Islam Slimani scored for both teams to top and tail a thrilling Champions League clash as Sporting Lisbon beat Schalke 4-2.
Fernandinho and Yaya Toure were sent off as Manchester City crashed to a damaging 2-1 home defeat to CSKA Moscow in the Champions League.
Arsenal spurned the chance to book their place in the Champions League knockout stages as they threw away a three-goal lead to draw 3-3 with Anderlecht.
Predictions of a rout proved to be well wide the mark as Liverpool's weakened side produced a disciplined if not ultimately successful performance at the Bernabeu.
Juventus just about edged a topsy-turvy Group A encounter with Olympiakos to put themselves in a strong position to qualify for the knockout stages of the Champions League.
Atletico Madrid moved ever closer towards a place in the knockout stages of the Champions League with a 2-0 win at Group A rivals Malmo on Tuesday night.
Borussia Dortmund put their domestic troubles to one side to book their place in the knock-out stages of the Champions League with a comfortable 4-1 win over Galatasaray marred by some ugly scenes in the stands.
Taslica scored a valuable goal to give Benfica their first win in Champions League Group C as they claimed a hard fought 1-0 victory over Monaco on Tuesday night.
A second-half double from Son Heung-min earned Bayer Leverkusen an impressive 2-1 win at Zenit St Petersburg which put them on the brink of the Champions League knockout stage.
Real Madrid showed exactly why they are European champions and how far Liverpool have fallen down the pecking order with a 3-0 victory in a display which oozed class at Anfield.
Substitute Lukas Podolski netted a dramatic late winner as Arsenal came from behind with two goals in the final two minutes to beat Anderlecht 2-1.
A Koke-inspired Atletico Madrid scored five second-half goals in a comprehensive victory over Malmo to go top of Champions League Group A on Wednesday.
Olympiakos edged Juventus 1-0 on Wednesday night in Piraeus after a first-half goal from Pajtim Kasami.
Borussia Dortmund maintained their perfect start to their Champions League campaign with a comprehensive 4-0 victory over Galatasaray in Group D.
Bayer Leverkusen boosted their hopes of advancing from Champions League Group C on Wednesday night with a 2-0 victory over previously unbeaten Zenit St Petersburg.
Monaco and Benfica played out a goalless Champions League Group C draw at the Stade Louis II on Wednesday.
Yordan Minev's last-gasp strike lifted Ludogorets to a famous Champions League victory over 10-man Basle.
Bayern Munich struck five times in the first half en route to a 7-1 demolition of hosts Roma on Tuesday to make it three wins out of three in Group E of the Champions League.
Lionel Messi drew level with fierce rival Cristiano Ronaldo in the race to become the Champions League's all-time top goalscorer as Barcelona warmed up for El Clasico with a 3-1 victory over Ajax.
Eric Maxim Choupo-Moting scored a 92nd-minute penalty to earn Schalke a 4-3 win after they had surrendered a two-goal lead at home to 10-man Sporting Lisbon on Tuesday night.
Shakhtar Donetsk's Luiz Adriano became the first player to score four goals in the first half of a Champions League game when he netted against Belarusian minnows BATE Borisov on Tuesday night -- with the game 6-0 at half-time.
Didier Drogba scored his first Chelsea goal since his decisive strike in the 2012 Champions League final as the Premier League leaders thrashed Maribor 6-0 at Stamford Bridge to strengthen their position at the top of Group G.
Edinson Cavani handed Paris St Germain a dramatic late 1-0 victory in Cyprus as APOEL were denied a hard-earned point.
Manchester City surrendered a two-goal lead as they again stuttered on the Champions League stage, drawing 2-2 amid more controversy at CSKA Moscow.
Substitute Adrian Ramos ensured Borussia Dortmund maintained a perfect start to their Champions League Group D campaign by sealing victory at Anderlecht.
Bayer Leverkusen turned in an impressive performance to open their account in Champions League Group C and leave Benfica staring an early exit in the face.
Real Madrid avoided the embarrassment of losing to minnows Ludogorets in the Champions League on Wednesday night.
Liverpool became the latest big-name English scalp to be claimed by Basel who capitalised on the Reds' well-known vulnerability at set-pieces.
Markus Rosenberg's brace gave Malmo a famous 2-0 victory over Olympiacos in their Champions League Group Group A encounter at Swedbank Stadion on Wednesday.
Arda Turan struck in the second half to inflict Juventus' first defeat of the season and get Atletico Madrid's Champions League Group A campaign up and running on Wednesday evening.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.
Mohamed Salah scored twice as Liverpool cruised to a 4-0 win over Red Star Belgrade in Champions League Group C action on Wednesday night.
Barcelona came through their first test without the injured Lionel Messi, earning a convincing 2-0 win at home to Inter Milan to take control of Champions League Group B on Wednesday.
Porto recovered from a shaky start to beat Lokomotiv Moscow 3-1 on Wednesday, with Mexico internationals Hector Herrera and Jesus Corona on the scoresheet.
Galatasaray missed the chance to overtake Schalke in the Champions League Group D standings as they were held to a 0-0 draw by the German side on Wednesday.
Big-spending Paris Saint-Germain avoided a defeat that could have derailed their Champions League campaign when Angel Di Maria curled in a delightful stoppage-time equaliser to rescue a 2-2 draw at home to Napoli on Wednesday.
Borussia Dortmund cruised past Atletico Madrid 4-0 in their Champions League match on Wednesday with two goals from substitute Raphael Guerreiro helping propel them to the top of Group A.
Monaco earned the first point of their disappointing Champions League campaign on Wednesday in their first European outing under Thierry Henry but their 1-1 draw at Club Brugge still left both sides with little chance of making the knockout stages.
Captain Luuk de Jong struck a late equaliser for PSV Eindhoven as they drew 2-2 with Tottenham Hotspur on Wednesday, a result that did little for either side's Champions League ambitions.
An impressive Juventus beat Manchester United 1-0 at Old Trafford on Tuesday to take command of Champions League Group H with a maximum nine points from three games and demonstrate just how far Jose Mourinho's side are from Europe's elite.
Manchester City began to pull their weight like proper Champions League heavyweights when they became the first English team to win at Shakhtar Donetsk in European competition with a 3-0 win in their group F match in Kharkiv on Tuesday.
Hoffenheim's Joelinton scored in stoppage time to give the German club a dramatic 3-3 draw against Olympique Lyon in a rollecoaster Champions League Group F match on Tuesday.
AS Roma's Edin Dzeko drew level with Barcelona's Lionel Messi at the top of this season's Champions League scoring charts as the Italians set the pace in Group G with a 3-0 win over CSKA Moscow at the Stadio Olimpico on Tuesday.
Real Madrid held onto a 2-1 win over Viktoria Plzen in Champions League Group G action on Tuesday.
Noussair Mazraoui scored an injury-time winner as Ajax claimed what could be a vital 1-0 win over Benfica in their Champions League Group E clash at the Johan Cruyff Arena on Tuesday.
Champions League debutants Young Boys scored their first goal and picked up their first ever point in the competition with a deserved 1-1 draw at home to Valencia on Tuesday.