Olivier Giroud proved the scourge of Southampton once again, setting Chelsea on course for FA Cup semifinal success and a mouth-watering clash with Manchester United.
A late flurry of goals saw Arsenal secure a 4-1 win over West Ham in their first game since Arsene Wenger revealed he is stepping down as boss.
Ander Herrera has Manchester United dreaming of FA Cup glory after Tottenham Hotspur again suffered semifinal sorrow.
A late strike from Salomon Rondon helped bottom-of-the-table West Bromwich Albion come from behind to draw 2-2 against Liverpool on Saturday at The Hawthorns.
Victor Moses was the match-winner as Chelsea eased the pressure on London rivals Arsenal by denting Burnley's surge for sixth place.
Southampton halted their losing run but a goalless draw at Leicester does little for their Premier League survival hopes.
Manchester United moved to within two points of securing a place in next season's Champions League with a 2-0 win at Bournemouth.
Tottenham's pursuit of Champions League football suffered a minor setback as they squandered a lead to draw 1-1 at Brighton.
Manchester United handed local rivals Manchester City the 2017-18 Premier League title after succumbing to a shock 1-0 defeat against West Bromwich Albion at Old Trafford that keeps the Baggies' slim survival hopes alive.
Arsenal's away woes in the Premier League continued on Sunday when they were beaten 2-1 by Newcastle United at St James' Park.
Mohamed Salah brought his remarkable goal tally to 40 in all competitions this season season by netting once more in a 3-0 win over Bournemouth.
Manchester City responded from a nightmare 10 days in style to put one hand on the Premier League title with a 3-1 win at Tottenham.
Olivier Giroud was the hero for Chelsea as the Blues fought back from two goals down to claim a 3-2 win over Premier League strugglers Southampton at St Mary's.
Javier Hernandez netted an equaliser for West Ham to thwart Chelsea again and dent their bid for Champions League football, while earning his side an important point in their bid to survive relegation in a 1-1 draw on Saturday.
Danny Welbeck scored twice as Arsenal deepened Southampton's relegation worries with a 3-2 win in a game that saw both sides reduced to 10 men in stoppage time at the Emirates Stadium.
Manchester United produced an incredible second-half comeback to beat rivals Manchester City 3-2 and leave them waiting for confirmation of the Premier League title after a thrilling game at the Etihad Stadium.
Christian Eriksen was credited with a brace as Harry Kane was denied a crucial goal in the Golden Boot race in Tottenham's 2-1 win over Stoke at the bet365 Stadium.
Everton and Liverpool had to settle for a share of the spoils as the Merseyside derby ended in a goalless stalemate at Goodison Park.
Dele Alli's double drove Tottenham to a first Stamford Bridge win over Chelsea since 1990 and left the Blues' Champions League qualification bid in tatters.
Arsenal scored three times in the last 15 minutes to condemn Premier League strugglers Stoke to defeat, despite a fairly positive showing from the Potters in north London.
Manchester City are just one win away from securing the Premier League title after a 3-1 victory over Everton at Goodison Park.
Romelu Lukaku's 100th Premier League goal set Manchester United on course for a comfortable victory against relegation-threatened Swansea.
Mohamed Salah's 37th goal of the season in all competitions handed Jurgen Klopp victory in his 100th Premier League match in charge of Liverpool.
Pedro's extra-time header saw Chelsea advance to the FA Cup semifinals at the expense of Leicester City.
Southampton are through to the FA Cup semi-finals for the first time in 15 years after a 2-0 victory over Wigan in Mark Hughes' first game in charge.
Manchester United were unable to match the intensity shown during Jose Mourinho's extraordinary pre-match press conference, but headers from Romelu Lukaku and Nemanja Matic saw them through to the FA Cup semi-finals at Brighton's expense.
Mohamed Salah's record-setting season shows no signs of slowing down as four goals in the 5-0 victory over Watford put him in pole position for the Premier League Golden Boot.
Tottenham Hotspur strolled into the semifinals of the FA Cup with a Christian Eriksen-inspired 3-0 victory over Swansea City.
David Silva struck twice as Manchester City took another stride towards their seemingly inevitable coronation as Premier League champions with a 2-0 victory at Stoke.
Tottenham Hotspur bounced back from their Champions League defeat to Juventus with a 4-1 win at Bournemouth in a game overshadowed by injury to Harry Kane.
Manchester United have reached an agreement with Shakhtar Donetsk for the transfer of Brazil international midfielder Fred, the Premier League club confirmed on Tuesday.
Stephan Lichtsteiner has become Unai Emery's first signing for Arsenal after joining the Premier League side on a free transfer from Juventus.
Frank Lampard has been appointed the new manager of Derby County on a three-year contract, with former Chelsea academy coach Jody Morris as his assistant.
Liverpool have announced a deal to sign Brazilian midfielder Fabinho from Monaco.
Arsenal have hired former Paris Saint-Germain manager Unai Emery to take them into a new era following Arsene Wenger's departure, with sources telling that he has signed a three-year contract.
Eden Hazard fired Chelsea to FA Cup glory against Manchester United as Antonio Conte's expected farewell ended with a memorable triumph against old foe Jose Mourinho.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.
Yaya Toure bade farewell to the Etihad Stadium as champions Manchester City set a hat trick of Premier League records in a routine 3-1 win over Brighton.
Jamie Vardy returned to haunt Arsene Wenger on his farewell tour as Leicester cruised past 10-man Arsenal 3-1.
Tottenham overcame a nervy night at Wembley to book their Champions League place for next season with a 1-0 win over Newcastle.
Huddersfield secured their Premier League status with a valiant 1-1 draw at Stamford Bridge which significantly dented Chelsea's slim top-four hopes.
Southampton took a huge step towards safety as a 1-0 win at Swansea inched their Welsh rivals towards the Premier League trapdoor and relegated West Brom in the process.
Arsenal gave Arsene Wenger a memorable Emirates Stadium send-off as the outgoing boss saw his side thrash Burnley.
Chelsea's Champions League hopes for next season received a boost following Sunday's narrow victory over Liverpool.
Manchester City failed to fire on the day they were presented with the Premier League trophy as Huddersfield Town claimed a vital point at the Etihad Stadium.
Tom Davies scored deep into added time as Everton salvaged a 1-1 draw against 10-man Southampton at Goodison Park, preventing their opponents from escaping the Premier League relegation zone.
West Bromwich Albion kept their slim survival hopes alive after Jake Livemore's dramatic injury time goal earned a 1-0 win against Tottenham Hotspur.
Pascal Gross scored the goal which sank Manchester United 1-0 to guarantee Premier League football for Brighton next season.
Harry Kane did his talking on the pitch as Tottenham reasserted themselves in the race for the Champions League with a 2-0 win over Watford.
Arsene Wenger was denied a point on his last visit to Old Trafford as Arsenal manager when Marouane Fellaini's injury-time header snatched victory for Manchester United.
Manchester City surpassed 100 Premier League goals for the season and left West Ham waiting to confirm top flight football next season with a 4-1 win at the London Stadium.
Chelsea's chase for a top-four Premier League spot gathered pace as Cesc Fabregas scored a landmark goal to deepen Swansea's relegation concerns.
Premier League leading scorer Mohamed Salah had a rare off day as Liverpool continue to stumble towards guaranteeing a top-four finish after a goalless draw at home to Stoke.
Manchester City celebrated their title success in style with a resounding 5-0 win over Swansea at the Etihad Stadium.