Kevin De Bruyne inspired Wolfsburg to a 3-1 win over Inter Milan to put the Germans in control of their Europa League last-16 tie.
Dnipro claimed a deserved win over Ajax from the first leg of their Europa League last-16 tie in Kiev, but may rue not building a bigger advantage to take to Amsterdam.
Zenit St Petersburg took a big step towards the Europa League quarterfinals with a 2-0 win over 10-man Torino in the first leg of their last-16 clash.
Everton will face Dynamo Kiev in the last 16 of the Europa League while holders Sevilla were drawn against fellow Spaniards Villarreal.
Liverpool lost their first European penalty shoot-out as Dejan Lovren was the only man to miss from the spot against Besiktas in Istanbul.
Torino got the better of a back-and-forth battle in torrential rain to eliminate Athletic Bilbao from the Europa League.
Roma progressed to the last 16 of the Europa League with victory over Feyenoord but the match was overshadowed by crowd trouble in Rotterdam.
Everton comfortably completed their progress into the last 16 of the Europa League as a Romelu Lukaku brace helped them beat Young Boys 3-1 at Goodison Park, sealing a 7-2 win on aggregate.
Celtic's Europa League campaign came to a frustrating end with a 1-0 defeat by Inter Milan at the San Siro after Hoops defender Virgil van Dijk was dismissed in the first half.
Roberto Soldado's embarrassing mistake paved the way for Tottenham's Europa League exit against Fiorentina.
Wolfsburg repelled a string of Sporting Lisbon attacks to reach the last 16 of the Europa League with a goalless draw in Portugal.
Sevilla put aside their domestic problems to move into the last 16 of the Europa League - although the reigning champions were made to sweat by Borussia Monchengladbach before claiming a 3-2 second-leg win.
Luciano Vietto scored twice as Villarreal booked their place in the last 16 of the Europa League.
Zenit St Petersburg eased to a 4-0 aggregate win over runaway Eredivisie leaders PSV Eindhoven to reach the last 16 of the Europa League.
Napoli cruised to a routine victory over Trabzonspor and confirmed their last-16 place in the Europa League in the process on Thursday night.
Substitute Mario Balotelli continued his penchant for late interventions with an 85th-minute penalty to give Liverpool a slender advantage to take to Istanbul in the last 32 of the Europa League.
Villarreal will take a narrow advantage into the second leg of their Europa League last-32 tie against Salzburg after a 2-1 win in Spain on Thursday night.
Napoli have one foot in the last 16 of the Europa League after claiming an emphatic 4-0 win at Trabzonspor.
Wolfsburg will take a 2-0 lead to Lisbon next week after the Bundesliga high-flyers claimed a comfortable victory over Sporting in the first-leg of their Europa League last-32 clash.
Substitute John Guidetti gave Celtic a dramatic Europa League lifeline with an injury-time leveller to draw 3-3 draw with Inter Milan at Parkhead.
Roberto Soldado's best moment in a Tottenham shirt was quickly followed by one to forget as he unnecessarily gave away the free-kick which allowed Fiorentina to secure a draw and what could prove a decisive away goal in this Europa League tie.
Everton look as good as assured of a place in the last 16 of the Europa League after a fine performance against Young Boys.
Liverpool will begin their Europa League campaign this season with a last-32 clash against Besiktas following Monday's draw at UEFA's headquarters in Nyon, Switzerland.
Substitutes Aaron Hunt and Nicklas Bendtner scored two apiece to inspire Wolfsburg to victory over Europa League Group F opponents FC Krasnodar.
Jose Antonio Reyes was on target as holders Sevilla were made to work to retain their position at the head of Europa League Group G.
Jonathan de Guzman scored a hat-trick as Napoli moved into the top half of Europa League Group I with a comfortable 3-0 home victory over Young Boys.
Manuel Pasqual spared Fiorentina from an embarrassing home defeat to PAOK Salonika by firing home the free-kick that sent the Italians into the Europa League knockout stages.
Everton took a major step towards the knockout stages of the Europa League as goals from Leon Osman, Phil Jagielka and Steven Naismith saw them claim a comfortable 3-0 victory over Lille at Goodison Park.
St Etienne denied Inter Milan the chance to secure their progression to the Europa League knockout stages by holding the Serie A club to a 1-1 draw at Stade Geoffroy-Guichard.
Tottenham continued their march towards the Europa League knock-out stages with victory in Greece, yet their shocking second-half display against Asteras Tripolis will be of major concern to Mauricio Pochettino.
Arsenal have been drawn against Swedish club Ostersunds FK in the Europa League round of 32, while Atletico Madrid take on Copenhagen.
Ademola Lookman's brace ensured a youthful Everton side did not miss Sam Allardyce's presence in Cyprus as they finished their woeful Europa League campaign with a victory.
AC Milan concluded their Europa League group stage with a 2-0 defeat at Croatian club Rijeka on Thursday.
Arsenal cruised to victory over BATE Borisov in their final Europa League group game as Arsene Wenger's fringe players made another case for Premier League involvement.
AC Milan booked their place in the Europa League's final 32 with a 5-1 win over Austria Vienna on Thursday night.
Arsenal failed to get the point they needed to guarantee topping Europa League Group H as Cologne beat them 1-0 in Germany -- but they finished first anyway as Red Star Belgrade and BATE Borisov drew 0-0.
Everton's season, like their search for a manager, continues to drift as an insipid display brought a 5-1 home Europa League home thrashing by Atalanta.
AC Milan were made to wait for confirmed qualification from the Europa League group stage after being held to a 0-0 draw in a mediocre game at AEK Athens.
Arsenal qualified from the Europa League group stage despite being held to a 0-0 home draw by Red Star Belgrade, with rivals BATE Borisov being thrashed 5-2 in Cologne.
Managerless Everton crashed out of the Europa League with two Group E games left to play as they were beaten 3-0 at Lyon.
Mario Balotelli gave Nice an early lead but it was not enough to prevent Lazio from emerging convincing 3-1 winners at the Stade de Nice.
Everton boss Ronald Koeman was forced to endure more disappointment as Lyon consigned his side to an ill-tempered defeat and more Europa League misery.
Olivier Giroud scored a stunning winner as a much-changed Arsenal side saw off 10-man Red Star Belgrade in their Europa League clash.
Theo Walcott scored twice and Olivier Giroud notched his 100th Arsenal goal as the Londoners secured a second successive Europa League win, triumphing 4-2 at BATE Borisov.
AC Milan lost a 2-0 lead at the San Siro but found an injury time goal to earn a 3-2 win over Croatian champions Rijeka in the Europa League.
Everton's poor start in the Europa League continued as they were held to a 2-2 draw at Goodison Park by Cypriot outfit Apollon Limassol, who finished the game with 10 men.
Arsenal came from behind to beat Cologne in their delayed Europa League opener against a backdrop of crowd trouble at the Emirates Stadium.
Everton produced another hugely disappointing display as they were beaten 3-0 by Atalanta in their Europa League Group E opener in Reggio Emilia.
Andre Silva scored a hat trick as AC Milan eased to a 5-1 victory over Austria Vienna in their Europa League group-stage opener.
Arsenal have been drawn alongside BATE Borisov, Cologne and Red Star Belgrade in the Europa League group stage.
AC Milan eased into the Europa League group stage with a 1-0 win over Shkendija on Thursday, though the result was in little doubt after the Rossoneri won the first leg 6-0 a week ago.
Gylfi Sigurdsson marked his first Everton start with a spectacular goal to help put Ronald Koeman's side into the group stages of the Europa League after a 1-1 away draw with Hajduk Split.
Everton play Croatian side Hajduk Split in the Europa League playoff round, while AC Milan have been drawn against Macedonian side Shkendija.
AC Milan are through to the Europa League playoff round after beating Universitatea Craiova 3-0 on aggregate following a 2-0 second-leg win in the third qualifying round on Thursday.
Dominic Calvert-Lewin's calm finish kept Everton's bid for Europa League qualification on course as Ronald Koeman's men edged MFK Ruzomberok 1-0 in Slovakia.
AC Milan's offseason spending spree paid a quick dividend when new signing Ricardo Rodriguez scored in a 1-0 win at CSU Craiova.
Wayne Rooney's Everton return threatened to turn into embarrassment before captain Leighton Baines struck to give his side a slender first-leg lead in their Europa League third qualifying round clash with Ruzemberok.
Ajax manager Peter Bosz was left unimpressed by Jose Mourinho's Manchester United in the wake of the Premier League side's 2-0 Europa League final triumph on Wednesday, though he admitted his side were deserved losers on the night.
Ander Herrera has admitted it was difficult for the Manchester United players to train in the build up to the Europa League final after the terrorist attack that devastated Manchester on Monday.
Jose Mourinho has labelled Manchester United's Europa League triumph as "the most important trophy" of his career, while adding he was happy to call time on a season that was perhaps his most difficult as a manager.