Shakhtar Donetsk kept their Europa League dreams alive with a 3-1 win over Anderlecht in the last-16 clash on Thursday evening.
Marcus Rashford was the unlikely hero in Manchester United's make-or-break clash with FC Midtjylland, marking an unexpected debut with a dream brace that saw Louis van Gaal's men through a tricky Europa League tie.
Tomas Pina's fortuitous second-half goal saw favourites Napoli crash out of the Europa League after a 1-1 draw against Villarreal.
Tottenham proved themselves capable of coping without Harry Kane as they sailed into the last 16 of the Europa League with a 3-0 win over Fiorentina.
Liverpool scraped past Augsburg and into the last 16 of the Europa League after a nervy 1-0 win at Anfield.
Borussia Dortmund recorded their fifth straight win in all competitions by defeating Porto 1-0 at the Estadio do Dragao to advance beyond the Europa League's last 32.
Manchester United's chances of progressing in the Europa League are in the balance after they threw away the lead to go down 2-1 at FC Midtjylland in the first leg of their Europa League last-32 tie.
Tottenham remain in the hunt for three trophies this season after leaving Italy with a hard-fought draw in their Europa League round of 32 tie against Fiorentina.
Goals from Lukasz Piszczek and Marco Reus handed Borussia Dortmund a 2-0 victory over Porto in the first leg of their Europa League last-32 tie.
Galatasaray and Lazio played out a 1-1 draw in the first leg of their Europa League last-32 clash in Istanbul.
Under-fire Valencia boss Gary Neville enjoyed the perfect 41st birthday as his side thrashed Rapid Vienna 6-0 in the first leg of their Europa League last-32 tie.
Denis Suarez's brilliant late free-kick gave Villarreal a narrow lead to take to Italy in their Europa League last-32 tie with Napoli.
Jurgen Klopp's homecoming did not go exactly to plan as his Liverpool side were held to a goalless draw against Augsburg in Germany.
Manchester United have been drawn against Danish champions Midtjylland in the Europa League round of 32, while Liverpool will play Augsburg.
Borussia Dortmund face a difficult draw for the Europa League round of 32 and could face the likes of Manchester United - or Jurgen Klopp's Liverpool - after losing 1-0 at home to PAOK and finishing as runners-up in Group C.
Celtic's Europa League hopes were ended for the season as Ajax substitute Vaclav Cerny scored a late winner for the visitors at Parkhead.
Christian Benteke's brilliant strike saw Liverpool beat Bordeaux 2-1 to qualify for the knockout stages of the Europa League with a match to spare.
Borussia Dortmund conceded a penalty in the first minute and ceded top spot in their Europa League group to opponents Krasnodar with a 1-0 defeat on Thursday.
Harry Kane fired Tottenham into the knockout stages of the Europa League as they finally overcame stubborn Group J minnows Qarabag 1-0 in Baku.
Jurgen Klopp is starting to build some momentum at Liverpool after a third successive victory - the club's first away from home in Europe for nearly three years.
Mousa Dembele scored a stunning late winner as Tottenham beat Anderlecht 2-1 to move top of Group J in the Europa League.
Borussia Dortmund secured their place in the knockout stage after routing Azerbaijan side Qabala 4-0 in Group C.
Stefano Okaka scored and Anderlecht rallied to hand Tottenham a 2-1 defeat in the Europa League on Thursday.
Liverpool settled for a 1-1 draw at Anfield against Swiss side FC Sion in the Europa League on Thursday.
Liverpool manager Brendan Rodgers' Europa League gamble almost paid off as the club's young guns were held to a 1-1 draw in Bordeaux.
Son Heung-Min scored a quick-fire brace on his home debut as Tottenham came from behind to beat Qarabag in their Europa League opener on Thursday night.
Basel took revenge on Paulo Sousa, as Fiorentina fumbled a lead to lose 2-1 at home with Gonzalo Rodriguez sent off.
Napoli started the Europa League in style, demolishing Club Brugge 5-0 with Jose Callejon and Dries Mertens braces.
Park Joo-Ho headed a last-gasp winner as Borussia Dortmund came from behind to launch their Europa League campaign with a 2-1 win over Krasnodar.
A late goal from substitute Lasse Schone gave Ajax a 2-2 draw against Celtic at the Amsterdam ArenA where Hoops left-back Emilio Izaguirre was sent off.
Italian leaders Napoli suffered a surprise 3-1 home defeat at the hands of RB Leipzig as Timo Werner scored twice.
Celtic defeated Zenit St Petersburg 1-0 at Hampden Park in the first leg of their Europa League.
Michy Batshuayi scored twice, including a late winner, to rally Borussia Dortmund to a 3-2 win over Atalanta in their opening game of the Europe League knockout stage.
Arsenal made light work of sub-zero temperatures and an artificial pitch to secure a comfortable Europa League victory over Ostersunds.
Patrick Cutrone scored a glancing header and earned a penalty converted by Ricardo Rodriguez as Milan conquered Ludogorets 3-0 in Bulgaria.
Arsenal have been drawn against Swedish club Ostersunds FK in the Europa League round of 32, while Atletico Madrid take on Copenhagen.
Ademola Lookman's brace ensured a youthful Everton side did not miss Sam Allardyce's presence in Cyprus as they finished their woeful Europa League campaign with a victory.
AC Milan concluded their Europa League group stage with a 2-0 defeat at Croatian club Rijeka on Thursday.
Arsenal cruised to victory over BATE Borisov in their final Europa League group game as Arsene Wenger's fringe players made another case for Premier League involvement.
AC Milan booked their place in the Europa League's final 32 with a 5-1 win over Austria Vienna on Thursday night.
Arsenal failed to get the point they needed to guarantee topping Europa League Group H as Cologne beat them 1-0 in Germany -- but they finished first anyway as Red Star Belgrade and BATE Borisov drew 0-0.
Everton's season, like their search for a manager, continues to drift as an insipid display brought a 5-1 home Europa League home thrashing by Atalanta.
AC Milan were made to wait for confirmed qualification from the Europa League group stage after being held to a 0-0 draw in a mediocre game at AEK Athens.
Arsenal qualified from the Europa League group stage despite being held to a 0-0 home draw by Red Star Belgrade, with rivals BATE Borisov being thrashed 5-2 in Cologne.
Managerless Everton crashed out of the Europa League with two Group E games left to play as they were beaten 3-0 at Lyon.
Mario Balotelli gave Nice an early lead but it was not enough to prevent Lazio from emerging convincing 3-1 winners at the Stade de Nice.
Everton boss Ronald Koeman was forced to endure more disappointment as Lyon consigned his side to an ill-tempered defeat and more Europa League misery.
Olivier Giroud scored a stunning winner as a much-changed Arsenal side saw off 10-man Red Star Belgrade in their Europa League clash.
Theo Walcott scored twice and Olivier Giroud notched his 100th Arsenal goal as the Londoners secured a second successive Europa League win, triumphing 4-2 at BATE Borisov.
AC Milan lost a 2-0 lead at the San Siro but found an injury time goal to earn a 3-2 win over Croatian champions Rijeka in the Europa League.
Everton's poor start in the Europa League continued as they were held to a 2-2 draw at Goodison Park by Cypriot outfit Apollon Limassol, who finished the game with 10 men.
Arsenal came from behind to beat Cologne in their delayed Europa League opener against a backdrop of crowd trouble at the Emirates Stadium.
Everton produced another hugely disappointing display as they were beaten 3-0 by Atalanta in their Europa League Group E opener in Reggio Emilia.
Andre Silva scored a hat trick as AC Milan eased to a 5-1 victory over Austria Vienna in their Europa League group-stage opener.
Arsenal have been drawn alongside BATE Borisov, Cologne and Red Star Belgrade in the Europa League group stage.
AC Milan eased into the Europa League group stage with a 1-0 win over Shkendija on Thursday, though the result was in little doubt after the Rossoneri won the first leg 6-0 a week ago.
Gylfi Sigurdsson marked his first Everton start with a spectacular goal to help put Ronald Koeman's side into the group stages of the Europa League after a 1-1 away draw with Hajduk Split.
Everton play Croatian side Hajduk Split in the Europa League playoff round, while AC Milan have been drawn against Macedonian side Shkendija.
AC Milan are through to the Europa League playoff round after beating Universitatea Craiova 3-0 on aggregate following a 2-0 second-leg win in the third qualifying round on Thursday.
Dominic Calvert-Lewin's calm finish kept Everton's bid for Europa League qualification on course as Ronald Koeman's men edged MFK Ruzomberok 1-0 in Slovakia.