Raheem Sterling celebrated his 21st birthday with a quickfire double to send Manchester City through to the Champions League last 16 as group winners.
PSV Eindhoven secured their place in the knockout stages of the Champions League with a late 2-1 win against Group B's bottom club CSKA Moscow.
Cristiano Ronaldo and Karim Benzema both scored hat-tricks as Real Madrid hammered Malmo 8-0 to equal the highest ever victory in the Champions League.
Shakhtar Donetsk held on to a Europa League place despite suffering a fifth defeat in six games in Champions League Group A against Paris Saint-Germain.
Atletico Madrid clinched first place in Champions League Group C after winning their top-of-the-table encounter with Benfica 2-1 at the Estadio da Luz.
Galatasaray secured themselves a Europa League spot with a 1-1 Champions League Group C draw against Astana.
Mario Mandzukic scored the only goal as Juventus leapfrogged Manchester City in Champions League Group D with a 1-0 win in Turin.
Manchester United were held to a goalless draw by PSV Eindhoven at Old Trafford on Wednesday night, meaning their Champions League hopes will depend on their final group game away at Wolfsburg.
Zlatan Ibrahimovic marked his return to his hometown club by helping PSG to a 5-0 Champions League victory over Malmo at the Swedbank Stadion.
Under-fire Rafael Benitez survived a late scare on a night when Real Madrid won their Champions League group, conceding three late goals against Shakhtar Donetsk.
Wolfsburg are on the brink of qualifying for the Champions League knock-out stages after winning 2-0 at CSKA Moscow.
Atletico Madrid made sure of their place in the Champions League knock-out stages with a comfortable 2-0 win against Galatasaray at the Vicente Calderon Stadium.
Sevilla's hopes of reaching the Champions League knockout stages ended in Germany with a 4-2 defeat to Borussia Monchengladbach.
Raul Jimenez scored twice as Benfica fought back from two goals down to draw 2-2 with FC Astana in their Champions League Group C fixture and move to the brink of reaching the tournament's last 16.
Bayern Munich booked their place in the Champions League group stage with an emphatic 4-0 victory over Olympiakos.
Lionel Messi, Luis Suarez and Neymar tore Roma to shreds as Barcelona heralded their Champions League glory march with a 6-1 thumping at the Camp Nou.
Arsenal kept their Champions League hopes alive with a routine victory over Dinamo Zagreb.
Chelsea's Champions League fate will go to the final group game after an unconvincing 4-0 win over 10-man Maccabi Tel Aviv earned successive victories for the first time in two months.
Lyon are out of the Champions League after they lost their crunch Group H clash with Gent 2-1 as the Stade de Gerland hosted its final European encounter.
Porto crashed to their first defeat of the season as Group G rivals Dynamo Kiev kept their Champions League hopes alive with goals from Andriy Yarmolenko and Derlis Gonzalez at the Estadio do Dragao.
Zenit St Petersburg maintained their 100 percent record in Group H of the Champions League and guaranteed themselves top spot with a 2-0 win against Valencia.
Admir Mehmedi struck a second-half equaliser against Champions League Group E rivals BATE Borisov in Belarus to keep Bayer Leverkusen's hopes of securing a place in the knockout stages alive.
Arsenal's Champions League hopes are hanging by a thread after they were blown away by Bayern Munich on Wednesday night.
Jose Mourinho was granted a reprieve as Willian's free-kick earned a 2-1 Champions League Group G victory over Dynamo Kiev at Stamford Bridge.
Miralem Pjanic's late penalty allowed Roma to edge a resilient Bayer Leverkusen 3-2 on Wednesday and keep their hopes of qualifying for the knockout stages of the Champions League alive.
Neymar struck twice as Barcelona moved ever closer towards a place in the knockout stages of the Champions League with a 3-0 win over Group E rivals BATE Borisov.
Two second-half strikes from substitute Felipe Pardo inspired Olympiakos to a 2-1 victory over 10-man Dinamo Zagreb, sending the hosts six points clear of third-placed Arsenal in Champions League Group F.
Porto moved closer to booking their place in the last 16 of the UEFA Champions League with a 3-1 win over Maccabi Tel Aviv in Israel.
Artem Dzyuba scored twice as Zenit St. Petersburg sealed their place in the Champions League knockout stages with a 2-0 win over Lyon in France.
Sven Kums' second-half penalty was enough for Gent to down Valencia in Belgium on Wednesday night and earn the hosts an historic first win in the Champions League.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.
Mohamed Salah scored twice as Liverpool cruised to a 4-0 win over Red Star Belgrade in Champions League Group C action on Wednesday night.
Barcelona came through their first test without the injured Lionel Messi, earning a convincing 2-0 win at home to Inter Milan to take control of Champions League Group B on Wednesday.
Porto recovered from a shaky start to beat Lokomotiv Moscow 3-1 on Wednesday, with Mexico internationals Hector Herrera and Jesus Corona on the scoresheet.
Galatasaray missed the chance to overtake Schalke in the Champions League Group D standings as they were held to a 0-0 draw by the German side on Wednesday.
Big-spending Paris Saint-Germain avoided a defeat that could have derailed their Champions League campaign when Angel Di Maria curled in a delightful stoppage-time equaliser to rescue a 2-2 draw at home to Napoli on Wednesday.
Borussia Dortmund cruised past Atletico Madrid 4-0 in their Champions League match on Wednesday with two goals from substitute Raphael Guerreiro helping propel them to the top of Group A.
Monaco earned the first point of their disappointing Champions League campaign on Wednesday in their first European outing under Thierry Henry but their 1-1 draw at Club Brugge still left both sides with little chance of making the knockout stages.
Captain Luuk de Jong struck a late equaliser for PSV Eindhoven as they drew 2-2 with Tottenham Hotspur on Wednesday, a result that did little for either side's Champions League ambitions.
An impressive Juventus beat Manchester United 1-0 at Old Trafford on Tuesday to take command of Champions League Group H with a maximum nine points from three games and demonstrate just how far Jose Mourinho's side are from Europe's elite.
Manchester City began to pull their weight like proper Champions League heavyweights when they became the first English team to win at Shakhtar Donetsk in European competition with a 3-0 win in their group F match in Kharkiv on Tuesday.
Hoffenheim's Joelinton scored in stoppage time to give the German club a dramatic 3-3 draw against Olympique Lyon in a rollecoaster Champions League Group F match on Tuesday.
AS Roma's Edin Dzeko drew level with Barcelona's Lionel Messi at the top of this season's Champions League scoring charts as the Italians set the pace in Group G with a 3-0 win over CSKA Moscow at the Stadio Olimpico on Tuesday.
Real Madrid held onto a 2-1 win over Viktoria Plzen in Champions League Group G action on Tuesday.
Noussair Mazraoui scored an injury-time winner as Ajax claimed what could be a vital 1-0 win over Benfica in their Champions League Group E clash at the Johan Cruyff Arena on Tuesday.
Champions League debutants Young Boys scored their first goal and picked up their first ever point in the competition with a deserved 1-1 draw at home to Valencia on Tuesday.