Roma's four-game winning run came to a halt as Luis Muriel settled a five-goal thriller in Samp's favour.
AC Milan's misery continued at Udinese as their dreams of qualifying for the Champions League diminished on Sunday.
In-form Inter Milan moved up to fourth place with a 3-0 success at home to bottom-of-the-table Pescara -- their seventh consecutive Serie A victory.
Juventus beat 10-man AC Milan 2-1 in the quarterfinals of the Coppa Italia on Wednesday.
Napoli beat Fiorentina 1-0 to advance to the Coppa Italia semifinals and extend their unbeaten streak in all competitions to 15 matches on Tuesday.
Juventus returned to winning ways on Sunday as early strikes from Paulo Dybala and Gonzalo Higuain steered the Serie A leaders to a 2-0 victory over fourth-placed Lazio.
Napoli extended their unbeaten run in Serie A to 10 games with a 2-1 victory over AC Milan at San Siro.
Roma are on course to face city rivals Lazio in the Coppa Italia semifinals after easing past Sampdoria 4-0 in the round of 16 on Thursday.
Jeison Murillo scored with a spectacular bicycle kick and Antonio Candreva got the winner in extra time as Inter Milan beat Bologna 3-2 on Tuesday to advance to the Coppa Italia quarterfinals.
Carlos Bacca's second-half penalty earned 10-man AC Milan their share of the points from a hard-fought 2-2 Serie A draw at Torino on Monday.
Fiorentina put a dent in Juventus' title charge with a 2-1 win at the Stadio Artemio Franchi.
Marek Hamsik moved to within two goals of Diego Maradona's record of 115 as he struck to help Napoli beat Pescara 3-1 on Sunday and keep up the pressure on the top two.
Inter Milan came from behind to beat Chievo 3-1 with late goals from Ivan Perisic and Eder at the San Siro to record a fifth straight Serie A victory.
AC Milan came back from a goal down to beat Torino 2-1 on Thursday and set up a meeting with Juventus in the Coppa Italia quarterfinals.
Paulo Dybala scored a stunning volley and provided an assist, but Juventus found it harder than expected to beat Atalanta 3-2 in the Coppa Italia.
Manolo Gabbiadini boosted his value in the transfer market by scoring for the third straight match as Napoli beat Serie B side Spezia 3-1 on Tuesday to advance to the Italian Cup quarterfinals.
Serie A leaders Juventus returned from their winter break to demonstrate their fearsome Scudetto credentials with a 3-0 dismantling of Bologna on Sunday night.
Fresh off their Italian Super Cup win over Juventus, fifth-placed AC Milan needed a late goal to beat visitors Cagliari 1-0 on Sunday.
An Armando Izzo own goal gave Roma a 1-0 victory over Genoa and secured their first win away from home since October.
Ivan Perisic scored twice as Inter Milan came from a goal down to beat Udinese and win a fourth straight Serie A game.
After sitting on the bench all season, Lorenzo Tonelli finally got a chance to play for Napoli on Saturday and he made quite an impact in their 2-1 win over Sampdoria.
Juventus have officially completed the signing of Tomas Rincon from Serie A rivals Genoa on a three-and-a-half-year contract.
Internazionale continued to enjoy home comforts as they brushed aside Lazio with three goals in 12 second-half minutes to claim a 3-0 win.
Lazio drew level on points with third-placed Napoli in the Serie A table by beating Fiorentina 3-1 at the Stadio Olimpico.
Dries Mertens scored four goals as Napoli reached third place in the Serie A table with a 5-3 victory over Torino at the Stadio San Paolo.
Ten-man Inter Milan claimed their third successive win for the first time this season after a hard-fought 1-0 victory at Sassuolo.
A fine solo goal from Gonzalo Higuain in a 1-0 victory over title rivals Roma extended Juventus' lead at the top of Serie A to seven points.
The respective ambitions of AC Milan and Atalanta took a hit following a goalless draw at San Siro.
Radja Nainggolan punished AC Milan for missing a first-half penalty by firing Roma to a 1-0 Serie A victory at the Stadio Olimpico.
Marcelo Brozovic's brace boosted Inter Milan to a 2-0 victory over Genoa and into the top half of the Serie A table.
Napoli forward Lorenzo Insigne scored his seventh goal of the campaign in a 2-0 victory over Sassuolo at the San Paolo.
Argentina forward Gonzalo Higuain scored twice as AC Milan secured a 3-1 victory over bottom side Chievo.
Genoa forward Krzysztof Piatek maintained his record of scoring in every Serie A match for his new club on Sunday although it was not enough to prevent them losing 3-1 at home to Parma.
Edin Dzeko continued his upturn in form as Roma made it four straight wins in all competitions to move third in Serie A with a 2-0 win over Empoli.
Unstoppable Juventus maintained their perfect start to the season after 10 matches when first-half goals from Rodrigo Bentancur and Cristiano Ronaldo gave them a 2-0 win at Udinese in Serie A on Saturday.
AC Milan made surprisingly light work of surprise squad Sassuolo -- who would have gone second with a win -- as they won 4-1 away to end a run of three successive draws.
Fiorentina beat Atalanta 2-0 in Serie A on Sunday having opened the scoring with disputed penalty that sparked an angry clash between coaches Stefano Pioli and Gian Piero Gasperini at the final whistle.
Cristiano Ronaldo played a part in all three goals as Juventus came from behind to defeat title rivals Napoli on Saturday.
Roma defender Federico Fazio went from villain to hero as his side continued their recent dominance over neighbours Lazio with a 3-1 win in a pulsating Derby della Capitale on Saturday.
AC Milan were foiled by heroic goalkeeping from Empoli's Pietro Terracciano as they were held 1-1 by the promoted side on Thursday, their third successive Serie A draw.
Paulo Dybala has been somewhat obscured by Cristiano Ronaldo's arrival at Juventus but the Argentine broke his goal scoring drought on Wednesday.
AS Roma ended a five-match winless run in all competitions by thumping Frosinone 4-0 with Cengiz Under, Javier Pastore, Stephan El Shaarawy and Aleksandar Kolarov sharing the goals.
Inter Milan overcame one of their notorious lapses to beat Fiorentina 2-1 in Serie A and notch their third win in a week on Tuesday, suggesting early-season troubles may be behind them.
Cristiano Ronaldo's late goal helped Juventus to maintain their perfect start to the Serie A season with a hard-fought 2-0 victory away to Frosinone on Sunday.
AC Milan conceded an injury-time goal as Atalanta twice fought back to claim a point in a 2-2 draw at the San Siro.
Roma's Serie A crisis deepened as they lost 2-0 away to Bologna at the weekend, and while a quick turnaround against on Wednesday might look desirable, it could be another potential banana skin for Eusebio di Francesco's side.
Inter Milan provided plenty of late drama as Marcelo Brozovic's last-gasp goal earned them a 1-0 victory at Sampdoria in a game featuring a number of VAR controversies.
Argentina forward Gonzalo Higuain scored his first goal for AC Milan to earn them a 1-1 draw at Cagliari.
Cristiano Ronaldo scored his first goals for Juventus as they beat Sassuolo 2-1 to continue their perfect start to the Serie A season.
Napoli exorcised some of the ghosts of last season by beating Fiorentina 1-0 in Serie A action on Saturday.
Just three years after going bankrupt, Parma returned to winning ways in Serie A with a surprise 1-0 win over Inter Milan at San Siro.
Serie A title hopefuls Napoli were thumped 3-0 at Sampdoria on Sunday after coach Carlo Ancelotti tinkered with the team, dropping captain Marek Hamsik and forward Jose Callejon.
Cristiano Ronaldo was left waiting for his first Juventus goal after drawing another blank as the titleholders won 2-1 at Parma in Serie A on Saturday to maintain their 100 percent record.
Radja Nainggolan scored on his delayed Inter Milan debut to set them on the way to their first win of the season on Saturday as they beat Bologna 3-0 away in Serie A.
A late stoppage-time goal by substitute Patrick Cutrone gave AC Milan a 2-1 home win over Roma in an electrifying Serie A clash on Friday and eased the pressure on manager Gennaro Gattuso.
Inter seemed to be in absolute control, but fumbled a 2-0 lead and risked losing the game against a plucky Torino.
Dries Mertens came off the bench to grab the winner as Napoli rallied from 2-0 down to beat visiting AC Milan 3-2 and seize a second victory in two matches.
Cristiano Ronaldo missed an open goal but inadvertently provided an assist for Mario Mandzukic to score as titleholders Juventus beat Lazio 2-0 in Serie A on Saturday.
Inter Milan's hopes of challenging for the Serie A title got off on the wrong foot with a shock 1-0 defeat at Sassuolo on Sunday.
Roma striker Edin Dzeko scored with a memorable volleyed goal following a mazy run by debutant Justin Kluivert to give his side a 1-0 win at Torino in their opening Serie A game on Sunday.