Inter Milan's as-yet-unnamed new head coach caught a glimpse of the size of the task awaiting him as the Nerazzurri struggled to put away basement boys Crotone.
Miralem Pjanic fired reigning champions Juventus four points clear at the top of the Serie A table with his late free-kick at Chievo.
Substitute Gianluca Lapadula grabbed his maiden AC Milan goal to earn the Rossoneri all three points from their trip to Palermo.
Lazio salvaged a point at Napoli after goals from Keita and Marek Hamsik cancelled each other out in a frenetic two-minute spell at Stadio San Paolo.
Andrea Belotti scored twice as Torino blew Cagliari away 5-1 to reassert their European ambitions.
Inter Milan have confirmed they have parted company with head coach Frank De Boer, less than three months after appointing the former Ajax boss.
The pressure ramped up another notch on Inter Milan manager Frank de Boer after Sampdoria inflicted a fourth defeat in five Serie A games.
Roma blew their chance to keep the pressure on Serie A leaders Juventus as they were held to a goalless draw at struggling Empoli on Sunday.
Giacomo Bonaventura's second-half strike proved enough as AC Milan bounced back from the midweek defeat at Genoa with a 1-0 victory over Pescara at San Siro to move up to third in Serie A.
Gonzalo Higuain's second-half winner saw Juventus clinch their 22nd consecutive home win in Serie A with a 2-1 victory over Napoli.
Mauro Icardi took a major step towards regaining the adoration of hardcore Inter Milan fans while also throwing boss Frank de Boer a lifeline as his brace helped beat Torino 2-1 at San Siro.
Edin Dzeko continued his hot streak in front of goal as Roma battled back from a goal down to win 3-1 at Sassuolo.
Juventus warmed up for their top-of-the-table clash with Napoli by beating Sampdoria 4-1 in Turin.
AC Milan missed the chance to go top of Serie A as they were beaten 3-0 at Genoa.
Roma reinforced their Serie A title credentials with a confident 4-1 home victory over Palermo.
Nikola Kalinic grabbed a hat-trick as Fiorentina came from behind to thump Cagliari 5-3.
Frank de Boer's future as Inter Milan head coach is under serious threat after the Nerazzurri went down 2-1 to Atalanta in Bergamo.
Teenager Manuel Locatelli fired AC Milan to a hard-earned 1-0 win over Serie A leaders Juventus at the San Siro as Vincenzo Montella's young side continued their impressive start to the season.
Two goals from Adem Ljajic helped Torino come from behind to pick up their third win on the bounce with a 4-1 Serie A victory over Palermo.
AC Milan extended their unbeaten run against Chievo to 20 matches and climbed up to third in Serie A with a 3-1 win on the road.
Samir Handanovic's late own goal secured Cagliari a third straight Serie A win and sent Inter Milan spiralling to a third successive defeat in all competitions.
Paulo Dybala's set-piece double saw Serie A leaders Juventus come from behind to defeat Udinese 2-1 at home and extend their lead at the top of the table to five points.
A counter-attacking masterclass saw Roma earn a 3-1 victory against Napoli in their Serie A clash at Stadio San Paolo.
Kostas Manolas had the final word in Roma's scintillating 2-1 victory over Inter Milan.
Gabriel Paletta's first ever AC Milan goal settled a 4-3 thriller against Sassuolo at San Siro.
Iago Falque scored one goal and set up another as Torino reached eighth place with a 2-1 Serie A victory over Fiorentina at the Stadio Olimpico.
Andrea Petagna ended Napoli's unbeaten start to the Serie A season by firing Atalanta to a 1-0 win.
Juventus ensured they would end the weekend in first place in Serie A with a convincing 3-0 victory at Empoli.
Ciro Immobile scored twice as Lazio won 3-0 at Udinese to move third in Serie A.
Josip Ilicic missed a first-half penalty as Fiorentina were held to a goalless draw by AC Milan, who were indebted to goalkeeper Gianluigi Donnarumma at the Artemio Franchi Stadium.
Juventus missed the chance to go seven points clear at the top of Serie A after being held to a 0-0 draw at struggling SPAL.
Juventus beat visiting Atalanta 2-0 on Wednesday to open up a four-point lead over Napoli that could prove decisive in pursuit of an unprecedented seventh straight Serie A title.
Napoli ceded control of the Serie A title race to reigning champions Juventus after failing to beat Inter Milan at San Siro.
AC Milan bounced back from their Europa League defeat to Arsenal as substitute Andre Silva fired the Rossoneri to a 1-0 success at Genoa with practically the last kick of the game.
Juventus returned to first place -- at least until Inter Milan host Napoli later on Sunday -- thanks to their 2-0 home victory against Udinese.
Daniele De Rossi was among the goalscorers as Roma recorded a 3-0 win over Torino on Friday night, the day after the funeral for Davide Astori.
Edin Dzeko scored twice as Roma dealt a major blow to Napoli's hopes of winning the Serie A title with a 4-2 victory at Stadio San Paolo.
Paulo Dybala's last-gasp goal avenged Juventus' October defeat to Lazio as the reigning Serie A champions won 1-0 at the Stadio Olimpico.
AC Milan's unbeaten streak in all competitions reached 13 matches with a 5-4 penalty shootout victory over Lazio on Wednesday to advance to the Coppa Italia final against Juventus.
Miralem Pjanic scored a controversial penalty as Juventus beat visiting Atalanta 1-0 Wednesday to reach the Italian Cup final.
Leaders Napoli sent their Serie A winning streak into double figures with an emphatic 5-0 success at Cagliari.
AC Milan's good form continued as Gennaro Gattuso's men defeated Roma 2-0 at the Stadio Olimpico.
Juventus' Serie A match against Atalanta was called off on Sunday due to heavy snowfall in Turin.
Two goals in three second-half minutes helped Inter Milan to a 2-0 victory at home to Benevento and moved them up to third in the Serie A table -- despite jeers from their own fans.
Napoli stayed one point ahead of Juventus at the top of Serie A on Sunday after both teams won their ninth league games in a row, this time beating SPAL and Torino 1-0 respectively.
Juventus climbed above Napoli with a 1-0 victory at Torino that maintains their pursuit of the Serie A title.
Inter Milan dropped to fourth place in Serie A after falling 2-0 at Genoa on Saturday.
Roma moved up to third in the Serie A table as second-half goals from Cengiz Under and Diego Perotti helped them to a 2-0 win at Udinese.
Yann Karamoh's first goal for Inter Milan settled their fraught 2-1 victory over nine-man Bologna at San Siro.
Napoli came from behind to produce a stunning 4-1 victory against Lazio to storm back to the top of the Serie A table.
Patrick Cutrone scored twice as AC Milan won 4-0 at SPAL to keep up their recent good form.
Juventus defeated Fiorentina 2-0 in Gianluigi Buffon's 500th league match for the club to leapfrog Napoli at the top of Serie A.
Diego Laxalt snatched a last-gasp victory for Genoa as Lazio fell further away from the title race with a 2-1 defeat at the Stadio Olimpico.
Gonzalo Higuain scored a hat trick as Juventus romped to a 7-0 Serie A demolition of sorry Sassuolo at the Allianz Stadium.
Cengiz Under's stunning early strike was enough for 10-man Roma to grind out a much-needed 1-0 win at Hellas Verona.
Inter Milan's winless streak in Serie A will stretch beyond two months after they drew with visiting Crotone 1-1 on Saturday.
AC Milan drew 0-0 at home to Lazio in the first leg of their Coppa Italia semifinal on Wednesday and could be left counting the cost of an embarrassing miss by Hakan Calhanoglu.
Gonzalo Higuain and Gianluigi Buffon combined to help Juventus beat Atalanta 1-0 for a crucial away victory in the first leg of their Coppa Italia semifinal on Tuesday.
Giacomo Bonaventura scored the winner as in-form AC Milan recorded a third successive Serie A victory by beating high-flying Lazio 2-1.
A brace from Dries Mertens took Napoli straight back to the top of Serie A with a 3-1 win over Bologna on Sunday while Inter Milan conceded a last-minute goal at SPAL to extend their winless run to nine games.