Marouane Fellaini was sent off as Manchester City and Manchester United settled for a share of the spoils in the Manchester derby, with the two neighbours playing out a goalless draw at the Etihad Stadium.
Manchester City head coach Pep Guardiola believes it is important to take all three points from the derby on Thursday to ensure Champions League football for next season.
Christian Eriksen kept Tottenham's title hopes alive with a crucial strike to sink Crystal Palace 1-0.
Arsenal kept their hopes of a top-four Premier League finish alive as a late Robert Huth own goal was enough for them to see off reigning champions Leicester.
Diego Costa ended his lean streak with a double as Premier League leaders Chelsea beat Southampton 4-2 to restore their seven-point advantage over Tottenham.
Crystal Palace took a giant step towards Premier League safety and inflicted a setback on Liverpool's top four hopes as Christian Benteke struck twice on his return to Anfield.
Manchester United cruised to a routine victory at Burnley to move to within a point of fourth-placed Manchester City.
Alexis Sanchez struck an extra-time winner as Arsenal came from behind to beat Manchester City 2-1 in their FA Cup semifinal at Wembley.
Eden Hazard came off the bench to help inspire Chelsea to a 4-2 victory over Tottenham and send them into the FA Cup final, condemning Mauricio Pochettino's men to yet more Wembley woe and giving them a bloody nose ahead of the title run-in.
Mesut Ozil kept alive Arsenal's hopes of a top-four finish as Middlesbrough slid closer to the Premier League exit door on Monday night.
Manchester United threw the Premier League title race open and boosted their hopes of a top-four finish as Jose Mourinho masterminded a 2-0 Old Trafford victory over his former club Chelsea.
Roberto Firmino scored Liverpool's winner as they saw off West Bromwich Albion with a 1-0 victory to move up to third in the Premier League.
Crystal Palace recovered from two goals down to secure a 2-2 draw with Leicester and take their latest step towards preserving their Premier League status.
Manchester City moved into third place in the Premier League as Vincent Kompany scored to spark a 3-0 win at Southampton.
Tottenham Hotspur made it seven home league wins in a row and cut the gap on leaders Chelsea to four points ahead of Sunday's games with a dominant display as they won 4-0 against Bournemouth.
Crystal Palace dominated Arsenal 3-0 on Monday night to increase the pressure on Arsene Wenger while boosting their own Premier League survival hopes.
Romelu Lukaku's good form in front of goal at Goodison Park continued with a double as Everton's 4-2 victory over Leicester ended Foxes boss Craig Shakespeare's six-game winning run.
Zlatan Ibrahimovic scored his 17th Premier League goal of the season to set Manchester United on course for a 3-0 victory over 10-man Sunderland which moves them up to fifth in the table.
Eden Hazard's wonderful finish carried Chelsea ever closer to the Premier League title as the Blues saw off Bournemouth 3-1 at Dean Court.
Goals from Philippe Coutinho and Roberto Firmino dug Jurgen Klopp out of a hole as Liverpool came from behind to beat Stoke 2-1.
Manchester City ended a run of four Premier League games without a win by easing to a comfortable 3-1 victory over relegation-threatened Hull.
Son Heung-Min hit a brace as Tottenham kept their Premier League title ambitions alive with a comprehensive win over Watford at White Hart Lane.
Eden Hazard scored twice as Chelsea fought off the challenge of Manchester City to take a step closer to the Premier League title with a 2-1 win at Stamford Bridge.
Tottenham kept their Premier League title ambitions alive by staging an extraordinary late show at relegation-threatened Swansea.
Liverpool let a lead slip away late on to draw 2-2 against Bournemouth and miss the chance to strengthen their grip on third place.
Arsenal returned to winning ways with a solid victory over West Ham as a fifth straight defeat plunged Slaven Bilic's side deeper into the fight for Premier League survival.
Leicester piled the misery on David Moyes and pushed Sunderland closer to relegation from the Premier League with a gritty 2-0 win.
Manchester United drew yet another league match at Old Trafford -- but the overriding emotion at the final whistle was relief rather than frustration after Zlatan Ibrahimovic struck a stoppage-time penalty against Everton.
Arsenal twice came back from a goal down to ease some of the pressure on manager Arsene Wenger in an entertaining 2-2 draw at the Emirates.
Crystal Palace stunned Chelsea with a 2-1 win to give the Blues' Premier League title rivals hope and their survival prospects a major boost.
Liverpool had far too much attacking power for Bournemouth to withstand as they moved back into the top four with a 4-0 win at the Vitality Stadium.
Manchester United held on for a 2-1 win at West Bromwich Albion to cut neighbours Manchester City's lead at the top of the Premier League back to 11 points.
Leaders Manchester City powered to their 16th successive win in the Premier League with a 4-1 thrashing of Tottenham at the Etihad Stadium.
Arsenal returned to winning ways but had Mesut Ozil to thank for scoring a wonderful winner as they toiled against out-of-form Newcastle.
Time was on Chelsea's side as Marcos Alonso's free-kick earned a 1-0 Premier League win over Southampton.
Arsenal lost further ground on the Premier League leaders after they were held to a goalless draw at West Ham.
Tottenham climbed back into the Premier League's top four as Serge Aurier's fluke-goal and a header from Son Heung-min sealed a 2-0 victory over Brighton.
Liverpool manager Jurgen Klopp reunited the "Fab Four" but his prolific attacking quartet were all distinctly off-key as West Brom held out for a goalless draw at Anfield.
Manchester City set a new Premier League record of 15 consecutive wins with a 4-0 victory at bottom club Swansea.
Romelu Lukaku got a much-needed goal as Manchester United moved on from their galling derby defeat by beating Bournemouth.
Willian scored one and made two others as Chelsea finally turned in a display worthy of Premier League champions to win 3-1 at Huddersfield.
Runaway Premier League leaders Manchester City opened up an eye-watering double-digit lead over rivals Manchester United after Nicolas Otamendi fired Pep Guardiola's men to derby victory.
Wayne Rooney's first Merseyside derby goal earned Everton a 1-1 draw at Anfield as Liverpool manager Jurgen Klopp's selection gamble backfired.
Olivier Giroud climbed off the bench to rescue a point for Arsenal in a 1-1 draw at Southampton.
Ayoze Perez's late own goal cost Newcastle a precious Premier League draw as Leicester ruined the Magpies' 125th birthday celebrations.
Tottenham ended a four-match Premier League winless streak in style with Harry Kane scoring a brace as they thrashed Stoke 5-1 at Wembley.
Marko Arnautovic's first West Ham goal secured a 1-0 victory over Chelsea and a first win for manager David Moyes.
Manchester City left it late for the third game in a row as they beat West Ham United 2-1 at the Etihad Stadium thanks to David Silva's strike and extended their Premier League lead.
Bournemouth and Southampton shared the spoils as an entertaining match on the south coast finished in a 1-1 draw.
Jesse Lingard scored twice but Paul Pogba was sent off as Manchester United beat Arsenal 3-1 in a breathless match at the Emirates Stadium.
Talk of Burnley qualifying for Europe was dealt a sobering blow with defeat at improving Leicester.
Gylfi Sigurdsson and Dominic Calvert-Lewin scored second-half goals as Sam Allardyce's first game in charge of Everton ended in a 2-0 home win over Huddersfield.
Davinson Sanchez's red card forced Tottenham to fight for a 1-1 draw at Watford, toughening their battle to climb back into the Premier League's top four.
Philippe Coutinho and Roberto Firmino demolished Brighton to keep Liverpool's top-four charge on track.
A sparkling two-goal performance from Eden Hazard helped Chelsea come from a goal down to beat Newcastle 3-1 at Stamford Bridge and go level on points with second-placed Manchester United.
Substitute Mohamed Salah's purple patch continued with two more goals as Liverpool ground out a controversial 3-0 win at Stoke.
Raheem Sterling scored a dramatic winner as Manchester City maintained their winning run with a last-gasp 2-1 defeat of Southampton.
Antonio Conte was sent off as Chelsea claimed a fifth Premier League win in six games with a 1-0 defeat of Swansea.
Arsenal strengthened their position in the Premier League top four as they made light work of Huddersfield to maintain their healthy home form.
Newcastle ended a run of four straight defeats after coming back from 2-0 down to claim a gutsy point at West Brom.