Barcelona will face Atletico Madrid in the Champions League quarterfinal draw, while Paris Saint-Germain will take on Manchester City.
Arsenal could not make the impossible possible on Wednesday night as Barcelona's renowned triumvirate all scored to knock the Gunners out of the Champions League at the Nou Camp.
Pep Guardiola's Bayern Munich completed an impressive Champions League comeback over 120 minutes to reach the quarter-finals at the expense of Juventus.
Atletico Madrid came through a tense penalty shootout to advance past PSV Eindhoven in their Champions League last-16 encounter.
Manchester City lost defenders Vincent Kompany and Nicolas Otamendi to injury as they limped into the Champions League quarterfinals after a dull goalless draw against Dynamo Kiev.
Zlatan Ibrahimovic sent Chelsea of the Champions League as Paris Saint-Germain claimed a 2-1 round-of-16 second-leg win at Stamford Bridge.
Late goals from Nicolas Gaitan and Talisca sent Benfica into the Champions League quarterfinals following a 3-1 aggregate victory over Zenit St Petersburg.
Real Madrid made Roma pay for wasted opportunities as they secured a place in the quarter-finals of the Champions League for the sixth season in a row with a 2-0 win at the Bernabeu.
Wolfsburg booked their expected place in the quarter-finals of the Champions League for the first time in their history as Andre Schurrle's late goal earned them an unconvincing 1-0 home win over Gent.
Manchester City produced one of their best performances of the season to seize the advantage in their Champions League last-16 tie with a superb 3-1 win at Dynamo Kiev.
PSV Eindhoven survived the dismissal of Gaston Pereiro to hold Atletico Madrid to a goalless Champions League draw at the Philips Stadion.
Barcelona took the advantage over Arsenal in their round of 16 clash at the Emirates on Tuesday night as they won 2-0 thanks to two goals from Lionel Messi.
Juventus came from two goals down to earn a 2-2 draw in the first leg of their Champions League last-16 tie with Bayern Munich.
Real Madrid beat Roma 2-0 in their Champions League last-16 first leg at the Stadio Olimpico, with away goals from Cristiano Ronaldo and Jese giving them the upper hand.
Gent gave themselves a Champions League lifeline with two late goals in a 3-2 home defeat against Wolfsburg.
Zlatan Ibrahimovic and Edinson Cavani scored as Paris Saint-Germain took a 2-1 advantage over Chelsea in the first leg of their Champions League last-16 clash on Tuesday.
Benfica have a slender 1-0 advantage over Zenit St Petersburg after Oliveira Jonas' injury-time goal at the Estadio da Luz.
Barcelona and Argentina star Lionel Messi was awarded the 2015 Ballon d'Or at Monday's gala event in Zurich.
With four players each from Barcelona and Real Madrid, the Spanish giants combined to put eight players on the 2015 FIFPro World XI.
The highlight of the Champions League last-16 draw sees Arsenal take on Barcelona and Juventus take on Bayern Munich.
Jose Mourinho received a slice of luck and another reprieve as Chelsea advanced to the knockout stages of the Champions League as Group G winners with a 2-0 victory over his former club Porto.
Olivier Giroud inspired Arsenal to complete a Champions League group stage comeback as his hat trick at Olympiakos sealed their place in the last 16.
Bayer Leverkusen could not find a winner against Barcelona as their final Champions League Group E match ended 1-1, which saw the German side fail to qualify for the last 16 and drop into the Europa League.
Robert Lewandowski notched a quickfire brace as Bayern Munich rounded off their Champions League Group F fixtures with a 2-0 win at Dinamo Zagreb.
Gent beat Group H winners Zenit St Petersburg 2-1 at Ghelamco Arena to become the first Belgian club to get through to the knockout stages of the Champions League in 15 years.
Gary Neville watched his Valencia team slide into the Europa League after his Mestalla debut saw Lyon claim a 2-0 Champions League victory.
Denys Garmash's goal was enough to give Dynamo Kiev a 1-0 win over Maccabi Tel Aviv and send them through to the knockout stages of the Champions League.
Roma squeezed through to the Champions League last 16 after being held to a 0-0 draw at home by BATE Borisov in their final Group E game.
CSKA Moscow were unable to pull off a shock win over PSV Eindhoven, and United now face the prospect of playing Europa League football in the new year.
Sevilla will try to defend their Europa League crown after a 1-0 home win over Juventus secured them third place in Champions League Group D.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.
Mohamed Salah scored twice as Liverpool cruised to a 4-0 win over Red Star Belgrade in Champions League Group C action on Wednesday night.
Barcelona came through their first test without the injured Lionel Messi, earning a convincing 2-0 win at home to Inter Milan to take control of Champions League Group B on Wednesday.
Porto recovered from a shaky start to beat Lokomotiv Moscow 3-1 on Wednesday, with Mexico internationals Hector Herrera and Jesus Corona on the scoresheet.
Galatasaray missed the chance to overtake Schalke in the Champions League Group D standings as they were held to a 0-0 draw by the German side on Wednesday.
Big-spending Paris Saint-Germain avoided a defeat that could have derailed their Champions League campaign when Angel Di Maria curled in a delightful stoppage-time equaliser to rescue a 2-2 draw at home to Napoli on Wednesday.
Borussia Dortmund cruised past Atletico Madrid 4-0 in their Champions League match on Wednesday with two goals from substitute Raphael Guerreiro helping propel them to the top of Group A.
Monaco earned the first point of their disappointing Champions League campaign on Wednesday in their first European outing under Thierry Henry but their 1-1 draw at Club Brugge still left both sides with little chance of making the knockout stages.
Captain Luuk de Jong struck a late equaliser for PSV Eindhoven as they drew 2-2 with Tottenham Hotspur on Wednesday, a result that did little for either side's Champions League ambitions.
An impressive Juventus beat Manchester United 1-0 at Old Trafford on Tuesday to take command of Champions League Group H with a maximum nine points from three games and demonstrate just how far Jose Mourinho's side are from Europe's elite.
Manchester City began to pull their weight like proper Champions League heavyweights when they became the first English team to win at Shakhtar Donetsk in European competition with a 3-0 win in their group F match in Kharkiv on Tuesday.
Hoffenheim's Joelinton scored in stoppage time to give the German club a dramatic 3-3 draw against Olympique Lyon in a rollecoaster Champions League Group F match on Tuesday.
AS Roma's Edin Dzeko drew level with Barcelona's Lionel Messi at the top of this season's Champions League scoring charts as the Italians set the pace in Group G with a 3-0 win over CSKA Moscow at the Stadio Olimpico on Tuesday.
Real Madrid held onto a 2-1 win over Viktoria Plzen in Champions League Group G action on Tuesday.
Noussair Mazraoui scored an injury-time winner as Ajax claimed what could be a vital 1-0 win over Benfica in their Champions League Group E clash at the Johan Cruyff Arena on Tuesday.
Champions League debutants Young Boys scored their first goal and picked up their first ever point in the competition with a deserved 1-1 draw at home to Valencia on Tuesday.