Paulo Dybala scored twice as Juventus thrashed 10-man Lazio 3-0 to take what should prove to be a decisive nine-point lead into the Serie A run-in.
Francesco Totti emphatically staked his claim for a new contract with a brace from the bench that boosted Roma to a dramatic 3-2 victory over Torino.
Sebastian De Maio dealt a heavy blow to Inter Milan's hopes of reaching the Champions League places by firing Genoa to a 1-0 victory at the Stadio Luigi Ferraris.
Napoli closed the gap on Serie A leaders Juventus back to six points with a crushing 6-0 victory over Bologna.
Carlos Bacca gave Cristian Brocchi a winning start to life as AC Milan coach as the striker's second-half goal sealed a 1-0 win at Sampdoria.
Juventus are within touching distance of a fifth straight Serie A title after pulling nine points clear at the top with a 4-0 home humbling of Palermo.
Struggling Atalanta dealt a blow to Roma's hopes of overhauling second-placed Napoli in Serie A by earning a thrilling 3-3 draw in Bergamo.
First-half goals from Mauro Icardi and Marcelo Brozovic sealed a comfortable 2-0 win for Inter Milan over second-placed Napoli in Serie A.
AC Milan have sacked head coach Sinisa Mihajlovic with youth-team boss Christian Brocchi replacing him until the end of the season.
Francesco Totti failed to inspire Roma to victory against Bologna, but the veteran forward did help secure a 1-1 draw which edges his side closer to Champions League qualification.
Lazio's first game since sacking boss Stefano Pioli and replacing him with Simone Inzaghi saw them record a comfortable 3-0 Serie A victory at strugglers Palermo.
Napoli showed they were able to cope without the suspended Gonzalo Higuain as they defeated 10-man Verona 3-0.
Fiorentina's fading Champions League qualification hopes suffered another blow as Empoli won the Tuscan derby for the first time since 1997.
Paul Pogba sustained Juventus' seemingly inexorable march towards a fifth straight Serie A title by completing a 2-1 comeback victory over AC Milan at San Siro.
Mauro Icardi's second-half goal spared Inter Milan from embarrassment against 10-man Frosinone.
Former Lazio striker Simone Inzaghi has replaced Stefano Pioli as manager following Sunday's heavy derby defeat to Roma.
Andrea Belotti's penalty completed a surprise comeback as Torino beat nine-man Inter Milan 2-1 at San Siro.
Roma have second place firmly in their sights after closing to within four points of Napoli with a humbling 4-1 derby victory over Lazio at the Stadio Olimpico.
AC Milan risk missing out on European football once again after slumping to a 2-1 defeat to Atalanta.
Gonzalo Higuain was sent off as Napoli's Serie A title hopes took a severe blow with a 3-1 defeat at relegation-battling Udinese.
Juventus took another step towards the Serie A title with a 1-0 home defeat of Empoli.
Lazio's slim hopes of qualifying for the Europa League all but ended following a 1-1 draw against AC Milan at the San Siro.
Gonzalo Higuain struck twice as Napoli came from behind to beat Genoa 3-1 at the Stadio San Paolo to keep their Serie A title hopes alive.
Goalkeeper Gianluigi Buffon made Serie A history in a Turin derby victory for Juventus as substitute Alvaro Morata's double helped ease their midweek Champions League heartache.
Radja Nainggolan scored a late equaliser to secure Roma a 1-1 draw against Serie A rivals Inter and remain in the driving seat for Champions League qualification.
Gonzalo Higuain's penalty saw Napoli squeeze past Palermo 1-0 and maintain their pursuit of the Serie A title.
Roma remain an outside bet in the Serie A title race after beating Udinese 2-1 to register an eighth straight victory.
Inter Milan moved up above Fiorentina into fourth place in Serie A following a 2-0 home win over Bologna, but saw forward Mauro Icardi forced off early on with a knee injury.
Paulo Dybala's superb first-half strike sent Juventus six points clear at the top of Serie A after a 1-0 victory over Sassuolo.
Inter Milan are back in the hunt for a top-three finish in Serie A after dominating Palermo to win 3-1 at San Siro.
Napoli forward Lorenzo Insigne scored his seventh goal of the campaign in a 2-0 victory over Sassuolo at the San Paolo.
Argentina forward Gonzalo Higuain scored twice as AC Milan secured a 3-1 victory over bottom side Chievo.
Genoa forward Krzysztof Piatek maintained his record of scoring in every Serie A match for his new club on Sunday although it was not enough to prevent them losing 3-1 at home to Parma.
Edin Dzeko continued his upturn in form as Roma made it four straight wins in all competitions to move third in Serie A with a 2-0 win over Empoli.
Unstoppable Juventus maintained their perfect start to the season after 10 matches when first-half goals from Rodrigo Bentancur and Cristiano Ronaldo gave them a 2-0 win at Udinese in Serie A on Saturday.
AC Milan made surprisingly light work of surprise squad Sassuolo -- who would have gone second with a win -- as they won 4-1 away to end a run of three successive draws.
Fiorentina beat Atalanta 2-0 in Serie A on Sunday having opened the scoring with disputed penalty that sparked an angry clash between coaches Stefano Pioli and Gian Piero Gasperini at the final whistle.
Cristiano Ronaldo played a part in all three goals as Juventus came from behind to defeat title rivals Napoli on Saturday.
Roma defender Federico Fazio went from villain to hero as his side continued their recent dominance over neighbours Lazio with a 3-1 win in a pulsating Derby della Capitale on Saturday.
AC Milan were foiled by heroic goalkeeping from Empoli's Pietro Terracciano as they were held 1-1 by the promoted side on Thursday, their third successive Serie A draw.
Paulo Dybala has been somewhat obscured by Cristiano Ronaldo's arrival at Juventus but the Argentine broke his goal scoring drought on Wednesday.
AS Roma ended a five-match winless run in all competitions by thumping Frosinone 4-0 with Cengiz Under, Javier Pastore, Stephan El Shaarawy and Aleksandar Kolarov sharing the goals.
Inter Milan overcame one of their notorious lapses to beat Fiorentina 2-1 in Serie A and notch their third win in a week on Tuesday, suggesting early-season troubles may be behind them.
Cristiano Ronaldo's late goal helped Juventus to maintain their perfect start to the Serie A season with a hard-fought 2-0 victory away to Frosinone on Sunday.
AC Milan conceded an injury-time goal as Atalanta twice fought back to claim a point in a 2-2 draw at the San Siro.
Roma's Serie A crisis deepened as they lost 2-0 away to Bologna at the weekend, and while a quick turnaround against on Wednesday might look desirable, it could be another potential banana skin for Eusebio di Francesco's side.
Inter Milan provided plenty of late drama as Marcelo Brozovic's last-gasp goal earned them a 1-0 victory at Sampdoria in a game featuring a number of VAR controversies.
Argentina forward Gonzalo Higuain scored his first goal for AC Milan to earn them a 1-1 draw at Cagliari.
Cristiano Ronaldo scored his first goals for Juventus as they beat Sassuolo 2-1 to continue their perfect start to the Serie A season.
Napoli exorcised some of the ghosts of last season by beating Fiorentina 1-0 in Serie A action on Saturday.
Just three years after going bankrupt, Parma returned to winning ways in Serie A with a surprise 1-0 win over Inter Milan at San Siro.
Serie A title hopefuls Napoli were thumped 3-0 at Sampdoria on Sunday after coach Carlo Ancelotti tinkered with the team, dropping captain Marek Hamsik and forward Jose Callejon.
Cristiano Ronaldo was left waiting for his first Juventus goal after drawing another blank as the titleholders won 2-1 at Parma in Serie A on Saturday to maintain their 100 percent record.
Radja Nainggolan scored on his delayed Inter Milan debut to set them on the way to their first win of the season on Saturday as they beat Bologna 3-0 away in Serie A.
A late stoppage-time goal by substitute Patrick Cutrone gave AC Milan a 2-1 home win over Roma in an electrifying Serie A clash on Friday and eased the pressure on manager Gennaro Gattuso.
Inter seemed to be in absolute control, but fumbled a 2-0 lead and risked losing the game against a plucky Torino.
Dries Mertens came off the bench to grab the winner as Napoli rallied from 2-0 down to beat visiting AC Milan 3-2 and seize a second victory in two matches.
Cristiano Ronaldo missed an open goal but inadvertently provided an assist for Mario Mandzukic to score as titleholders Juventus beat Lazio 2-0 in Serie A on Saturday.
Inter Milan's hopes of challenging for the Serie A title got off on the wrong foot with a shock 1-0 defeat at Sassuolo on Sunday.
Roma striker Edin Dzeko scored with a memorable volleyed goal following a mazy run by debutant Justin Kluivert to give his side a 1-0 win at Torino in their opening Serie A game on Sunday.