An injury to star striker Sergio Aguero cast a shadow over Manchester City's narrow 1-0 victory over Everton on Saturday.
Brendan Rodgers' decision to rest Steven Gerrard failed to pay dividends as even the Liverpool captain's emergence off the bench failed to inspire his side to break down a resolute Sunderland.
Stoke held on to beat Arsenal 3-2 after a dramatic afternoon at the Britannia Stadium.
Newcastle striker Papiss Cisse came off the bench to condemn Barclays Premier League leaders Chelsea to a first defeat of the season.
Ruthless Chelsea extended Tottenham's torment at Stamford Bridge with a 3-0 win that saw Jose Mourinho's unbeaten Blues consolidate their lead at the top of the Premier League.
Sergio Aguero turned on the magic once more as Manchester City maintained the pressure on Premier League leaders Chelsea by cruising to a 4-1 win over Sunderland at the Stadium of Light.
Alexis Sanchez fired Arsenal to a late 1-0 victory over Southampton at Emirates Stadium to narrow the gap on the Premier League top four to two points.
Liverpool may want to boost the contract extension offered to Steven Gerrard after the captain bailed them out in a 3-1 comeback victory at Leicester.
Juan Mata and Marcos Rojo both claimed the winner as Manchester United survived a nerve-jangling finish to beat Stoke 2-1 at Old Trafford.
Yaya Toure and Frank Lampard's strikes took Manchester City up to second in the Premier League table and handed Southampton an ominous start to a daunting run of festive fixtures coming up.
Roberto Soldado's barren run came to a timely end as Tottenham rallied to secure a much-needed 2-1 comeback win against Everton.
Willian and Santiago Vergini both hit the woodwork as Sunderland extended their run of good results against Chelsea with a 0-0 draw.
Glen Johnson ensured Steven Gerrard's demotion to the substitutes' bench became a secondary talking point as the full-back proved the unlikely match-winner as Liverpool stumbled to a 1-0 Premier League win.
Manchester United looked more like their old selves as they cruised to a convincing 3-0 win over lacklustre Hull at Old Trafford.
Danny Welbeck bagged a crucial winner for Arsenal as the Gunners clinched a comfortable 1-0 win at West Brom.
Christian Eriksen conjured a last-minute winner for Tottenham Hotspur as Hull City paid in full for Gaston Ramirez's reckless red card.
Liverpool's season went from bad to worse as they let an early lead slip to lose 3-1 at struggling Crystal Palace on Sunday afternoon.
Manchester United moved back into the top four of the Premier League with a 2-1 smash-and-grab raid at Arsenal.
Yaya Toure responded to Manuel Pellegrini's rallying call as he fired champions Manchester City to a 2-1 Premier League win over Swansea.
Chelsea's title charge shows no signs of abating, with West Brom the latest side swatted away by Jose Mourinho's men as the Blues won 2-0.
Swansea stunned Arsenal with two late goals to run out 2-1 winners at the Liberty Stadium and inflict the Gunners' second Premier League defeat of the season.
Tottenham's woes at White Hart Lane took another turn for the worse as Mauricio Pochettino's side slumped to a 2-1 defeat at home to Stoke in the Premier League.
Sergio Aguero saved Manchester City further embarrassment with a double in Saturday's 2-2 Premier League draw at QPR.
Juan Mata stepped off the bench to score the winner as Manchester United returned to winning ways despite a lacklustre display against Crystal Palace.
Diego Costa's 10th goal of the season maintained Premier League leaders Chelsea's unbeaten record and inflicted yet more pain on Liverpool at Anfield.
Harry Kane hit a late winner as Tottenham clinched a 2-1 victory in a bad-tempered clash with 10-man Aston Villa.
Sergio Aguero scored the only goal of the game as Manchester City beat United in the derby.
An Oscar special and an Eden Hazard penalty earned Premier League leaders Chelsea a 2-1 win in a hard-fought west London derby with QPR at Stamford Bridge.
Alexis Sanchez scored twice as Arsenal moved back into the top four of the Barclays Premier League with a 3-0 victory over stubborn Burnley at the Emirates Stadium.
Ayoze Perez was Newcastle's match-winner for the second time in a week as they edged past Liverpool to claim a fourth successive victory.
Manchester City's quadruple trophy bid was sensationally derailed by a shocking 1-0 defeat at third-division Wigan in the FA Cup fifth round on Monday.
Substitute Steve Davies earned Rochdale an FA Cup fifth-round replay at Wembley Stadium with his remarkable stoppage-time equaliser against Tottenham Hotspur at Spotland.
Manchester United overcame the video assistant referee's controversial intervention and reached the FA Cup quarterfinals thanks to Romelu Lukaku's brace at Huddersfield.
Willian dispatched two inch-perfect finishes as Chelsea cruised past Hull 4-0 and into the FA Cup quarter-finals.
Sheffield Wednesday fan Jamie Vardy put the Blades to the sword as Leicester knocked Sheffield United out of the FA Cup.
Chelsea eased the growing pressure on Antonio Conte and returned to the Premier League's top four with a convincing 3-0 win over West Brom.
Liverpool moved back above Tottenham and into third place in the Premier League table as two first-half goals gave them a routine 2-0 victory at struggling Southampton.
Matt Ritchie scored a second-half winner for Newcastle as they lifted themselves out of the relegation places with a 1-0 victory over Manchester United at St James' Park.
Sergio Aguero scored four times as Manchester City extended their Premier League lead to 16 points with a 5-1 demolition of Leicester at the Etihad Stadium.
Everton's Sam Allardyce won the battle of ex-England managers at Goodison Park to ease growing pressure with a 3-1 victory over Roy Hodgson's struggling Crystal Palace.
Harry Kane proved Arsenal's nemesis again as his bullet header earned Tottenham a deserved 1-0 victory in the North London derby.
Erik Lamela scored his first goal in 17 months as Tottenham sauntered past Newport and into the fifth round of the FA Cup.
Swansea recorded their biggest-ever FA Cup win as Notts County were demolished 8-1 at the Liberty Stadium.
Antonio Conte's future as Chelsea boss was cast into further doubt as his 10 men were thrashed 4-1 by Watford on Monday night.
Mohamed Salah and Harry Kane traded stoppage-time goals as Liverpool and Tottenham drew 2-2 in a wild affair at Anfield on Sunday.
Newcastle resisted intense pressure from Crystal Palace to earn a 1-1 draw at Selhurst Park that again took them clear of the bottom three.
`Aaron Ramsey hit a hat trick with Arsenal fans treated to their first showing of their January transfers in tandem as both Henrikh Mkhitaryan and Pierre-Emerick Aubameyang shone in a comfortable 5-1 win over Everton.
Alexis Sanchez's first goal for Manchester United wrapped up a 2-0 victory against Huddersfield on a day when the clubs came together to remember those who lost their lives in the Munich air disaster.
Swansea's resurgence continued as they climbed out of the Premier League relegation zone with a 1-1 draw at Leicester, who were again without want-away midfielder Riyad Mahrez.
Johann Berg Gudmundsson struck a late equaliser as Burnley grabbed a 1-1 draw against Premier League leaders Manchester City at Turf Moor.
Christian Eriksen scored within 11 seconds as Tottenham brushed aside a below-par Manchester United to seal a crunch 2-0 victory in the race for the top four.
Kevin De Bruyne was again the inspiration as Manchester City opened up a 15-point lead at the top of the Premier League with a 3-0 win over West Brom.
Theo Walcott's maiden Everton goals secured a first win in eight matches as a 2-1 triumph over Leicester arrested their slide under Sam Allardyce.
Bournemouth scored three goals in 16 remarkable second-half minutes to record a sensational 3-0 victory against Chelsea at Stamford Bridge on Wednesday evening.
Arsenal have completed the signing of striker Pierre-Emerick Aubameyang from Borussia Dortmund for a fee of €63.75 million (£56m).
Chelsea have completed the signing of Olivier Giroud from Arsenal for a reported £16.25 million on an 18-month contract.
Tottenham Hotspur have completed the signing of winger Lucas Moura from Paris Saint-Germain for a fee of в‚¬28 million.
Liverpool bounced back to winning ways in the Premier League and maintained their Champions League challenge with a 3-0 win at Huddersfield.
Swansea climbed out of the relegation zone for the first time in three months as Petr Cech's dreadful howler helped condemn Arsenal to a 3-1 defeat at the Liberty Stadium.
Two first-half goals were enough to see Manchester City comfortably through to the FA Cup fifth round at Championship side Cardiff City.