Champions League qualifiers FC Porto and Shakhtar Donetsk shared the spoils with a 1-1 draw in Portugal after their progress to the competition's last-16 had already been secured.
A goalless draw with Atletico Madrid in Turin was enough to secure Juventus their progression to the last 16 of the Champions League.
Olympiakos failed to qualify for the Champions League last 16 despite a 4-2 Group A victory over Malmo at the Karaiskakis Stadium.
Cristiano Ronaldo surpassed Raul's Champions League goals haul as Real Madrid thumped Ludogorets 4-0 to complete a flawless Group B campaign.
Monaco clawed their way to the Champions League's last 16 by overhauling Bayer Leverkusen to top Group C with a gritty 2-0 victory over Zenit St Petersburg.
Bayer Leverkusen had to settle for second place in Champions League Group C after they were held to a goalless draw by Benfica in Portugal.
Ciro Immobile's second-half goal was enough to make sure Borussia Dortmund finished top of Group D following a 1-1 Champions League draw against Anderlecht at the Westfalenstadion.
Arsenal produced the perfect response to silence their critics with a 4-1 Champions League win over Galatasaray in Istanbul, where Aaron Ramsey scored one of the goals of the season.
Ten-man Liverpool were masters of their own downfall as they exited the Champions League after coming up short in their must-win encounter at home to Basel.
Juventus ended their away day blues to reignite their chances of progressing from Group A of the Champions League with a 2-0 win over Malmo.
Mario Mandzukic's hat trick in a 4-0 win over Olympiakos saw Atletico Madrid qualify in emphatic style for the Champions League round of 16.
Lucas Ocampos' tap-in guided Monaco to a 1-0 Champions League victory at Bayer Leverkusen to ensure Group C is wide open.
Zenit St Petersburg captain Danny threw Andre Villas-Boas' side a Champions League lifeline as his goal earned them a patchy 1-0 victory over Benfica.
Anderlecht picked up their first win in the Champions League group stage with victory over 10-man Galatasaray, but still exited the competition after Arsenal beat Borussia Dortmund.
Arsenal put their recent troubles behind them to beat Borussia Dortmund 2-0 at the Emirates Stadium and qualify for the knockout stages of the Champions League with a match to spare.
Real Madrid ensured they will go through to the Champions League knockout stages as group winners after a 1-0 win over Basel.
Liverpool's Champions League hopes remain alive after their first goals in the competition since mid-September but a late Ludogorets equaliser saw them leave Bulgaria disappointed.
Lionel Messi became the record Champions League goalscorer and Luis Suarez opened his account for Barcelona as the Catalan giants cruised to a 4-0 win over APOEL Nicosia.
Sergio Aguero struck twice in the closing minutes to complete a hat-trick and revive Manchester City's Champions League hopes with a 3-2 win over 10-man Bayern Munich.
Roberto Di Matteo played down the talk of a revenge mission as Chelsea visited Gelsenkirchen to take on his Schalke side, but it was embarrassment that greeted the Italian as his former side eased into the knockout stages of the Champions League with a 5-
Hector Herrera helped ease Porto into pole position to claim top spot in Champions League Group H with a 3-0 victory over BATE Borisov.
Mikel San Jose kept Athletic Bilbao's European hopes alive by ending Shakhtar Donetsk's chances of topping Champions League Group H.
Paris Saint-Germain maintained their edge over Barcelona at the top of Champions League Group F with a comfortable 3-1 win over Ajax at the Parc des Princes.
Vasili Berezutski kept CSKA Moscow's Champions League campaign alive with a last-gasp equaliser against Roma which also did Manchester City a huge favour.
Lionel Messi equalled Raul's record of 71 Champions League goals with a brace to earn Barcelona a 2-0 win over Ajax in Group F.
Bayern Munich ensured they will finish top of Group E in the Champions League with two games to spare after a 2-0 victory over Roma.
Chelsea must wait to secure qualification from Champions League Group G after Eden Hazard missed a late penalty in a 1-1 draw against minnows Maribor.
Paris Saint-Germain caught Apoel Nicosia cold to open the scoring 58 seconds into their Champions League encounter in the French capital, and were glad they did as they endured growing frustration for the rest of the night.
For the second time in a fortnight BATE Borisov were thrashed by Shakhtar Donetsk, who followed up their 7-0 romp in Belarus with a 5-0 victory on Wednesday night.
In-form Porto sealed their place in the Champions League knockout stages with a 2-0 win over Group H strugglers Athletic Bilbao.
Cristiano Ronaldo scored a stunning first Champions League goal for Juventus but former club Manchester United fought back for a 2-1 win in Turin.
Real Madrid took a huge step towards clinching a spot in the Champions League knockout stage on Wednesday with a 5-0 rout of Viktoria Plzen as Karim Benzema scored two of four first-half goals for the Spanish giants.
Bayern Munich forward Robert Lewandowski scored once in each half to give his team a 2-0 victory over AEK Athens in the Champions League on Wednesday that put them two points clear at the top of Group E with two matches left.
Gabriel Jesus hit a hat-trick, including two penalties, as Manchester City marched closer to the knockout stage of the Champions League after crushing Ukraine's Shakhtar Donetsk 6-0 at the Etihad Stadium on Wednesday.
Ajax Amsterdam goalkeeper Andre Onana went from villain to hero as the Dutch side drew 1-1 at Benfica on Wednesday, gifting the hosts the lead before making a brilliant save with the last kick of the game to rescue a point.
Hoffenheim kept their slim hopes of extending their Champions League season afloat on Wednesday when they came back from 2-0 down to draw 2-2 with only 10 men at a rain-sodden Olympique Lyonnais.
Valencia's Carlos Soler had a hand in all three goals as they beat Young Boys 3-1 in the Champions League on Wednesday, boosting their last-16 hopes with their first home win of the season.
AS Roma put themselves on the brink of a place in the Champions League knockout stage when Lorenzo Pellegrini's first goal in the competition gave them a 2-1 win at 10-man CSKA Moscow on Wednesday.
Napoli and Paris Saint-Germain battled to a 1-1 draw in their Champions League match on Tuesday as Neymar produced a performance mixed with brilliance and petulance.
Tottenham's Champions League campaign is still alive after two late Harry Kane goals game them a 2-1 win over PSV Eindhoven at Wembley.
Porto all but guaranteed themselves a place in the knockout stage of the Champions League on Tuesday with a 4-1 win over Lokomotiv Moscow, who have yet to register a point in the competition.
Atletico Madrid dominated a toothless Borussia Dortmund to win 2-0 in their Champions League Group A match on Tuesday, exacting some revenge for last month's heavy loss in Germany and snapping their opponents' unbeaten run this season.
Barcelona qualified for the knockout stage of the Champions League on Tuesday after a compelling 1-1 draw away to Inter Milan as a late leveller from Mauro Icardi ended the Catalans' perfect record in this season's competition.
Liverpool face an uphill task to qualify for the knockout rounds of the Champions League after suffering a 2-0 defeat away to Red Star Belgrade.
Club Brugge kept their Champions League hopes alive on Tuesday with a crushing 4-0 win over AS Monaco that extended coach Thierry Henry's winless start in the principality to five games.
Mohamed Salah scored twice as Liverpool cruised to a 4-0 win over Red Star Belgrade in Champions League Group C action on Wednesday night.
Barcelona came through their first test without the injured Lionel Messi, earning a convincing 2-0 win at home to Inter Milan to take control of Champions League Group B on Wednesday.
Porto recovered from a shaky start to beat Lokomotiv Moscow 3-1 on Wednesday, with Mexico internationals Hector Herrera and Jesus Corona on the scoresheet.
Galatasaray missed the chance to overtake Schalke in the Champions League Group D standings as they were held to a 0-0 draw by the German side on Wednesday.
Big-spending Paris Saint-Germain avoided a defeat that could have derailed their Champions League campaign when Angel Di Maria curled in a delightful stoppage-time equaliser to rescue a 2-2 draw at home to Napoli on Wednesday.
Borussia Dortmund cruised past Atletico Madrid 4-0 in their Champions League match on Wednesday with two goals from substitute Raphael Guerreiro helping propel them to the top of Group A.
Monaco earned the first point of their disappointing Champions League campaign on Wednesday in their first European outing under Thierry Henry but their 1-1 draw at Club Brugge still left both sides with little chance of making the knockout stages.
Captain Luuk de Jong struck a late equaliser for PSV Eindhoven as they drew 2-2 with Tottenham Hotspur on Wednesday, a result that did little for either side's Champions League ambitions.
An impressive Juventus beat Manchester United 1-0 at Old Trafford on Tuesday to take command of Champions League Group H with a maximum nine points from three games and demonstrate just how far Jose Mourinho's side are from Europe's elite.
Manchester City began to pull their weight like proper Champions League heavyweights when they became the first English team to win at Shakhtar Donetsk in European competition with a 3-0 win in their group F match in Kharkiv on Tuesday.
Hoffenheim's Joelinton scored in stoppage time to give the German club a dramatic 3-3 draw against Olympique Lyon in a rollecoaster Champions League Group F match on Tuesday.
AS Roma's Edin Dzeko drew level with Barcelona's Lionel Messi at the top of this season's Champions League scoring charts as the Italians set the pace in Group G with a 3-0 win over CSKA Moscow at the Stadio Olimpico on Tuesday.
Real Madrid held onto a 2-1 win over Viktoria Plzen in Champions League Group G action on Tuesday.
Noussair Mazraoui scored an injury-time winner as Ajax claimed what could be a vital 1-0 win over Benfica in their Champions League Group E clash at the Johan Cruyff Arena on Tuesday.
Champions League debutants Young Boys scored their first goal and picked up their first ever point in the competition with a deserved 1-1 draw at home to Valencia on Tuesday.