Tottenham paid the price for a Dele Alli horror-tackle as Mauricio Pochettino's side drew 2-2 with Gent and crashed out of the Europa League last 32.
Lyon trounced AZ Alkmaar 7-1 to win their Europa League last-32 tie 11-2 on aggregate, while Borussia Monchengladbach staged a comeback to knock out Fiorentina.
Manchester United wrapped up a commanding 4-0 aggregate Europa League victory over St Etienne, winning 1-0 in the away leg thanks to an early Henrikh Mkhitaryan goal and easing into the round of 16.
Edin Dzeko's hat trick helped Roma run out 4-0 winners against Villarreal at the Estadio El Madrigal.
Zlatan Ibrahimovic's first Manchester United hat trick saw off St Etienne as Jose Mourinho's men took control of this Europa League round-of-32 tie.
A below-par Tottenham Hotspur lost the first leg of their Europa League round-of-32 game against Gent 1-0 in Belgium.
Manchester United will take on St Etienne in the Europa League's round of 32, while Tottenham Hotspur will face Gent and Villarreal have been drawn against Roma.
Celta Vigo claimed their place in the last 32 of the Europa League with a straightforward 2-0 win over Panathinaikos in Athens.
Manu Trigueros scored a superb late winner as Villarreal reached the Europa League knockout stages with a nervy 2-1 victory over 10-man Steaua Bucharest.
Toothless Southampton missed the chance for a best European run since 1977 after Israeli minnows Hapoel Be'er Sheva drew 1-1 at St Mary's to knock them out of the Europa League.
Fine goals by Henrikh Mkhitaryan and Zlatan Ibrahimovic gave Manchester United a 2-0 away win over Zorya Luhansk and booked their place in the Europa League knockout stages as group runners-up.
Wayne Rooney became Manchester United's all-time leading scorer in Europe as Jose Mourinho's side defeated Feyenoord 4-0 to move to the brink of qualifying for the Europa League's last 32.
Southampton's hopes of reaching the Europa League's knockout stages have been left in the balance after a 1-0 defeat at Sparta Prague.
The battle to join Ajax in progressing from Group G of the Europa League will go to the final day as Celta Vigo and Standard Liege drew 1-1.
Substitute Ben Sahar scored an injury-time winner as Hapoel Be'er Sheva came from two goals down to beat 10-man Inter Milan 3-2 and set up a winner-takes-all clash with Southampton.
Wayne Rooney's late long-range strike was not enough to salvage a draw for Manchester United as they lost 2-1 to Fenerbahce in the Europa League.
Edin Dzeko struck twice as Roma beat Europa League rivals Austria Vienna 4-2 at the Ernst Happel Stadium to move top of Group E.
A brace from Giuliano undid Dundalk in Europa League Group D as they went down 2-1 to Zenit St Petersburg in Russia.
Southampton beat Inter Milan 2-1 to secure a famous victory that takes them to the brink of the Europa League's knockout stages.
Paul Pogba scored twice as Manchester United defeated Fenerbahce 4-1 to move to the top of Europa League Group A.
Southampton wasted the chance to take a significant step towards the Europa League's knockout stages with a disappointing 1-0 defeat at Inter Milan.
Alassane Plea's first-half strike handed Nice their first ever European away victory as they secured a 1-0 Europa League win over Salzburg.
Celta Vigo and Ajax shared four goals in an entertaining 2-2 draw to keep themselves at the head of Europa League Group G.
Dundalk tasted bitter disappointment as they went from the verge of an historic victory to defeat against Zenit St Petersburg.
Manchester United laboured to a 1-0 Europa League victory over Zorya Luhansk at Old Trafford as Zlatan Ibrahimovic headed home in the second half to seal the points for the below-par hosts.
Francesco Totti capped a memorable week with three assists as Roma thrashed Astra Giurgiu 4-0 in Group E of the Europa League.
Southampton secured a valuable point in their bid to progress to the Europa League's knockout stages with a 0-0 draw as Hapoel Be'er Sheva continued their extraordinary undefeated record at the Turner Stadium.
Some terrible defensive errors and a sluggish approach saw Inter beaten 3-1 at Sparta Prague in the Europa League, plus Andrea Ranocchia sent off.
An undercooked and underperforming Manchester United started their Europa League campaign with a 1-0 defeat as Tonny Vilhena secured Feyenoord a late victory.
Sassuolo marked their debut in the Europa League with a 3-0 win over seasoned campaigners Athletic Bilbao.
Sevilla suffered a shock defeat by Russians Krasnodar, going down 2-1 in Europa League Group J.
Ten-man Celtic threw away an early lead to succumb to a 3-1 defeat to Red Bull Salzburg in Austria.
Alvaro Morata provided the lone goal in Chelsea's 1-0 win over Vidi in Europa League group-stage action on Thursday.
Emile Smith Rowe scored his first career goal in Arsenal's 3-0 win over FK Qarabag in Europa League group-stage action on Thursday.
Substitute Patrick Cutrone netted twice in nine minutes to lift AC Milan to a 3-1 comeback win at home to Olympiakos in Europa League group-stage action.
Arsenal's superb form continued into the Europa League as they thrashed Ukrainian side Vorksla Poltava 4-2 on Thursday.
Gonzalo Higuain's deflected effort in the 59th minute sealed a 1-0 victory for AC Milan over Luxembourg side F91 Dudelange on Thursday night in Europa League action.
Chelsea's Europa League campaign kicked off in style with a 1-0 win at PAOK Salonika on Thursday.
Leigh Griffiths made the difference for Celtic in their Europa League opener, coming off the bench to score a late winner against Rosenborg.
Burnley's European adventure came to an end on Friday as the Premier League side crashed out of the Europa League playoff round with a 1-1 draw against Olympiakos.
Celtic were held to a 1-1 draw by Lithuanian side Suduva Marijampole in the first leg of their Europa League play-off at the ARVI Futbolo Arena.
Antoine Griezmann struck twice as Atletico Madrid powered past Marseille to lift their third Europa League title in nine years.
Atletico Madrid advanced to the Europe League final 2-1 on aggregate after a 1-0 victory over Arsenal at the Wanda Metropolitano on Thursday.
Marseille scored a dramatic extra-time decider against Red Bull Salzburg to earn a Europa League final showdown with Atletico Madrid in Lyon on May 16.
If Arsene Wenger's Arsenal finale is to be a Europa League final in Lyon his side will have to do it the hard way after surrendering a well-deserved lead to draw against 10-man Atletico Madrid in the first leg of their semi-final.
Florian Thauvin put Marseille within touching distance of a place in the UEFA Europa League final with a controversial opener as his side beat Red Bull Salzburg 2-0 at the Stade Velodrome.
Arsenal will face Atletico Madrid later this month in their first appearance in the Europa League semifinals since 2000.
Marseille stunned RB Leipzig 4-2 in a thrilling Europa League quarterfinal second leg at the Orange Velodrome on Thursday evening to secure a 5-3 aggregate victory.
Red Bull Salzburg came from behind to earn a stunning 4-1 victory that secured an unlikely Europa League semifinal berth at the expense of Lazio.
Arsenal edged into the semifinals of the Europa League, but only after surviving a major scare as CSKA Moscow threatened a memorable comeback.
Atletico Madrid overcame a scare to see off the challenge of a fired-up Sporting Lisbon and book their place in the semifinals of the Europa League.
Aaron Ramsey and Alexandre Lacazette each scored twice as Mesut Ozil put on a Europa League masterclass to overwhelm CSKA Moscow and all but book Arsenal's place in the semifinals.
Timo Werner pounced in first-half injury time as RB Leipzig edged the first leg of their quarter-final against Marseille.
Two goals in two second-half minutes helped Lazio beat Salzburg 4-2 and take control of their Europa League quarter-final.
Koke scored after 23 seconds to set Atletico Madrid on their way to a routine 2-0 win over Sporting Lisbon in the first leg of their Europa League quarterfinal.
Arsenal will play Russian club CSKA Moscow in the quarterfinals as they look to win the Europa League for the first time and seal a place in next season's Champions League.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Fernando Torres scored twice as Europa League favourites Atletico Madrid hammered Lokomotiv Moscow 5-1 in Russia to advance to the quarterfinal stage.
Valon Berisha scored twice as Salzburg earned a 2-1 win away to Borussia Dortmund in the first leg of their Europa League round-of-16 tie on Thursday.
Arsenal eased to victory over AC Milan to move towards a place in the quarterfinals of the Europa League and end a run of four consecutive defeats in the process.