie to a replay with a goalless draw at the John Smith's Stadium.
Sergio Aguero offered a reminder of his value to Manchester City as they moved to second in the Premier League with a 2-0 win at Bournemouth.
Robbie Brady's stunning debut goal checked Chelsea's Premier League title charge as Burnley maintained their impressive home form in a 1-1 draw at Turf Moor.
Champions Leicester City fell deeper into the Premier League relegation mire as fellow strugglers Swansea took another stride towards survival with a 2-0 win at the Liberty Stadium.
Manchester City's quadruple trophy bid was sensationally derailed by a shocking 1-0 defeat at third-division Wigan in the FA Cup fifth round on Monday.
Substitute Steve Davies earned Rochdale an FA Cup fifth-round replay at Wembley Stadium with his remarkable stoppage-time equaliser against Tottenham Hotspur at Spotland.
Manchester United overcame the video assistant referee's controversial intervention and reached the FA Cup quarterfinals thanks to Romelu Lukaku's brace at Huddersfield.
Willian dispatched two inch-perfect finishes as Chelsea cruised past Hull 4-0 and into the FA Cup quarter-finals.
Sheffield Wednesday fan Jamie Vardy put the Blades to the sword as Leicester knocked Sheffield United out of the FA Cup.
Chelsea eased the growing pressure on Antonio Conte and returned to the Premier League's top four with a convincing 3-0 win over West Brom.
Liverpool moved back above Tottenham and into third place in the Premier League table as two first-half goals gave them a routine 2-0 victory at struggling Southampton.
Matt Ritchie scored a second-half winner for Newcastle as they lifted themselves out of the relegation places with a 1-0 victory over Manchester United at St James' Park.
Sergio Aguero scored four times as Manchester City extended their Premier League lead to 16 points with a 5-1 demolition of Leicester at the Etihad Stadium.
Everton's Sam Allardyce won the battle of ex-England managers at Goodison Park to ease growing pressure with a 3-1 victory over Roy Hodgson's struggling Crystal Palace.
Harry Kane proved Arsenal's nemesis again as his bullet header earned Tottenham a deserved 1-0 victory in the North London derby.
Erik Lamela scored his first goal in 17 months as Tottenham sauntered past Newport and into the fifth round of the FA Cup.
Swansea recorded their biggest-ever FA Cup win as Notts County were demolished 8-1 at the Liberty Stadium.
Antonio Conte's future as Chelsea boss was cast into further doubt as his 10 men were thrashed 4-1 by Watford on Monday night.
Mohamed Salah and Harry Kane traded stoppage-time goals as Liverpool and Tottenham drew 2-2 in a wild affair at Anfield on Sunday.
Newcastle resisted intense pressure from Crystal Palace to earn a 1-1 draw at Selhurst Park that again took them clear of the bottom three.
`Aaron Ramsey hit a hat trick with Arsenal fans treated to their first showing of their January transfers in tandem as both Henrikh Mkhitaryan and Pierre-Emerick Aubameyang shone in a comfortable 5-1 win over Everton.
Alexis Sanchez's first goal for Manchester United wrapped up a 2-0 victory against Huddersfield on a day when the clubs came together to remember those who lost their lives in the Munich air disaster.
Swansea's resurgence continued as they climbed out of the Premier League relegation zone with a 1-1 draw at Leicester, who were again without want-away midfielder Riyad Mahrez.
Johann Berg Gudmundsson struck a late equaliser as Burnley grabbed a 1-1 draw against Premier League leaders Manchester City at Turf Moor.
Christian Eriksen scored within 11 seconds as Tottenham brushed aside a below-par Manchester United to seal a crunch 2-0 victory in the race for the top four.
Kevin De Bruyne was again the inspiration as Manchester City opened up a 15-point lead at the top of the Premier League with a 3-0 win over West Brom.
Theo Walcott's maiden Everton goals secured a first win in eight matches as a 2-1 triumph over Leicester arrested their slide under Sam Allardyce.
Bournemouth scored three goals in 16 remarkable second-half minutes to record a sensational 3-0 victory against Chelsea at Stamford Bridge on Wednesday evening.
Arsenal have completed the signing of striker Pierre-Emerick Aubameyang from Borussia Dortmund for a fee of €63.75 million (£56m).
Chelsea have completed the signing of Olivier Giroud from Arsenal for a reported £16.25 million on an 18-month contract.
Tottenham Hotspur have completed the signing of winger Lucas Moura from Paris Saint-Germain for a fee of в‚¬28 million.
Liverpool bounced back to winning ways in the Premier League and maintained their Champions League challenge with a 3-0 win at Huddersfield.
Swansea climbed out of the relegation zone for the first time in three months as Petr Cech's dreadful howler helped condemn Arsenal to a 3-1 defeat at the Liberty Stadium.
Two first-half goals were enough to see Manchester City comfortably through to the FA Cup fifth round at Championship side Cardiff City.