Higuain scored twice and Buffon preserved a clean sheet with a spectacular save as Serie A leader Juventus won 2-0 at 10-man Cagliari.
Roma overtook Napoli to move into second place in Serie A with a 2-0 victory at Crotone on Sunday.
Inter Milan returned to winning ways with a 2-0 victory against Empoli at the San Siro to move them up to fourth in the Serie A table.
Borja Valero inspired Fiorentina back to winning ways with a 3-0 victory over Udinese at Stadio Artemio Franchi.
Napoli moved up to second in the Serie A table with a 2-0 home victory over strugglers Genoa.
Juventus moved seven points clear at the top of Serie A following a comfortable 2-0 victory against Crotone on Wednesday evening.
Edin Dzeko is going from strength to strength in his second season in Italian football, scoring twice as Roma beat Fiorentina 4-0 in Serie A on Tuesday.
Juan Cuadrado's first-half thunderbolt fired Juventus to a 1-0 Derby d'Italia victory over Inter Milan in Turin.
Injury-hit AC Milan were plunged further into crisis by a surprise 1-0 defeat at home to Sampdoria in Serie A on Sunday.
Dries Mertens and Marek Hamsik each scored hat tricks as Napoli extended their unbeaten streak to 17 matches in all competitions with a 7-1 rout at Bologna in Serie A on Saturday.
Francesco Totti converted a penalty deep into stoppage time to send Roma through to the Coppa Italia semifinal against city rival Lazio with a narrow 2-1 win over second-division Cesena on Wednesday.
Lazio defeated Inter Milan 2-1 in the Coppa Italia quarterfinals on Tuesday as both sides finished with 10 men.
Gonzalo Higuain reached 15 goals for the Serie A season as Juventus reinforced their position as league leaders with a 2-0 victory at Sassuolo.
Roma's four-game winning run came to a halt as Luis Muriel settled a five-goal thriller in Samp's favour.
AC Milan's misery continued at Udinese as their dreams of qualifying for the Champions League diminished on Sunday.
In-form Inter Milan moved up to fourth place with a 3-0 success at home to bottom-of-the-table Pescara -- their seventh consecutive Serie A victory.
Juventus beat 10-man AC Milan 2-1 in the quarterfinals of the Coppa Italia on Wednesday.
Napoli beat Fiorentina 1-0 to advance to the Coppa Italia semifinals and extend their unbeaten streak in all competitions to 15 matches on Tuesday.
Juventus returned to winning ways on Sunday as early strikes from Paulo Dybala and Gonzalo Higuain steered the Serie A leaders to a 2-0 victory over fourth-placed Lazio.
Napoli extended their unbeaten run in Serie A to 10 games with a 2-1 victory over AC Milan at San Siro.
Roma are on course to face city rivals Lazio in the Coppa Italia semifinals after easing past Sampdoria 4-0 in the round of 16 on Thursday.
Jeison Murillo scored with a spectacular bicycle kick and Antonio Candreva got the winner in extra time as Inter Milan beat Bologna 3-2 on Tuesday to advance to the Coppa Italia quarterfinals.
Carlos Bacca's second-half penalty earned 10-man AC Milan their share of the points from a hard-fought 2-2 Serie A draw at Torino on Monday.
Fiorentina put a dent in Juventus' title charge with a 2-1 win at the Stadio Artemio Franchi.
Marek Hamsik moved to within two goals of Diego Maradona's record of 115 as he struck to help Napoli beat Pescara 3-1 on Sunday and keep up the pressure on the top two.
Inter Milan came from behind to beat Chievo 3-1 with late goals from Ivan Perisic and Eder at the San Siro to record a fifth straight Serie A victory.
AC Milan came back from a goal down to beat Torino 2-1 on Thursday and set up a meeting with Juventus in the Coppa Italia quarterfinals.
Paulo Dybala scored a stunning volley and provided an assist, but Juventus found it harder than expected to beat Atalanta 3-2 in the Coppa Italia.
Manolo Gabbiadini boosted his value in the transfer market by scoring for the third straight match as Napoli beat Serie B side Spezia 3-1 on Tuesday to advance to the Italian Cup quarterfinals.
Serie A leaders Juventus returned from their winter break to demonstrate their fearsome Scudetto credentials with a 3-0 dismantling of Bologna on Sunday night.
Argentina forward Gonzalo Higuain scored his first goal for AC Milan to earn them a 1-1 draw at Cagliari.
Cristiano Ronaldo scored his first goals for Juventus as they beat Sassuolo 2-1 to continue their perfect start to the Serie A season.
Napoli exorcised some of the ghosts of last season by beating Fiorentina 1-0 in Serie A action on Saturday.
Just three years after going bankrupt, Parma returned to winning ways in Serie A with a surprise 1-0 win over Inter Milan at San Siro.
Serie A title hopefuls Napoli were thumped 3-0 at Sampdoria on Sunday after coach Carlo Ancelotti tinkered with the team, dropping captain Marek Hamsik and forward Jose Callejon.
Cristiano Ronaldo was left waiting for his first Juventus goal after drawing another blank as the titleholders won 2-1 at Parma in Serie A on Saturday to maintain their 100 percent record.
Radja Nainggolan scored on his delayed Inter Milan debut to set them on the way to their first win of the season on Saturday as they beat Bologna 3-0 away in Serie A.
A late stoppage-time goal by substitute Patrick Cutrone gave AC Milan a 2-1 home win over Roma in an electrifying Serie A clash on Friday and eased the pressure on manager Gennaro Gattuso.
Inter seemed to be in absolute control, but fumbled a 2-0 lead and risked losing the game against a plucky Torino.
Dries Mertens came off the bench to grab the winner as Napoli rallied from 2-0 down to beat visiting AC Milan 3-2 and seize a second victory in two matches.
Cristiano Ronaldo missed an open goal but inadvertently provided an assist for Mario Mandzukic to score as titleholders Juventus beat Lazio 2-0 in Serie A on Saturday.
Inter Milan's hopes of challenging for the Serie A title got off on the wrong foot with a shock 1-0 defeat at Sassuolo on Sunday.
Roma striker Edin Dzeko scored with a memorable volleyed goal following a mazy run by debutant Justin Kluivert to give his side a 1-0 win at Torino in their opening Serie A game on Sunday.
Ciro Immobile scored a magnificent opener, but Arkadiusz Milik and Lorenzo Insigne completed the Napoli comeback to conquer Lazio.
Federico Bernardeschi scored in stoppage time to make Cristiano Ronaldo a winner on his Juventus debut as the Italian champions rallied to win 3-2 at Chievo Verona on Saturday.
Keita Balde completed his move from Monaco to Inter Milan on Monday after just one season at the Ligue 1 club.
Gonzalo Higuain has left Juventus and joined AC Milan in a deal that also sees Leonardo Bonucci return to Juve after a year away in a swap for fellow centre-back Mattia Caldara.
Cristiano Ronaldo is leaving Real Madrid to sign with Italian champions Juventus, both clubs announced on Tuesday.
AC Milan have been excluded from playing in the Europa League next season after breaching UEFA's financial fair play (FFP) regulations, pending an appeal.
Juventus have completed the signing of Portugal full-back Joao Cancelo from Valencia for a fee of €40.4 million, which will be paid in three installments.
Radja Nainggolan has completed his move from Roma to Inter Milan in a deal worth €38 million with Davide Santon and Nicolo Zaniolo moving in the opposite direction as part of the transfer.
Emre Can has joined Serie A champions Juventus from Liverpool on a four-year contract.
Juventus have confirmed the permanent signing of Bayern Munich winger Douglas Costa for a fee of €40 million.
Carlo Ancelotti has signed a three-year contract to replace Maurizio Sarri as Napoli's head coach.
Inter Milan came from behind to snatch the final Champions League place in their 3-2 winner-takes-all victory at Lazio.
AC Milan qualified for the Europa League group stage on the final day in Serie A, following a 5-1 win over Fiorentina.
Gianluigi Buffon said an emotional farewell to Juventus as the veteran goalkeeper marked his 640th and last Serie A appearance in a 2-1 victory over relegated Hellas Verona.
Juventus clinched a seventh straight Serie A title to continue their dominance in Italy despite labouring to a 0-0 draw at 10-man Roma.
Lazio missed a chance to clinch the fourth and final Italian place in next season's Champions League group stage when they were held to a 2-2 draw at relegation-threatened Crotone on Sunday.
Inter Milan's Champions League hopes suffered a huge blow as Sassuolo shocked them again at the San Siro in Serie A on Saturday.