Gonzalo Higuain plundered a hat trick as Napoli recovered from an early fright to seize a commanding advantage against 10-man Dinamo Moscow in the Europa League.
Everton once again produced a Europa League performance in contrast to their domestic displays as Romelu Lukaku's late penalty secured them a 2-1 come-from-behind victory in their last-16 first leg against Dynamo Kiev.
Kevin De Bruyne inspired Wolfsburg to a 3-1 win over Inter Milan to put the Germans in control of their Europa League last-16 tie.
Dnipro claimed a deserved win over Ajax from the first leg of their Europa League last-16 tie in Kiev, but may rue not building a bigger advantage to take to Amsterdam.
Zenit St Petersburg took a big step towards the Europa League quarterfinals with a 2-0 win over 10-man Torino in the first leg of their last-16 clash.
Everton will face Dynamo Kiev in the last 16 of the Europa League while holders Sevilla were drawn against fellow Spaniards Villarreal.
Liverpool lost their first European penalty shoot-out as Dejan Lovren was the only man to miss from the spot against Besiktas in Istanbul.
Torino got the better of a back-and-forth battle in torrential rain to eliminate Athletic Bilbao from the Europa League.
Roma progressed to the last 16 of the Europa League with victory over Feyenoord but the match was overshadowed by crowd trouble in Rotterdam.
Everton comfortably completed their progress into the last 16 of the Europa League as a Romelu Lukaku brace helped them beat Young Boys 3-1 at Goodison Park, sealing a 7-2 win on aggregate.
Celtic's Europa League campaign came to a frustrating end with a 1-0 defeat by Inter Milan at the San Siro after Hoops defender Virgil van Dijk was dismissed in the first half.
Roberto Soldado's embarrassing mistake paved the way for Tottenham's Europa League exit against Fiorentina.
Wolfsburg repelled a string of Sporting Lisbon attacks to reach the last 16 of the Europa League with a goalless draw in Portugal.
Sevilla put aside their domestic problems to move into the last 16 of the Europa League - although the reigning champions were made to sweat by Borussia Monchengladbach before claiming a 3-2 second-leg win.
Luciano Vietto scored twice as Villarreal booked their place in the last 16 of the Europa League.
Zenit St Petersburg eased to a 4-0 aggregate win over runaway Eredivisie leaders PSV Eindhoven to reach the last 16 of the Europa League.
Napoli cruised to a routine victory over Trabzonspor and confirmed their last-16 place in the Europa League in the process on Thursday night.
Substitute Mario Balotelli continued his penchant for late interventions with an 85th-minute penalty to give Liverpool a slender advantage to take to Istanbul in the last 32 of the Europa League.
Villarreal will take a narrow advantage into the second leg of their Europa League last-32 tie against Salzburg after a 2-1 win in Spain on Thursday night.
Napoli have one foot in the last 16 of the Europa League after claiming an emphatic 4-0 win at Trabzonspor.
Wolfsburg will take a 2-0 lead to Lisbon next week after the Bundesliga high-flyers claimed a comfortable victory over Sporting in the first-leg of their Europa League last-32 clash.
Substitute John Guidetti gave Celtic a dramatic Europa League lifeline with an injury-time leveller to draw 3-3 draw with Inter Milan at Parkhead.
Roberto Soldado's best moment in a Tottenham shirt was quickly followed by one to forget as he unnecessarily gave away the free-kick which allowed Fiorentina to secure a draw and what could prove a decisive away goal in this Europa League tie.
Everton look as good as assured of a place in the last 16 of the Europa League after a fine performance against Young Boys.
Liverpool will begin their Europa League campaign this season with a last-32 clash against Besiktas following Monday's draw at UEFA's headquarters in Nyon, Switzerland.
Substitutes Aaron Hunt and Nicklas Bendtner scored two apiece to inspire Wolfsburg to victory over Europa League Group F opponents FC Krasnodar.
Jose Antonio Reyes was on target as holders Sevilla were made to work to retain their position at the head of Europa League Group G.
Jonathan de Guzman scored a hat-trick as Napoli moved into the top half of Europa League Group I with a comfortable 3-0 home victory over Young Boys.
Manuel Pasqual spared Fiorentina from an embarrassing home defeat to PAOK Salonika by firing home the free-kick that sent the Italians into the Europa League knockout stages.
Everton took a major step towards the knockout stages of the Europa League as goals from Leon Osman, Phil Jagielka and Steven Naismith saw them claim a comfortable 3-0 victory over Lille at Goodison Park.
Burnley's European adventure came to an end on Friday as the Premier League side crashed out of the Europa League playoff round with a 1-1 draw against Olympiakos.
Celtic were held to a 1-1 draw by Lithuanian side Suduva Marijampole in the first leg of their Europa League play-off at the ARVI Futbolo Arena.
Antoine Griezmann struck twice as Atletico Madrid powered past Marseille to lift their third Europa League title in nine years.
Atletico Madrid advanced to the Europe League final 2-1 on aggregate after a 1-0 victory over Arsenal at the Wanda Metropolitano on Thursday.
Marseille scored a dramatic extra-time decider against Red Bull Salzburg to earn a Europa League final showdown with Atletico Madrid in Lyon on May 16.
If Arsene Wenger's Arsenal finale is to be a Europa League final in Lyon his side will have to do it the hard way after surrendering a well-deserved lead to draw against 10-man Atletico Madrid in the first leg of their semi-final.
Florian Thauvin put Marseille within touching distance of a place in the UEFA Europa League final with a controversial opener as his side beat Red Bull Salzburg 2-0 at the Stade Velodrome.
Arsenal will face Atletico Madrid later this month in their first appearance in the Europa League semifinals since 2000.
Marseille stunned RB Leipzig 4-2 in a thrilling Europa League quarterfinal second leg at the Orange Velodrome on Thursday evening to secure a 5-3 aggregate victory.
Red Bull Salzburg came from behind to earn a stunning 4-1 victory that secured an unlikely Europa League semifinal berth at the expense of Lazio.
Arsenal edged into the semifinals of the Europa League, but only after surviving a major scare as CSKA Moscow threatened a memorable comeback.
Atletico Madrid overcame a scare to see off the challenge of a fired-up Sporting Lisbon and book their place in the semifinals of the Europa League.
Aaron Ramsey and Alexandre Lacazette each scored twice as Mesut Ozil put on a Europa League masterclass to overwhelm CSKA Moscow and all but book Arsenal's place in the semifinals.
Timo Werner pounced in first-half injury time as RB Leipzig edged the first leg of their quarter-final against Marseille.
Two goals in two second-half minutes helped Lazio beat Salzburg 4-2 and take control of their Europa League quarter-final.
Koke scored after 23 seconds to set Atletico Madrid on their way to a routine 2-0 win over Sporting Lisbon in the first leg of their Europa League quarterfinal.
Arsenal will play Russian club CSKA Moscow in the quarterfinals as they look to win the Europa League for the first time and seal a place in next season's Champions League.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Fernando Torres scored twice as Europa League favourites Atletico Madrid hammered Lokomotiv Moscow 5-1 in Russia to advance to the quarterfinal stage.
Valon Berisha scored twice as Salzburg earned a 2-1 win away to Borussia Dortmund in the first leg of their Europa League round-of-16 tie on Thursday.
Arsenal eased to victory over AC Milan to move towards a place in the quarterfinals of the Europa League and end a run of four consecutive defeats in the process.
Atletico Madrid grabbed a sizable advantage over Lokomotiv Moscow by earning a 3-0 victory in the first leg of their Europa League round-of-16 clash on Thursday.
Celtic crashed out of the Europa League in calamitous style with a 3-0 defeat to Zenit St Petersburg in Russia.
Kevin Gameiro scored Atletico Madrid's only goal as a 1-0 win over Copenhagen was enough to advance from the Europa League round of 32 on the back of a big victory last week.
Serie A leaders Napoli were knocked out on away goals despite a 2-0 win away to RB Leipzig on Thursday.
Arsenal survived a major scare to secure their spot in the last 16 of the Europa League despite suffering an embarrassing 2-1 home defeat to Ostersund.
Borussia Dortmund made nervous work of their Europa League second leg against Atalanta in a 1-1 draw that saw the Bundesliga side reach the round of 16 courtesy of a 4-3 aggregate final.
Italian leaders Napoli suffered a surprise 3-1 home defeat at the hands of RB Leipzig as Timo Werner scored twice.
Celtic defeated Zenit St Petersburg 1-0 at Hampden Park in the first leg of their Europa League.
Michy Batshuayi scored twice, including a late winner, to rally Borussia Dortmund to a 3-2 win over Atalanta in their opening game of the Europe League knockout stage.