Wayne Rooney's first Merseyside derby goal earned Everton a 1-1 draw at Anfield as Liverpool manager Jurgen Klopp's selection gamble backfired.
Olivier Giroud climbed off the bench to rescue a point for Arsenal in a 1-1 draw at Southampton.
Ayoze Perez's late own goal cost Newcastle a precious Premier League draw as Leicester ruined the Magpies' 125th birthday celebrations.
Tottenham ended a four-match Premier League winless streak in style with Harry Kane scoring a brace as they thrashed Stoke 5-1 at Wembley.
Marko Arnautovic's first West Ham goal secured a 1-0 victory over Chelsea and a first win for manager David Moyes.
Manchester City left it late for the third game in a row as they beat West Ham United 2-1 at the Etihad Stadium thanks to David Silva's strike and extended their Premier League lead.
Bournemouth and Southampton shared the spoils as an entertaining match on the south coast finished in a 1-1 draw.
Jesse Lingard scored twice but Paul Pogba was sent off as Manchester United beat Arsenal 3-1 in a breathless match at the Emirates Stadium.
Talk of Burnley qualifying for Europe was dealt a sobering blow with defeat at improving Leicester.
Gylfi Sigurdsson and Dominic Calvert-Lewin scored second-half goals as Sam Allardyce's first game in charge of Everton ended in a 2-0 home win over Huddersfield.
Davinson Sanchez's red card forced Tottenham to fight for a 1-1 draw at Watford, toughening their battle to climb back into the Premier League's top four.
Philippe Coutinho and Roberto Firmino demolished Brighton to keep Liverpool's top-four charge on track.
A sparkling two-goal performance from Eden Hazard helped Chelsea come from a goal down to beat Newcastle 3-1 at Stamford Bridge and go level on points with second-placed Manchester United.
Substitute Mohamed Salah's purple patch continued with two more goals as Liverpool ground out a controversial 3-0 win at Stoke.
Raheem Sterling scored a dramatic winner as Manchester City maintained their winning run with a last-gasp 2-1 defeat of Southampton.
Antonio Conte was sent off as Chelsea claimed a fifth Premier League win in six games with a 1-0 defeat of Swansea.
Arsenal strengthened their position in the Premier League top four as they made light work of Huddersfield to maintain their healthy home form.
Newcastle ended a run of four straight defeats after coming back from 2-0 down to claim a gutsy point at West Brom.
Ashley Young struck twice against former club Watford as Manchester United won a thrilling contest at Vicarage Road to close to within five points of leaders Manchester City.
Tottenham Hotspur's hopes of returning to the Premier League top four were dashed as they lost 2-1 at Leicester, who rose to ninth in the table thanks to fine finishes from Jamie Vardy and Riyad Mahrez.
Raheem Sterling claimed a lucky late winner as Manchester City came from behind to restore their eight-point Premier League lead with a 2-1 win at Huddersfield.
Alexis Sanchez converted a stoppage-time penalty as Arsenal snatched all three points in a 1-0 win at Burnley.
Mohamed Salah returned to haunt former club Chelsea but Liverpool were denied a hugely significant victory as Willian conjured an equaliser out of nothing at Anfield.
Gary Megson made his case for a longer stay as West Brom manager as his resilient side held Tottenham to a 1-1 draw at Wembley.
Ashley Young's deflected strike proved the slice of luck Manchester United needed to sneak past promoted Brighton.
West Ham secured their first point under David Moyes as Cheikhou Kouyate's header earned a 1-1 draw with Leicester.
David Moyes failed to inspire West Ham as their Premier League woes deepened with defeat in his first match in charge at Watford.
Paul Pogba returned from injury to inspire Manchester United to a 4-1 win over Newcastle at Old Trafford.
Tony Pulis' position at West Brom looks increasingly under threat after Chelsea inflicted the joint-heaviest defeat of his near three-year reign at The Hawthorns.
A virtuoso performance from Mohamed Salah ran Southampton ragged as his two goals inspired Liverpool's 3-0 win at Anfield and fired the Egyptian to the top of the Premier League scoring charts.
Chelsea have completed the signing of Jorginho, beating Manchester City to the signature of the former Napoli midfielder.
Chelsea completed the long-expected hiring of Maurizio Sarri as their new manager on Saturday, appointing him after parting ways with Antonio Conte.
Chelsea have sacked coach Antonio Conte, paving the way for Maurizio Sarri to take over.
Manchester City have completed the signing of attacking midfielder Riyad Mahrez from Leicester City, the clubs announced on Tuesday.
Liverpool have announced that new signing Naby Keita will be given the No. 8 shirt last worn by former captain Steven Gerrard.
Manchester United have reached an agreement with Shakhtar Donetsk for the transfer of Brazil international midfielder Fred, the Premier League club confirmed on Tuesday.
Stephan Lichtsteiner has become Unai Emery's first signing for Arsenal after joining the Premier League side on a free transfer from Juventus.
Frank Lampard has been appointed the new manager of Derby County on a three-year contract, with former Chelsea academy coach Jody Morris as his assistant.
Liverpool have announced a deal to sign Brazilian midfielder Fabinho from Monaco.
Arsenal have hired former Paris Saint-Germain manager Unai Emery to take them into a new era following Arsene Wenger's departure, with sources telling that he has signed a three-year contract.
Eden Hazard fired Chelsea to FA Cup glory against Manchester United as Antonio Conte's expected farewell ended with a memorable triumph against old foe Jose Mourinho.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.
Yaya Toure bade farewell to the Etihad Stadium as champions Manchester City set a hat trick of Premier League records in a routine 3-1 win over Brighton.
Jamie Vardy returned to haunt Arsene Wenger on his farewell tour as Leicester cruised past 10-man Arsenal 3-1.
Tottenham overcame a nervy night at Wembley to book their Champions League place for next season with a 1-0 win over Newcastle.
Huddersfield secured their Premier League status with a valiant 1-1 draw at Stamford Bridge which significantly dented Chelsea's slim top-four hopes.
Southampton took a huge step towards safety as a 1-0 win at Swansea inched their Welsh rivals towards the Premier League trapdoor and relegated West Brom in the process.
Arsenal gave Arsene Wenger a memorable Emirates Stadium send-off as the outgoing boss saw his side thrash Burnley.
Chelsea's Champions League hopes for next season received a boost following Sunday's narrow victory over Liverpool.
Manchester City failed to fire on the day they were presented with the Premier League trophy as Huddersfield Town claimed a vital point at the Etihad Stadium.
Tom Davies scored deep into added time as Everton salvaged a 1-1 draw against 10-man Southampton at Goodison Park, preventing their opponents from escaping the Premier League relegation zone.
West Bromwich Albion kept their slim survival hopes alive after Jake Livemore's dramatic injury time goal earned a 1-0 win against Tottenham Hotspur.
Pascal Gross scored the goal which sank Manchester United 1-0 to guarantee Premier League football for Brighton next season.
Harry Kane did his talking on the pitch as Tottenham reasserted themselves in the race for the Champions League with a 2-0 win over Watford.