Louis van Gaal's dream turned into reality as Manchester United put four goals past City in a superb derby win at Old Trafford.
Cesc Fabregas scored an 88th-minute winner as Chelsea restored their seven-point lead at the top of the table with a 1-0 victory at West London rivals QPR.
Aaron Ramsey marked his 150th Premier League appearance with a first half winner as Arsenal closed the gap on leaders Chelsea to four points with a hard-fought 1-0 win at Turf Moor.
Christian Benteke scored his eighth goal in six games to hand Tim Sherwood a winning return to Tottenham and ease Aston Villa's relegation fears.
Playmaker Philippe Coutinho was Liverpool's FA Cup saviour again as his solitary goal beat Blackburn 1-0 to book a Wembley semifinal with Aston Villa.
Manchester City's grip on the Premier League title was loosened further after a controversial Glenn Murray goal put Crystal Palace on the way to a 2-1 victory.
Harry Kane's first outing as captain of Tottenham failed to inspire Spurs in an insipid 0-0 draw at Burnley.
Chelsea responded from conceding a Charlie Adam goal from his own half and losing Diego Costa to a hamstring injury to beat Stoke 2-1 and move seven points clear in the Premier League title race.
Manchester United climbed above their 'noisy neighbours' into third position thanks to a 3-1 win over Aston Villa which included a stunning strike from Wayne Rooney.
Arsenal kept up the pressure at the top of the Premier League as Liverpool were blown away 4-1 at the Emirates Stadium, where Reds contract rebel Raheem Sterling failed to make an impact.
A moment of madness from Liverpool captain Steven Gerrard saw him sent off just 43 seconds after coming on in his final appearance against Manchester United, whose 2-1 victory at Anfield.
Chelsea survived a major scare to secure a 3-2 win at Hull City and restore their six-point lead at the top of the Premier League.
Referee Neil Swarbrick took the gloss off Manchester City's return to winning ways as the Premier League suffered yet another mistaken identity controversy.
Harry Kane's dream week got even better on Saturday as the Tottenham striker followed his first England callup with a maiden Premier League hat trick as embattled Leicester were defeated in a thrilling 4-3 encounter.
Olivier Giroud's first-half double handed Arsenal a sixth successive Premier League victory as they survived a spirited fightback to win 2-1 at Newcastle.
Liverpool maintained the pressure in the race for Champions League qualification as Jordan Henderson's fortunate second-half goal saw off Swansea at the Liberty Stadium to seal a 1-0 win.
Wayne Rooney and Manchester United delivered a knockout performance as Tottenham were blown away at Old Trafford.
Chelsea missed the opportunity to go eight points clear at the top of the Premier League by drawing 1-1 against Southampton.
George Boyd struck a stunning second-half winner as Burnley enhanced their survival hopes by further ravaging Manchester City's fading title quest with a 1-0 victory at Turf Moor.
Olivier Giroud's thunderbolt helped Arsenal see off the challenge of West Ham and cement their place in the top four of the Premier League with a 3-0 victory.
Danny Welbeck came back to haunt Louis van Gaal as the Manchester United manager was subjected to a night of despair and defeat at Old Trafford.
There was little magic in this FA Cup quarterfinal on an afternoon when, for once, Liverpool's free-flowing football deserted them in the face of a committed and well-organised Blackburn side.
QPR's hopes of beating the drop received a major blow as Harry Kane underlined his England credentials with a match-winning brace for Tottenham.
Fabian Delph's first goal in a year helped fire Aston Villa to Wembley as they beat West Brom 2-0 to reach the FA Cup semifinals.
Olivier Giroud and Alexis Sanchez guided Arsenal to a routine 2-1 Premier League victory at struggling QPR, despite Charlie Austin striking back late on.
Chelsea followed up their Capital One Cup victory with a hard-fought 1-0 win on their return to Premier League business at West Ham.
Ashley Young fired Manchester United to a last-minute victory at Newcastle to maintain their charge for a top-four finish.
Tottenham got their top-four tilt back on track by overcoming Swansea 3-2 on a night when Bafetimbi Gomis' collapse had those inside White Hart Lane fearing the worst.
Stand-in captain Jordan Henderson led from the front with his second goal in successive matches as Liverpool maintained their pursuit of a top-four place.
David Silva and James Milner struck late in each half as under-fire reigning champions Manchester City grabbed a scrappy but much-needed 2-0 win over Leicester in the Premier League.
Manchester City midfielder Kevin De Bruyne is facing a spell on the sidelines after injuring his right knee in training on Wednesday.
Manchester City, who romped to Premier League success by 19 points last season, began the defence of their title with a 2-0 win away against Arsenal and new manager Unai Emery on Sunday.
Sadio Mane had two goals for the first time since February 2017 and Mohamed Salah also scored as Liverpool opened their Premier League season with a 4-0 victory over West Ham United at Anfield.
Richarlison scored twice in his first Premier League appearance for 10-man Everton, but a late goal from Raul Jimenez helped Wolverhampton Wanderers salvage a 2-2 draw at the Molineux Stadium.
Chelsea manager Maurizio Sarri made a winning start to life in the Premier League as his team enjoyed a 3-0 win over Huddersfield Town at the John Smith's Stadium on Saturday.
Jan Vertonghen and Dele Alli scored first-half goals as Tottenham Hotspur opened their Premier League season with a 2-1 victory over Newcastle United at St James' Park.
Paul Pogba and Luke Shaw scored as Manchester City beat Leicester City 2-1 to open the 2018-19 Premier League season at Old Trafford on Friday night.
Leicester City striker Jamie Vardy has signalled his intention to see out his career with the Foxes as he signed a new contract until June 2022.
Athletic Bilbao have confirmed that Kepa Arrizabalaga has paid the €80 million buyout clause in his contract as he edges closer to completing a move to Chelsea.
Real Madrid midfielder Mateo Kovacic will join Chelsea on a season-long loan deal as part of the deal that sees goalkeeper Thibaut Courtois move to Real in a permanent deal.
Two goals from Sergio Aguero -- his 200th and 201st for the club -- proved decisive as Manchester City easily saw off FA Cup winners Chelsea 2-0 to win the Community Shield at Wembley.
Liverpool have completed the signing of Alisson on a six-year contract after agreeing with Roma on a world-record transfer for a goalkeeper.
Chelsea have completed the signing of Jorginho, beating Manchester City to the signature of the former Napoli midfielder.
Chelsea completed the long-expected hiring of Maurizio Sarri as their new manager on Saturday, appointing him after parting ways with Antonio Conte.
Chelsea have sacked coach Antonio Conte, paving the way for Maurizio Sarri to take over.
Manchester City have completed the signing of attacking midfielder Riyad Mahrez from Leicester City, the clubs announced on Tuesday.
Liverpool have announced that new signing Naby Keita will be given the No. 8 shirt last worn by former captain Steven Gerrard.
Manchester United have reached an agreement with Shakhtar Donetsk for the transfer of Brazil international midfielder Fred, the Premier League club confirmed on Tuesday.
Stephan Lichtsteiner has become Unai Emery's first signing for Arsenal after joining the Premier League side on a free transfer from Juventus.
Frank Lampard has been appointed the new manager of Derby County on a three-year contract, with former Chelsea academy coach Jody Morris as his assistant.
Liverpool have announced a deal to sign Brazilian midfielder Fabinho from Monaco.
Arsenal have hired former Paris Saint-Germain manager Unai Emery to take them into a new era following Arsene Wenger's departure, with sources telling that he has signed a three-year contract.
Eden Hazard fired Chelsea to FA Cup glory against Manchester United as Antonio Conte's expected farewell ended with a memorable triumph against old foe Jose Mourinho.
Michael Carrick bade farewell to Old Trafford by helping set up the goal that delivered a 1-0 win for Manchester United over Watford.
Champions Manchester City became the first club to amass 100 Premier League points after Gabriel Jesus scored a dramatic stoppage-time winner at Southampton.
Tottenham said goodbye to Wembley in style as they came from behind to beat Leicester 5-4 in a thrilling final-day Premier League encounter.
Ayoze Perez struck twice to end Chelsea's faint hopes of Champions League qualification as Newcastle secured a top-10 finish on their return to the Premier League.
Liverpool secured a top-four spot with very little fuss as Mohamed Salah's new Premier League goalscoring record paved the way for a 4-0 victory over Brighton.
Arsene Wenger bowed out with a victory as Pierre-Emerick Aubameyang's first-half goal secured a 1-0 win for Arsenal in their season finale against Huddersfield.
West Ham and Manchester United played out a dull goalless draw at the London Stadium -- although the result was enough to see Jose Mourinho's side secure second place in the Premier League.