Manchester City secured their place in the last 16 of the Champions League as they came from behind to claim a 1-1 draw at Borussia Monchengladbach.
Celtic were knocked out of Europe as a Lionel Messi double gave Barcelona a 2-0 Champions League win at Parkhead.
Napoli failed to open up a lead at the top of Champions League Group B as Dynamo Kiev held them to a goalless draw at the Stadio San Paolo.
Besiktas produced a stunning comeback to keep their Champions League hopes alive with a 3-3 home draw against Benfica.
Ludogorets' and Basel's battle to get out of the Champions League basement and into the Europa League will go to the sixth matchday after the teams could not be separated in Bulgaria.
Arsenal passed up the opportunity to assure themselves of qualifying for the knockout stages of the Champions League as group winners after being held to an entertaining draw at home to Paris Saint-Germain.
Hugo Lloris' penalty heroics could not rescue Tottenham's Champions League campaign as Mauricio Pochettino's men slipped to a 2-1 defeat against Monaco.
Borussia Dortmund and Legia Warsaw created Champions League history as the German side maintained their 100 percent record with a stunning 8-4 victory at a rain-soaked Signal Iduna Park.
Substitute Karim Benzema headed a late winner as holders Real Madrid secured their place in the knockout stages of the Champions League with a 2-1 victory over 10-man Sporting Lisbon at Estadio Jose Alvalade.
Late goals from Leonardo Bonucci and Mario Mandzukic saw Juventus seal their place in the Champions League knockout stages with a 3-1 win over 10-man Sevilla at the Ramon Sanchez Pizjuan.
Leicester booked their place in the knockout stages of the Champions League after surviving a second-half rally to beat Club Brugge 2-1.
Copenhagen held on despite a dominant second-half showing from Porto to record a goalless draw in their Champions League Group G clash at Telia Parken.
Lyon kept alive their hopes of reaching the Champions League knockout stages after easing to a 1-0 win over eliminated Dinamo Zagreb in Croatia.
Bayer Leverkusen are on the verge of qualifying for the Champions League knockout stages after a 1-1 draw away to CSKA Moscow on Tuesday.
Juventus will have to wait to book their place in the last 16 of the Champions League after a late Lyon goal denied them victory in Turin.
Borussia Dortmund booked their place in the knockout stages of the Champions League, despite suspending star striker Pierre-Emerick Aubameyang ahead of the 1-0 Group F win over Sporting Lisbon.
Tottenham's Wembley curse struck again as Mauricio Pochettino's men slipped to a 1-0 defeat against Bayer Leverkusen in the Champions League.
Sevilla thrashed 10-man Dinamo Zagreb 4-0 to go top of Group H and put one foot in the round of 16.
Porto moved up to second in Champions League Group G with a 1-0 home victory over Club Brugge.
Leicester missed the chance to seal qualification to the knockout stages of the Champions League after a forgettable 0-0 draw in Copenhagen.
Gareth Bale scored Real Madrid's fastest-ever goal in Champions League play but Los Blancos dropped points in an entertaining 3-3 group stage draw with Legia Warsaw behind closed doors at the Pepsi Arena on Wednesday.
Radamel Falcao scored his first Champions League goals for Monaco as they comfortably defeated CSKA Moscow 3-0 at the Stade Louis II.
Manchester City produced an outstanding second-half performance to sweep past Barcelona 3-1 at the Etihad Stadium.
A late Mesut Ozil strike saw Arsenal come from two goals down to beat Ludogorets and book a place in the round of 16 of the Champions League.
Thomas Meunier volleyed home a stunning late winner as Paris Saint-Germain guaranteed their place in the last 16 of the Champions League with a dramatic 2-1 win over Basel.
Robert Lewandowski scored twice as Bayern Munich came from behind to beat PSV Eindhoven 2-1 at Philips Stadion and secure their place in the knockout stages of the Champions League.
Antoine Griezmann grabbed a stoppage-time winner as Atletico Madrid maintained their 100 per cent record in Champions League Group D with a 2-1 win over Rostov at the Vicente Calderon Stadium.
Moussa Dembele's second-half penalty gave Celtic a 1-1 draw at Borussia Monchengladbach on Tuesday to keep their Champions League hopes alive.
Eduardo Salvio's cool first-half penalty was enough to earn Benfica a valuable 1-0 win in their Champions League Group B clash with Dynamo Kiev at the Estadio da Luz.
A brilliant late goal from Napoli captain Marek Hamsik secured a 1-1 draw at Besiktas to keep the Italians a point ahead of their opponents in Champions League Group B.
Bayern Munich look assured of a Champions League quarterfinal spot for a seventh straight season after thrashing 10-man Besiktas 5-0 in Germany.
Lionel Messi broke his goal duck against Chelsea to deny Antonio Conte's side a crucial lead over Barcelona in their Champions League showdown.
Sadio Mane scored a hat trick and Mohamed Salah continued his phenomenal run with a 30th goal of the season as Liverpool won 5-0 at Porto to virtually assure themselves a Champions League quarterfinal place.
Cristiano Ronaldo scored twice and Marcelo got another as Real Madrid came from a goal down to take a 3-1 lead over Paris Saint-Germain in the first leg of their Champions League clash at the Bernabeu.
Ilkay Gundogan scored twice as Manchester City put one foot in the Champions League quarterfinals with an emphatic 4-0 win over Basel.
Christian Eriksen completed a remarkable Tottenham comeback as they rallied from two down to draw with Juventus in the Champions League last 16.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.
Willian scored twice and was fouled for two penalties as Chelsea cruised into the Champions League knockout stages with a 4-0 win over 10-man Qarabag at the Olympic Stadium in Baku.
Antoine Griezmann's stunning goal kept Atletico Madrid's Champions League hopes alive as they grabbed a vital victory over Roma.