Zlatan Ibrahimovic spared Manchester United's blushes at Ewood Park as the FA Cup holders came from behind to beat Blackburn Rovers 2-1 and reach the quarterfinals.
Harry Kane scored a hat trick as Tottenham Hotspur saw off Fulham 3-0 at Craven Cottage to reach the quarterfinals of the FA Cup.
Pedro and Diego Costa were on target as Chelsea ended Wolves' FA Cup run at Molineux.
Ten-man Millwall booked their place in the sixth round of the FA Cup after Shaun Cummings' last-minute strike condemned Leicester to another miserable defeat.
Championship Huddersfield frustrated Manchester City to take their FA Cup fifth-round tie to a replay with a goalless draw at the John Smith's Stadium.
Sergio Aguero offered a reminder of his value to Manchester City as they moved to second in the Premier League with a 2-0 win at Bournemouth.
Robbie Brady's stunning debut goal checked Chelsea's Premier League title charge as Burnley maintained their impressive home form in a 1-1 draw at Turf Moor.
Champions Leicester City fell deeper into the Premier League relegation mire as fellow strugglers Swansea took another stride towards survival with a 2-0 win at the Liberty Stadium.
Sadio Mane scored twice against Tottenham as Jurgen Klopp's Liverpool recorded their first Premier League victory of 2017.
Anthony Martial impressed on his return to the Manchester United starting lineup, scoring one and providing the other as Jose Mourinho's men comfortably overcame Watford.
A double from Alexis Sanchez saw Arsenal seal a crucial home win over Hull in a largely forgettable Premier League clash at the Emirates Stadium on Saturday.
Leicester provided some much-needed joy for boss Claudio Ranieri with a 3-1 win against East Midlands rivals Derby in the FA Cup.
Two goals in less than two minutes at the end of the first half put Manchester United on their way to an easy 3-0 victory at Leicester City as the Premier League champions' relegation worries deepened.
Gabriel Jesus scored a stoppage-time winner as Manchester City snatched a 2-1 victory over Swansea City in the Premier League.
Harry Kane put Tottenham clear in second place at the top of the Premier League table by scoring a second-half penalty to seal a 1-0 victory over Middlesbrough.
Jurgen Klopp's Liverpool lurched to another painful and potentially costly defeat as Italian defender Andrea Ranocchia inspired a famous 2-0 win for relegation-threatened Hull at the KC Stadium.
Marcos Alonso, Eden Hazard and Cesc Fabregas were all on target as Chelsea defeated Arsenal 3-1 at Stamford Bridge to consolidate their lead at the top of the Premier League table.
Manchester United failed to capitalise on their top-four rivals' struggles as rejuvenated Hull left Old Trafford with a hard-fought point from a goalless stalemate.
Gabriel Jesus scored on his full Premier League debut as Manchester City mauled West Ham 4-0.
Liverpool manager Jurgen Klopp delivered on his promise of a big performance after a miserable week of results but Chelsea had the better night at Anfield.
Sunderland boss David Moyes was given some respite at the end of a frustrating January as Tottenham wasted the chance to maintain their pursuit of Premier League leaders Chelsea.
Arsenal suffered a setback in their Premier League title bid as Watford secured a surprise 2-1 victory at Emirates Stadium on Tuesday night.
Burnley's run of home victories continued as a controversial late goal from substitute Sam Vokes secured a 1-0 triumph over Leicester -- the Foxes' third successive Premier League defeat.
Bastian Schweinsteiger enjoyed a memorable Manchester United return, wrapping up a comprehensive FA Cup fourth-round win against Wigan on his first start for more than a year.
Talk of a crisis may be premature but Liverpool's season is certainly in freefall after an FA Cup exit to Wolves heaped more scrutiny on Jurgen Klopp and his players.
Son Heung-Min scored in the sixth minute of stoppage time as Tottenham completed an incredible 4-3 comeback victory against a spirited Wycombe in the fourth round of the FA Cup.
Branislav Ivanovic scored on his potential farewell appearance as Chelsea beat neighbours Brentford 4-0 in the FA Cup fourth round at Stamford Bridge.
Theo Walcott's hat trick helped Arsenal coast past Southampton 5-0 and into the FA Cup fifth round, with Danny Welbeck also scoring his first goals in eight months.
Manchester City eased into the fifth round of the FA Cup with a 3-0 win at Crystal Palace that showed why their hosts are at such risk of relegation.
Wes Morgan gave Leicester an FA Cup lifeline after his late equaliser denied Derby in a 2-2 draw at Pride Park.
Liverpool had far too much attacking power for Bournemouth to withstand as they moved back into the top four with a 4-0 win at the Vitality Stadium.
Manchester United held on for a 2-1 win at West Bromwich Albion to cut neighbours Manchester City's lead at the top of the Premier League back to 11 points.
Leaders Manchester City powered to their 16th successive win in the Premier League with a 4-1 thrashing of Tottenham at the Etihad Stadium.
Arsenal returned to winning ways but had Mesut Ozil to thank for scoring a wonderful winner as they toiled against out-of-form Newcastle.
Time was on Chelsea's side as Marcos Alonso's free-kick earned a 1-0 Premier League win over Southampton.
Arsenal lost further ground on the Premier League leaders after they were held to a goalless draw at West Ham.
Tottenham climbed back into the Premier League's top four as Serge Aurier's fluke-goal and a header from Son Heung-min sealed a 2-0 victory over Brighton.
Liverpool manager Jurgen Klopp reunited the "Fab Four" but his prolific attacking quartet were all distinctly off-key as West Brom held out for a goalless draw at Anfield.
Manchester City set a new Premier League record of 15 consecutive wins with a 4-0 victory at bottom club Swansea.
Romelu Lukaku got a much-needed goal as Manchester United moved on from their galling derby defeat by beating Bournemouth.
Willian scored one and made two others as Chelsea finally turned in a display worthy of Premier League champions to win 3-1 at Huddersfield.
Runaway Premier League leaders Manchester City opened up an eye-watering double-digit lead over rivals Manchester United after Nicolas Otamendi fired Pep Guardiola's men to derby victory.
Wayne Rooney's first Merseyside derby goal earned Everton a 1-1 draw at Anfield as Liverpool manager Jurgen Klopp's selection gamble backfired.
Olivier Giroud climbed off the bench to rescue a point for Arsenal in a 1-1 draw at Southampton.
Ayoze Perez's late own goal cost Newcastle a precious Premier League draw as Leicester ruined the Magpies' 125th birthday celebrations.
Tottenham ended a four-match Premier League winless streak in style with Harry Kane scoring a brace as they thrashed Stoke 5-1 at Wembley.
Marko Arnautovic's first West Ham goal secured a 1-0 victory over Chelsea and a first win for manager David Moyes.
Manchester City left it late for the third game in a row as they beat West Ham United 2-1 at the Etihad Stadium thanks to David Silva's strike and extended their Premier League lead.
Bournemouth and Southampton shared the spoils as an entertaining match on the south coast finished in a 1-1 draw.
Jesse Lingard scored twice but Paul Pogba was sent off as Manchester United beat Arsenal 3-1 in a breathless match at the Emirates Stadium.
Talk of Burnley qualifying for Europe was dealt a sobering blow with defeat at improving Leicester.
Gylfi Sigurdsson and Dominic Calvert-Lewin scored second-half goals as Sam Allardyce's first game in charge of Everton ended in a 2-0 home win over Huddersfield.
Davinson Sanchez's red card forced Tottenham to fight for a 1-1 draw at Watford, toughening their battle to climb back into the Premier League's top four.
Philippe Coutinho and Roberto Firmino demolished Brighton to keep Liverpool's top-four charge on track.
A sparkling two-goal performance from Eden Hazard helped Chelsea come from a goal down to beat Newcastle 3-1 at Stamford Bridge and go level on points with second-placed Manchester United.
Substitute Mohamed Salah's purple patch continued with two more goals as Liverpool ground out a controversial 3-0 win at Stoke.
Raheem Sterling scored a dramatic winner as Manchester City maintained their winning run with a last-gasp 2-1 defeat of Southampton.
Antonio Conte was sent off as Chelsea claimed a fifth Premier League win in six games with a 1-0 defeat of Swansea.
Arsenal strengthened their position in the Premier League top four as they made light work of Huddersfield to maintain their healthy home form.
Newcastle ended a run of four straight defeats after coming back from 2-0 down to claim a gutsy point at West Brom.