Napoli cruised to a routine victory over Trabzonspor and confirmed their last-16 place in the Europa League in the process on Thursday night.
Substitute Mario Balotelli continued his penchant for late interventions with an 85th-minute penalty to give Liverpool a slender advantage to take to Istanbul in the last 32 of the Europa League.
Villarreal will take a narrow advantage into the second leg of their Europa League last-32 tie against Salzburg after a 2-1 win in Spain on Thursday night.
Napoli have one foot in the last 16 of the Europa League after claiming an emphatic 4-0 win at Trabzonspor.
Wolfsburg will take a 2-0 lead to Lisbon next week after the Bundesliga high-flyers claimed a comfortable victory over Sporting in the first-leg of their Europa League last-32 clash.
Substitute John Guidetti gave Celtic a dramatic Europa League lifeline with an injury-time leveller to draw 3-3 draw with Inter Milan at Parkhead.
Roberto Soldado's best moment in a Tottenham shirt was quickly followed by one to forget as he unnecessarily gave away the free-kick which allowed Fiorentina to secure a draw and what could prove a decisive away goal in this Europa League tie.
Everton look as good as assured of a place in the last 16 of the Europa League after a fine performance against Young Boys.
Liverpool will begin their Europa League campaign this season with a last-32 clash against Besiktas following Monday's draw at UEFA's headquarters in Nyon, Switzerland.
Substitutes Aaron Hunt and Nicklas Bendtner scored two apiece to inspire Wolfsburg to victory over Europa League Group F opponents FC Krasnodar.
Jose Antonio Reyes was on target as holders Sevilla were made to work to retain their position at the head of Europa League Group G.
Jonathan de Guzman scored a hat-trick as Napoli moved into the top half of Europa League Group I with a comfortable 3-0 home victory over Young Boys.
Manuel Pasqual spared Fiorentina from an embarrassing home defeat to PAOK Salonika by firing home the free-kick that sent the Italians into the Europa League knockout stages.
Everton took a major step towards the knockout stages of the Europa League as goals from Leon Osman, Phil Jagielka and Steven Naismith saw them claim a comfortable 3-0 victory over Lille at Goodison Park.
St Etienne denied Inter Milan the chance to secure their progression to the Europa League knockout stages by holding the Serie A club to a 1-1 draw at Stade Geoffroy-Guichard.
Tottenham continued their march towards the Europa League knock-out stages with victory in Greece, yet their shocking second-half display against Asteras Tripolis will be of major concern to Mauricio Pochettino.
Celtic waste a chance to wrap up qualification to the Europa League knockout stages as they draw 1-1 with Astra Giurgiu in Romania.
Fiorentina maintained their perfect start in Europa League Group K with a 1-0 win away at PAOK Salonika.
Stefan Scepovic scored his first goal for Celtic as the Hoops made hard work of beating Astra Giurgiu 2-1 in their Europa League clash at Parkhead.
Torino's defence once again proved unbeatable in the Europa League as the Italian side claimed a 2-0 win over HJK Helsinki that moves them to the top of Group B.
Villarreal powered on at the top of Europa League Group A with a 4-1 home victory over FC Zurich.
Inter Milan maintained their unbeaten start to Group F but were booed off after being held to a goalless home draw by St Etienne on Thursday evening.
Erik Lamela scored one of the finest goals ever seen at White Hart Lane on a night in which Tottenham's hat trick hero Harry Kane ended the thrashing of Asteras Tripolis in goal.
Everton remain top of Europa League Group H after playing out a 0-0 stalemate at Lille in a game overshadowed by trouble involving Toffees fans in the build-up.
Substitute Stephane Mbia scored in the last minute to salvage a 2-2 draw for 10-man Sevilla at Europa League Group G opponents Rijeka.
Napoli's perfect start to their Europa League campaign continued as Marek Hamsik inspired them to victory over former club Slovan Bratislava at the Stadion Pasienky on Thursday.
Fiorentina made it two wins from as many games to take control of Group K in the Europa League after brushing aside Dinamo Minsk 3-0.
Inter Milan beat Qarabag 2-0 on Thursday evening at the San Siro to open up a four-point lead in Group F of the Europa League.
Wolfsburg were frustrated by an inspired display from Lille goalkeeper Vincent Enyeama and some awful finishing as they were held to a 1-1 draw in their Europa League clash in Germany.
Everton striker Samuel Eto'o marked his return to Russia with a late equaliser as his side snatched a 1-1 draw at FK Krasnodar in Europa League Group H.
Arsenal will play Russian club CSKA Moscow in the quarterfinals as they look to win the Europa League for the first time and seal a place in next season's Champions League.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Fernando Torres scored twice as Europa League favourites Atletico Madrid hammered Lokomotiv Moscow 5-1 in Russia to advance to the quarterfinal stage.
Valon Berisha scored twice as Salzburg earned a 2-1 win away to Borussia Dortmund in the first leg of their Europa League round-of-16 tie on Thursday.
Arsenal eased to victory over AC Milan to move towards a place in the quarterfinals of the Europa League and end a run of four consecutive defeats in the process.
Atletico Madrid grabbed a sizable advantage over Lokomotiv Moscow by earning a 3-0 victory in the first leg of their Europa League round-of-16 clash on Thursday.
Celtic crashed out of the Europa League in calamitous style with a 3-0 defeat to Zenit St Petersburg in Russia.
Kevin Gameiro scored Atletico Madrid's only goal as a 1-0 win over Copenhagen was enough to advance from the Europa League round of 32 on the back of a big victory last week.
Serie A leaders Napoli were knocked out on away goals despite a 2-0 win away to RB Leipzig on Thursday.
Arsenal survived a major scare to secure their spot in the last 16 of the Europa League despite suffering an embarrassing 2-1 home defeat to Ostersund.
Borussia Dortmund made nervous work of their Europa League second leg against Atalanta in a 1-1 draw that saw the Bundesliga side reach the round of 16 courtesy of a 4-3 aggregate final.
Italian leaders Napoli suffered a surprise 3-1 home defeat at the hands of RB Leipzig as Timo Werner scored twice.
Celtic defeated Zenit St Petersburg 1-0 at Hampden Park in the first leg of their Europa League.
Michy Batshuayi scored twice, including a late winner, to rally Borussia Dortmund to a 3-2 win over Atalanta in their opening game of the Europe League knockout stage.
Arsenal made light work of sub-zero temperatures and an artificial pitch to secure a comfortable Europa League victory over Ostersunds.
Patrick Cutrone scored a glancing header and earned a penalty converted by Ricardo Rodriguez as Milan conquered Ludogorets 3-0 in Bulgaria.
Arsenal have been drawn against Swedish club Ostersunds FK in the Europa League round of 32, while Atletico Madrid take on Copenhagen.
Ademola Lookman's brace ensured a youthful Everton side did not miss Sam Allardyce's presence in Cyprus as they finished their woeful Europa League campaign with a victory.
AC Milan concluded their Europa League group stage with a 2-0 defeat at Croatian club Rijeka on Thursday.
Arsenal cruised to victory over BATE Borisov in their final Europa League group game as Arsene Wenger's fringe players made another case for Premier League involvement.
AC Milan booked their place in the Europa League's final 32 with a 5-1 win over Austria Vienna on Thursday night.
Arsenal failed to get the point they needed to guarantee topping Europa League Group H as Cologne beat them 1-0 in Germany -- but they finished first anyway as Red Star Belgrade and BATE Borisov drew 0-0.
Everton's season, like their search for a manager, continues to drift as an insipid display brought a 5-1 home Europa League home thrashing by Atalanta.
AC Milan were made to wait for confirmed qualification from the Europa League group stage after being held to a 0-0 draw in a mediocre game at AEK Athens.
Arsenal qualified from the Europa League group stage despite being held to a 0-0 home draw by Red Star Belgrade, with rivals BATE Borisov being thrashed 5-2 in Cologne.
Managerless Everton crashed out of the Europa League with two Group E games left to play as they were beaten 3-0 at Lyon.
Mario Balotelli gave Nice an early lead but it was not enough to prevent Lazio from emerging convincing 3-1 winners at the Stade de Nice.
Everton boss Ronald Koeman was forced to endure more disappointment as Lyon consigned his side to an ill-tempered defeat and more Europa League misery.
Olivier Giroud scored a stunning winner as a much-changed Arsenal side saw off 10-man Red Star Belgrade in their Europa League clash.
Theo Walcott scored twice and Olivier Giroud notched his 100th Arsenal goal as the Londoners secured a second successive Europa League win, triumphing 4-2 at BATE Borisov.