Toothless Southampton missed the chance for a best European run since 1977 after Israeli minnows Hapoel Be'er Sheva drew 1-1 at St Mary's to knock them out of the Europa League.
Fine goals by Henrikh Mkhitaryan and Zlatan Ibrahimovic gave Manchester United a 2-0 away win over Zorya Luhansk and booked their place in the Europa League knockout stages as group runners-up.
Wayne Rooney became Manchester United's all-time leading scorer in Europe as Jose Mourinho's side defeated Feyenoord 4-0 to move to the brink of qualifying for the Europa League's last 32.
Southampton's hopes of reaching the Europa League's knockout stages have been left in the balance after a 1-0 defeat at Sparta Prague.
The battle to join Ajax in progressing from Group G of the Europa League will go to the final day as Celta Vigo and Standard Liege drew 1-1.
Substitute Ben Sahar scored an injury-time winner as Hapoel Be'er Sheva came from two goals down to beat 10-man Inter Milan 3-2 and set up a winner-takes-all clash with Southampton.
Wayne Rooney's late long-range strike was not enough to salvage a draw for Manchester United as they lost 2-1 to Fenerbahce in the Europa League.
Edin Dzeko struck twice as Roma beat Europa League rivals Austria Vienna 4-2 at the Ernst Happel Stadium to move top of Group E.
A brace from Giuliano undid Dundalk in Europa League Group D as they went down 2-1 to Zenit St Petersburg in Russia.
Southampton beat Inter Milan 2-1 to secure a famous victory that takes them to the brink of the Europa League's knockout stages.
Paul Pogba scored twice as Manchester United defeated Fenerbahce 4-1 to move to the top of Europa League Group A.
Southampton wasted the chance to take a significant step towards the Europa League's knockout stages with a disappointing 1-0 defeat at Inter Milan.
Alassane Plea's first-half strike handed Nice their first ever European away victory as they secured a 1-0 Europa League win over Salzburg.
Celta Vigo and Ajax shared four goals in an entertaining 2-2 draw to keep themselves at the head of Europa League Group G.
Dundalk tasted bitter disappointment as they went from the verge of an historic victory to defeat against Zenit St Petersburg.
Manchester United laboured to a 1-0 Europa League victory over Zorya Luhansk at Old Trafford as Zlatan Ibrahimovic headed home in the second half to seal the points for the below-par hosts.
Francesco Totti capped a memorable week with three assists as Roma thrashed Astra Giurgiu 4-0 in Group E of the Europa League.
Southampton secured a valuable point in their bid to progress to the Europa League's knockout stages with a 0-0 draw as Hapoel Be'er Sheva continued their extraordinary undefeated record at the Turner Stadium.
Some terrible defensive errors and a sluggish approach saw Inter beaten 3-1 at Sparta Prague in the Europa League, plus Andrea Ranocchia sent off.
An undercooked and underperforming Manchester United started their Europa League campaign with a 1-0 defeat as Tonny Vilhena secured Feyenoord a late victory.
Sassuolo marked their debut in the Europa League with a 3-0 win over seasoned campaigners Athletic Bilbao.
Southampton made a winning start to their Europa League campaign and gave Claude Puel his first win as manager with a convincing 3-0 defeat of Sparta Prague.
Three-time European champions Inter Milan were humbled at home by Hapoel Be'er Sheva in a 2-0 defeat in their Europa League opener on Thursday.
Jairo Riedewald scored the winner as Ajax came from behind to record a 2-1 Europa League victory at Panathinaikos as English referee Andre Marriner showed three red cards.
On-loan defender Baba Rahman scored the only goal as Schalke got their Europa League Group I campaign off to a winning start in Nice.
Manchester United will face Fenerbahce and Feyenoord in Group A in the 2016-17 Europa League.
Premier League side West Ham failed to claim a place in the group stage of the Europa League as they were beaten by Romanian champions Astra Giurgiu.
West Ham suffered more jitters against Astra Giurgiu as they were held to a 1-1 draw in the first leg of their Europa League playoff on Thursday.
West Ham must navigate a trip to Romania if they are to reach the Europa League group stages after being pitted against Astra Giurgiu in the play-off round.
West Ham United marked their first match at the Olympic Stadium with a 3-0 win over Slovenian side NK Domzale on Thursday as Cheikhou Kouyate scored twice to help secure a place in the Europa League playoff round.
Burnley's European adventure came to an end on Friday as the Premier League side crashed out of the Europa League playoff round with a 1-1 draw against Olympiakos.
Celtic were held to a 1-1 draw by Lithuanian side Suduva Marijampole in the first leg of their Europa League play-off at the ARVI Futbolo Arena.
Antoine Griezmann struck twice as Atletico Madrid powered past Marseille to lift their third Europa League title in nine years.
Atletico Madrid advanced to the Europe League final 2-1 on aggregate after a 1-0 victory over Arsenal at the Wanda Metropolitano on Thursday.
Marseille scored a dramatic extra-time decider against Red Bull Salzburg to earn a Europa League final showdown with Atletico Madrid in Lyon on May 16.
If Arsene Wenger's Arsenal finale is to be a Europa League final in Lyon his side will have to do it the hard way after surrendering a well-deserved lead to draw against 10-man Atletico Madrid in the first leg of their semi-final.
Florian Thauvin put Marseille within touching distance of a place in the UEFA Europa League final with a controversial opener as his side beat Red Bull Salzburg 2-0 at the Stade Velodrome.
Arsenal will face Atletico Madrid later this month in their first appearance in the Europa League semifinals since 2000.
Marseille stunned RB Leipzig 4-2 in a thrilling Europa League quarterfinal second leg at the Orange Velodrome on Thursday evening to secure a 5-3 aggregate victory.
Red Bull Salzburg came from behind to earn a stunning 4-1 victory that secured an unlikely Europa League semifinal berth at the expense of Lazio.
Arsenal edged into the semifinals of the Europa League, but only after surviving a major scare as CSKA Moscow threatened a memorable comeback.
Atletico Madrid overcame a scare to see off the challenge of a fired-up Sporting Lisbon and book their place in the semifinals of the Europa League.
Aaron Ramsey and Alexandre Lacazette each scored twice as Mesut Ozil put on a Europa League masterclass to overwhelm CSKA Moscow and all but book Arsenal's place in the semifinals.
Timo Werner pounced in first-half injury time as RB Leipzig edged the first leg of their quarter-final against Marseille.
Two goals in two second-half minutes helped Lazio beat Salzburg 4-2 and take control of their Europa League quarter-final.
Koke scored after 23 seconds to set Atletico Madrid on their way to a routine 2-0 win over Sporting Lisbon in the first leg of their Europa League quarterfinal.
Arsenal will play Russian club CSKA Moscow in the quarterfinals as they look to win the Europa League for the first time and seal a place in next season's Champions League.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Fernando Torres scored twice as Europa League favourites Atletico Madrid hammered Lokomotiv Moscow 5-1 in Russia to advance to the quarterfinal stage.
Valon Berisha scored twice as Salzburg earned a 2-1 win away to Borussia Dortmund in the first leg of their Europa League round-of-16 tie on Thursday.
Arsenal eased to victory over AC Milan to move towards a place in the quarterfinals of the Europa League and end a run of four consecutive defeats in the process.
Atletico Madrid grabbed a sizable advantage over Lokomotiv Moscow by earning a 3-0 victory in the first leg of their Europa League round-of-16 clash on Thursday.
Celtic crashed out of the Europa League in calamitous style with a 3-0 defeat to Zenit St Petersburg in Russia.
Kevin Gameiro scored Atletico Madrid's only goal as a 1-0 win over Copenhagen was enough to advance from the Europa League round of 32 on the back of a big victory last week.
Serie A leaders Napoli were knocked out on away goals despite a 2-0 win away to RB Leipzig on Thursday.
Arsenal survived a major scare to secure their spot in the last 16 of the Europa League despite suffering an embarrassing 2-1 home defeat to Ostersund.
Borussia Dortmund made nervous work of their Europa League second leg against Atalanta in a 1-1 draw that saw the Bundesliga side reach the round of 16 courtesy of a 4-3 aggregate final.
Italian leaders Napoli suffered a surprise 3-1 home defeat at the hands of RB Leipzig as Timo Werner scored twice.
Celtic defeated Zenit St Petersburg 1-0 at Hampden Park in the first leg of their Europa League.
Michy Batshuayi scored twice, including a late winner, to rally Borussia Dortmund to a 3-2 win over Atalanta in their opening game of the Europe League knockout stage.