Arsenal will have to produce something special to reach a first Champions League quarterfinal since 2010 after suffering a 5-1 defeat to a rampant Bayern Munich side in the first leg of their round-of-16 tie at the Allianz Arena.
Two goals from Angel Di Maria and one apiece from Julian Draxler and Edinson Cavani gave Paris Saint-Germain an unexpected and potentially unassailable 4-0 lead against Barcelona in their Champions League round of 16 first leg tie.
Kostas Mitroglou scored the only goal of the game as Benfica took advantage of Pierre-Emerick Aubameyang's off day to grab control of their Champions League last-16 tie against Borussia Dortmund in Lisbon.
Cristiano Ronaldo scored a hat trick as Real Madrid claimed their second Club World Cup title in three years, but the Spanish giants needed extra time to see off the spirited Kashima Antlers 4-2 in Yokohama.
Arsenal have been drawn against Bayern Munich in the Champions League's round of 16, while Barcelona will take on Paris Saint-Germain.
Real Madrid's Cristiano Ronaldo won the Ballon d'Or for a fourth time on Monday night, beating Barcelona's Lionel Messi and Atletico Madrid's Antoine Griezmann to world football's top individual prize for 2016.
Sevilla qualified for the last 16 of the Champions League after holding Lyon to a goalless draw.
Legia Warsaw secured a place in the Europa League at the expense of 10-man Sporting Lisbon after a 1-0 Champions League Group F win at the Polish Army Stadium.
FC Copenhagen ended their Champions League Group G with a 2-0 victory over Club Brugge but Porto's thumping win over Leicester condemned them to the Europa League.
Bayer Leverkusen inflicted a first defeat in 10 matches on Monaco in their Champions League Group E match on Wednesday.
Woeful Leicester lost their unbeaten Champions League record as a second string side suffered a humiliating 5-0 thumping in Porto.
Tottenham's winless Wembley run is over but their Europa League campaign has just begun after Mauricio Pochettino's men sealed a 3-1 win over CSKA Moscow.
Gonzalo Higuain's stunning strike saw Juventus finish on top of Champions League Group H as they beat Dinamo Zagreb 2-0 in Turin.
Real Madrid squandered a two-goal lead and with it top spot in Group F as record-breaking Borussia Dortmund fought back to draw 2-2 late on at the Bernabeu.
Napoli secured top spot in Group B with a 2-1 victory at Benfica as both sides progressed into the knockout stages of the Champions League.
Rostov battled to a goalless draw in their final Champions League Group D fixture away at PSV Eindhoven, which was enough for the Russians to reach the Europa League.
Robert Lewandowski's first-half free kick proved enough to give Bayern Munich a 1-0 win over Atletico Madrid at the Allianz Arena and end the Spanish side's hopes of finishing their Champions League Group D campaign with six wins from six.
Patrick Roberts scored against his parent club as Celtic held Manchester City to a 1-1 draw in their final Champions League Group C game.
Arda Turan scored a second-half hat-trick as Barcelona took out their domestic frustrations on Borussia Monchengladbach with a 4-0 mauling at the Nou Camp.
Paris Saint-Germain missed out on the chance to top Champions League Group A as they were held to a 2-2 draw by Ludogorets.
Lucas Perez scored a hat trick as Arsenal beat Basel 4-1 in the Champions League to top Group A ahead of Paris Saint-Germain.
Dynamo Kiev crashed out of the Champions League on a high after crushing nine-man Besiktas 6-0 at the Olympic Stadium.
Rostov went toe to toe with Bayern Munich and emerged with a shock 3-2 victory thanks to Christian Noboa's decisive free-kick.
Kevin Gameiro and Antoine Griezmann scored the goals as Atletico Madrid locked down top spot in Champions League Group D with victory over PSV Eindhoven.
Manchester City secured their place in the last 16 of the Champions League as they came from behind to claim a 1-1 draw at Borussia Monchengladbach.
Celtic were knocked out of Europe as a Lionel Messi double gave Barcelona a 2-0 Champions League win at Parkhead.
Napoli failed to open up a lead at the top of Champions League Group B as Dynamo Kiev held them to a goalless draw at the Stadio San Paolo.
Besiktas produced a stunning comeback to keep their Champions League hopes alive with a 3-3 home draw against Benfica.
Ludogorets' and Basel's battle to get out of the Champions League basement and into the Europa League will go to the sixth matchday after the teams could not be separated in Bulgaria.
Arsenal passed up the opportunity to assure themselves of qualifying for the knockout stages of the Champions League as group winners after being held to an entertaining draw at home to Paris Saint-Germain.
Cristiano Ronaldo scored from a free kick to help Real Madrid beat Gremio 1-0 and claim the Club World Cup in Saturday's final in Abu Dhabi.
Gareth Bale was the surprise hero as Real Madrid survived a shock against outsiders Al Jazira to win 2-1 in Wednesday's extra dramatic Club World Cup semifinal in Abu Dhabi.
Reigning champions Real Madrid will face Paris Saint-Germain in the Champions League round of 16, while Chelsea take on Barcelona.
Real Madrid star Cristiano Ronaldo won the fifth Ballon d'Or of his career on Thursday, matching Lionel Messi as the most-awarded winner of one of the sport's top individual honours.
A scintillating display of football from Liverpool's Fab Four saw Jurgen Klopp's side blaze their way into the Champions League knockout phase with a 7-0 victory over Spartak Moscow.
Manchester City slumped to their first defeat of the season with a 2-1 loss to Shakhtar Donetsk in their final Champions League Group F game.
Fernando Llorente and Georges-Kevin Nkoudou scored their first goals for Tottenham goal as Spurs strolled into the Champions League round of 16 by beating Apoel Nicosia.
Cristiano Ronaldo became the first player to score in every Champions League group stage match as Real Madrid beat Borussia Dortmund 3-2 at the Bernabeu.
Feyenoord finally secured their first points in Champions League Group F, rallying from a goal down to beat Napoli 2-1 on Wednesday, costing the Serie A side a spot in the round of 16.
Sevilla qualified for the round of 16 of the Champions League with a 1-1 draw at Maribor on Wednesday.
Ten-man Porto advanced out of Group G with a 5-2 defeat of a disappointing Monaco side, who also went down a man at the Estadio do Dragao.
RB Leipzig's Champions League debut ended in a 2-1 home loss to Group G winner Besiktas on Wednesday.
Bayern Munich got a little payback against Paris Saint-Germain with a 3-1 win at the Allianz Arena on Tuesday night in Group B.
Juventus secured their place in the round of 16 of the Champions League with a 2-0 victory against Olympiakos in Greece.
Barcelona completed their Champions League Group D campaign with a 2-0 win over Sporting Lisbon at the Camp Nou.
Manchester United came from behind to beat CSKA Moscow and top their Champions League group as Jose Mourinho's men took their unbeaten home run to a club record-equalling 40th match.
Chelsea missed a chance to finish top of Champions League Group C after a 1-1 draw at home to Atletico Madrid, who will settle for a Europa League spot.
Roma progressed to the Champions League knockout stage as Group C winners after beating Qarabag 1-0 on Tuesday.
Celtic will be playing European football after Christmas despite a 1-0 Champions League defeat by Anderlecht at Parkhead.
Lionel Messi started on the bench as Barcelona secured their passage into the round of 16 of the Champions League with a 0-0 draw at Juventus.
Corentin Tolisso set up one goal and scored another to give Bayern Munich a 2-1 win over Anderlecht on Wednesday in Group B of the Champions League.
Manchester United were denied a place in the Champions League knockout phase as Michael Lang's late strike secured Basel a memorable, and deserved, victory.
Willian scored twice and was fouled for two penalties as Chelsea cruised into the Champions League knockout stages with a 4-0 win over 10-man Qarabag at the Olympic Stadium in Baku.
Antoine Griezmann's stunning goal kept Atletico Madrid's Champions League hopes alive as they grabbed a vital victory over Roma.
Celtic suffered another night of European anguish against Paris St Germain in a 7-1 thrashing in the Parc des Princes.
Raheem Sterling struck a late winner as Manchester City secured top spot in Champions League Group F with a 1-0 win over Feyenoord.
Cristiano Ronaldo set another Champions League record as holders Real Madrid sealed their place in the knockout stages with a comprehensive victory against Apoel Nicosia.
Lorenzo Insigne's magical strike broke Shakhtar Donetsk's defences and Napoli went on to a 3-0 win, which gives them hope of Champions League progress.
Liverpool squandered a three-goal half-time lead to throw away the chance of early Champions League qualification as Sevilla netted a 93rd-minute equaliser in Spain.
Son Heung-Min proved the scourge of Borussia Dortmund again as his late winner ensured Tottenham will go through to the Champions League round of 16 as group winners.