Atletico Madrid have a mountain to climb if they are to qualify for the Champions League quarterfinals after they endured a night to forget at Bayer Leverkusen.
Juventus claimed a 2-1 advantage after the first leg of their Champions League last-16 tie against Borussia Dortmund.
Luis Suarez struck twice on his return to England as Barcelona taught Manchester City another Champions League lesson with a 2-1 win at the Etihad Stadium.
Cristiano Ronaldo returned to goal-scoring form and Marcelo was also on target as holders Real Madrid opened their Champions League last-16 tie with a 2-0 win at Schalke.
Danilo was on target with a second-half penalty as Porto struck back for a 1-1 draw against Basel in the last-16 first-leg Champions League clash at St. Jakob-Park on Wednesday evening.
Stubborn resistance and a Branislav Ivanovic header earned Chelsea a 1-1 draw in the Champions League last-16 first leg with Paris St Germain at Parc des Princes.
Xabi Alonso saw his 100th Champions League appearance ended prematurely, although his red card did not cost Bayern Munich as they secured a goalless draw against Shakhtar Donetsk.
Cristiano Ronaldo is officially the world's best player for the second straight year, as he received the 2014 Ballon d'Or on Monday night.
All three players shortlisted for the FIFA Ballon d'Or award were selected by their peers for the 2014 FIFPro World XI team.
Germany manager Joachim Low wins FIFA World Coach of the Year award after leading the team to the World Cup in Brazil in 2014.
Real Madrid landed their fourth title of the year by recording their 22nd straight victory to win the Club World Cup.
Manchester City will face Barcelona in the last 16 of the Champions League for a second year running following Monday's draw at UEFA's headquarters in Nyon, Switzerland.
Samir Nasri and Pablo Zabaleta struck in the second half as Manchester City reached the Champions League knockout stage with a brilliant 2-0 win at Roma.
Barcelona avenged their September defeat in the French capital by beating Paris St Germain 3-1 at Camp Nou to claim top spot in Champions League Group F.
CSKA Moscow's Champions League and indeed their European campaign ended with a 3-0 defeat to Group E winners Bayern Munich.
Serious Champions League business begins for Chelsea in February after Jose Mourinho's men completed their unbeaten Group G campaign with a 3-1 win over Sporting Lisbon.
Max Meyer secured Schalke's progression to the last 16 of the Champions League as his goal sealed a 1-0 win at Maribor in Group G on Wednesday night.
Athletic Bilbao secured a place in the Europa League after two second-half goals saw them home 2-0 against Champions League Group H opponents BATE Borisov at San Mames.
Lasse Schone scored a double as Ajax booked their place in the Europa League with a comprehensive 4-0 win over APOEL Nicosia in Champions League Group F on Wednesday night.
Champions League qualifiers FC Porto and Shakhtar Donetsk shared the spoils with a 1-1 draw in Portugal after their progress to the competition's last-16 had already been secured.
A goalless draw with Atletico Madrid in Turin was enough to secure Juventus their progression to the last 16 of the Champions League.
Olympiakos failed to qualify for the Champions League last 16 despite a 4-2 Group A victory over Malmo at the Karaiskakis Stadium.
Cristiano Ronaldo surpassed Raul's Champions League goals haul as Real Madrid thumped Ludogorets 4-0 to complete a flawless Group B campaign.
Monaco clawed their way to the Champions League's last 16 by overhauling Bayer Leverkusen to top Group C with a gritty 2-0 victory over Zenit St Petersburg.
Bayer Leverkusen had to settle for second place in Champions League Group C after they were held to a goalless draw by Benfica in Portugal.
Ciro Immobile's second-half goal was enough to make sure Borussia Dortmund finished top of Group D following a 1-1 Champions League draw against Anderlecht at the Westfalenstadion.
Arsenal produced the perfect response to silence their critics with a 4-1 Champions League win over Galatasaray in Istanbul, where Aaron Ramsey scored one of the goals of the season.
Ten-man Liverpool were masters of their own downfall as they exited the Champions League after coming up short in their must-win encounter at home to Basel.
Juventus ended their away day blues to reignite their chances of progressing from Group A of the Champions League with a 2-0 win over Malmo.
Mario Mandzukic's hat trick in a 4-0 win over Olympiakos saw Atletico Madrid qualify in emphatic style for the Champions League round of 16.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.
Willian scored twice and was fouled for two penalties as Chelsea cruised into the Champions League knockout stages with a 4-0 win over 10-man Qarabag at the Olympic Stadium in Baku.
Antoine Griezmann's stunning goal kept Atletico Madrid's Champions League hopes alive as they grabbed a vital victory over Roma.
Celtic suffered another night of European anguish against Paris St Germain in a 7-1 thrashing in the Parc des Princes.
Raheem Sterling struck a late winner as Manchester City secured top spot in Champions League Group F with a 1-0 win over Feyenoord.
Cristiano Ronaldo set another Champions League record as holders Real Madrid sealed their place in the knockout stages with a comprehensive victory against Apoel Nicosia.
Lorenzo Insigne's magical strike broke Shakhtar Donetsk's defences and Napoli went on to a 3-0 win, which gives them hope of Champions League progress.
Liverpool squandered a three-goal half-time lead to throw away the chance of early Champions League qualification as Sevilla netted a 93rd-minute equaliser in Spain.
Son Heung-Min proved the scourge of Borussia Dortmund again as his late winner ensured Tottenham will go through to the Champions League round of 16 as group winners.